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整合药理学视角下的红花治疗冠心病作用机制研究 认领 被引量:2

Study on the Mechanism of Safflower in the Treatment of Coronary Heart Disease from the Perspective of Integrated Pharmacology
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摘要 目的:基于整合药理学探究红花治疗冠心病的潜在分子机制。方法:以“红花”,“Coronary heart disease”为限定词,借助整合药理学平台,通过挖掘红花活性成分及其相关作用靶标,与CHD潜在的靶点、分析其相关的信号通路,构建“中药-成分-靶标-通路”多位网络,从多角度、多层次探索红花治疗CHD的潜在分子机制。结果:红花对CHD的干预作用可能与多种化合物相关,主要集中于红色的和黄色的色素和多酚类成分。从关键靶标与作用通路可以看出,红花治疗CHD的主要作用于COX7C、COX5A、GCK、ATP5A1、COX5B基因等,涉及能量代谢、氧化磷酸化、循环系统等信号通路。结论:红花是通过多分子、多靶点、多信号通路共同作用来发挥治疗CHD的作用,为今后为进一步系统的研究其基础研究及临床应用提供理论基础及为新药的研制提供一定的参考价值。 Objective: To explore the potential molecular mechanism of safflower treatment of coronary heart disease based on integrated pharmacology. Methods: Using “Safflower” and “Coronary heart disease” as the qualifiers,this study explores the active constituents of safflower and their related targets based on the integrated pharmacology platform.It also explores the potential targets of CHD and analyzes its related signal pathways.This study constructs the “Chinese medicine ingredient target” in order to explore the potential molecular mechanism of safflower treatment of CHD from multiple perspectives. Results: It was found that the intervention of safflower to CHD may be related to a variety of compounds,mainly in red and yellow pigments and polyphenols.From the key target and action pathway,it can be seen that safflower CHD is mainly used in COX7C,COX5A,GCK,ATP5A1 and COX5B genes,including the signal pathways such as energy metabolism,oxidative phosphorylation and circulatory system. Conclusion: The safflower plays a role in the treatment of CHD through multi-molecule,multi-target and multi-signal pathways,and provides a theoretical basis for further systematic research and clinical application as well as providing a certain reference value for the development of new drugs.
作者 郑思成 滑振 王群 刘悦 张帆 张哲 贾连群 杨关林 Zheng Sicheng;Hua Zhen;Wang Qun;Liu Yue;Zhang Fan;Zhang Zhe;Jia Lianqun;Yang Guanlin(Graduate school,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;First clinical college,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Key Laboratory for TCM Viscera-State Theory and Applications of Major Scientific Research Platform under Ministry of Education,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;XHNB national and local joint engineering laboratory of integrated Chinese and western medicine and prevention technology,Shenyang 110847,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)
出处 《世界中医药》 CAS 2019年第9期2501-2504,2508共5页 World Chinese Medicine
基金 国家重点基础研究发展计划(“973”计划)项目(2013CB531704).
关键词 整合药理学 红花 冠心病 分子机制 Integrated pharmacology Safflower Coronary heart disease Molecular mechanism
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