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机械取栓器取栓效果的影响因素

Influence Factors of the Thrombectomy Effects for Mechanical Thrombectomy Devices
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摘要 目的研究取栓口形状、抽吸流量以及血流速度对旋切抽吸式取栓器血栓抽吸效果的影响,为旋切抽吸式取栓器的设计和优化提供理论支持。方法建立3种取栓口("L"、"8"和"0"型)模型,研究取栓口形状对取栓的影响;以"8"型取栓口为基础,设置不同抽吸流量(75、100、125、150 mL/min)以及不同血液入口流速(0~10 cm/s,间距为1 cm/s),分析抽吸流量和血液流速对取栓效果的影响。结果"L"型取栓口无法均匀地抽吸血栓,"8"型与"0"型取栓口的取栓效果差别不大,但"8"型取栓口附壁血栓清除率优于"0"型取栓口。当抽吸流量大于100mL/min时,继续增大抽吸流量对取栓效果的提升有限。当血液流速小于1cm/s时,抽吸效果最佳;随着血流速度增加,取栓效果逐渐下降。结论取栓口的形状、抽吸流量以及血液流速对取栓效果影响明显。选择宽而短的取栓口形状设计、适当提高抽吸流量以及降低血液流速,对取栓效果的提升有显著影响。研究结果可为旋切抽吸式取栓器的优化设计作指导。 Objective To investigate the influence of thrombus entrance shape, suction rate and blood flow velocity on thrombus aspiration of rotary cutting and suctioned thrombectomy devices, so as to provide theoretical support for the design and optimization of such devices. Methods Three models with different thrombus entrance shapes(‘L’-style,‘8’-style and ‘0’-style) were established to study the influence of thrombus entrance shape on the thrombectomy;different suction rates(75, 100, 125, 150 mL/min) and different blood flow velocities(0-10 cm/s, at interval of 1 cm/s) were set to discuss how the suction rate and blood flow velocity affected the thrombectomy based on ‘8’-style thrombus entrance. Results The thrombus could not be aspirated evenly in ‘L’-style model, and there was no significantly difference in aspiration between ‘8’-style model and ‘0’-style model. But the ‘8’-style model was better than ‘0’-style model in lateral thrombus suction. The suction rate that was greater than 100 mL/min provided a limited effect on improvement of thrombectomy effect. The best suction effect was reached when blood flow velocity was less than 1 cm/s, and the effect of thrombectomy was decreasing gradually with blood flow velocity increasing. Conclusions The thrombus entrance shape, suction rate and blood flow velocity had a great impact on thrombectomy greatly. A wide and short thrombus entrance shape, an appropriate increase of suction rate and decrease of blood flow velocity would contribute significantly to the improvement of thrombectomy effect. These results can be used as guidance for the optimal design of rotary cutting and suctioned thrombectomy devices.
作者 陆立程 谷雪莲 王陶涛 LU Licheng;GU Xuelian;WANG Taotao(School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093, China)
出处 《医用生物力学》 CAS CSCD 北大核心 2019年第3期289-294,共6页 Journal of Medical Biomechanics
基金 上海市生物医学工程研究生示范实践基地(1017308011) 微创励志创新基金(YS30810147).
关键词 机械取栓器 计算流体力学 抽吸流量 取栓效果 mechanical thrombectomy device computational fluid dynamic(CFD) suction rate thrombectomy effect
作者简介 通信作者:谷雪莲,副教授,E-mail:guxuelian@usst.edu.cn.
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