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Rice molecular markers and genetic mapping: Current status and prospects 预览
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作者 Ghulam Shabir Kashif Aslam +8 位作者 Abdul Rehman Khan Muhammad Shahid Hamid Manzoor Sibgha Noreen Mueen Alam Khan Muhammad Baber Muhammad Sabar Shahid Masood Shah Muhammad Arif 《农业科学学报:英文版》 SCIE CAS CSCD 2017年第9期1879-1891,共13页
Dramatic changes in climatic conditions that supplement the biotic and abiotic stresses pose severe threat to the sustainable rice production and have made it a difficult task for rice molecular breeders to enhance pr... Dramatic changes in climatic conditions that supplement the biotic and abiotic stresses pose severe threat to the sustainable rice production and have made it a difficult task for rice molecular breeders to enhance production and productivity under these stress factors. The main focus of rice molecular breeders is to understand the fundamentals of molecular pathways involved in complex agronomic traits to increase the yield. The availability of complete rice genome sequence and recent improvements in rice genomics research has made it possible to detect and map accurately a large number of genes by using linkage to DNA markers. Linkage mapping is an effective approach to identify the genetic markers which are co-segregating with target traits within the family. The ideas of genetic diversity, quantitative trait locus(QTL) mapping, and marker-assisted selection(MAS) are evolving into more efficient concepts of linkage disequilibrium(LD) also called association mapping and genomic selection(GS), respectively. The use of cost-effective DNA markers derived from the fine mapped position of the genes for important agronomic traits will provide opportunities for breeders to develop high-yielding, stress-resistant, and better quality rice cultivars. Here we focus on the progress of molecular marker technologies, their application in genetic mapping and evolution of association mapping techniques in rice. 展开更多
关键词 分子标记技术 遗传作图 农艺性状基因 水稻品种 非生物胁迫 展望 分子育种 基因组学
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Antibiotic resistance and cagA gene correlation:A looming crisis of Helicobacter pylori 预览 被引量:5
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作者 Adnan Khan Amber Farooqui +3 位作者 Hamid Manzoor Syed Shakeel Akhtar Muhammad Saeed Quraishy Shahana Urooj Kazmi 《世界胃肠病学杂志:英文版》 SCIE CAS CSCD 2012年第18期 2245-2252,共8页
瞄准:决定 Helicobacter pylori 的抗菌素抵抗(H。pylori ) 在有主人和病原体的巴基斯坦和它的关联联系了因素。方法:H 的 178 紧张的一个总数。pylori 从消化不良的病人的胃的活体检视被孤立。对第一的危险性模式和第二线的抗菌素被... 瞄准:决定 Helicobacter pylori 的抗菌素抵抗(H。pylori ) 在有主人和病原体的巴基斯坦和它的关联联系了因素。方法:H 的 178 紧张的一个总数。pylori 从消化不良的病人的胃的活体检视被孤立。对第一的危险性模式和第二线的抗菌素被决定,抵抗的趋势在与采样时期,胃的条件和 cagA 基因马车的关系被分析。抵抗的获得上的 cagA 基因的效果被变异的选择试金调查。结果:观察证明 monoresistant 紧张为 metronidazole 与 89% 的率是流行的, 36% 为 clarithromycin, 37% 为 amoxicillin, 18.5% 为 ofloxacin 并且 12% 为四圜素。而且, clarithromycin 抵抗在从 2005 ~ 2008 的上升(32% 对 38% , P = 0.004 ) 并且它显著地被观察在非 ulcerative 与胃炎,胃的溃疡和十二指肠的溃疡案例相比的消化不良的病人(53% 对 20% , 18% 和 19% , P = 0.000 ) 。相反, metronidazole 和 ofloxacin 抵抗在胃炎和胃的溃疡案例是更普通的。在 vitro 的抵抗异种的分发分析和频率与 metronidazole 和 ofloxacin 抵抗与 cagA 基因的缺席相关。结论:学习证实在 H 与胃的发炎和 cagA 基因马车的度联系的抗菌素抵抗的惊人层次。pylori 紧张。 展开更多
关键词 抗生素耐药性 幽门螺旋杆菌 基因突变 幽门螺杆菌 氧氟沙星 消化不良 克拉霉素 甲硝唑
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