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Clinical efficacy of gemcitabine and cisplatin-based transcatheter arterial chemoembolization combined with radiotherapy in hilar cholangiocarcinoma 预览
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作者 Wen-Heng Zheng Tao Yu +7 位作者 Ya-Hong Luo Ying Wang Ye-Fu Liu Xiang-Dong Hua Jie Lin Zuo-Hong Ma Fu-Lu Ai Tian-Lu Wang 《世界胃肠肿瘤学杂志:英文版(电子版)》 CAS 2019年第6期489-498,共10页
BACKGROUND Radical surgical resection is regarded as the best treatment for hepatic hilar cholangiocarcinoma. However, 60%-70% of patients have lost the chance of surgery at the time of diagnosis. Simple biliary stent... BACKGROUND Radical surgical resection is regarded as the best treatment for hepatic hilar cholangiocarcinoma. However, 60%-70% of patients have lost the chance of surgery at the time of diagnosis. Simple biliary stent or drainage tube placement may fail in a short time due to tumor invasion or overgrowth, bile accumulation, or biofilm formation. Effective palliative treatments to extend the effective drainage time are of great significance for improving the quality of life of patients and changing the prognosis of patients. AIM To investigate the clinical efficacy of gemcitabine and cisplatin-based transcatheter arterial chemoembolization (TACE) combined with radiotherapy in hilar cholangiocarcinoma.METHODS A retrospective analysis was conducted on patients clinically diagnosed with hilar cholangiocarcinoma from June 2014 to January 2017 at the Liaoning Provincial Cancer Hospital. Patients were evaluated by specialists, and those who were not suitable for surgery or unwilling to undergo surgery and met the inclusion criteria were included in the study. There were a total of 72 patients (34 males and 38 females) with an average age of 59.9 years (range, 40-72 years). According to percutaneous transhepatic biliary angiography and the patients’ wishes, stent implantation or biliary drainage tube implantation was used to relieve biliary obstruction. The patients were divided into either a control group or a combined treatment group according to their follow-up treatment. The control group consisted of a total of 35 patients who received simple biliary drainage tube placement and biliary stent implantation (7 patients with bilateral stents and 6 with a unilateral stent) and 22 patients receiving biliary drainage tube placement alone. The combined treatment group received TACE and extracorporeal radiotherapy after biliary drainage or biliary stent implantation and consisted of a total of 37 patients, including 21 patients receiving combined treatment after biliary stent placement (14 patients with bilateral stents an 展开更多
