ObjectiveTo explore the level of serum progranulin (PGRN) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its clinical significance. Methods Ninety-seven patients with AECOPD (AECOPD group) were selected, and there were 21 cases in grade Ⅰ, 30 cases in grade Ⅱ, 27 cases in grade Ⅲ, and 19 cases in grade Ⅳ according to the classification of pulmonary function. During the same period, 60 stable COPD patients (SCOPD group) and 60 healthy persons (control group) were selected. Fasting elbow venous blood was collected from all subjects in the morning, the serum PGRN was detected by ELISA. The forced expiratory volume in the first second (FEV 1) and forced vital capacity (FVC) were measured by Masterscope pulmonary function instrument in quiet environment, and FEV 1/FVC was calculated. The changes of serum PGRN level and FEV 1, FVC and FEV 1/FVC in the three groups were compared, and the changes of the above indexes in the AECOPD patients with different pulmonary function grades were compared. Pearson correlation analysis was used to analyze the relationships between serum PGRN level and FEV 1, FVC, and FEV 1/FVC in patients with AECOPD. Twenty AECOPD patients died and 77 survived within 28 days of admission, the serum levels of PGRN in survivors and dead patients were compared, the predictive value ratio of serum PGRN to AECOPD mortality was evaluated by receiver operating characteristic curve (ROC). Results Serum PGRN levels in the AECOPD group, SCOPD group, and control group decreased gradually, while FEV 1, FVC and FEV 1/FVC increased gradually, with statistically significant difference (all P<0.05). With the increase of pulmonary function grading, the serum PGRN levels in AECOPD patients increased gradually, while FEV 1, FVC and FEV 1/FVC decreased gradually (all P< 0.05 ). Pearson correlation analysis showed that the serum PGRN levels in AECOPD patients were negatively correlated with FEV 1, FVC and FEV 1/FVC (r=-0.672,-0.716, and -0.758, respectively;all P<0.05).
Shandong Medical Journal
acute exacerbation of chronic obstructive pulmonary disease
receiver operating characteristic curve