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Alkaloids, flavonoids, polyphenols might be responsible for potent antiarthritic effect of Solanum nigrum
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作者 Alamgeer Shanila Akhter +1 位作者 Ambreen Malik Uttra Umme Habiba Hasan 《中医杂志:英文版》 SCIE CAS CSCD 2019年第5期632-641,共10页
OBJECTIVE: To evaluate in vitro and in vivo antiarthritic potential of Solanum nigrum (S. nigrum). METHODS: Aqueous methanolic (70∶30) extract of S. nigrum was prepared. The in vitro antiarthritic effect was evaluate... OBJECTIVE: To evaluate in vitro and in vivo antiarthritic potential of Solanum nigrum (S. nigrum). METHODS: Aqueous methanolic (70∶30) extract of S. nigrum was prepared. The in vitro antiarthritic effect was evaluated in terms of its inhibition of protein denaturation and membrane stabilization. While, formaldehyde, complete Freund's adjuvant (CFA) and Collagen induced arthritis rat models were used to study in vivo antiarthritic activities of S. nigrum at dose level of 200, 400 and 800 mg/kg. RESULTS: The extract exhibited inhibition of protein denaturation and protected red blood cell by stabilizing the membranes in a concentration dependent manner, with maximum effect attained at 800 μg/mL. Moreover, there was a marked reduction in paw edema observed in extract treated animals, when compared to arthritic control animals in all in vivo models and 800 mg/kg dose got maximum reduction of paw edema. In CFA and collagen models, plant extract restored body weight, hematologic parameters, radiographic and histopathoOBJECTIVE: To evaluate in vitro and in vivo antiarthritic potential of Solanum nigrum (S. nigrum). METHODS: Aqueous methanolic (70∶30) extract of S. nigrum was prepared. The in vitro antiarthritic effect was evaluated in terms of its inhibition of protein denaturation and membrane stabilization. While, formaldehyde, complete Freund's adjuvant (CFA) and Collagen induced arthritis rat models were used to study in vivo antiarthritic activities of S. nigrum at dose level of 200, 400 and 800 mg/kg. RESULTS: The extract exhibited inhibition of protein denaturation and protected red blood cell by stabilizing the membranes in a concentration dependent manner, with maximum effect attained at 800 μg/mL. Moreover, there was a marked reduction in paw edema observed in extract treated animals, when compared to arthritic control animals in all in vivo models and 800 mg/kg dose got maximum reduction of paw edema. In CFA and collagen models, plant extract restored body weight, hematologic parameters, radiographic an 展开更多
关键词 ARTHRITIS SOLANUM nigrum Protein DENATURATION Formaldehyde Freund's ADJUVANT Collagen
Traditional medicines of plant origin used for the treatment of inflammatory disorders in Pakistan:A review
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作者 Alamgeer Ambreen Malik Uttra +2 位作者 Haseeb Ahsan Umme Habiba Hasan Mueen Ahmad Chaudhary 《中医杂志:英文版》 SCIE CAS CSCD 2018年第4期636-656,共21页
在 Pakistan.METHODS 为煽动性的混乱的处理在人类植物学的药上分享数据的目的我们在巴基斯坦从六个省基于数据考察了 237 份研究出版物(旁遮普= 85 , Khyber Pakhtunkhwa = 65 , Sindh = 15 , Balochistan = 8 , Gilgit Baltista... 在 Pakistan.METHODS 为煽动性的混乱的处理在人类植物学的药上分享数据的目的我们在巴基斯坦从六个省基于数据考察了 237 份研究出版物(旁遮普= 85 , Khyber Pakhtunkhwa = 65 , Sindh = 15 , Balochistan = 8 , Gilgit Baltistan = 22 , Azad Jammu 和克什米尔= 42 )在各种各样的杂志出版了直到2015年6月。这用七个联机数据库被完成:ScienceDirect, Google, Google 学者, PubMed, Wiley 联机图书馆, SpringerLink,和 MEDLINE。数据从从巴基斯坦的人使用了 371 植物种类属于的不同 perspectives.RESULTS 被分析为煽动性的混乱的处理的 263 个类和 99 个家庭。从 Asteraceae 家庭的植物最经常被使用。植物是主导的生长形式。叶子是最经常使用的植物部分。煎是主要准备方法。九植物种在巴基斯坦的大多数区域的居民最经常被使用。111 植物的一个总数试验性地被显示举办既不反关节炎也不反煽动性的活动,并且 148 植物种类被威胁。84 种有商业重要性。12 植物种被进口,并且 25 植物种类从这评论提供的 Pakistan.CONCLUSION 被出口为在巴基斯坦的植物种类的基线数据举办潜在的 anti-inflammatory/anti-arthritic 活动。 展开更多
关键词 巴基斯坦 植物起源 治疗 Google 联机数据库 传统 评论 克什米尔
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