关键词 HILAR cholangiocarcinoma BILIARY stent Percutaneous BILIARY drainage GEMCITABINE CISPLATIN RADIOTHERAPY Transcatheter arterial CHEMOEMBOLIZATION
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Effects of Niaoduqing Particles(尿毒清颗粒)on Delaying Progression of Renal Dysfunction:A Post-trial,Open-Label,Follow-up Study
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作者 ZHENG Ying WANG Nian-song +24 位作者 LIU Yu-ning HE Li-qun JIAN Gui-hua LIU Xu-sheng NI Zhao-hui CHENG Xiao-hong LIN Hong-li ZHOU Wen-hua WANG Ya-ping FANG Jing-ai HE Ya-ni YANG Hong-tao ZHAO Li-juan DING Hart-lu WANG Li-hua YU Ren-huan LI Wen-ge YE Zhi-ming GUO Wang ZHAN Yong-li MAO Hui-juan HU Zhao YAO Chen CAI Guang-yan CHEN Xiang-mei 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第3期168-174,共7页
Objective:To follow up the participants of the randomized clinical trial "Efficacy and Safety of Niaoduqing Particles(尿毒清颗粒) for Delaying Moderate-to-Severe Renal Dysfunction", and assess the long-term ... Objective:To follow up the participants of the randomized clinical trial "Efficacy and Safety of Niaoduqing Particles(尿毒清颗粒) for Delaying Moderate-to-Severe Renal Dysfunction", and assess the long-term effects of Niaoduqing Particles on delaying the progression of renal dysfunction. Methods: Participants, who had previously been randomly assigned to receive Niaoduqing Particles or placebo for 24 weeks(146 cases in each group), were invited to follow-up and all were administered Niaoduqing Particles 5 g thrice daily and 10 g before bedtime for 24 weeks. The primary endpoints were changes in baseline serum creatinine(Scr) and estimated glomerular filtration rate(e GFR) after completion of the open-label treatment period. Results: After the double-blind period, the median(interquartile range) changes in Scr were 1.1(–13.0–24.1) and 11.7(–2.6–42.9) μmol/L for the Niaoduqing Particle and placebo groups, respectively(P=0.008), and the median changes in e GFRs were –0.2(–4.3–2.7) and –2.21(–5.7–0.8) mL·min^-1·1.73 m^-2, respectively(P=0.016). There were significant differences in the double-blind period changes in renal function between groups. After the open-label period, the median changes in Scr were 9.0(–10.0–41.9) and 17.5(–6.0–50.0) μmol/L for the Niaoduqing Particle and placebo groups according to baseline grouping, respectively(P=0.214), and the median changes in eGFRs were –2.3(–6.4–1.9) and –3.7(–7.5–1.1) mL·min^-1·1.73 m^-2, respectively(P=0.134). There were no statistical differences in the open-label period changes in renal function between groups. The eGFR reduction of participants who accepted Niaoduqing Particle treatment for 48 weeks was projected to 2.5 m L·min^-1·1.73 m^-2 per year. Conclusions: Niaoduqing Particles appear to have long-term efficacy for patients with moderate-to-severe renal dysfunction. Although there was no statistical difference, the early use of Niaoduqing Paticles seems to ameliorate the worsening of renal function. 展开更多
