Objective To evaluate the correlation between vancomycin serum trough concentration and its clinical efficacy and safety. Methods A retrospective study was conducted to investigate the relationship between serum concentration of vancomycin and the effect of vancomycin and the renal toxicity of vancomycin in 118 patients who were examined as Gram-positive bacterial infection.Specifically,we measured the serum trough concentration of vancomycin in the department of ICU of our hospital. Results Patients were stratified into three groups according to the concentration of serum trough levels of vancomycin.The majority in the three groups were all elderly male patients.Nearly half of the patients had no standard blood concentration,and half of the patients in the unsatisfied concentration groups did not receive continuous monitoring of drug concentration.With the increase of vancomycin concentration,the creatinine level gradually increased,and the proportion of patients who had continuously monitored the concentration of drugs increased.There was no statistical correlation between serum drug concentration and the improvement of blood index and clinical total effective ratio.With the increase of serum concentration of vancomycin,the incidence of nephrotoxicity increased,but it was not statistically significant.The level of serum creatinine in patients with nephrotoxicity was significantly higher than that in patients without renal toxicity. Conclusion The standardized drug concentration monitoring ensures the safty and effectiveness of the clinical application of vancomycin.Especially for patients with renal impairment,the monitoring of serum drug concentration should be paid more attention to reduce the renal toxicity.
Labeled Immunoassays and Clinical Medicine
Therapeutic drug monitoring