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扶正抗毒汤治疗复发型单纯疱疹病毒性角膜炎54例临床研究

Clinical Study on Fuzheng Kangdu tang for 54 Cases of Recurrent Herpes Simplex Keratitis
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摘要 目的:观察扶正抗毒汤治疗复发型单纯疱疹病毒性角膜炎(HSK)正虚邪留证的临床疗效。方法:将108例HSK患者随机分为观察组和对照组各54例。对照组54例(57眼),采用更昔洛韦滴眼液和硫酸软骨素滴眼液滴眼,同时口服维生素C和B。观察组54例(56眼),在对照组的基础加服扶正抗毒汤。2组共治疗4周。治疗前后观察主要症状、体征评分、视力检查和角膜荧光染色,并计算病损面愈合指数。结果:经Ridit分析,观察组患者临床疗效优于对照组(χ~2=5.524,P <0.05)。经Ridit分析,观察组角膜病损面愈合指数优于对照组(χ~2=5.271,P <0.05)。治疗后,2组患者的视力均较治疗前提高(P <0.01),观察组患者的视力好于对照组(P <0.01)。观察组视力恢复正常的患者为34眼(60.71%),对照组为23眼(40.35%),差异有统计学意义(χ~2=4.685,P <0.05)。治疗后,2组患者主要症状、体征评分均较治疗前下降(P <0.01),观察组低于对照组(P <0.01)。结论:采用扶正抗毒汤内服可进一步恢复视力,提高角膜病损面愈合指数,减轻临床症状,临床疗效优于单纯的西医治疗。 Objective:To observe the clinical effect of Fuzheng Kangdu tang for recurrent herpes simplex keratitis(HSK)with syndrome of lingering evil due to vital qi deficiency. Methods:Divided 108 cases of patients with HSK randomly into the observation group and the control group,54 cases in each group. 54 cases in the control group(57 eyes)were treated with ganciclovir eye drops and chondroitin sulfate eye drops while taking vitamin C and B,and other 54 cases(56 eyes)in the observation group were additionally given Fuzheng Kangdu tang. The treatment for both groups lasted for 4 weeks. Graded the main symptoms and physical signs,detected the visual acuity,and stained corneal fluorescence in the two groups before and after treatment,and calculated the healing index of lesion surface. Results:According to Ridit analysis,the clinical effect of the observation group was better than that of the control group(χ~2=5.524,P < 0.05). According to Ridit analysis,the healing index of corneal lesion in the observation group was better than that in the control group(χ~2=5.271,P < 0.05). After treatment,the visual acuity in the two groups was higher than that before treatment(P < 0.01),and the visual acuity in the observation group was better than that in the control group(P < 0.01). 34 eyes(60.71%)in patients in the observation group and 23 eyes(40.35%) in the control group returned to normal visual acuity, difference being significant(χ~2=4.685, P < 0.05). After treatment,the main symptoms and signs in the two groups were lower than those before treatment(P < 0.01),and these in the observation group were lower than those in the control group(P < 0.01). Conclusion:The oral administration of Fuzheng Kangdu tang can further help visual recovery,improve the healing index of corneal lesions,and alleviate clinical symptoms.The clinical effect is better than that of simple western medicine.
作者 成雪梅 CHENG Xuemei(不详)
机构地区 静宁县人民医院
出处 《新中医》 CAS 2019年第3期217-219,共3页 New Journal of Traditional Chinese Medicine
关键词 单纯疱疹病毒性角膜炎(HSK) 复发型 正虚邪留证 扶正抗毒汤 Herpes simplex keratitis(HSK) Recurrence type Syndrome of lingering evil due to vital qi deficiency Fuzheng Kangdu tang
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