关键词 chronic kidney disease moderate-to-severe renal dysfunction NIAODUQING PARTICLES post-trial FOLLOW-UP Chinese medicine
3,6-脱水己糖构建方法的研究进展
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作者 王洪 卢路 +3 位作者 黄宇豪 徐进宜 谢唯佳 吴晓明 《药学进展》 CAS 2019年第1期51-58,共8页
3,6-脱水己糖是一种独特而重要的糖类物质。在某些天然产物以及化学合成活性小分子中因有3,6-脱水己糖片段的存在而使其具有特殊的物理化学性质以及生物活性,因此化学家研究了不同方法来构建3,6-脱水己糖结构。主要介绍近年来3,6-脱水... 3,6-脱水己糖是一种独特而重要的糖类物质。在某些天然产物以及化学合成活性小分子中因有3,6-脱水己糖片段的存在而使其具有特殊的物理化学性质以及生物活性,因此化学家研究了不同方法来构建3,6-脱水己糖结构。主要介绍近年来3,6-脱水己糖的构建方法及其在类似结构化合物合成上的运用,为研究者在合成此类化合物时提供参考。 展开更多
关键词 3 6-脱水己糖 活性天然产物 化学合成
POE-g-MAH低温增韧聚酰胺6的研究 预览
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作者 郭红 王秀秀 +4 位作者 关宏宇 李亚林 陆星宇 陈利猛 吕通建 《中国塑料》 CAS CSCD 北大核心 2019年第4期1-5,共5页
以聚酰胺6(PA6)为基体树脂,采用增韧剂马来酸酐接技聚烯烃弹性体(POE-g-MAH)对PA6进行增韧改性研究。制备了不同增韧剂含量的改性PA6,研究了POE-g-MAH的含量对复合材料力学性能及流动性能的影响,以及复合材料在常温、低温及高寒条件下... 以聚酰胺6(PA6)为基体树脂,采用增韧剂马来酸酐接技聚烯烃弹性体(POE-g-MAH)对PA6进行增韧改性研究。制备了不同增韧剂含量的改性PA6,研究了POE-g-MAH的含量对复合材料力学性能及流动性能的影响,以及复合材料在常温、低温及高寒条件下的韧性及拉伸性能,并利用扫描电子显微镜对复合材料的微观形貌进行表征。结果表明,当增韧剂含量为20%(质量分数,下同)时,材料的综合性能较优;复合材料在低温下韧性良好,在-50℃高寒条件下,当增韧剂含量为20%、30%时仍具有良好的韧性,冲击强度较纯PA6提高了130%、350%,断裂伸长率较纯PA6提高了195%、230%;低温拉伸强度随着温度的降低呈上升趋势。 展开更多
关键词 聚酰胺6 增韧剂 低温
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Reduced blister quantity in damaged tungsten exposed to deuterium plasma
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作者 Xiu-Li Zhu Long Cheng +6 位作者 ShiWei Wang Yue Yuan Guang-Hong Lu Ying Zhang Er-Yang Lu Xing-Zhong Cao Jian-Jun Huang 《中国科学:物理学、力学、天文学英文版》 SCIE EI CAS CSCD 2019年第5期125-128,共4页
Tungsten (W) is a promising candidate for plasma-facing materials (PFMs) in fusion reactors owing to its excellent thermal conductivity, sputtering resistance, and low hydrogen isotope solubility [1]. W PFMs encounter... Tungsten (W) is a promising candidate for plasma-facing materials (PFMs) in fusion reactors owing to its excellent thermal conductivity, sputtering resistance, and low hydrogen isotope solubility [1]. W PFMs encounter the challenges of triple irradiations generated by high-heat loads;high-flux particles, including helium/deuterium (D)/tritium (T);and high-energy neutrons. 展开更多
关键词 damaged TUNGSTEN DEUTERIUM PLASMA
肝静脉系统栓堵术在第二阶段根治性肝癌切除术中的应用
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作者 刘畅 张晓赟 +9 位作者 金遽 杨家印 吴泓 王文涛 卢强 李伟 焦河 严律南 文天夫 卢武胜 《中国普外基础与临床杂志》 CAS 2019年第7期841-846,共6页
目的初步探讨肝静脉系统栓堵术(liver venous deprivation, LVD)在乙肝背景的肝癌患者第二阶段根治性肝癌切除术中的应用。方法1例术前诊断为中央型肝癌(V、Ⅷ段交界处)的53岁男性患者,因剩余肝脏体积(future liver remnant, FLR)不足... 目的初步探讨肝静脉系统栓堵术(liver venous deprivation, LVD)在乙肝背景的肝癌患者第二阶段根治性肝癌切除术中的应用。方法1例术前诊断为中央型肝癌(V、Ⅷ段交界处)的53岁男性患者,因剩余肝脏体积(future liver remnant, FLR)不足无法行标准右半肝切除术,而行LVD术诱导FLR增生。LVD术后1、2及3周评估患者一般情况并复查腹部CT评估FLR体积和剩余肝脏/体质量比。结果患者LVD术前FLR为24.2%,剩余肝脏/体质量比为0.459%;LVD术后第1、2及3周复查FLR,分别为29.5%、38.3%和44.4%,剩余肝脏/体质量比分别为0.545%、0.707%和0.820%.患者于LVD术后第25天顺利施行了标准右半肝切除术,术后安全康复出院。结论LVD可使剩余肝脏体积快速增大,可让预计FLR不足的肝癌患者有接受第二阶段根治性手术治疗的机会,是一项有效诱导FLR增生的新技术。 展开更多
