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肺表面活性物质联合呼吸机治疗新生儿胎粪吸入综合征的效果 预览

Effect of pulmonary surfactant combined with ventilator in treatment of neonatal meconium aspiration syndrome
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摘要 目的评价肺表面活性物质(PS)联合呼吸机治疗新生儿胎粪吸入综合征(MAS)的临床效果.方法将本院收治的200例MAS患儿按数字随机表法分为对照组(n=100)、观察组(n=100),对照组接受呼吸机治疗,观察组在对照组基础上接受PS治疗.比较2组患儿肺氧合功能及并发症发生率.结果观察组治疗后肺氧合功能、血气分析指标较对照组显著改善,治疗12、24h平均气道压(MAP)、吸入气氧浓度(FiO2)低于对照组,上机时间短于对照组,呼吸机相关性肺炎、肺气漏发生率、病死率低于对照组,差异有统计学意义(P<0.05).结论PS联合呼吸机治疗MAS效果理想,可改善肺功能,降低并发症发生率. Objective To evaluate the clinical effect of pulmonary surfactant (PS) combined with ventilator in the treatment of neonatal meconium aspiration syndrome (MAS). Methods A total of 200 children with MAS admitted to our hospital were randomly divided into control group ( n = 100) and observation group ( n =100). The control group received ventilator treatment, and the observation group received PS treatment on the basis of the control group. The pulmonary oxygenation function and incidence of complication were compared between the two groups. Results After treatment, the pulmonary oxygenation function and blood gas analysis indicators were improved compared with the control group;the mean airway pressure(MAP) and fraction of inspiration oxygen(FiO 2) were lower than that of the control group at 12 and 24 h after treatment. The application time of ventilator was shorter than that of the control group. The incidence of ventilator-associated pneumonia and lung air leakage as well as mortality were lower than that of the control group, there were significant differences in two groups ( P <0.05). Conclusion PS combined with ventilator for MAS has ideal therapeutic efficacy, which can improve lung function, and reduce the incidence of complications.
作者 张彬钰 王辉 杜芸芸 ZHANG Binyu;WANG Hui;DU Yunyun(Neonates Department, Ankang City Maternal and Child Health Care Hospital in ShaanxiProvince, Ankang, Shaanxi, 725000;Department of Pediatrics, Ziyang County People′s Hospital in Shaanxi Province, Ankang, Shaanxi, 725399)
出处 《实用临床医药杂志》 CAS 2019年第15期53-55,59共4页 Journal of Clinical Medicine in Practice
关键词 肺表面活性物质 呼吸机相关性肺炎 新生儿胎粪吸入综合征 肺功能 肺气漏 pulmonary surfactant ventilator-associated pneumonia neonatal meconium aspiration syndrome pulmonary function lung air leakage
作者简介 通信作者:杜芸芸,E-mail:251973948@qq.com.
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