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Ectopic expression of fungal EcGDH improves nitrogen assimilation and grain yield in rice
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作者 Dongying Tang Yuchong Peng +9 位作者 Jianzhong Lin Changqing Du Yuanzhu Yang Dan Wang Cong Liu Lu Yan Xiaoying Zhao Xia Li Liangbi Chen Xuanming Liu 《植物学报:英文版》 SCIE CAS CSCD 2018年第2期85-88,共4页
关键词 氮吸收效率 谷物产量 米饭 真菌 转基因 有机体 脱氢酶 植物
一种高分子保护的铅卤钙钛矿纳米晶
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作者 李晓 薛振杰 +8 位作者 罗聃 黄川辉 刘立志 乔学志 刘聪 宋倩 闫聪 李迎春 王铁 《中国科学:材料科学(英文版)》 CSCD 2018年第3期363-370,共8页
有机-无机杂化铅卤钙钛矿易于加工、带隙可调、电荷转移速率高,是一种具有广泛应用前景的新型光电半导体材料.在潮湿空气中的稳定性是钙钛矿实现产业化应用亟待解决的问题.本文介绍了聚甲基丙烯酸甲酯作为配体利用配体辅助再沉淀实现了... 有机-无机杂化铅卤钙钛矿易于加工、带隙可调、电荷转移速率高,是一种具有广泛应用前景的新型光电半导体材料.在潮湿空气中的稳定性是钙钛矿实现产业化应用亟待解决的问题.本文介绍了聚甲基丙烯酸甲酯作为配体利用配体辅助再沉淀实现了钙钛矿纳米晶的聚合物包裹.聚合物作为疏水性骨架通过功能性酯羰基与钙钛矿表面铅化学键合实现了表面铅位点的全覆盖,有效阻止该位点被水分子占据,形成的紧密界面层有效延缓水分子扩散到钙钛矿纳米晶中.制备的薄膜表现出超高的浸水稳定性. 展开更多
关键词 钙钛矿 纳米晶 高分子保护 聚甲基丙烯酸甲酯 有机-无机杂化 光电半导体材料 水稳定性
套细胞淋巴瘤迟发性结直肠脑回样浸润1例并文献复习 预览
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作者 盛佳琪 刘莲 +1 位作者 刘聪 黎培员 《世界华人消化杂志》 CAS 2018年第2期137-142,共6页
套细胞淋巴瘤(mantlecelllymphoma,MCL)是一类以染色体t(11:14)(q13;q32)易位和cyclinD1过度表达为特征的非霍奇金淋巴瘤亚型.MCL以老年男性多见,大多数患者在发现时已处于晚期,常伴淋巴结外浸润,尤其以胃肠道浸润常见.... 套细胞淋巴瘤(mantlecelllymphoma,MCL)是一类以染色体t(11:14)(q13;q32)易位和cyclinD1过度表达为特征的非霍奇金淋巴瘤亚型.MCL以老年男性多见,大多数患者在发现时已处于晚期,常伴淋巴结外浸润,尤其以胃肠道浸润常见.多发性淋巴瘤性息肉病是MCL浸润胃肠道的典型表现,浸润部位以结肠最常见.本文报道1例53岁的老年女性MCL患者,诊断为经典型MCL两年,予以6周期的联合化疗取得完全缓解后,出现迟发性结直肠浸润,临床表现为间歇性血便.内镜表现为较少见的黏膜皱襞脑回样增厚,伴糜烂、出血和浅小溃疡.活检组织免疫组化染色显示:淋巴样浸润的结肠黏膜中cyclinD1、CD5、CD19、CD20、CD21、CD43、CD79a、Bcl-2、PAX.5和SOX11(分散)均为阳性,而CD2、CD3、CD7、CD10、CD23、Bcl-6、c-myc和Mum一1均为阴性.增殖指数Ki.67约为15%. 展开更多
关键词 套细胞淋巴瘤 结直肠浸润 内镜检查
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First-principles investigations on structural stability,mechanical,and thermodynamic properties of LaT2Al20(T=Ti,V,Cr,Nb,and Ta) intermetallic cage compounds
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作者 权善玉 张旭东 +1 位作者 刘聪 姜伟 《中国物理B:英文版》 SCIE EI CAS CSCD 2018年第12期397-404,共8页
First principles calculations were used to explore the structural stability, mechanical properties, and thermodynamic properties of LaT2 Al20(T = Ti, V, Cr, Nb, and Ta) intermetallics. The calculated formation enthalp... First principles calculations were used to explore the structural stability, mechanical properties, and thermodynamic properties of LaT2 Al20(T = Ti, V, Cr, Nb, and Ta) intermetallics. The calculated formation enthalpy and phonon frequencies indicate that LaT2Al20 intermetallics exhibit the structural stability. The elastic moduli(B, G, E, and Hv) indicate that these intermetallics possess the better elastic properties than pure Al. The values of Poisson’s ratio v and B/G demonstrate that LaT2Al20 intermetallics are all brittle materials. The anisotropy of elasticity and Young’s modulus(three-and two-dimensional figures) indicate that LaT2Al20 compounds are anisotropic. Importantly, the calculated thermal quantities demonstrate that LaT2Al20 intermetallics possess the better thermal physical properties than pure Al at high temperatures. 展开更多
关键词 LaT2Al20 INTERMETALLICS MECHANICAL PROPERTIES anisotropic PROPERTIES dynamical and thermodynamic PROPERTIES FIRST-PRINCIPLES calculations
