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干细胞治疗皮肤缺损:是未来研究的重点 预览

Stem cells in the treatment of skin defects: a focus of future research
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摘要 背景:干细胞作为一种具备自我更新和多向分化能力的特殊细胞,有潜力应用于治疗皮肤缺损,并因其来源丰富、低免疫原性、能够分化为多个谱系细胞等特性,有望克服现有治疗手段的局限性并发展为新的治疗手段。目的:阐明不同干细胞治疗皮肤缺损的机制及研究热点,寻求一种能够符合临床需求的细胞来源。方法:由第一作者检索1998至2018年PubMed数据库收录的与干细胞治疗皮肤缺损相关的文献。检索词为"stem cell,skin defect,wound healing",按纳入、排除标准最后共纳入文献63篇进行综述。结果与结论:干细胞在皮肤缺损治疗上具有巨大潜力,其不仅可以重建损伤的组织,而且可以通过免疫调节及血管新生促进伤口愈合。间充质干细胞与其他种类干细胞相比拥有更大优势,近年来间充质干细胞应用于皮肤缺损修复的研究取得了令人满意的结果,成为目前最理想的细胞来源,也是未来研究的重点。 BACKGROUND: As a kind of special cells capable of self-renewal and multidirectional differentiation, stem cells have the potential in the treatment of skin defects. Owing to their rich sources, low immunogenicity, and multipotent differentiation ability, stem cells are expected to overcome the limitations of existing therapies and develop into new therapies.OBJECTIVE: To overview the mechanisms and research focus of different stem cells in the treatment of skin defects, and to seek a kind of stem cells that meet clinical needs.METHODS: The first author retrieved the databases of PubMed for relevant articles about stem cell-based therapies for skin defects published from 1998 to 2018. The key words were "stem cell, skin defect, wound healing" in English. In accordance with the inclusion and exclusion criteria, 63 articles were finally reviewed.?RESULTS AND CONCLUSION: Stem cells have tremendous potential in the treatment of skin defects. These cells cannot only regenerate damaged tissue, but also promote the wound healing by immunomodulation and angiogenesis. Compared with other types of stem cells, mesenchymal stem cells have more advantages. Studies concerning mesenchymal stem cells have achieved satisfactory results in recent years. Mesenchymal stem cells have become the most ideal cells for the treatment of skin defects, and they are also the focus of future research.
作者 刘博宇 蒲磊 张应杰 杨应南 李亚雄 Liu Boyu;Pu Lei;Zhang Yingjie;Yang Yingnan;Li Yaxiong(Department of Cardiovascular Surgery, AffiliatedYan’an Hospital of Kunming Medical University, Kunming 650051, Yunnan Province, China)
出处 《中国组织工程研究》 CAS 北大核心 2019年第25期4082-4088,共7页 Journal of Clinical Rehabilitative Tissue Engineering Research
基金 云南省科技人才和平台计划(2018DG008).
关键词 干细胞 间充质干细胞 皮肤缺损 伤口愈合 免疫调节 血管新生 细胞分化 stem cells mesenchymal stem cells skin defect wound healing immune regulation angiogenesis cell differentiation
作者简介 刘博宇,男,1993年生,云南省昆明市人,汉族,2019年昆明医科大学毕业,硕士,主要从事间充质干细胞研究;通讯作者:李亚雄,教授,昆明医科大学附属延安医院心脏大血管外科,云南省昆明市 650051.
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