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帕罗西汀联合微生态制剂治疗伴有功能性消化不良症状的焦虑障碍患者疗效

The effect of Paroxetine Combined with probiotics on anxiety disorder patients with functional dyspepsia
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摘要 目的观察帕罗西汀联合微生态制剂对伴有功能性消化不良症状的焦虑障碍患者临床疗效。方法选取伴有功能性消化不良症状的焦虑障碍患者128例,随机分成两组,每组64例:单用组给予帕罗西汀治疗;联用组除帕罗西汀治疗外,加用微生态制剂(双歧杆菌三联活菌肠溶胶囊)早晚各210mg(本品为复方制剂,每克含长型双歧杆菌≥1.0×106 CFU、嗜酸乳杆菌≥1.0×106 CFU、粪肠球菌≥1.0×106 CFU),最多早晚各840mg,共10周。治疗前后应用HAMA量表和水负荷试验进行疗效评定,应用需处理的不良反应症状的量表(treatment emergent symptoms scale,TESS)进行安全性评定。结果在10周末,两组患者治疗后HAMA评分均低于治疗前,联用组的显效率高于单用组(P<0.05);水负荷试验水负荷量高于治疗前,联用组水负荷量高于单用组。在治疗后第10周末单用组常见胃肠道不良反应有便秘、恶心等,联用组不良反应少,联用组TESS评分显著降低(P<0.05)。结论联合微生态制剂对伴有功能性消化不良的焦虑症患者有显著疗效,胃肠道不良反应小。 Objective To observe the clinical effect of Paroxetine Combined with probiotic on anxiety disorder patients with functional dyspepsia.Methods 128 patients with anxiety disorder accompanied by functional dyspepsia were randomly divided into two groups,64 in each group.Paroxetine was given in the single group.In the combined group,besides Paroxetine,210 mg of microecological agents(bifidobacterium triple viable enteric-coated capsules)were added in the morning and evening(compound preparation,containing Bifidobacterium longum ≥1.0×106 CFU/g,Lactobacillus acidophilus ≥1.0×106 CFU/g,Enterococcus faecalis ≥1.0×106 CFU/g).The efficacy was assessed by HAMA scale and water load test before and after treatment,and the safety was assessed by treatment emergent symptoms scale(TESS).Results At the end of 10 weeks,the HAMA scores of the two groups after treatment were lower than those before treatment,and the marked efficiency of the combined group was higher than that of the single group(P<0.05);the water load of was higher than that before treatment,and the water load of the combined group was higher than that of the single group.At the end of the 10 th week after treatment,the common gastrointestinal adverse reactions,such as constipation,nausea,fewer side effects in the combined group,TESS score in the combined group decreased significantly(P<0.05).Conclusion The combination of probiotic has a significant effect on anxiety patients with functional dyspepsia,with less gastrointestinal side effects.
作者 梁亮 马勇 高文婷 LIANG Liang;MA Yong;GAO Wenting(The Seventh People′s Hospital of Dalian,Dalian,Liaoning116023,China)
出处 《中国微生态学杂志》 CAS CSCD 2019年第1期94-96,共3页 Chinese Journal of Microecology
关键词 焦虑障碍 微生态制剂 功能性消化不良 Anxiety disorder Probiotic Functional dyspepsia
作者简介 梁亮(1974-),女,副主任医师,从事精神心理研究,E-mail:1503032594@qq.com;通信作者:高文婷(1973-),女,实验师,E-mail:gwtpkwy@163.com.
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