Synthesis and application of transition metal phosphides as electrocatalyst for water splitting
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作者 Jinzhan Su Jinglan Zhou +2 位作者 Lu Wang Cong Liu Yubin Chen 《科学通报:英文版》 SCIE EI CSCD 2017年第9期633-644,共12页
With continuous research on photocatalytic water splitting, searching for efficient catalyst for hydrogen evolution reaction(HER) becomes popular topic in addition to main catalyst research. Transition metal phosphide... With continuous research on photocatalytic water splitting, searching for efficient catalyst for hydrogen evolution reaction(HER) becomes popular topic in addition to main catalyst research. Transition metal phosphides are receiving intense attention due to its abundance in the Earth's crust and comparable catalytic properties to noble metals. In this review, the synthesis approaches, HER reaction mechanism,photocatalytic activity, approaches to improve the activity of transition metal phosphides were reviewed and discussed. It was showed that the transition metal phosphides have great potential to reduce the cost of photocatalyst and promising application on water splitting. The stability problem and participation of poisonous reactant and product in its synthesis reaction limit its application and developing in a certain extent, but with the continuous efforts on the development and improvement of the synthesis methods,transition metal phosphides will find wide application in water splitting. 展开更多
Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease 预览 被引量:1
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作者 Cong Liu Jia-Zhi Liao Pei-Yuan Li 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第11期1964-1973,共10页
Non-alcoholic fatty liver disease(NAFLD) is one of the leading causes of chronic liver diseases around the world due to the modern sedentary and food-abundant lifestyle, which is characterized by excessive fat accumul... Non-alcoholic fatty liver disease(NAFLD) is one of the leading causes of chronic liver diseases around the world due to the modern sedentary and food-abundant lifestyle, which is characterized by excessive fat accumulation in the liver related with causes other than alcohol abuse. It is widely acknowledged that insulin resistance, dysfunctional lipid metabolism, endoplasmic reticulum stress, oxidative stress, inflammation, and apoptosis/necrosis may all contribute to NAFLD. Autophagy is a protective self-digestion of intracellular organelles, including lipid droplets(lipophagy), in response to stress to maintain homeostasis. Lipophagy is another pathway for lipid degradation besides lipolysis. It is reported that impaired autophagy also contributes to NAFLD. Some studies have suggested that the histological characteristics of NAFLD(steatosis, lobular inflammation, and peri-sinusoid fibrosis) might be improved by treatment with traditional Chinese herbal extracts, while autophagy may be induced. This review will provide insights into the characteristics of autophagy in NAFLD and the related role/mechanisms of autophagy induced by traditional Chinese herbal extracts such as resveratrol, Lycium barbarum polysaccharides, dioscin, bergamot polyphenol fraction, capsaicin, and garlic-derived S-allylmercaptocysteine, which may inhibit the progression of NAFLD. Regulation of autophagy/lipophagy with traditional Chinese herbal extracts may be a novel approach for treating NAFLD, and the molecular mechanisms should be elucidated further in the near future. 展开更多
