慢性精神分裂症男性患者血清抗氧化物与临床症状的关系认领被引量：1

Relationship between serum antioxidants and psychopathology in male patients with chronic schizophrenia

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摘要目的:探索慢性精神分裂症男性患者超氧化物歧化酶、白蛋白、尿酸等血清抗氧化物的特点。方法:纳入符合美国精神障碍诊断与统计手册第4版修订版(DSM-IV-TR)的慢性精神分裂症住院男性患者136例及年龄匹配的正常男性对照139例。测定血清总超氧化物歧化酶(TSOD)[包括铜锌超氧化物歧化酶(CuZnSOD)、锰超氧化物歧化酶(MnSOD)亚型]、尿酸、白蛋白、间接胆红素浓度,用阳性和阴性症状量表(PANSS)评定患者临床症状。结果:与正常对照组相比,精神分裂症组血清TSOD[(76.7±7.0)U/mLvs.(68.0±10.1)U/mL,P<0.001]及CuZnSOD[(58.3±15.3)U/mLvs.(49.9±14.8)U/mL,P<0.001]较高;间接胆红素浓度较低[(8.9±4.1)μmol/Lvs.(13.1±6.7)μmol/L,P<0.001],MnSOD、白蛋白、尿酸浓度差异无统计学意义。患者组各抗氧化物与PANSS各分量表分(阳性、阴性、一般病理症状)和量表总分无相关,与抗精神病药种类、剂量(氯丙嗪等效剂量)及疗程无相关;两组中MnSOD与CuZnSOD均明显负相关(r=-0.78、-0.74);SOD与各非酶抗氧化物间未显示相关性;两组中白蛋白均与年龄负相关(r=-0.40、-0.28)。结论:SOD升高是慢性精神分裂症疾病进化阶段稳定的特征指标,与临床症状、抗精神病药物及非酶抗氧化物无相关。 Objects:To characterize several serum antioxidants in male patients with chronic schizophrenia.Methods:One hundred and thirty six male hospitalized patients with chronic schizophrenia and 139 age-matched normal male controls were enrolled in the study.Their serum superoxide dismutases(including CuZnSOD and MnSOD subtypes)and non-enzyme antioxidants including uric acid(UA),albumin,indirect bilirubin(IBIL)were tested The patients were assessed of their clinic symptoms with Positive and Negative Symptom Scale(PANSS).Results:Comparing with the controls,the patients exhibited higher serum total SOD(TSOD)[(76.7±7.0)U/mL vs.(68.0±10.1)U/mL,P<0.001]and higher CuZnSOD[(58.3±15.3)U/mL vs.(49.9±14.8)U/mL,P<0.001],remarkable lower IBIL[(8.9±4.1)μmol/L vs.(13.1±6.7)μmol/L,P<0.001].No group differences were observed on MnSOD,albumin and UA.In patient group,no antioxidant tested was related to PANSS scores(including positive,negative and general psychopathological symptom subscores and total score)and the antipsychotics[including their kinds,dosage(chlorpromazine equivalency)and treatment duration]administered to the patients.Both groups displayed remarkable negative correlations between the two subtypes of SOD(r=-0.78,-0.74)as well as that between albumin and age(r=-0.40,-0.28).No correlated relationships were observed between SOD and other non-enzyme antioxidants.Conclusion:The increased serum level of SOD is suggested to be a stable characteristic of the evolutional stage for chronic schizophrenia,and is not related to clinic symptoms,antipsychotics administered and non-enzyme antioxidants.

作者付卫红宋佳起赵青于健瑾高岚刘美岑陈大春杨贵刚 FU Weihong;SONG Jiaqi;ZHAO Qing;YU Jianjin;GAO Lan;LIU Meicen;CHEN Dachun;YANG Guigang(Beijing Huilongguan Hospital,Peking University Huilongguan Clinical Medical School,Beijing 100096,China;The Seventh People's Hospital of Anyang City,Anyang 455004,Henan Province,China)

机构地区北京回龙观医院北京大学回龙观临床医学院河南省安阳市第七人民医院

出处《中国心理卫生杂志》 CSSCI CSCD 北大核心 2020年第6期493-498,共6页 Chinese Mental Health Journal

基金首都卫生发展科研专项项目(编号:首发2018-2-2131)。

关键词精神分裂症抗氧化物超氧化物歧化酶尿酸白蛋白间接胆红素 schizophrenia antioxidant superoxide dismutase uric acid albumin indirect bilirubin

分类号 R749.3 [医药卫生—神经病学与精神病学][医药卫生—临床医学]

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参考文献2

1陈大春,杨可冰,王宁,聂鹰,修梅红,李艳丽,卞清涛,张向阳,李占江.首发和慢性精神分裂症患者、正常对照者超氧化物歧化酶及脑源性神经营养因子水平的差异[J].上海精神医学,2011,23(5):284-290. 被引量：10
2李艳丽,杨甫德,谭云龙,朱凤艳,王宁,陈松,王志仁,周东丰.首发精神分裂症患者血浆非酶抗氧化物浓度与临床特征[J].中国心理卫生杂志,2011,25(10):756-759. 被引量：9

二级参考文献29

1陈大春,周东丰,曹连元,谭云龙,李艳丽,王宁,聂鹰,杨可冰,姚付新,张向阳.利培酮和氟哌啶醇对精神分裂症患者超氧化物歧化酶及催乳素影响的临床对照研究[J].中华精神科杂志,2007,40(1):5-9. 被引量：5
2Gawryluk JW,Wang JF,Andreazza AC,et al.Decreased levels of glutathione,the major brain antioxidant,in post-mortem prefrontal cortex from patients with psychiatric disorders[J].J Neuropsychopharmacol,2010,16(1):1-8. 被引量：1
3Miller NJ,Rice-Evans C,Davies MJ,et al.A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates[J].Clin Sci,1993,84(3):407-412. 被引量：1
4Kunz M,Gama CS,Andreazza AC,et al.Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia[J].Prog Neuropsychopharmacol Biol Psychiatry,2008,32(7):1677-1681. 被引量：1
5Ximenes VF,Rodrigues AP,Cabello C,et al.The co-catalytic effect of chlorpromazine on peroxidase-mediated oxidation of melatonin:enhanced production of N1-acetyl-N2-formyl-5-me-thoxykynuramine[J].J Pineal Res,2008,44(2):115-120. 被引量：1
6Sarandol A,Kirli S,Akkaya C,et al.Oxidative-antioxidative systems and their relation with serum S100 B levels in patients with schizophrenia:effects of short term antipsychotic treatment[J].Prog Neuropsychopharmacol Biol Psychiatry,2007,31(6):1164-1169. 被引量：1
7Huang SY,Chiu CC,Shen ww,et al.Hypoalbuminemia in drug-free patients with major depressive disorder compared with a dietary matched control group:a clinical meaning beyond malnutrition[J].Eur Neuropsychopharmacol,2005,15(2):227-230. 被引量：1
8Tan HY,Callicott JH,Weinberger DR.Intermediate phenotypes in schizophrenia genetics redux:is it a no brainer?[J].Mol Psychiatry,2008,13(3):233-238. 被引量：1
9Fanous AH,Kendler KS.Genetic heterogeneity,modifier genes,and quantitative phenotypes in psychiatric illness:searching for a framework[J],Mol Psychiatry,2005,10(1):6-13. 被引量：1
10World Health Organization.The ICD-10 classification of mental and behavioural disorders.Diagnostic criteria for research[M].Geneva:World Health Organization,1993. 被引量：1