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炎性细胞因子作为淋巴瘤生物标志物和分子靶点的研究进展

Progress of inflammatory cytokines as lymphoma biomarkers and molecular targets
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摘要 炎症反应存在于大多数疾病的发展过程中,近年来,肿瘤相关炎症反应在肿瘤微环境中的作用逐渐受到重视.炎症反应可促进局部淋巴瘤发生,同时淋巴瘤细胞的生长、增殖亦依赖于炎性肿瘤微环境,炎症反应在淋巴瘤的发生、发展及治疗过程中具有重要作用.炎性细胞因子是炎症介质的主要类别,其表达水平反映机体的炎症反应状态,具有作为淋巴瘤生物标志物和分子靶点的潜力. The inflammatory response is involved in the development of most diseases. In recent years, tumor associated inflammatory response in tumor microenvironment has been paid more attention. Inflammation promotes the progress of lymphoma, and the growth and proliferation of lymphoma cells also depend on the inflammatory tumor microenvironment. Inflammatory response plays an important role in the development and treatment of lymphoma. Inflammatory cytokines are main types of inflammatory mediators, their expression levels reflect the inflammatory response state of the body, and have potential to be biomarkers and molecular targets of lymphoma.
作者 王艳荣 韩晓红 石远凯 Wang Yanrong;Han Xiaohong;Shi Yuankai(Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs,Beijing 100021,China;Department of Clinical Laboratory,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100021,China)
出处 《白血病.淋巴瘤》 CAS 2019年第8期501-505,共5页 Journal of Leukemia & Lymphoma
基金 中国医学科学院医学与健康科技创新工程(2016-I2M-1-001)。
关键词 系统性炎症反应综合征 淋巴瘤 肿瘤标记 生物学 分子靶向治疗 Systemic inflammatory response syndrome Lymphoma Tumor markers,biological Molecular targeted therapy
作者简介 通信作者:石远凯,Email:syuankai@cicams.ac.cn。
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