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Economic Analysis of Diesel Fuel Subsidy Policy in China’s Fishery 预览
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作者 Jiahua LE Cong LIU Weijiang WANG 《亚洲农业研究:英文版》 2017年第1期19-21,27共4页
In this paper,on the basis of an overview of the evolution of diesel fuel subsidy policy in China’s fishery,we perform an economic analysis of the existing diesel fuel subsidy policy,and believe that it is fishing sh... In this paper,on the basis of an overview of the evolution of diesel fuel subsidy policy in China’s fishery,we perform an economic analysis of the existing diesel fuel subsidy policy,and believe that it is fishing shareholders rather than fishermen who benefit most from the diesel fuel subsidy policy. The diesel fuel subsidy policy is not conducive to fishery resources protection,it will cause no fluctuation in the supply price of aquatic products,and it can not effectively increase the income of all fishermen. It is necessary to focus on subsidy method,subsidy links and subsidy level to improve diesel fuel subsidy efficiency,lower production costs,stabilize fishery production,and increase the income of fishermen. 展开更多
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竹茹中天然乙酰化半纤维素的分离、化学结构和免疫活性研究
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作者 Ju-qing HUANG Rui-ting QI +3 位作者 Mei-rong PANG Cong LIU Guang-yu LI Ying ZHANG 《浙江大学学报:B卷英文版》 SCIE CAS CSCD 2017年第2期138-151,共14页
目的:以竹材加工中产生的大宗副产物(竹茹)为原料,对其中的半纤维素进行分离纯化、结构解析及体外免疫活性的评价,旨在为竹茹半纤维素(BSH)作为免疫功能因子的研发和竹材加工副产物的高值转化提供理论依据和实践指导。创新点:首... 目的:以竹材加工中产生的大宗副产物(竹茹)为原料,对其中的半纤维素进行分离纯化、结构解析及体外免疫活性的评价,旨在为竹茹半纤维素(BSH)作为免疫功能因子的研发和竹材加工副产物的高值转化提供理论依据和实践指导。创新点:首次采用蒸汽爆破预处理联合热水提取法从竹茹中获得有免疫调节活性的天然乙酰化半纤维素。方法:采用蒸汽爆破预处理联合热水抽提法从竹茹中提取半纤维素;通过阴离子交换柱层析法对优化条件下制得的BSH进行分离;利用化学法和波谱法对分离得到的两个半纤维素组分(BSH-1和BSH-2)进行化学结构解析;采用小鼠脾脏淋巴细胞转化增殖试验、小鼠巨噬细胞RAW264.7吞噬中性红以及分泌NO试验评价BSH、BSH-1和BSH-2的体外免疫调节活性。结论:当蒸汽爆破压力为2.2 MPa和维压时间为1 min时,BSH的得率达到最大,为(2.05±0.22)%(以脱蜡样品干重计),高于未经处理对照样品5.7倍。通过DEAE-Sepharose Fast Flow阴离子交换柱对BSH进行分离,获得一个中性组分BSH-1(得率0.79%,纯度95.3%)和一个酸性组分BSH-2(得率1.06%,纯度92.5%)。化学结构解析结果表明BSH-1为乙酰化的阿拉伯木聚糖(分子量:12 800),而BSH-2为乙酰化的4-甲氧基-葡萄糖醛酸阿拉伯木聚糖(分子量:11 300)。体外免疫试验结果表明BSH和BSH-2能够显著刺激小鼠脾脏淋巴细胞增殖,而BSH-1无此活性;BSH、BSH-1和BSH-2三者均能显著促进巨噬细胞RAW264.7吞噬中性红及分泌释放NO,且呈现明显的剂量依赖性。综上所述,采用蒸汽爆破预处理联合热水提取法从竹茹中获得的半纤维素含天然乙酰基,并具有体外免疫刺激活性。 展开更多
关键词 竹茹 蒸汽爆破预处理 天然乙酰化半纤维素 化学结构 免疫调节活性
航天器指向运动目标的姿态机动路径规划 预览
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作者 刘聪 韩闻清 《军民两用技术与产品》 2017年第24期25-26,39共3页
针对航天器对运动目标的快速指向问题,研究了一种rest-to-move型姿态机动路径实时规划算法.考虑机动过程中的最大角加速度和最大角速度约束,以及角加速度阶跃变化带来的振动问题,设计了角加速度按正弦形式过渡的机动路径,既提高了快速性... 针对航天器对运动目标的快速指向问题,研究了一种rest-to-move型姿态机动路径实时规划算法.考虑机动过程中的最大角加速度和最大角速度约束,以及角加速度阶跃变化带来的振动问题,设计了角加速度按正弦形式过渡的机动路径,既提高了快速性,又满足了稳定性.将路径规划与反馈控制器相结合进行了仿真,仿真结果表明,该规划算法能够实现航天器对运动目标的快速指向,并具有很高的指向精度和稳定性. 展开更多
关键词 路径规划 运动目标 快速指向 姿态机动
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Orbital-angular-momentum-based reconfigurable optical switching and routing
