期刊文献+

治疗脊髓损伤之建立星形胶质细胞模型的研究进展 预览

Advances in research of the establishment of astrocyte models for treatment of spinal cord injury
在线阅读 下载PDF
收藏 分享 导出
摘要 脊髓损伤(spinal cord injury,SCI)是一种极为复杂的破坏性疾病,一旦脊髓损伤发生,治疗棘手,对患者家庭、国家带来巨大的经济、社会负担。近年来,通过建立大鼠脊髓损伤细胞相关模型,对于脊髓损伤的病因病机治疗等方面有了进一步的认识,而星形胶质细胞模型的建立对脊髓损伤治疗有深远意义。研究发现,星形胶质细胞作为靶细胞通过血-脑脊液屏障直接或间接对脊髓损伤有双向调控作用。本文通过对近年来星形胶质细胞模型培养制备方案等研究进行总结,以期为建立一个客观化、定量化、可模拟化的星形胶质细胞模型提供指导对脊髓损伤的治疗提供新的思路。 Spinal cord injury is an extremely complex and debilitating condition.Once spinal cord injury occurs,it is difficult to treat,and thus poses a great economic and social burden to both caregivers and healthcare resources.In recent years,the establishment of rat spinal cord injury cell models has contributed to our understanding of the etiology and pathogenesis of spinal cord injury,in particular,the establishment of an astrocyte model has a profound significance for the treatment of spinal cord injury.Studies have found that astrocytes,as target cells that can effectively promote tissue protection and functional repair after spinal cord injury,directly or indirectly regulate spinal cord injury through blood-brain barrier barrier.This paper reviews the recent studies on the preparation of astrocyte culture models to provide guidance for the establishment of an objective,quantitative,and simulative astrocyte model,and presents new ideas for the treatment of spinal cord injury.
作者 杜凯然 邓强 张彦军 朱宝 马同 彭冉东 李军杰 徐浩军 王雨榕 郭挺 DU Kairan;DENG Qiang;ZHANG Yanjun;ZHU Bao;MA Tong;PENG Randong;LI Junjie;XU Haojun;WANG Yurong;GUO Ting(Gansu University of Traditional Chinese Medicine,Clinical College of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of TCM,Division 2 of the Spinal Column,Lanzhou 730050)
出处 《中国实验动物学报》 CAS CSCD 北大核心 2019年第4期540-544,共5页 Acta Laboratorium Animalis Scientia Sinica
基金 国家自然科学基金(8186150544)。
关键词 脊髓损伤 星形胶质细胞 细胞造模 血-脑脊液屏障 小胶质细胞 spinal cord injury astrocytes cell modeling blood-brain barrier microglia
作者简介 杜凯然(1993—),男,硕士研究生在读,主要从事脊髓损伤防治及治疗。Email:616361469@qq.com;通信作者:邓强,男,硕士,主任医师,教授,硕士生导师,主要从事中医药防治脊柱相关疾病。Email:dengqiang11576@sohu.com.
  • 相关文献
投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