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探讨多种血清指标联合检测在评估糖尿病周围神经病变中的应用价值 预览

Application value of multiple serum factors combination test in the evaluation of diabetic peripheral neuropathy
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摘要 目的探讨血清C肽(C-PR)、胱抑素C(Cys-C)和同型半胱氨酸(Hcy)在评估糖尿病周围神经病变(DPN)中的价值。方法选取2016年5月至2017年5月到某院就诊并确诊为DPN的患者70例为观察组,选取单纯糖尿病患者70例为对照组。通过比浊法进行生化指标的检测,高效液相色谱层析法进行HbA1c的检测,采用东芝2000全自动生化分析仪对血清C-PR进行检测。比较两组的各项指标(包含血清C-PR、Cys-C和Hcy)的含量变化。选取可能会对DPN产生影响的因素进行多因素Logistics分析,评估DPN的危险因素。结果与对照组相比,观察组中的血清C-PR的含量低于对照组(P<0.01),Cys-C和Hcy的含量均高于对照组(P<0.01);血清C-PR、Cys-C和Hcy为DPN发病的主要危险因素(P<0.05)。结论血清C-PR、Cys-C和Hcy这些指标与DPN的病情发展有密切的关系,可以有效地分析评估DPN的发生。 Objective To investigate the value of serum C-peptide(C-PR);cystatin C(Cys-C) and homocysteine (Hcy) in the evaluation of diabetic peripheral neuropathy(DPN).Methods 70 patients with diabetes peripheral neuropathy (DPN) admitted in a hospital from May 2016 to May 2017 were selected as the observation group while 70 patients with diabetes were selected as the control group.By means of the turbidimetric method to detect biochemical indicators;HbA1c was detected by high performance liquid chromatography and serum C-PR was detected by Toshiba 2000 automatic biochemical analyzer.The change of contents of serum C-PR;Cys-C and Hcy were compared between the two groups.The factors that might affect DPN were selected and given logistics analysis.Results Compared with the control group;the content of serum C-PR in the observation group was lower than that of the control group(P<0.01) while the content of Cys-C and Hcy were higher than those of the control group(P<0.01).Serum C-PR;Cys-C and Hcy were the main risk factors for DPN(P<0.05).Conclusion Serum C-PR;Cys-C and Hcy were closely related to the development of DPN and could effectively analyze and evaluate the occurrence of DPN.
作者 黄莹 Huang Ying(不详)
出处 《中国疗养医学》 2019年第7期686-688,共3页 Chinese Journal of Convalescent Medicine
关键词 糖尿病 周围神经病变 血清C肽 胱抑素C 同型半胱氨酸 Diabetes Peripheral neuropathy Serum C peptide Cystatin C Homocysteine
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