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从脂肪组织血管生成探讨益气活血方药治疗肥胖症

A Review of Benefiting Qi and Activating Blood Herb on Treating Obesity from Adipose Tissue Angiogenesis
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摘要 脂肪组织血管系统与脂肪细胞功能活性关系密切,其不仅为脂肪细胞提供氧气及营养物质,而且在调节脂肪细胞代谢中也发挥重要作用。在机体生命周期内,因代谢需求的变化,脂肪组织类别、形态、功能亦随之发生改变,而血管生成直接参与了调控脂肪细胞可塑性。因而明确血管生成在脂肪组织中的作用,可能为肥胖症及相关代谢性疾病的治疗提供新思路。益气活血方药可用于治疗肥胖症,可能具有调节脂肪组织血管系统作用。本文回顾近年研究,阐述血管生成与脂肪组织功能关系,并探讨益气活血方药对脂肪组织血管生成的作用。 Recent studies showed that adipose vasculature system,which not only supplied oxygen and nutrients for adipocytes and also played an important role in adipocytes metabolism,was closely associated with adipocyte activity.During the entire adulthood,the type,form and function of adipose tissue change with the metabolic status of the host,and angiogenesis is directly involved in regulating adipocyte plasticity.Therefore,to clarify the effect of angiogenesis in adipose tissue may provide a new therapeutic strategy for obesity and related metabolic diseases.Benefiting qi and activating blood(BQAB)was used for clinical treatment of obesity,suggesting the possibility of regulating vasculature function in adipose tissue.This paper reviews the recent studies,elaborates the relationship between angiogenesis and adipose tissue function,and explore the effect of BQAB on adipose tissue angiogenesis.
作者 吴凡 陈广 胡美霖 陆付耳 WU Fan;CHEN Guang;HU Mei-lin;LU Fu-er(Institute of Integrated Chinese and Western Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030;Department of Integrated Chinese and Western Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030)
出处 《中国中西医结合杂志》 CAS CSCD 北大核心 2019年第4期491-494,共4页 Chinese Journal of Integrated Traditional and Western Medicine
基金 国家自然科学基金资助项目(No.81774259,No.81673928).
关键词 血管生成 益气活血 脂肪组织 肥胖症 angiogenesis benefiting qi and activating blood adipose tissue obesity
作者简介 通讯作者:陆付耳,Tel:027-83663237,E-mail:felu@tjh.tjmu.edu.cn
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