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两性霉素B制剂及肾损害的研究进展 预览

Research Progress of Amphotericin B Preparations and Renal Damage
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摘要 两性霉素B对绝大部分真菌治疗有效且具有广谱抗真菌活性,目前临床主要用于治疗深部真菌感染。两性霉素B的耐药菌株相对较少,但仍可作为真菌病治疗最有效的药物。但两性霉素B具有严重的不良反应,尤其是肾毒性即肾损害从而限制其临床应用。新剂型两性霉素B通过改变两性霉素B在体内的分布及代谢可以降低肾损害等不良反应的发生率。故临床探究两性霉素B不同制剂的作用机制及其肾损害成为关键问题,从而为临床诊断与防治肾损害提供重要参考。 Amphotericin B is effective in the treatment of most fungi and has broad-spectrum antifungal activity,which is currently widely used in the treatment of deep fungal infections.Amphotericin B has relatively few resistant strains,but it can still be used as the most effective drug for fungal treatment.However,amphotericin B has serious adverse reactions and side effects,especially nephrotoxicity,that is,renal damage,which limits its clinical application.New dosage forms of amphotericin B could reduce the incidence of renal damage and other adverse reactions by changing its distribution and metabolism in vivo.Therefore,exploring the mechanism of action of different amphotericin B preparations and their renal damage has become a key clinical issue,so as to provide important reference for the diagnosis and prevention of renal damage.
作者 张剑 吴晓娇 苏兰 刘春雨 陈泽莲 ZHANG Jian;WU Xiaojiao;SU Lan;LIU Chunyu;CHEN Zelian(Department of Clinical Pharmacy,West China Hospital of Sichuan University,Chengdu 610000,China)
出处 《医学综述》 2019年第14期2868-2871,2878共5页 Medical Recapitulate
关键词 两性霉素B 肾损害 真菌感染 Amphotericin B Renal damage Fungal infections
作者简介 通信作者:陈泽莲,E-mail:mjf0202@163.com.
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