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度洛西汀与氯米帕明治疗强迫障碍的疗效对照研究 预览

A comparative study of duloxetine and clomipramine in the treatment of obsessive-compulsive disorder
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摘要 目的探讨度洛西汀与氯米帕明在强迫障碍临床治疗中的应用效果。方法108例强迫障碍患者作为研究对象,随机分为观察组和对照组,每组54例。两组患者均接受心理治疗,在此基础上,观察组患者给予度洛西汀治疗,对照组患者给予氯米帕明治疗。观察比较两组患者的治疗前后症状改善情况、治疗期间副反应量表(TESS)评分。结果治疗后,两组患者的Yale-Brown强迫量表(Y-BOCS)评分、焦虑自评量表(SAS)评分和简明精神病评定量表(BPRS)评分均明显低于治疗前,且观察组患者的Y-BOCS、SAS及BPRS评分分别为(7.22±3.28)、(38.74±2.89)、(23.14±4.45)分,均明显低于对照组的(12.54±3.41)、(50.03±2.45)、(28.05±5.14)分,差异均有统计学意义(P<0.05)。观察组患者治疗后2、4、8周的TESS评分分别为(3.02±0.65)、(2.89±0.52)、(2.46±0.63)分,均明显低于对照组的(10.11±1.42)、(9.64±1.31)、(9.18±1.55)分,差异均有统计学意义(P<0.05)。结论在强迫障碍的药物治疗中,度洛西汀与氯米帕明均有良好的应用效果,其中度洛西汀在疗效和安全性方面有着显著优势。 Objective To discuss the application effect of duloxetine and clomipramine in the treatment of obsessive-compulsive disorder.Methods A total of 108 patients with obsessive-compulsive disorder as study subjects were randomly divided into observation group and control group,with 54 cases in each group.Both groups received psychological therapy,and on its basis,the observation group was treated with duloxetine.The control group was treated with clomipramine.The symptom improvement before and after treatment and treatment emergent symptom scale (TESS) score was observed and compared in two groups.Results After treatment,both groups had obviously lower Yale-Brown obsessive-compulsive scale (Y-BOCS) score,self-rating anxiety scale (SAS) score and brief psychiatric ratmg scale (BPRS) score than those before treatment,and the observation group had obviously lower Y-BOCS,SAS and BPRS score respectively as (7.22±3.28),(38.74±2.89) and (23.14± 4.45) points than (12.54±3.41),(50.03±2.45) and (28.05±5.14) points in the control group.Their difference was statistically significant (P<0.05).After 2,4 and 8 weeks of treatment,observation group had obviously lower TESS score respectively as (3.02±0.65),(2.89±0.52) and (2.46±0.63) points than (10.11±1.42),(9.64±1.31) and (9.18±1.55) points in the control group.Their difference was statistically significant (P<0.05).Conclusion Duloxetine and clomipramine have good effects in the treatment of obsessive-compulsive disorder,and duloxetine has significant advantages in efficacy and safety.
作者 秦海燕 QIN Hai-yan(Department of Psychological Rehabilitation,Liaocheng Fourth People’s Hospital,Liaocheng 252000,China)
出处 《中国现代药物应用》 2019年第13期12-14,共3页 Chinese Journal of Modern Drug Application
关键词 度洛西汀 氯米帕明 强迫障碍 Duloxetine Clomipramine Obsessive-compulsive disorder
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