关键词 肝癌 肝静脉系统栓堵术 二阶段肝切除术 门静脉栓塞 肝静脉栓塞
动脉内溶栓联合高压氧对重症缺血性脑卒中患者血清CGRP、sICAM-1水平的影响 预览
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作者 卢先富 麦用军 +3 位作者 阳洪 卢韬 周树明 莫崇洋 《心血管康复医学杂志》 CAS 2019年第2期192-196,共5页
目的:探讨经动脉内溶栓联合高压氧对重症缺血性脑卒中患者血清可溶性细胞间黏附分子-1(sICAM-1)、降钙素基因相关肽(CGRP)水平的影响。方法:选择我院重症缺血性脑卒中患者96例,随机均分为溶栓治疗组和联合治疗组(动脉内溶栓+高压氧治疗... 目的:探讨经动脉内溶栓联合高压氧对重症缺血性脑卒中患者血清可溶性细胞间黏附分子-1(sICAM-1)、降钙素基因相关肽(CGRP)水平的影响。方法:选择我院重症缺血性脑卒中患者96例,随机均分为溶栓治疗组和联合治疗组(动脉内溶栓+高压氧治疗)。采用神经功能缺损量表(NIHSS)评估神经功能恢复情况,采用改良Rankin量表(mRS)评估临床症状恢复情况,治疗两周后,比较两组临床疗效,NIHSS等的变化。结果:治疗后,与溶栓治疗组比较,联合治疗组总有效率显著提高(77.08%比93.75%,P=0.021);NIHSS[(8.10±3.45)分比(5.36±2.11)分]及mRS[(2.58±0.80)分比(1.81±0.76)分]评分显著降低(P均=0.001);血清sICAM-1[(237.31±18.04) ng/ml比(220.25±16.40) ng/ml]水平显著降低,血清CGRP[(27.02±6.06) pg/ml比(35.24±6.13) pg/ml]水平显著升高(P均=0.001);两组间两周血管再通情况比较差异无统计学意义(P>0.05)。结论:联合动脉内溶栓与高压氧治疗重症缺血性脑卒中效果显著,可缓解患者临床症状,恢复认知功能,提高血管再通率。 展开更多
关键词 卒中 血栓溶解疗法 高压氧
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The enhanced X-ray Timing and Polarimetry mission eXTP
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作者 ShuangNan Zhang Andrea Santangelo +112 位作者 Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang S?ren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J. M. in 't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jorn Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen YuPeng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino José Luis Gálvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng 《中国科学:物理学、力学、天文学英文版》 SCIE EI CAS CSCD 2019年第2期3-27,共25页
In this paper we present the enhanced X-ray Timing and Polarimetry mission----eXTP,eXTP is a space science mission designed to study fundamental physics under extreme conditions of density,gravity and magnetism.The mi... In this paper we present the enhanced X-ray Timing and Polarimetry mission----eXTP,eXTP is a space science mission designed to study fundamental physics under extreme conditions of density,gravity and magnetism.The mission aims at determining the equation of state of matter at supra-nuclear density,measuring effects of QED,and understanding the dynamics of matter in strong-field gravity.In addition to investigating fundamental physics,eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects.In particular,its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources. The paper provides a detailed description of:(1)the technological and technical aspects,and the expected performance of the instruments of the scientific payload;(2)the elements and functions of the mission,from the spacecraft to the ground segment. 展开更多