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作者 Alan E.Willner Long Li +12 位作者 Guodong Xie Yongxiong Ren Hao Huang Yang Yue Nisar Ahmed Moshe J.Willner Asher J.Willner Yan Yan Zhe Zhao Zhe Wang Cong Liu Moshe Tur Solyman Ashrafi 《光子学研究:英文版》 2016年第5期5-8,共4页
Orbital angular momentum(OAM) has gained interest due to its potential to increase capacity in optical communication systems as well as an additional domain for reconfigurable networks. This is due to the following:(i... Orbital angular momentum(OAM) has gained interest due to its potential to increase capacity in optical communication systems as well as an additional domain for reconfigurable networks. This is due to the following:(i) coaxially propagated OAM beams with different charges are mutually orthogonal,(ii) OAM beams can be efficiently multiplexed and demultiplexed, and(iii) OAM charges can be efficiently manipulated. Therefore, multiple data-carrying OAM beams could have the potential capability for reconfigurable optical switching and routing. In this paper, we discuss work involving reconfigurable OAM-based optical add/drop multiplexing, space switching,polarization switching, channel hopping, and multicasting. 展开更多
胃十二指肠恶性黑色素瘤1例并文献复习 预览
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作者 刘莲 刘聪 +1 位作者 田德安 黎培员 《世界华人消化杂志》 CAS 2016年第35期4733-4738,共6页
胃十二指肠恶性黑色素瘤(malignant melanoma,MM)是一种十分罕见的高度恶性黏膜黑色素瘤,早期即易发生血行转移,因其临床表现的不典型性以及缺乏统一的诊断标准,患者往往不能得到及时的诊治,预后较差.本文报道一例81岁男性患者,因纳... 胃十二指肠恶性黑色素瘤(malignant melanoma,MM)是一种十分罕见的高度恶性黏膜黑色素瘤,早期即易发生血行转移,因其临床表现的不典型性以及缺乏统一的诊断标准,患者往往不能得到及时的诊治,预后较差.本文报道一例81岁男性患者,因纳差、消瘦行胃镜检查,发现胃十二指肠MM,组织病理学予以证实.此病例胃镜及组织病理学表现与特征有助于提高大家对此疾病的认识.本文另外结合现有资料和以往文献,对此疾病的发病情况、诊断、治疗及预后进行文献复习和讨论. 展开更多
关键词 胃十二指肠恶性黑色素瘤 诊断 预后
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Strain-induced insulator–metal transition in ferroelectric BaTiO_3(001) surface:First-principles study
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作者 杨林 王长安 +5 位作者 刘聪 秦明辉 陆旭兵 高兴森 曾敏 刘俊明 《中国物理B:英文版》 SCIE EI CAS CSCD 2016年第7期378-381,共4页
The electronic properties of TiO2-terminated BaTiO3(001) surface subjected to biaxial strain have been studied using first-principles calculations based on density functional theory. The Ti ions are always inward sh... The electronic properties of TiO2-terminated BaTiO3(001) surface subjected to biaxial strain have been studied using first-principles calculations based on density functional theory. The Ti ions are always inward shifted either at compressive or tension strains, while the inward shift of the Ba ions occurs only for high compressive strain, implying an enhanced electric dipole moment in the case of high compressive strain. In particular, an insulator–metal transition is predicted at a compressive biaxial strain of 0.0475. These changes present a very interesting possibility for engineering the electronic properties of ferroelectric BaTiO3(001) surface. 展开更多
关键词 第一性原理计算 应变诱导 绝缘体 表面 密度泛函理论 电子性质 TiO2 拉伸应变
区、县级防震减灾规划现状与存在问题——以宁夏吴忠市红寺堡区为例 预览
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作者 杨银科 刘聪 +1 位作者 苗丁丁 南静静 《农业科学与技术:英文版》 CAS 2016年第6期1488-1492,1497共6页
文章介绍了国内外防震减灾规划现状,我国防震减灾规划历史沿革、发展历程及在西北地区开展区、县级防震减灾规划的迫切性和现实意义。以宁夏吴忠市红寺堡区为例,详细分析了西北地区的区、县防震减灾规划现状与存在的特殊问题,并提出了... 文章介绍了国内外防震减灾规划现状,我国防震减灾规划历史沿革、发展历程及在西北地区开展区、县级防震减灾规划的迫切性和现实意义。以宁夏吴忠市红寺堡区为例,详细分析了西北地区的区、县防震减灾规划现状与存在的特殊问题,并提出了相应的解决措施。为我国西北地区防震减灾规划的科学编制与有效实施提供参考。 展开更多
