目的探讨液基细胞学检查(TCT)、高危型人乳头瘤病毒(HPV)联合阴道镜在宫颈癌前病变筛查中的应用价值。方法采用回顾性方法分析,选取123例疑似宫颈癌患者的临床资料,所有患者均给予阴道镜检查、TCT检查、HPV检查,比较三种检查结果。结果 TCT与HPV联合检测的阳性率达到100%,有较严重的宫颈病变。CINⅢ及鳞状细胞癌的检出率均高于CINⅠ、CINⅡ,其差异有统计学意义(P <0. 05)。HPV+TCT的检出率为100%,TCT、HPV的检出率分别为79. 67%、93. 59%,两者进行对比分析,其差异有统计学意义(P <0. 05)。液基细胞联合HPV检查的敏感度(94. 12%)与准确度(93. 67%)高于液基细胞(83. 23%、87. 45%)、HPV检查(84. 34%、89. 56%),经过统计学分析,其差异有统计学意义(P <0. 05)。结论临床采用TCT、HPV联合阴道镜检查可提高宫颈癌癌前病变筛查的检出率,有着较高的敏感性、准确度,值得临床推广应用。
Objective To evaluate the value of liquid-based cytology test( TCT) and high-risk human papillomavirus( HPV) combined colposcopy in the screening of cervical precancerous lesions. Methods Retrospective analysis was used to select 123 patients with suspected cervical cancer. All patients were given colposcopy,TCT,and HPV examination. Results The positive rate of combined detection of TCT and HPV reached 100%,with severe cervical lesions. The detection rate of CINⅢ and squamous cell carcinoma was higher than that of CINⅠ and CINⅡ,and the difference was statistically significant( P < 0. 05).The detection rate of HPV + TCT was 100%,and the detection rates of TCT and HPV were 79. 67% and 93. 59% respectively.There was a significant difference between the 2 groups( P < 0. 05). The sensitivity( 94. 12%) and accuracy( 93. 67%) of liquid-based cells combined with HPV examination were higher than those of liquid-based cells( 83. 23%,87. 45%),HPV tests( 84. 34%,89. 56%),and the differences were statistically significant( P < 0. 05). Conclusion The clinical use of TCT,HPV combined colposcopy can improve the detection rate of precancerous lesions of cervical cancer,has a high sensitivity,accuracy,and is worthy of clinical application.
The Practical Journal of Cancer