Objective:To study the anti-depression effect and mechanism of Live Combined Bifidobacterium and Combined Clostridium Butyricum and Bifidobacterium in mice.Methods:Male Kunming mice were randomly divided into 5 groups:blank control group,model group,Bifidobacterium group,Combined Clostridium Butyricum and Bifidobacterium group and fluoxetine positive control group,with 8 mice in each group.Mice model of depression was established by chronic repeated tail suspension method lasting for 30 days.The immobility time of tail suspension and the level of 5-hydroxytryptamine(5-HT)in hippocampal tissue and the content of cortistatin(CORT)in serum were measured.Results:The two microecologics significantly decreased the mice immobility time of tail suspension.Live Combined Clostridium Butyricum and Bifidobacterium could significantly increase the level of 5-HT in hippocampal tissue,however,there was no significant difference among the 5 groups(P>0.05).Conclusion:Live Combined Clostridium Butyricum and Bifidobacterium had the anti-depression effect,and the potential mechanism might be related to the elevation of central 5-HT content.
Journal of Guangxi Medical University
Live Combined Bifidobacterium
Lactobacillus and Enterococcus
Live Combined Clostridium Butyricum and Bifidobacterium
mice chronic repeated tail suspension method