关键词 防震减灾规划 现状 影响因素 红寺堡区
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Mid-Infrared Raman Fiber Lasers 预览
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作者 Cong Liu Han Zhang +1 位作者 Chen Wei Yong Liu 《电子科技学刊:英文版》 CSCD 2015年第4期291-297,共7页
As mid-infrared(MIR) lasers show numerous applications in the field of defense, medical, materials processing, and optical communications. Investigation on MIR Raman fiber lasers(RFLs) increasingly becomes a hot topic... As mid-infrared(MIR) lasers show numerous applications in the field of defense, medical, materials processing, and optical communications. Investigation on MIR Raman fiber lasers(RFLs) increasingly becomes a hot topic. Compared with the traditional silica fibers, fluoride and chalcogenide glass fibers possess higher nonlinear coefficients and excellent MIR transmittances. In this article, the latest developments of the MIR RFLs using fluoride and chalcogenide glass fibers as gain media are introduced, respectively. This review article mainly focuses on the developments of MIR RFLs in aspects of output wavelength, output power, and optical efficiency. Besides, the prospect of MIR RFLs is also discussed. 展开更多
关键词 拉曼光纤激光器 中红外 硫系玻璃光纤 输出功率 红外透过率 激光显示 材料处理 石英光纤
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Biological removal of antiandrogenic activity in gray wastewater and coking wastewater by membrane reactor process
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作者 Dehua Ma Lujun Chen +2 位作者 Cong Liu Chenjun Bao Rui Liu 《环境科学学报:英文版》 SCIE EI CAS CSCD 2015年第7期195-202,共8页
A recombinant human androgen receptor yeast assay was applied to investigate the occurrence of antiandrogens as well as the mechanism for their removal during gray wastewater and coking wastewater treatment. The membr... A recombinant human androgen receptor yeast assay was applied to investigate the occurrence of antiandrogens as well as the mechanism for their removal during gray wastewater and coking wastewater treatment. The membrane reactor(MBR) system for gray wastewater treatment could remove 88.0% of antiandrogenic activity exerted by weakly polar extracts and 97.3% of that by moderately strong polar extracts, but only 32.5%of that contributed by strong polar extracts. Biodegradation by microorganisms in the MBR contributed to 95.9% of the total removal. After the treatment, the concentration of antiandrogenic activity in the effluent was still 1.05 μg flutamide equivalence(FEQ)/L, 36.2%of which was due to strong polar extracts. In the anaerobic reactor, anoxic reactor, and membrane reactor system for coking wastewater treatment, the antiandrogenic activity of raw coking wastewater was 78.6 mg FEQ/L, and the effluent of the treatment system had only 0.34 mg FEQ/L. The antiandrogenic activity mainly existed in the medium strong polar and strong polar extracts. Biodegradation by microorganisms contributed to at least 89.2%of the total antiandrogenic activity removal in the system. Biodegradation was the main removal mechanism of antiandrogenic activity in both the wastewater treatment systems. 展开更多
关键词 焦化废水 抗雄激素 膜反应器 活性 水生物 膜生物反应器 微生物降解 反应器系统
枯草芽孢杆菌形成生物被膜的研究进展 被引量:6
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作者 刘伟杰 刘聪 蒋继宏 《微生物学报》 CAS CSCD 北大核心 2014年第9期977-983,共7页
