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蛋白质乙酰化修饰在细胞自噬中的作用进展

Progress About The Role of Protein Acetylation on Autophagy
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摘要 蛋白质翻译后修饰与细胞自噬的关系是近几年来的研究热点.自噬的发生需要多类蛋白质协同完成.在此过程中,蛋白质的乙酰化修饰对细胞自噬起着十分重要的调节作用.本文就近年来的研究从两个角度进行了总结:一方面总结了蛋白质乙酰化修饰与自噬关系的功能性研究,主要涉及组蛋白、转录因子以及与乙酰辅酶A代谢过程中相关酶的研究进展;另一方面概括了细胞自噬过程中蛋白质乙酰化修饰组学的研究进展.乙酰化酶/去乙酰化酶是蛋白质乙酰化修饰水平的主要调控者,阐明酶与底物的关系将是深入探讨乙酰化修饰与细胞自噬关系的关键所在.这些研究结果必将为揭开细胞自噬机制提供理论基础. The relationship between protein post-translational modification and autophagy has become a hot topic in recent years.A series of proteins are required to participate in the process of autophagy.Protein acetylation has been demonstrated to emerge as the main regulator to autophagy.In this paper,we reviewed related findings from two perspectives.On one hand,the role of protein acetylation on autophagy has been discussed,mainly including histones,transcription factors and most of enzymes to regulate the level of AcCoA.On the other hand,we presented the advancement with the acetylome profile in the process of autophagy.Acetylase and deacetylase are the main enzymes to be responsible for protein acetylation.The relationship between these enzymes and their substrates merited to be intensively investigated in the future studies.All of data would be very valuable to explore the mechanism with autophagy.
作者 陈宇 万群 金露琪 闫春兰 丁世萍 CHEN Yu;WAN Qun;JIN Lu-Qi;YAN Chun-Lan;DING Shi-Ping(Institute of Cell Biology,Zhejiang University School of Medicine,Hangzhou 310058,China;The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China;Institute of Neuroscience,Zhejiang University School of Medicine,Hangzhou 310058,China)
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2019年第4期379-385,共7页 Progress In Biochemistry and Biophysics
基金 国家科技重大专项基金(2013ZX10003007) 浙江省自然科学基金(LR12H26001)资助项目 传染病诊治国家重点实验室开放课题(2010KF12).
关键词 自噬 蛋白质乙酰化修饰 乙酰化组学 乙酰化酶 去乙酰化酶 autophagy protein acetylation acetylome acetylase deacetylase
作者简介 通讯联系人:丁世萍,Tel:13958174612,E-mail:dingshiping@zju.edu.cn
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