期刊文献+

产妇血清、宫颈分泌物MCP-1、sTNFRⅠ、HMGB1与感染性早产的关系 认领

The Relationship between Maternal Serum,Cervical Secretions MCP-1,sTNFR Ⅰ,HMGB1 and Infectious Preterm Labor
收藏 分享 导出
摘要 目的探究产妇血清、宫颈分泌物单核细胞趋化蛋白-1、可溶性肿瘤坏死因子受体Ⅰ、高迁移率蛋白1与感染性早产的关系。方法选取2017年1月1日-2019年8月31日某院142例产妇作为研究对象,根据是否发生绒毛膜羊膜炎分为感染组(37例)、非感染组(105例)。比较2组血清、宫颈分泌物MCP-1、sTNFRⅠ、HMGB1水平,分析各指标在血清与宫颈分泌物之间相关性,采用受试者工作特征曲线分析上述指标对感染性产妇的诊断价值,并对比感染性早产、感染性足月产产妇血清、宫颈分泌物MCP-1、sTNFRⅠ、HMGB1水平,分析各指标与感染性早产的关系。结果感染组血清、宫颈分泌物MCP-1、sTNFRⅠ、HMGB1水平高于非感染组(P<0.05);血清MCP-1、sTNFRⅠ、HMGB1水平与宫颈分泌物各指标水平存在正相关关系(P<0.05);血清、宫颈分泌物各指标中,宫颈分泌物sTNFRⅠ诊断感染性产妇的曲线下面积(AUC)高达0.808,高于血清sTNFRⅠ及血清、宫颈分泌物MCP-1、HMGB1,其截断值下诊断敏感度为62.16%,特异度为96.24%;感染性早产的发生与血清、宫颈分泌物MCP-1、sTNFRⅠ、HMGB1关系密切(P<0.05)。结论发生绒毛膜羊膜炎的产妇血清、宫颈分泌物MCP-1、sTNFRⅠ、HMGB1水平均呈异常高表达状态,可作为诊断感染性产妇的生物学指标,同时与感染性早产的发生密切相关,有助于临床预防感染性早产,改善母婴预后。 Objective To explore the relationship between maternal serum,cervical secretion monocyte chemotactic protein-1,soluble tumor necrosis factor receptorⅠ,high mobility protein 1 and infectious preterm labor.Methods From January 1 st,2017 to August 31 st,2019,142 maternal patients in a hospital were selected as the research object,they were divided into infection group(37 cases)and non-infection group(105 cases)according to whether chorioamnionitis occurred.The levels of MCP-1,sTNFRⅠand HMGB1 in serum and cervical secretion of the two groups were compared,the correlation between serum and cervical secretion was analyzed,the receiver operating characteristic curve was used to analyze the diagnostic value of the above indicators for infectious parturients,and the levels of MCP-1,sTNFRⅠ,HMGB1 in sera and cervical secretions of infectious preterm labor,infective term maternal were compared,the relationship between each index and infectious preterm birth was analyzed.Results The levels of serum and cervical secretions MCP-1,sTNFRⅠ,HMGB1 in the infected group were higher than those in the non-infected group(P<0.05),there was a positive correlation between serum MCP-1,sTNFRⅠ,HMGB1 levels and levels of cervical secretion indicators(P<0.05);Among the serum and cervical secretions,the area under the curve(AUC)of cervical secretions sTNFRⅠin the diagnosis of infectious parturients was as high as 0.808,it was higher than sTNFRⅠ,MCP-1 and HMGB1 in serum and cervical secretion,the diagnostic sensitivity at the cutoff value was 62.16%,and the specificity was96.24%;The occurrence of infectious preterm labor was closely related to serum,cervical secretions MCP-1,sTNFRⅠ,HMGB1(P<0.05).Conclusions The levels of maternal serum and cervical secretions MCP-1,sTNFRⅠ,HMGB1 in chorioamnionitis were abnormally high expression,it could be used as a biological indicator for diagnosing infectious parturients and was closely related to the occurrence of infectious preterm labor,it was helpful for the clinical prevention of infect
作者 马玥 Ma Yue(Department of Obstetrics,Panzhihua Central Hospital,Panzhihua 617067,Sichuan Province,China)
出处 《中国病案》 2020年第5期105-108,共4页 Chinese Medical Record
关键词 感染性早产 血清 宫颈分泌物 单核细胞趋化蛋白-1 可溶性肿瘤坏死因子受体Ⅰ 高迁移率蛋白1 Infectious preterm birth Serum Cervical secretion Monocyte chemotactic protein-1 Soluble tumor necrosis factor receptorⅠ High mobility protein 1
  • 相关文献

参考文献15

二级参考文献103

共引文献62

202103读书月活动
维普数据出版直通车
今日学术
投稿分析
职称考试

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