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丹皮酚衍生物及其药理活性研究进展 被引量:1

Paeonol derivatives and their pharmacological activities
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摘要 丹皮酚具有广泛的药理活性,主要具有保护心脑血管系统、促进微循环、抗菌、抗炎、抗肿瘤、抗氧化、抗变态反应、增强免疫力以及治疗糖尿病、骨质疏松症等作用。近年来,为了提高丹皮酚生物利用度,不仅改进其人工合成的方法,还对丹皮酚进行了大量的结构修饰及改造,包括羰基、酚羟基、羰基α-氢、甲氧基以及苯环,生成了羧酸酯类、磺酸酯类、磷酸酯类、醚类、NO供体类、糖苷化类、丹皮酚钠盐、Schiff碱类、噻唑类、肟类、羟烷基化类、α,β-不饱和酮类、胺甲基化类、α-氢卤代类、去甲基化类、苯环卤代类16种丹皮酚衍生物。结合国内外有关丹皮酚衍生物的文献,对丹皮酚衍生物及其药理活性方面进行综述,为此类化合物的进一步研究提供参考。 Paeonol has a wide range of pharmacological activities.It is mainly used to protect cardiovascular and cerebrovascular system,promote microcirculation,antibacterial and anti-inflammatory,antitumor,anti-oxidation,anti-allergic reaction,enhance immunity,and treat diabetic osteoporosis,etc.In recent years,it not only improves the method of artificially synthesizing paeonol,but also carries out a large number of structural modification and transformation of paeonol.Five major parts,carbonyl,phenolic hydroxyl,carbonylα-H,methoxy,and benzene rings,have been mainly modified.About 16 kinds of paeonol derivatives were produced including carboxylic acid esters,sulfonates esters,phosphates esters,ethers,NO donors,glycosidation,paeonol sodium,Schiff bases,thiazoles,oximes,hydroxyalkylation,α,β-unsaturated ketones,aminomethylation,α-H halogenation,demethylation,and benzene ring halogenation.In this paper,the derivatives of paeonol and their pharmacological activities were reviewed in combination with the literatures on paeonol derivatives at home and abroad.This article may provide basis for further study of this type of compound.
作者 吴桂莹 亓玉玲 郝宝燕 王积磊 孙敬勇 WU Gui-ying;QI Yu-ling;HAO Bao-yan;WANG Ji-lei;SUN Jing-yong(School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250200,China;Key Laboratory for Biotech-Drugs of Ministry of Health,Key Laboratory for Rare&Uncommon Diseases of Shandong Province,Institute of Materia Medica,Shandong Academy of Medical Sciences,Jinan 250062,China;Jinan Tianqiao Hospital,Jinan 250031,China)
出处 《中草药》 CAS CSCD 北大核心 2019年第4期1001-1006,共6页 Chinese Traditional and Herbal Drugs
基金 山东省高等学校科技计划项目(J15LM07) 山东省医学科学院医药卫生科技创新工程.
关键词 丹皮酚 衍生物 结构修饰 结构改造 保护心脑血管系统 促进微循环 抗菌 抗炎 抗肿瘤 paeonol derivatives structural modification structural transformation protecting cardiovascular and cerebrovascular system promoting microcirculation antibacterial activity anti-inflammatory activity antitumor activity
作者简介 吴桂莹(1993—),女,在读硕士,研究方向为药物化学。Tel:13853172896 E-mail:1301086070@qq.com;通信作者:孙敬勇(1970—),男,副研究员,研究方向为药物化学。Tel:(0531)82919963 E-mail:sunjingyong08@hotmail.com
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