双酚A暴露与儿童青少年肥胖关系的Meta分析被引量：1

Meta analysis of the association of Bisphenol A with obesity in children and adolescents

收藏分享导出

摘要目的采用Meta分析系统评价双酚A(Bisphenol A,BPA)暴露与儿童青少年肥胖的关系,为预防和控制儿童青少年肥胖的发生提供思路。方法全面检索Medline、Web of Science、中国生物医学文献数据库、中国知网数据库、维普数据库和万方数据库等中文和外文数据库,查找国内外关于BPA暴露与儿童青少年肥胖关系的中英文文献。使用Stata12.0进行Meta分析,选择标准化均数差(standardized mean difference,SMD)及其置信区间和随机效应模型合并效应值。Q检验和I2统计量用于评价研究的异质性,漏斗图、Egger和Begg检验评价发表偏倚。结果共纳入13项研究,3 932名研究对象,其中病例组1 046例,对照组2 886人。尿液中BPA水平与肥胖呈正相关(SMD=0.26,95%CI=0.01~0.51),而血清中BPA水平与肥胖不存在相关性(SMD=0.07,95%CI=-0.44~0.58)。各研究之间存在高度异质性(I^2=87. 3%,P <0.01)。亚组分析发现,美国(SMD=0.27,95%CI=0. 16~0. 39)和欧洲(SMD=3. 76,95%CI=2. 77~4. 74)地区的研究显示BPA暴露与肥胖正相关,而亚洲地区的研究显示肥胖儿童青少年与正常儿童青少年差异无统计学意义(SMD=0.10,95%CI=-0.08~0.27)。敏感性分析表明,Meta分析合并结果稳定,漏斗图、Egger检验和Begg检验均未发现发表偏倚(P值均>0.05)。结论 BPA暴露与儿童和青少年肥胖有关,BPA可能会促进儿童和青少年肥胖的发生。 Objective To evaluate the relationship between the bisphenol A( BPA) exposure and obesity in children and adolescents with Meta-analysis, and to provide a new idea for prevention and control of obesity. Methods Reviewer independently searched and screened potentially relevant studies that reported the association between BPA and obesity in children and adolescents through Medline, Web of Science, CBM, CNKI, WANFANG DATA and CQVIP to March 7, 2019. Chi-square based Q test and I~2 statistic were used to assess the heterogeneity. Forest plot was used to display results graphically. Potential publication bias was assessed by the Egger and Begg tests and funnel plot. Results In total, 13 studies with 3 932 participants met the eligibility criteria,13 articles were indentified involving 1 046 obesity children and 2 886 normal control children. Overall summary estimates indicated significant positive correlation between urinary BPA and obesity( SMD = 0.26,95%CI = 0.01-0.51), and a nonsignificant association between serum BPA and obesity( SMD = 0.07,95% CI =-0.44-0.58). Significant heterogeneity was observed in overall estimates( I^2= 87.3%, P<0.01). In additon, a significant positive association was estimated in American( SMD = 0.27, 95%CI = 0.16-0.39) and Europe( SMD = 3.76, 95 CI = 2.77-4.74). The association between BPA and obesity was not changed in each individual( sensitivity analysis by leaving one out approach). The funnel plots did not reveal severe asymmetry, and both Egger and Begg tests were non-significant( P>0.05);therefore, publication bias was assessed as "undetected". Conclusion The finding from our systematic review and Meta-analysis suggest that children and adolescents exposure to BPA may result in obesity.

作者雷凡谌丁艳周丽 LEI Fan;CHEN Dingyan;ZHOU Li(Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen,Shenzhen 518000,Guangdong Province,China;不详)

机构地区中国医学科学院阜外医院深圳医院医务部深圳市疾病预防控制中心

出处《中国学校卫生》 CAS 北大核心 2020年第2期268-272,共5页 Chinese Journal of School Health

基金国家自然科学基金面上项目(81673201),深圳市知识创新计划基础研究项目(JCYJ20160428143108182)。

关键词双酚A 内分泌干扰物肥胖症 META分析儿童青少年 Bisphenol A Endocrine disruptors Obesity Meta-analysis Child Adolescent

分类号 R179 [医药卫生—妇幼卫生保健][医药卫生—公共卫生与预防医学] R589.9

引文网络
相关文献

参考文献5

1王盈灿,沈理笑,陈瑶,黄红,伊媛媛.上海市学龄儿童双酚A暴露现状及与肥胖关系的初步研究[J].中国儿童保健杂志,2015,0(4):344-347. 被引量：5
2章英,李骄阳,孙雪华,刘文清,熊文艳,赖肖,谢许情,邓志强,范广勤.南昌市近郊区超重与肥胖儿童血清双酚A水平调查[J].环境与健康杂志,2016,33(11):964-968. 被引量：1
3曾宪涛,刘慧,陈曦,冷卫东.Meta分析系列之四：观察性研究的质量评价工具[J].中国循证心血管医学杂志,2012,4(4):297-299. 被引量：322
4唐传喜,王和兴,周颖,吴金贵,姜庆五.体重正常和肥胖儿童青少年尿中双酚A的分析[J].中华疾病控制杂志,2013(3):273-274. 被引量：6
5季成叶.中国学龄儿童青少年超重、肥胖筛查体重指数值分类标准[J].中华流行病学杂志,2004,25(2):97-102. 被引量：1586

二级参考文献51

1Bellizzi MC, Dietz WH. Workshop on childhood obesity: summary of the discussion. Am J Clin Nutr,1999,70∶s173-s175. 被引量：2
2Zhou BF. Predictive values of body mass index and waist circumfer-ence for risk factors of certain related disease in Chinese adults-study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomedical and Environ ment 被引量：1
3Cole TJ, Bellizzi MC, Flegal KM, et al. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ, 2000, 320∶1240-1243. 被引量：1
4Malina RM, Katzmarzyk PT. Validity of the body mass index as an indicator of the risk and presencr of overweight in adolescents. Am J Clin Nutr,1999,70∶131-136. 被引量：1
5Flegal KM, Carrol MD, Kuczmarski RJ, et al.Overweight and obesity in the United States: Prevalence and trends.Int J Obes,1998,22∶39-47. 被引量：1
6He Q, Albertsson-Wikland K,Karlberg J.Population-based body mass index reference values from Goteborg Sweden: birth to 18 years of age. Acta Paediatr,2000,89∶582-592. 被引量：1
7Deniels SR, Khoury PR, Morrison JA.The utility of body mass index as a measure of body fatness in childhood and adolescents: differences by race and gender.Pediatrics,1997,99∶804-807. 被引量：1
8WHO. Obesity: preventing and managing. The global epidemic. Report of a WHO consultation on obesity. Technical Report Series,Geneva,WHO,2000,894∶83. 被引量：1
9日本肥满学会肥满症诊断基准检讨委员会.肥满筛查和肥满症诊断新基准[J].(日)肥满研究,2000,6:18-28. 被引量：2
10Grimes DA,Schulz KF.An overview of clinical research:the lay of the land[J].Lancet,2002,359(9300):57-61. 被引量：1