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单核细胞/淋巴细胞比值与非ST段抬高型心肌梗死严重程度及预后关系研究

Study on the Relationship of Monocyte-to-lymphocyte Ratio with Severity and Prognosis of Non-ST-elevation Myocardial Infarction
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摘要 目的探讨单核细胞/淋巴细胞比值与非ST段抬高型心肌梗死严重程度及预后关系。方法选取2016年6月至2018年9月于新泰市人民医院行冠状动脉介入治疗且资料完整的NSTEMI患者220例,收集所有患者的临床资料,并进一步定期临床随访12个月,记录MACCE发生情况。采用SPSS20.0统计软件处理数据。结果 (1)外周血MLR水平与NSTEMI患者SYNTAX评分呈正相关(r=0.575,P<0.05);(2)多因素COX回归分析显示,MLR、年龄、2型糖尿病、高血压病是NSTEMI患者MACCE的独立预测因素;(3)ROC曲线分析结果显示,外周血MLR水平预测MACCE的曲线下面积为0.749(95%CI:0.701~0.791),最佳截断值为0.43,灵敏度为78.68%,特异度为71.71%。结论外周血MLR水平与NSTEMI患者冠状动脉病变严重程度呈正相关,且是NSTEMI患者MACCE的独立预测因素,在临床工作中可辅助细化NSTEMI患者危险分层管理。 Objective To investigate the relationship between the ratio of monocyte to lymphocyte and the severity and prognosis of non-ST-segment elevation myocardial infarction. Methods Two hundred and twenty patients with NSTEMI who underwent coronary intervention in Xintai People’s Hospital from June 2016 to September 2018 were selected. The clinical data of all patients were collected and followed up regularly for 12 months to record the occurrence of MACCE. SPSS 20 statistical software was used to process data. Results(1) Peripheral bloodmLR level was positively correlated with SYNTAX score of NSTEMI patients(r=0.575, P<0.05);(2) Multivariate COX regression analysis showed thatmLR, age, type 2 diabetes mellitus and hypertension were independent predictors of MACCE in NSTEMI patients;(3) ROC curve analysis showed that the area under the curve of predicting MACCE bymLR level in peripheral blood was 0.749(95% CI: 0.701~0.791), the best truncation value was 0.43, the sensitivity was 78.68%, and the specificity was 71.71%. Conclusion The level ofmLR in peripheral blood is positively correlated with the severity of coronary artery disease in NSTEMI patients, and it is an independent predictor of MACCE in NSTEMI patients. It can help to refine the risk stratification management of NSTEMI patients in clinical work.
作者 耿琨 柴强 GENG Kun;CHAI Qiang(School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences;Institute of Basic Medicine,Shandong Academy of Medical Sciences,Ji’nan,Shandong 250062;The People’s Hospital of Xintai,Xintai,Shandong 271200)
出处 《智慧健康》 2019年第2期51-53,共3页 Smart Healthcare
关键词 单核细胞 淋巴细胞 非ST段抬高型心肌梗死 预后 Monocyte Lymphocyte Non-ST-elevation myocardial infarction Prognosis
作者简介 通讯作者:柴强,男,硕士研究生导师,邮箱:cq_sdyky@163.com。
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