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胃黏膜保护剂联合质子泵抑制剂治疗消化性溃疡伴出血的临床效果观察 认领

The clinical effect of gastric mucosa protective agent combined with proton pump inhibitor in the treatment of peptic ulcer with bleeding
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摘要 目的分析胃黏膜保护剂联合质子泵抑制剂(PPI)治疗消化性溃疡伴出血的临床效果。方法选取2018年9月至2019年9月本院接收的100例消化性溃疡伴出血患者作为研究对象,采取随机分组法分为对照组和观察组,每组50例。对照组采取PPI三联疗法(奥美拉唑+阿莫西林+甲硝唑)进行治疗,观察组在对照组基础上增加胃黏膜保护剂(磷酸铝凝胶)。比较两组患者临床效果。结果两组不良反应发生率比较差异无统计学意义;观察组总有效率、HP根除率均高于对照组(P<0.05);观察组腹痛缓解时间、止血时间及溃疡愈合时间均短于对照组(P<0.05)。结论胃黏膜保护剂联合PPI治疗消化性溃疡伴出血,可快速消除HP,缩短止血、腹痛缓解、溃疡愈合时间,且不良反应较少,风险低,值得临床推广应用。 Objective To analyze the clinical effect of gastric mucosa protective agent combined with proton pump inhibitor(PPI)in the treatment of peptic ulcer with bleeding.Methods 100 patients with peptic ulcer and bleeding received by our hospital from September 2018 to September 2019 were selected as the research subjects,and they were randomly divided into control group and observation group,with 50 cases in each group.The control group was treated with PPI triple therapy(omeprazole+amoxicillin+metronidazole),and the observation group added gastric mucosa protective agent(Aluminium Phosphate Gel)on the basis of the control group.The treatment effect of the two groups were compared.Results There was no statistically significant difference in the incidence of adverse reactions between the two groups.The total effective rate and HP eradication rate in the observation group were both higher than those in the control group(P<0.05).The time of abdominal pain relief,hemostasis and ulcer healing in the observation group were shorter than those in the control group(P<0.05).Conclusion Gastric mucosa protective agent combined with PPI can rapidly eliminate HP,shorten bleeding,reliere abdominal pain and ulcer healing time,and has less adverse reactions and low risk,which is worth clinical promotion and application.
作者 黄洋 HUANG Yang(Department of Medical Affair,Jiujiang NO.1 People's Hospital,Jiujiang,Jiangxi,332000,China)
出处 《当代医学》 2021年第3期103-105,共3页 Contemporary Medicine
关键词 胃黏膜保护剂 消化性溃疡 PPI 出血 Gastric mucosa protective agent Peptic ulcer PPI Hemorrhage
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