生物被膜是菌体在自然界中一种常见的生存状态,直接影响着人类生产和生活的各个方面。枯草芽孢杆菌是重要的工业菌株,同时也是研究生物被膜的模式菌株。本文结合作者目前的研究,综述了目前对枯草芽孢杆菌形成生物被膜研究所取得的重要进... 生物被膜是菌体在自然界中一种常见的生存状态,直接影响着人类生产和生活的各个方面。枯草芽孢杆菌是重要的工业菌株,同时也是研究生物被膜的模式菌株。本文结合作者目前的研究,综述了目前对枯草芽孢杆菌形成生物被膜研究所取得的重要进展,包括枯草芽孢杆菌形成生物被膜的主要过程、特征、研究模型及分子调控机制,并提出了今后研究的热点问题。 展开更多
关键词 枯草芽孢杆菌 生物被膜 调控机制
Decreased histone H2B monoubiquitination in malignant gastric carcinoma 预览
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作者 Zi-Jing Wang Jing-Lin Yang +4 位作者 Yi-Ping Wang Jiang-Yan Lou Jie Chen Cong Liu Lian-Di Guo 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2013年第44期8099-8107,共9页
AIM:To investigate H2B monoubiquitination(uH2B)and H3K4 di-and tri-methylation(H3K4-2me,H3K4-3me)levels and their clinical significance in gastric cancer(GC).METHODS:Immunohistochemistry(IGC)was used to detect the di... AIM:To investigate H2B monoubiquitination(uH2B)and H3K4 di-and tri-methylation(H3K4-2me,H3K4-3me)levels and their clinical significance in gastric cancer(GC).METHODS:Immunohistochemistry(IGC)was used to detect the differential levels of uH2B,H3K4-2me and H3K4-3me modifications in GC specimens from chemo/radiotherapy-na ve patients who underwent potentially curative surgical resection(n=159)and in a random sampling of non-tumor gastric epithelium specimens(normal controls,n=20).The immunohistochemistry(IHC)-detected modifications were classified as negative,low-level,or high-level using a dual-rated(staining intensity and percentage of positively-stained cells)semi-quantitative method.The relationships between uH2B modification levels and clinicopathological parameters of GC were assessed by a Wilcoxon rank sum test(pairwise comparisons)and the Kruskal-Wallis H test(multiple comparisons).The correlation between uH2B modification and survival was estimated by Kaplan-Meier analysis,and the role of uH2B as an independent prognostic factor for survival was assessed by multivariate Cox regression analysis.RESULTS:The presence and level of H3K4-2me and H3K4-3me IHC staining was similar between the normal controls and GC specimens.In contrast,the level of uH2B was significantly lower in the malignant gastric tissues(vs normal control tissues)and decreased along with increases in dedifferentiation(well differentiated】moderately differentiated】poorly differentiated).The level of uH2B correlated with tumor differentiation(P【0.001),Lauren’s diffuse-and intestinal-type classification(P【0.001),lymph node metastasis(P=0.049)and tumor-node-metastasis stage(P=0.005).Patients with uH2B+staining had higher 5-year survival rates than patients with uH2B-staining(52.692±2.452 vs23.739±5.207,P【0.001).The uH2B level was an independent prognostic factor for cancer-specific survival(95%CI:0.237-0.677,P=0.001).CONCLUSION:uH2B displays differential IHC staining patterns corresponding to progressive stages of GC.uH2B may 展开更多
关键词 Gastric cancer EPIGENETICS HISTONE modification H2B monoubiquination Nuclear IMMUNOSTAINING
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青光眼单病种付费下医院收益及个人支付影响因素探析 预览
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作者 刘聪 唐忻 陈莹 《中国医疗保险》 2013年第8期60-62,共3页
