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猪去氧胆酸合成熊去氧胆酸的研究进展

Progress on the synthesis of ursodeoxycholic acid from hyodeoxycholic acid
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摘要 临床上用于治疗肝胆疾病的熊去氧胆酸最初是从熊的胆汁中提取得到,受熊胆汁来源的限制目前主要是以胆酸为原料合成而得。之后随着鹅去氧胆酸提取工艺和鹅去氧胆酸合成熊去氧胆酸工艺的成熟,鹅去氧胆酸逐渐代替胆酸成为生产熊去氧胆酸的主要原料。由于猪去氧胆酸来源丰富、价格低廉,近几年由猪去氧胆酸合成熊去氧胆酸的研究成为甾类药物合成研究的热点之一。本文对这一领域的研究进展进行综述,以期为相关研究提供有价值的参考。 Ursodeoxycholic acid,a drug for the treatment of hepatobiliary disease,was initially extracted from the bear bile.With the increase in the amount of clinical applications,it begins to be synthesized by cholic acid.Because the cost of ursodeoxycholic acid by using chenodeoxycholic acid is lower than cholic acid,after the industrialized production of chenodeoxycholic acid,it has gradually replaced cholic acid as the raw material for the synthesis of ursodeoxycholic acid.In recent years,the synthesis of ursodeoxycholic acid from hyodeoxycholic acid has become one of the hot spots in the research of steroid drug synthesis due to hyodeoxycholic acid is rich and low in price.In this paper,the research progress in recent years is reviewed in order to provide guidance for the relevant researchers.
作者 胡祥正 史小亚 HU Xiang-zheng;SHI Xiao-ya(College of Chemical Engineering and Materials Science,Tianjin University of Science and Technology,Tianjin 300457,China;College of Food Engineering and Biotechnology,Tianjin University of Science and Technology,Tianjin 300457,China)
出处 《中国药物化学杂志》 CAS CSCD 北大核心 2019年第3期224-233,共10页 Chinese Journal of Medicinal Chemistry
基金 天津科技计划项目(14ZXCXSY00109,14RCH2SY00159).
关键词 猪去氧胆酸 鹅去氧甲酸 熊去氧胆酸 化学合成 hyodeoxycholic acid chenodeoxycholic acid ursodeoxycholic acid chemical synthesis
作者简介 胡祥正(1968-),男(汉族),天津人,教授,博士,主要从事天然产物的开发与应用,Tel:13802023915,E-mail:2350292763@qq.com。
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