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疏肝健消汤治疗脾虚肝郁证功能性消化不良的临床研究

Clinical Study on Shugan Jianxiao Decoction in Treating Functional Dyspepsia with Syndrome of Spleen Deficiency and Liver Depression
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摘要 【目的】观察疏肝健消汤治疗脾虚肝郁证功能性消化不良(FD)的临床疗效,并探讨其可能作用机制。【方法】将70例FD脾虚肝郁证患者随机分为治疗组和对照组,每组各35例,分别给予疏肝健消汤和莫沙必利胶囊治疗,疗程均为4周。观察2组患者治疗前后中医证候评分和血清学指标[5-羟色胺(5-HT)、胃泌素(GAS)和胃动素(MTL)]的变化情况,并评价2组的临床疗效。【结果】(1)2组各有3例患者退出研究,即治疗组和对照组各有32例患者完成研究。(2)治疗4周后,治疗组的总有效率为90.63%,对照组为75.00%,治疗组的疗效优于对照组(P <0.05)。(3)治疗后,治疗组各项中医证候评分均较治疗前明显降低(P <0.01),而对照组仅胃胀不适、胃痛不适、烧心或灼热感、嗳气反酸4个中医证候评分降低(P <0.05或P <0.01),治疗组对各项中医证候的改善作用均优于对照组(P <0.01)。(4)治疗后,2组患者血清GAS和MTL水平均升高(P <0.05或P <0.01),血清5-HT水平均下降(P <0.05或P <0.01),且治疗组对血清5-HT、GAS和MTL水平的改善作用均优于对照组(P <0.05)。【结论】疏肝健消汤可能是通过升高FD患者血中GAS、MTL水平和降低血中5-HT水平,促进胃肠排空,从而有效地改善FD脾虚肝郁证患者的临床症状,提高生活质量。 Objective To observe the clinical efficacy of Shugan Jianxiao Decoction in treating functional dyspepsia(FD) with the syndrome of spleen deficiency and liver depression, and to explore its possible mechanism.Methods Seventy FD patients with the syndrome of spleen deficiency and liver depression were randomly dividedinto treatment group and control group, 35 cases in each group. The treatment group was treated with Shugan Jianxiao Decoction orally and the control group was treated with Mosapride Citrate Hydrate Capsules orally,thetreatment of the two groups lasting for 4 weeks. Before and after treatment, the scores of traditional Chinesemedicine(TCM)symptoms and levels of serum parameters of 5-hydroxytryptamine(5-HT),gastrin(GAS)andmotilin(MTL)in the two groups were observed. And after treatment, the clinical efficacy was also evaluated.Results(1)There were 3 cases in each group dropping out the trial,and finally 32 cases in each group completedthe trial.(2)After treatment for 4 weeks,the total effective rate of the treatment group was 90.63%,which washigher than 75.00% in the control group(P < 0.05).(3)After treatment,the scores of each TCM symptom scoresof the treatment group were decreased significantly(P < 0.01),while in the control group only the scores of gastricdistention,stomachache,burning sensation in the stomach,belching and acid regurgitation were decreased(P <0.05 or P < 0.01 compared with those before treatment);the treatment group showed stronger effect on improvingTCM symptoms than the control group(P < 0.01).(4)After treatment,serum GAS and MTL levels of the twogroups were increased,and serum 5-HT level was decreased(P < 0.05 or P < 0.01 compared with those beforetreatment);the treatment group showed stronger effect on improving serum 5-HT,GAS and MTL levels than thecontrol group(P < 0.05). Conclusion Shugan Jianxiao Decoction is effective on improving the clinical symptomsand the quality of life of FD patients with the syndrome of spleen deficiency and liver depression, and itsmechanism is proba
作者 王景科 WANG Jing-Ke(Haikou People’s Hospital ,Haikou 570208 Hainan,China)
机构地区 海口市人民医院
出处 《广州中医药大学学报》 CAS 2019年第3期327-331,共5页 Journal of Guangzhou University of Traditional Chinese Medicine
关键词 功能性消化不良 脾虚肝郁证 疏肝健消汤 胃泌素 胃动素 functional dyspepsia syndrome of spleen deficiency and liver depression Shugan Jianxiao Decoction gastrin motilin
作者简介 王景科(1980-),男,主治中医师;E-mail:wjk197@126.com

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