关键词 X-RAY INSTRUMENTATION X-RAY POLARIMETRY X-RAY TIMING space mission:eXTP
黄芪、冬虫夏草对新生鼠肾积水病肾TGF-β1、IGF-1表达的影响 预览
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作者 赵鹏 马洪 +4 位作者 吴谋东 刘红 杨远贵 鲁强 董淑荃 《贵州医药》 CAS 2019年第5期683-687,I0001共6页
目的了解黄芪、冬虫夏草对新生鼠肾积水病肾转化生长因子-β1(TGF-β1)和胰岛素样生长因子-1(IGF-1)表达的影响,探讨其对病肾损害有否保护作用。方法选用生后48h内的Wistar鼠96只,随机分为8组,各12只。随机选1组行假手术,作为对照组;余... 目的了解黄芪、冬虫夏草对新生鼠肾积水病肾转化生长因子-β1(TGF-β1)和胰岛素样生长因子-1(IGF-1)表达的影响,探讨其对病肾损害有否保护作用。方法选用生后48h内的Wistar鼠96只,随机分为8组,各12只。随机选1组行假手术,作为对照组;余7组采用腰大肌压迫左输尿管上段制作动物模型,再任选1组做模型组(生理盐水1mL/kg/d),余6组随机分为黄芪组[低剂量1mL/kg/d+高剂量3mL/kg/d]、冬虫夏草组[低剂量0.5mL/kg/d+高剂量2mL/kg/d]、联合用药组[低剂量(黄芪1mL/kg/d+冬虫夏草0.5mL/kg/d)和高剂量(黄芪3mL/kg/d+冬虫夏草2mL/kg/d)],并按相应剂量定时皮下注射。饲养3周处死动物,切取不同组别的病肾组织,HE染色观察组织结构改变,免疫组化及RT-PCR检测病肾TGF-β1、IGF-1的蛋白及基因变化;收集肾盂尿液、ELISA法检测尿TGF-β1、IGF-1水平。结果对照组双肾大小、形态一致,肾小球、肾小管发育正常,肾组织内TGF-β1低表达、IGF-1高表达。模型组病肾较健肾大,肾盂扩张、积水,肾小球结构异常,肾小球鲍曼囊扩张、肾小管扩张;病肾组织TGF-β1在肾小管高表达、IGF-1低表达;病肾尿TGF-β1升高、IGF-1降低。黄芪、冬虫夏草组病肾虽仍大于健肾,但镜下肾小球、肾小管的损害较模型组明显减轻;病肾组织TGF-β1、IGF-1的蛋白及基因不同程度表达,尿TGF-β1、IGF-1水平介于对照组和模型组之间,与相应的对照组、模型组比较,差异均有统计学意义(P<0.05)。结论黄芪、冬虫夏草可能通过调控新生鼠肾积水病肾组织TGF-β1和IGF-1的表达,以阻止或减轻病肾的损害,从而起到保护效应。 展开更多
关键词 WISTAR鼠 肾积水 黄芪 冬虫夏草 转化生长因子-β1 胰岛素样生长因子-1
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基于形态学性状和SSR标记的花生品种遗传多样性分析和特异性鉴定 预览
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作者 刘洪 徐振江 +6 位作者 饶得花 鲁清 李少雄 刘海燕 陈小平 梁炫强 洪彦彬 《作物学报》 CAS CSCD 北大核心 2019年第1期26-36,共11页
以101份南方花生区试品种为材料, 利用形态学性状和SSR标记进行品种遗传多样性分析和特异性鉴定。结果表明, 29个形态学性状中有7个无多样性, 其余22个的多样性指数为0.23~0.77, 平均为0.43。在相似系数为0.76处, 将供试品种划分为七大... 以101份南方花生区试品种为材料, 利用形态学性状和SSR标记进行品种遗传多样性分析和特异性鉴定。结果表明, 29个形态学性状中有7个无多样性, 其余22个的多样性指数为0.23~0.77, 平均为0.43。在相似系数为0.76处, 将供试品种划分为七大类群, 同一育种单位的品种倾向于聚在一起。用40个SSR标记共检测出167个等位基因,单个标记检测的等位基因数2~6 个, 平均为4.18个。标记的多态性信息量(PIC)差异较大, 最大为0.79, 最小为0.26,平均为0.55。在相似系数为0.70处, 供试品种可被划分为六大类群, 同一省份育成的品种多聚为一类。Mantel检验发现品种间的形态学性状和SSR 标记的相似系数矩阵相关性弱(r = 0.36), SSR 标记无法取代形态学性状单独用于花生品种特异性鉴定, 但两者相结合能有效提高花生品种特异性鉴定的准确性。 展开更多
关键词 花生 形态学 SSR 遗传多样性 DUS
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Shuxuetong injection protects cerebral microvascular endothelial cells against oxygen-glucose deprivation reperfusion 预览
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作者 Zuo-Yan Sun Fu-Jiang Wang +6 位作者 Hong Guo Lu Chen Li-Juan Chai Rui-Lin Li Li-Min Hu Hong Wang Shao-Xia Wang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第5期783-793,共11页
