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PCT联合IL-6检测对高龄呼吸机相关性肺炎患者G~-、G~+感染和预后的临床研究 预览

The significance of combination detection of PCT with IL 6 in diagnosis of infection of G~- and G~+ bacteria and prognosis in elderly patients with ventilator-associated pneumonia
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摘要 目的了解PCT联合IL-6检测对高龄呼吸机相关性肺炎患者G~-、G~+感染和预后的临床疗效,同时可为肺炎患者护理提供临床资料。方法选取2016年3月至2017年5月治疗的159例患者根据病情分成健康对照组、病毒性肺炎感染组和呼吸机相关性肺炎组,每组53例。比较PCT联合IL-6检测对高龄呼吸机相关性肺炎患者G~-和G~+感染和预后的临床疗效的统计学差异。结果 3组患者HCY含量、IL-6含量、CPIS评分差异有统计学意义(P<0.05),病毒性肺炎感染组和呼吸机相关性肺炎组患者HCY含量、IL-6含量、CPIS评分显著高于健康对照组,呼吸机相关性肺炎组患者HCY含量、IL-6含量、CPIS评分显著高于病毒性肺炎感染组(P<0.05)。G~+感染患者HCY含量、IL-6含量、CPIS评分显著高于G~-感染患者(P<0.05)。G~-感染与HCY、IL-6呈正相关(P<0.05);G~+感染与HCY、IL-6呈正相关(P<0.05)。G~-感染和G~+感染死亡患者HCY、IL-6含量和CPIS评分显著高于转归患者(P<0.05)。HCY联合IL-6对呼吸机相关性肺炎G~-和G~+感染的鉴别效果显著优于HCY和IL-6检测,其灵敏度、特异度、约登指数显著高于HCY和IL-6检测(P<0.05)。结论血清PCT联合IL-6对于鉴别高龄呼吸机相关性肺炎患者具有特殊的临床意义,值得临床推广。 Objective To investigate the significance of combination detection of PCT with IL 6 in diagnosis of infection of G~-and G~+bacteria and prognosis in elderly patients with ventilator-associated pneumonia(VAP),and to provide clinical data for nursing the patients with pneumonia.Methods A total of 159 patients who were treated in our hospital from March 2016 to May 2017 were enrolled in the study.According to their disease condition,these patients were divided into healthy control group(n=53),viral pneumonia infection group(n=53)and VAP group(n=53).The clinical efficacy of PCT combined with IL-6 on the infections of G~-and G~+bacteria and prognosis in elderly patients with ventilator related pneumonia was observed and compared between the two groups.Results There were significant differences in the levels of HCY,IL-6 and CPIS scores among the three groups(P<0.05).The levels of HCY,IL-6,and CPIS scores in viral pneumonia infection group and VAP group were significantly higher than those in healthy control group(P<0.05).Moreover the levels of HCY,IL-6,and CPIS scores in VAP group were significantly higher than those in viral pneumonia infection group(P<0.05).In addition the levels of HCY,IL-6,and CPIS scores in the patients with G~+bacteria infection were significantly higher than those in patients with G~-bacteria infection(P<0.05).The G~-bacteria infection was positively correlated with HCY and IL-6,moreover the G~+bacteria infection was positively correlated with HCY and IL-6.The levels of HCY,IL-6 and CPIS scores in patients who died of G~-bacteriainfection and G~+bacteria infection were significantly higher than those in the patients with disease turnover(P<0.05).The distinguishing effects of combination detection of HCY with IL 6 on the G~-and G~+bacteria infection of patients with VAP were superior to those of HCY and IL-6 detection alone(P<0.05).The sensitivity,specificity,and Youden index of combination detection of HCY with IL-6 were significantly higher than those by HCY detection or IL-6 detection alone(P<
作者 李哲 莫锦荷 翁玉玲 陈加家 刘树佳 陆青竹 刘倩文 LI Zhe;MO Jinhe;WENG Yuling(Wanjiang Hospital of Dongguan City,Guangdong,Dongguan 523040,China)
出处 《河北医药》 CAS 2019年第6期891-894,共4页 Hebei Medical Journal
基金 广东省东莞市社会科教发展(一般)项目(编号:2018507150301515).
关键词 降钙素原 白细胞介素-6 呼吸相关性肺炎 预后 PCT IL-6 ventilator-associated pneumonia prognosis
作者简介 通讯作者:翁玉玲,E-mail:450872679@qq.com
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