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五倍子水煎剂联合顺铂对荷瘤小鼠抑瘤作用的实验研究 预览

Experimental Study on Anti-Tumor Effect of Galla Chinensis Decoction Combined with Cisplatin in Tumor-bearing Mice
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摘要 目的:研究五倍子水煎剂联合顺铂对荷瘤小鼠的抑瘤作用。方法:预先接种HCT8荷瘤小鼠随机分组,每组12只,采用不同浓度(2.5 g/kg、5.0 g/kg、10 g/kg)五倍子水煎剂每日一次灌胃与顺铂联合用药,连用15天。检测各组荷瘤小鼠体重等一般状况及肿瘤重量和抑瘤率的变化。结果:五倍子各剂量组荷瘤小鼠的平均瘤体重量与生理盐水组相比有显著性差别(P<0.01),而五倍子水煎剂(5.0g/kg、10g/kg)组和顺铂组小鼠比较瘤重及抑瘤率均有显著性差别(P<0.01)。结论:五倍子水煎剂对荷瘤小鼠具有一定的辅助抑瘤作用。 Objective: To study the anti-tumor effect of gallnut decoction combined with cisplatin on mice bearing tumors. METHODS: Twelve mice in each group were randomly divided into two groups with different concentrations(2.5 g/kg, 5.0 g/kg, 10 g/kg) of Galla chinensis Decoction once a day and combined with cisplatin for 15 days. The weight of tumor-bearing mice and the changes of tumor weight and inhibition rate were detected. RESULTS: The average weight of tumors in gallnut-bearing mice was significantly different from that in saline group(P<0.01), while there were significant differences between gallnut Decoction group(5.0 g/kg, 10 g/kg) and cisplatin group(P<0.01). CONCLUSION: Galla chinensis decoction has a certain auxiliary anti-tumor effect on tumor-bearing mice.
作者 张宝成 刘艳波 张昆 徐振宇 马春艳 Zhang Baocheng;Liu Yanbo;Zhang Kun;Xu Zhenyu;Ma Chunyan(Basic Medical College of Jiamusi University,Jiamusi 54007;Three Oncology Departments of Jiamusi Cancer Hospital,Jiamusi 154007,China)
出处 《广东化工》 CAS 2019年第6期103-103,58共2页 Guangdong Chemical Industry
关键词 五倍子水煎剂 辅助抑瘤作用 荷瘤小鼠 gallnut water decoction auxiliary anti-tumor effect tumor-bearing mice
作者简介 张宝成(1982-),男,黑龙江人,理学学士,主要研究方向为基础医学,医学机能学。
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