期刊文献+

重症急性胰腺炎继发胰腺感染的临床特点和影响因素分析

Clinical characteristics of severe acute pancreatitis patients with secondary pancreatic infection and influencing factors
分享 导出
摘要 目的探究重症急性胰腺炎(SAP)继发胰腺感染的临床特点和影响因素。方法选取2015年10月-2017年10月本院收治的SAP患者147例为研究对象。根据是否继发胰腺感染分为感染组(45例)、未感染组(102例)。收集患者临床资料,分析继发感染的临床特点;并对可能危险因素行多因素分析。结果 SAP继发感染45例,感染率30.61%。检出57株病原菌,革兰阴性菌35株(61.40%)中以阴沟肠杆菌(24.56%)占比最高;革兰阳性菌22株(38.60%)中以金黄色葡萄球菌(15.79%)占比最高。单因素分析示SAP继发感染与禁食时间、胃肠功能障碍时间、低氧血症、APACHE II评分、机械通气有关,差异均有统计学意义(P<0.05)。多因素分析示禁食时间≥15d、胃肠功能障碍时间≥5d、低氧血症、APACHE II评分≥11、机械通气是SAP继发胰腺感染的影响因素(P<0.05)。结论 SAP继发胰腺感染受多项影响因素影响,临床应实施针对性干预,降低感染发生率,促进患者预后改善。 OBJECTIVE To explore the clinical characteristics and influencing factors for severe acute pancreatitis(SAP)with secondary pancreatic infection.METHODS A total of 147 patients with SAP who were treated in the hospital from Oct 2015 to Oct 2017 were recruited as the study objects and divided into the infection group with 45 cases and the non-infection group with 102 cases according to the status of secondary infection.The clinical data were collected from the patients,the clinical characteristics of the secondary infection were analyzed,and multivariate analysis was performed for the risk factors.RESULTS Totally 45 SAP patients had secondary infection,with the infection rate 30.61%.Totally 57 strains of pathogens were isolated,35(61.40%)of which were gram-negative bacteria,and 22(38.60%)were gram-positive bacteria;Enterobacter cloacae was the predominant species of gram-negative bacteria,accounting for 24.56%;Staphylococcus aureus was dominant among the gram-positive bacteria,accounting for 15.79%.Univariate analysis indicated that the secondary infection in the SAP patients was associated with the fasting time,gastrointestinal dysfunction time,hyoxemia,APACHE II score and mechanical ventilation,and there were significant differences(P<0.05).Multivariate analysis showed that the fasting time no less than 15 days,gastrointestinal dysfunction time no less than 5 days,hyoxemia,APACHE II score no less than 11 and mechanical ventilation were the influencing factors for the secondary pancreatic infection in the SAP patients(P<0.05).CONCLUSIONThere are a variety of influencing factors for the secondary pancreatic infection in the SAP patients,and it is necessary for the hospital to take targeted intervention measures so as to reduce the infection rate and improve the prognosis of the patients.
作者 谢红 张雅卫 吴丹阳 XIE Hong;ZHANG Ya-wei;WU Dan-yang(Deyang People’s Hospital,Deyang,Sichuan 618000,China)
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2019年第5期730-733,共4页 Chinese Journal of Nosocomiology
基金 德阳市科技计划支撑基金资助项目(201511081).
关键词 重症急性胰腺炎 胰腺感染 临床特点 影响因素 Severe acute pancreatitis Pancreatic infection Clinical characteristic Influencing factor
  • 相关文献

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