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Usher综合征患者血清离子浓度的变化 预览

Changes in the serum ion concentration in patients with Usher syndrome
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摘要 目的探讨Usher综合征(Usher syndrome,USH)患者血清离子浓度的变化情况。方法选取2015年9月至2018年9月北京同仁医院眼科中心的46例临床诊断为USH患者作为USH组;同时选取同期于北京同仁医院体检中心体检的90例正常人为对照组。检测各组受试者血清离子浓度。将USH组与对照组的各血清离子浓度进行比较。结果 USH组患者血清钙离子浓度为(2.364±0.101)mmol·L-1,高于对照组的血清钙离子浓度(2.304±0.082)mmol·L-1,差异有统计学意义(P=0.000);USH组患者钾离子浓度为(4.124±0.360)mmol·L-1,高于对照组的钾离子浓度(3.965±0.288)mmol·L-1,差异有统计学意义(P=0.006);两组间的钠离子、氯离子、无机磷离子浓度相比,差异均无统计学意义(均为P>0.05)。结论 USH患者的钙离子与钾离子浓度异常,这种异常可能与其发病有关。 Objective To investigate concentration changes of the serum ions in the patients of Usher syndrome(USH).Methods Based on case-control,46 patients with USH(USH group)were enrolled and 90 matched healthy volunteers from Physical Examination Center of Our Hospital(control group)were collected as controls.The serum ion concentration is tested blindly by a professionals in hospital.Data were analyzed statistically between USH group and control group.Results The concentration of calcium(2.364±0.101)mmol·L-1 in USH group was higher those(2.304±0.082)mmol·L-1 in control group,and the difference was statistically significant(P=0.000);Meanwhile the concentration of potassium(4.124±0.360)mmol·L-1 in USH group was higher than those(3.965±0.288)mmol·L-1 in control group,and the difference was statistically significant(P=0.006).While there was no statistical difference in sodium ion concentration,chloride concentration and phosphorus concentration between two groups(all P>0.05).Conclusion The concentration of calcium and potassium are abnormal in patients of USH,which may be related to its pathogenesis.The conclusion may provide new ideas for the intervention of USH.
作者 代贺华 张芷萌 王蕾 陶天畅 许静 李如意 李根林 DAI He-Hua;ZHANG Zhi-Meng;WANG Lei;TAO Tian-Chang;XU Jing;LI Ru-Yi;LI Gen-Lin(Beijing Tongren Eye Center,Beijing Tongren Hospital of Capital Medical University,Beijing Ophthalmology & Visual Sciences Key Laboratory,Beijing 100730,China)
出处 《眼科新进展》 CAS 北大核心 2019年第7期645-648,共4页 Recent Advances in Ophthalmology
基金 国家自然科学基金资助(编号:81271046) 北京市自然科学基金项目暨北京市教育委员会科技发展计划重点项目(编号KZ201510025025).
关键词 USHER综合征 血清浓度 钙离子 钾离子 钠离子 氯离子 无机磷离子 Usher syndrome serum concentration calcium potassium sodium chloride phosphorus
作者简介 代贺华,女,1987年3月出生,山东泰安人,硕士。联系电话:18801120171;E-mail:724528287@qq.com;通讯作者:李根林,E-mail:ligenglin@263.net.
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