背景小儿腹泻为一种由多种病原体和因素导致的疾病,腹痛、发热、大便次数增多和大便性状改变为其主要临床表现.近年来针对小儿腹泻研究表明,肠道微生态的重建在小儿腹泻治疗中有重大意义.本文主要探讨思连康(双歧杆菌四联活菌片)治疗小儿非感染性腹泻的临床疗效及其对患儿血清炎症因子的影响.目的探究思连康治疗小儿非感染性腹泻的临床疗效及其对血清炎症因子的影响.方法选择2015-08/2017-08到浙江省医疗健康集团杭州医院治疗的90例非感染性腹泻小儿患者作为研究对象,按照随机数表法将患者分为观察组与对照组,每组45例.对照组采用补液、纠酸等常规治疗方法,观察组在常规治疗基础上给予思连康治疗,对两组患儿的临床疗效进行记录分析,并检测患儿血清中的炎症因子水平.结果治疗后两组患儿的大便次数和大便性状评分较治疗前均明显降低,但观察组改善效果更好,两组比较有统计学意义(P <0.05).观察组的腹痛和呕吐症状缓解时间、止泻及粪便成形时间明显短于对照组,两组比较有统计学意义(P <0.05).观察组患儿治疗有效率为88.88%,明显高于对照组患者的有效率73.33%,两组比较有统计学意义(P <0.05).治疗前两组患儿的炎症因子水平相近,但治疗后观察组患儿的超敏C反应蛋白、肿瘤坏死因子α、白介素6及白介素10水平明显低于治疗前和对照组,其差异比较有统计学意义(P <0.05).结论在小儿非感染性腹泻的治疗中,思连康优于常规治疗方法,临床症状改善效果良好,其治疗有效率较高,能明显降低炎症因子水平.其疗效显著,值得临床推广和应用.
BACKGROUND Pediatric diarrhea is a disease caused by a variety of pathogens and factors, with abdominal pain, fever, increased frequency of stools, and changes in stool characteristics being its main clinical manifestations. In recent years, studies on diarrhea in children have shown that the reconstruction of intestinal micro-ecology is of great significance in the treatment of diarrhea in children. This study mainly explored the clinical efficacy of Si Liankang (Bifidobacterium quadruple live bacteria tablets) in the treatment of non-infectious diarrhea in children and its effect on serum inflammatory factors. AIM To investigate the clinical efficacy of Si Liankang in the treatment of non-infectious diarrhea in children and its effect on serum inflammatory factors. METHODS A total of 90 children with non-infectious diarrhea who were treated at our hospital from August 2015 to August 2017 were selected as study subjects. The patients were randomly divided into either an observation group or a control group, with 45 cases in each group. The control group was treated by conventional methods such as fluid replacement and acid correction. The observation group was treated with Si Liankang on the basis of conventional treatment. The clinical efficacy of the two groups was recorded and analyzed, and serum levels of inflammatory factors were detected. RESULTS After treatment, the stool frequency and stool trait scores of the two groups were significantly lower than those before treatment, but the improvement was more significant in the observation group (P < 0.05). The times to relief of abdominal pain, vomiting, and diarrhea and recovery of normal stool were significantly shorter in the observation group than in the control group (P < 0.05). The effective rate in the observation group was 88.88%, which was significantly higher than that in the control group (73.33%;P < 0.05). The levels of inflammatory factors were similar in the two groups before treatment, but the levels of hypersensitive C-reactive protein, tumor n
World Chinese Journal of Digestology