目的分析癫痫患儿丙戊酸血药浓度监测结果 ,为临床用药提供参考。方法选取427例使用丙戊酸治疗并进行血药浓度监测的癫痫患儿,统计分析患儿的年龄、性别、合并用药及血药浓度分布情况。结果 427例癫痫患儿中丙戊酸血药浓度<50μg/ml的有72例,占比16.9%;50~100μg/ml有331例,占比77.5%;>100μg/ml有24例,占比5.6%。不同年龄段及不同合并用药情况的患儿的丙戊酸血药浓度分布比较差异均有统计学意义(P<0.05),而不同性别患儿的丙戊酸血药浓度分布比较差异无统计学意义(P>0.05)。结论丙戊酸血药浓度个体差异较大,临床使用丙戊酸进行治疗时应考虑患儿特殊的生理状态及用药史,同时常规进行血药浓度的监测。
Objective To analyze the monitoring results of valproic acid blood concentration in children with epilepsy, and provide reference for clinical medication. Methods 427 children with epilepsy treated with valproic acid and monitored by blood concentration were selected, and their distribution of age, sex, combined medication and blood concentration were statistically analyzed. Results A total of 427 children with epilepsy were enrolled, 72 cases of them had a valproic acid concentration <50 μg/ml, accounting for 16.9%;and 331 cases were 50~100 μg/ml, accounting for 77.5%;24 cases were >100 μg, accounting for 5.6%. There were significant differences in the distribution of valproic acid in children of different age and different medications(P<0.05), but there was no statistically significant in the distribution of valproic acid concentrations in children of different genders(P>0.05). Conclusion The blood concentration of valproic acid varies greatly among individuals. When using valproic acid in clinical treatment, special physiological status and medication history of children should be taken into account, while routine monitoring of blood concentration should be carried out.
China Practical Medical
Children with epilepsy