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脑安胶囊联合低分子肝素治疗脑梗死的临床研究

Clinical study of Naoan Capsules combined with low molecular weight heparin in treatment of cerebral infarction
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摘要 目的探讨脑安胶囊联合低分子肝素钙注射液治疗脑梗死的临床疗效。方法选取2015年6月-2018年6月西宁市第一人民医院接收的126例脑梗死患者为研究对象,将所有患者采用随机数字表法分为对照组和治疗组,每组各63例。对照组皮下注射低分子肝素钙注射液,5 000 U/次,2次/d;治疗组患者在对照组基础上口服脑安胶囊,2粒/次,2次/d。两组患者连续治疗4周。观察两组的临床疗效,比较两组的美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)评分、血流动力学指标、血清炎性因子水平。结果治疗后,对照组和治疗组的总有效率分别为82.26%、95.16%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分显著降低,BI评分显著升高,同组治疗前后比较差异有统计学意义(P<0.05);并且治疗组NIHSS评分显著低于对照组,BI评分显著高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血浆黏度、血细胞比容、全血高切黏度均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);并且治疗组血流动力学指标均显著低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、和白细胞介素-6(IL-6)水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);并且治疗组患者血清炎性因子水平显著低于对照组,两组比较差异有统计学意义(P<0.05)。结论脑安胶囊联合低分子肝素钙注射液治疗脑梗死具有较好的临床疗效,可改善患者神经功能和日常生活能力,降低凝血指标水平,安全性较高,具有一定的临床推广应用价值。 Objective To investigate the effect of Naoan Capsules combined with Low Molecular Weight Heparin Calcium Injection in treatment of cerebral infarction. Methods Patients(126 cases) with cerebral infarction in Xining First People’s Hospital from June 2015 to June 2018 were randomly divided into control and treatment groups, and each group had 63 cases. Patients in the control group were subcutaneous injection administered with Low Molecular Weight Heparin Calcium Injection, 5 000 U/time, twice daily. Patients in the treatment group were po administered with Naoan Capsules on the basis of the control group, 2 grains/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and NIHSS scores, BI scores, hemodynamic indexes, and serum levels of inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.26% and 95.16%, respectively, and there was difference between two groups(P < 0.05). After treatment, NIHSS scores in two groups were significantly decreased, but BI scores in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the scores in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, plasma viscosity, hematocrit, and whole blood high shear viscosity in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the hemodynamic indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of TNF-α, hs-CRP, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the serum levels of inflammatory factors in the treatment group were significantly
作者 姜瑞 杨生琴 JIANG Rui;YANG Sheng-qin(Xining City Medical Institutions of Pharmaceutical Affairs Service Center,Xining 810000,China;Department of Neurosurgery,Xining First People’s Hospital,Xining 810000,China)
出处 《现代药物与临床》 CAS 2019年第11期3228-3231,共4页 Drugs & Clinic
关键词 脑安胶囊 低分子肝素钙注射液 脑梗死 NIHSS评分 BARTHEL指数 血流动力学 炎性因子 Naoan Capsules Low Molecular Weight Heparin Calcium Injection cerebral infarction NIHSS score BI score hemodynamics inflammatory factor
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