Urea in soil can be decomposed into ammonia under the action of urease, which reduces the utili-zation rate of nitrogen. Urease in human body causes various diseases. The structure of urease ac-tive centers from different sources and the binding modes of several inhibitors with active centers are introduced. The urease inhibitors of metal ions, hydroxamic acids, phosphoramides, phosphates, heterocyclic compounds and metal complexes are reviewed;the problems and prospect are put forward.
Hans Journal of Medicinal Chemistry