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慢性精神分裂症男性患者血清抗氧化物与临床症状的关系 认领 被引量:1

Relationship between serum antioxidants and psychopathology in male patients with chronic schizophrenia
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摘要 目的:探索慢性精神分裂症男性患者超氧化物歧化酶、白蛋白、尿酸等血清抗氧化物的特点。方法:纳入符合美国精神障碍诊断与统计手册第4版修订版(DSM-IV-TR)的慢性精神分裂症住院男性患者136例及年龄匹配的正常男性对照139例。测定血清总超氧化物歧化酶(TSOD)[包括铜锌超氧化物歧化酶(CuZnSOD)、锰超氧化物歧化酶(MnSOD)亚型]、尿酸、白蛋白、间接胆红素浓度,用阳性和阴性症状量表(PANSS)评定患者临床症状。结果:与正常对照组相比,精神分裂症组血清TSOD[(76.7±7.0)U/mLvs.(68.0±10.1)U/mL,P<0.001]及CuZnSOD[(58.3±15.3)U/mLvs.(49.9±14.8)U/mL,P<0.001]较高;间接胆红素浓度较低[(8.9±4.1)μmol/Lvs.(13.1±6.7)μmol/L,P<0.001],MnSOD、白蛋白、尿酸浓度差异无统计学意义。患者组各抗氧化物与PANSS各分量表分(阳性、阴性、一般病理症状)和量表总分无相关,与抗精神病药种类、剂量(氯丙嗪等效剂量)及疗程无相关;两组中MnSOD与CuZnSOD均明显负相关(r=-0.78、-0.74);SOD与各非酶抗氧化物间未显示相关性;两组中白蛋白均与年龄负相关(r=-0.40、-0.28)。结论:SOD升高是慢性精神分裂症疾病进化阶段稳定的特征指标,与临床症状、抗精神病药物及非酶抗氧化物无相关。 Objects:To characterize several serum antioxidants in male patients with chronic schizophrenia.Methods:One hundred and thirty six male hospitalized patients with chronic schizophrenia and 139 age-matched normal male controls were enrolled in the study.Their serum superoxide dismutases(including CuZnSOD and MnSOD subtypes)and non-enzyme antioxidants including uric acid(UA),albumin,indirect bilirubin(IBIL)were tested The patients were assessed of their clinic symptoms with Positive and Negative Symptom Scale(PANSS).Results:Comparing with the controls,the patients exhibited higher serum total SOD(TSOD)[(76.7±7.0)U/mL vs.(68.0±10.1)U/mL,P<0.001]and higher CuZnSOD[(58.3±15.3)U/mL vs.(49.9±14.8)U/mL,P<0.001],remarkable lower IBIL[(8.9±4.1)μmol/L vs.(13.1±6.7)μmol/L,P<0.001].No group differences were observed on MnSOD,albumin and UA.In patient group,no antioxidant tested was related to PANSS scores(including positive,negative and general psychopathological symptom subscores and total score)and the antipsychotics[including their kinds,dosage(chlorpromazine equivalency)and treatment duration]administered to the patients.Both groups displayed remarkable negative correlations between the two subtypes of SOD(r=-0.78,-0.74)as well as that between albumin and age(r=-0.40,-0.28).No correlated relationships were observed between SOD and other non-enzyme antioxidants.Conclusion:The increased serum level of SOD is suggested to be a stable characteristic of the evolutional stage for chronic schizophrenia,and is not related to clinic symptoms,antipsychotics administered and non-enzyme antioxidants.
作者 付卫红 宋佳起 赵青 于健瑾 高岚 刘美岑 陈大春 杨贵刚 FU Weihong;SONG Jiaqi;ZHAO Qing;YU Jianjin;GAO Lan;LIU Meicen;CHEN Dachun;YANG Guigang(Beijing Huilongguan Hospital,Peking University Huilongguan Clinical Medical School,Beijing 100096,China;The Seventh People's Hospital of Anyang City,Anyang 455004,Henan Province,China)
出处 《中国心理卫生杂志》 CSSCI CSCD 北大核心 2020年第6期493-498,共6页 Chinese Mental Health Journal
基金 首都卫生发展科研专项项目(编号:首发2018-2-2131)。
关键词 精神分裂症 抗氧化物 超氧化物歧化酶 尿酸 白蛋白 间接胆红素 schizophrenia antioxidant superoxide dismutase uric acid albumin indirect bilirubin
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