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中国流感死亡负担研究系统综述 被引量:1

The mortality burden of influenza in China:a systematic review
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摘要 目的系统了解我国流感死亡负担研究进展和主要结果。方法以流感、流行性感冒、流感大流行、H1N1、死亡、病死和负担,以及influenza、flu、H1N1、pandemic、mortality、death、fatality、burden、China、Chinese为关键词,检索中国知网、万方数据知识服务平台、维普资讯、PubMed、Web of Science和Embase数据库中1990—2018年发表的有关中国的流感死亡负担研究的文献(不包括中国香港、澳门和台湾地区文献),语种限定为中文和英文。共纳入17篇有效文献,对纳入文献的基本信息、模型方法学及结果等信息进行摘录和整理分析。结果17篇文献均采用了间接模型的研究方法,研究指标均为超额死亡率,其中14篇采用回归模型;主要以全死因(16篇)、呼吸及循环系统疾病(14篇)和肺炎及流感(10篇)作为流感相关死因。老人死亡负担较重,相关全死因、呼吸及循环系统疾病和肺炎及流感超额死亡率最低分别为49.57/10万、30.80/10万和0.69/10万,最高分别为228.16/10万、170.20/10万和30.35/10万;非老年组最低分别为-0.27/10万、-0.08/10万和0.04/10万,最高为3.63/10万、2.6/10万和0.91/10万人。北方地区全人群流感相关全死因超额死亡率较高,最低为7.8/10万,最高为18.0/10万,南方略低,最低为6.11/10万,最高为18.7/10万。不同流感病毒亚型导致的死亡也存在差异,其中A(H3N2)和B型导致的死亡负担较重。结论我国流感死亡负担相关研究以间接模型估计为主,老人、北方地区及感染A(H3N2)和B型毒株患者的负担水平较重。 Objective To systematically review the mortality burden study of influenza in mainland China.Method"influenza","flu","H1N1","pandemic","mortality","death","fatality","burden","China"and"Chinese"were used as keywords,and a systematic literature search was conducted to identify articles in three English databases(PubMed,Web of Science and Embase)and three Chinese database(CNKI,WanFang and VIP)during 1990-2018(excluding Hong Kong,Macao and Taiwan).The language of literature was restricted to Chinese and English.The inclusion criteria were human-oriented researches with method based on population,and research indexes included mortality and excess mortality.The exclusion criteria were non-primary research materials,predictive research and research on the burden of avian influenza related deaths.A total of 17 literatures were included,and the basic information to descriptive characteristics,methodology of modeling and the corresponding results were extracted.Results All the 17 studies adopted indirect statistical models,with 14 of which adopted the regression model,and all the research index was excess mortality.All causes(16 studies),respiratory and circulatory diseases(14 studies)and pneumonia and influenza(10 studies)were the main causes of death associated with influenza.Influenza associated mortality burden in the elderly was higher,with the lowest excess mortality rates of all causes,respiratory and circulatory diseases,pneumonia and influenza being 49.57,30.80 and 0.69 per 100000 people,and the highest rates being 228.16,170.20 and 30.35 per 100000 people,respectively.In the non-elderly,the corresponding lowest rates were-0.27,-0.08 and 0.04 per 100000 people respectively,and the highest rates were 3.63,2.6 and 0.91 per 100000 people,respectively.The influenza-related excess mortality was higher in the north,with a minimum of 7.8 per 100000 and a maximum of 18.0 per 100000,and slightly lower in the south,with a minimum of 6.11 per 100000 and a maximum of 18.7 per 100000.There were also differences in deaths caus
作者 李飒 刘思家 朱爱琴 崔金朝 秦颖 郑建东 冯录召 王丽萍 李中杰 Li Sa;Liu Sijia;Zhu Aiqin;Cui Jinzhao;Qin Ying;Zheng Jiandong;Feng Luzhao;Wang Liping;Li Zhongjie(Changping District Center for Disease Control and Prevention,Beijing 102200,China;School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Wenzhou 325035,China;Division of Infectious Disease/Key Laboratory of Infectious Disease Surveillance and Ear-warning,Chinese Center for Disease Control and Prevention,Beijing 102206,China)
出处 《中华预防医学杂志》 CAS CSCD 北大核心 2019年第10期1049-1055,共7页 Chinese Journal of Preventive Medicine
基金 国家自然科学基金项目(91846302) 北京市自然科学基金(7192136) 国家科技重大专项(2018ZX10713001)。
关键词 流感 死亡 死亡负担 系统综述 Influenza,human Death Mortality burden Systematic Reviews
作者简介 李飒和,对本文有同等贡献;刘思家,对本文有同等贡献;通信作者:李中杰,Email:lizj@chinacdc.cn,电话:010-58900543。
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