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普萘洛尔与甲巯咪唑治疗甲状腺功能亢进的效果 预览

Effect of Propranolol and Methimazole on Hyperthyroidism
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摘要 目的探讨普萘洛尔与甲巯咪唑联合治疗甲亢的临床效果。方法选择重钢总医院内分泌科60 例2017 年5 月—2018 年7 月甲亢患者。随机分组,药物单一治疗组的患者在治疗的时候单纯采用甲巯咪唑治疗,药物联合治疗组的患者在治疗的时候除了采取甲巯咪唑治疗,还给予普萘洛尔,比较两组治疗效率;甲亢患者的相关症状改善的天数、实验室检查的相关指标恢复到正常水平的时间、心律失常得到纠正的时间;治疗前后患者T4 血清甲状腺素以及T3 血清三碘甲状腺原氨酸;不良作用。结果药物联合治疗组治疗效率、甲亢患者的相关症状改善的天数、实验室检查的相关指标恢复到正常水平的时间、心律失常得到纠正的时间、T4 血清甲状腺素以及 T3 血清三碘甲状腺原氨酸相比较药物单一治疗组更好,P < 0.05。两组未见严重不良作用,P > 0.05。结论普萘洛尔+甲巯咪唑治疗甲亢可获得较好预后,可有效改善T4 血清甲状腺素以及 T3 血清三碘甲状腺原氨酸,改善心功能,缩短症状改善的时间,提高治疗效率,且无严重不良反应,安全性高。 Objective To investigate the clinical effect of propranolol and methimazole in the treatment of hyperthyroidism. Methods Sixty patients with endocrine department of Chongqing Iron and Steel General Hospital were selected from May 2017 to July 2018 hyperthyroidism patients. Randomly, patients in the drug monotherapy group were treated with methimazole only at the time of treatment. Patients in the drug combination group were treated with methimazole at the time of treatment, and propranolol was given to compare the treatment efficiencies of the two groups;The number of days of symptomatic improvement in patients with hyperthyroidism, the time to return to normal levels of laboratory tests, and the time to correct arrhythmia;T4 serum thyroxine and T3 serum triiodothyronine before and after treatment;adverse effects. Results Therapeutic efficiency of the combination therapy group, the number of days of improvement in symptoms associated with hyperthyroidism, the time to return to normal levels of laboratory tests, the time to correct arrhythmia, T4 serum thyroxine, and T3 serum triiodothyronine ammonia The acid phase was better compared with the drug monotherapy group, P < 0.05. No serious adverse effects were observed in the two groups, P > 0.05. Conclusion Propranolol + methimazole can improve the prognosis of hyperthyroidism, improve T4 serum thyroxine and T3 serum triiodothyronine, improve heart function, shorten the time of symptom improvement and improve treatment efficiency. No serious adverse reactions, high safety.
作者 黄卫红 HUANG Weihong(Department of Endocrinology, Chongqing GeneralHospital, Chongqing 400082, China)
出处 《中国继续医学教育》 2019年第26期125-127,共3页 China Continuing Medical Education
关键词 普萘洛尔 甲巯咪唑 甲亢 联合效果 甲状腺素指标 心律失常 propranolol methimazole hyperthyroidism combined effect thyroxine index arrhythmia
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