通过对2012年12月至2013年3月期间127份青光眼医保病例的统计学分析,发现医院收益与药费、医事服务费、材料费、床位费、住院天数、护理费、麻醉费、人工器官及检查治疗费之间为负相关关系;个人现金支付与人工器官、手术费、检查治疗... 通过对2012年12月至2013年3月期间127份青光眼医保病例的统计学分析,发现医院收益与药费、医事服务费、材料费、床位费、住院天数、护理费、麻醉费、人工器官及检查治疗费之间为负相关关系;个人现金支付与人工器官、手术费、检查治疗费、其他及年龄之间为正相关关系。所以,医院收益与医保政策、医院效率等因素密切相关,个人现金支付与医保政策等因素密切相关。 展开更多
关键词 青光眼 医院收益 个人支付 影响因素
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Inhibiting the expression of hepatocyte nuclear factor 4 alpha attenuates lipopolysaccharide/ D-galactosamine-induced fulminant hepatic failure in mice 预览
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《国际肝胆胰疾病杂志:英文版》 SCIE CAS 2012年第6期624-629,共6页
BACKGROUND: Hepatocyte nuclear factor 4 alpha (HNF4α) plays an important role in regulating cytokine-induced inflammatory responses. This study aimed to investigate the role of HNF4α in the development of fulminant... BACKGROUND: Hepatocyte nuclear factor 4 alpha (HNF4α) plays an important role in regulating cytokine-induced inflammatory responses. This study aimed to investigate the role of HNF4α in the development of fulminant hepatic failure (FHF) induced by lipopolysaccharide/D-galactosamine (LPS/D-GalN). METHODS: The FHF model was induced by simultaneous intraperitoneal injection of LPS/D-GalN in mice. Three days prior to LPS/D-GalN administration, HNF4α short-hairpin interfering RNA expression plasmid or physiological saline was injected via the tail vein with a hydrodynamics-based procedure. The degree of hepatic damage and cumulative survival rate were subsequently assessed. RESULTS: The expression of HNF4α was increased in the early stage after LPS/D-GalN administration. Inhibiting the expression of HNF4α reduced serum levels of alanine aminotransferase and aspartate aminotransferase, alleviated histological injury, and improved the survival of mice with FHF. In addition, both serum and hepatic tumor necrosis factor alpha expression were suppressed when HNF4α expression was inhibited in mice with FHF. CONCLUSION: Inhibiting HNF4α expression protects mice from FHF induced by LPS/D-GalN, but the exact mechanism behind this needs further investigation. 展开更多
关键词 HEPATOCYTE nuclear factor short-hairpin RNA FULMINANT hepatic failure LIPOPOLYSACCHARIDE D-GALACTOSAMINE
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Application of hepatitis B virus replication mouse model 预览
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作者 Gao, Zhan Liu, Feng-Jun +7 位作者 Liu, Li Zhou, Tao-You Lei, Jun Xu, Lu Liu, Cong Dai, Jie Chen, En-Qiang Tang, Hong 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2010年第16期共7页
AIM:To evaluate the value of the hepatitis B virus(HBV) replication mouse model with regard to several aspects of the study of HBV biology.METHODS:To evaluate the HBV replication mouse model in detecting the efficacy ... AIM:To evaluate the value of the hepatitis B virus(HBV) replication mouse model with regard to several aspects of the study of HBV biology.METHODS:To evaluate the HBV replication mouse model in detecting the efficacy of anti-HBV agents,the interferon inducer polyinosinic-polytidylin acid(polyIC) and nucleotide analogues adefovir and entecavir were administered to mice injected with wild type pHBV4.1,and the inhibiting effect of these agents on HBV DNA replication was evaluated.To identify the model's value ... 展开更多
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