Shuxuetong injection composed of leech(Hirudo nipponica Whitman)and earthworm(Pheretima aspergillum)has been used for the clinical treatment of acute stroke for many years in China.However,the precise neuroprotective ... Shuxuetong injection composed of leech(Hirudo nipponica Whitman)and earthworm(Pheretima aspergillum)has been used for the clinical treatment of acute stroke for many years in China.However,the precise neuroprotective mechanism of Shuxuetong injection remains poorly understood.Here,cerebral microvascular endothelial cells(bEnd.3)were incubated in glucose-free Dulbecco’s modified Eagle’s medium containing 95%N2/5%CO2 for 6 hours,followed by high-glucose medium containing 95%O2 and 5%CO2 for 18 hours to establish an oxygen-glucose deprivation/reperfusion model.This in vitro cell model was administered Shuxuetong injection at 1/32,1/64,and 1/128 concentrations(diluted 32-,64-,and 128-times).Cell Counting Kit-8 assay was used to evaluate cell viability.A fluorescence method was used to measure lactate dehydrogenase,and a fluorescence microplate reader used to detect intracellular reactive oxygen species.A fluorescent probe was also used to measure mitochondrial superoxide production.A cell resistance meter was used to measure transepithelial resistance and examine integrity of monolayer cells.The fluorescein isothiocyanate-dextran test was performed to examine blood-brain barrier permeability.Real-time reverse transcription polymerase chain reaction was performed to analyze mRNA expression levels of tumor necrosis factor alpha,interleukin-1β,interleukin-6,and inducible nitric oxide synthase.Western blot assay was performed to analyze expression of caspase-3,intercellular adhesion molecule 1,vascular cell adhesion molecule 1,occludin,vascular endothelial growth factor,cleaved caspase-3,B-cell lymphoma 2,phosphorylated extracellular signal-regulated protein kinase,extracellular signal-regulated protein kinase,nuclear factor-κB p65,I kappa B alpha,phosphorylated I kappa B alpha,I kappa B kinase,phosphorylated I kappa B kinase,claudin-5,and zonula occludens-1.Our results show that Shuxuetong injection increases bEnd.3 cell viability and B-cell lymphoma 2 expression,reduces cleaved caspase-3 expression,inhibits produ 展开更多
关键词 nerve REGENERATION SHUXUETONG injection brain MICROVASCULAR endothelial cells oxygen-glucose deprivation/reperfusion tight junction proteins mitochondrial function inflammatory factors blood-brain barrier neuroprotection neural REGENERATION
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体外膜氧合支持呼吸衰竭新生儿乳酸水平与预后分析 预览
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作者 梁洪 洪小杨 +2 位作者 赵喆 陆妹 刘颖悦 《中国体外循环杂志》 2019年第3期157-160,共4页
目的 分析体外膜氧合(ECMO)支持下呼吸衰竭新生儿乳酸(Lac)水平与预后关系。方法 收集原陆军总医院附属八一儿童医院2012年10月至2017年10月ECMO呼吸支持的36例新生儿严重呼吸衰竭临床资料,根据预后分为存活组和死亡组,比较两组患儿的... 目的 分析体外膜氧合(ECMO)支持下呼吸衰竭新生儿乳酸(Lac)水平与预后关系。方法 收集原陆军总医院附属八一儿童医院2012年10月至2017年10月ECMO呼吸支持的36例新生儿严重呼吸衰竭临床资料,根据预后分为存活组和死亡组,比较两组患儿的性别、日龄、体重、ECMO前处理、氧合指数(OI)值、ECMO前的动脉血气pH值、动脉氧分压(PaO2)和二氧化碳分压(PaCO2)、BE、Lac和ECMO支持后6h、12h、24h、36h、48h的Lac水平及清除率。结果 存活组和死亡组患儿在性别、日龄、体重、ECMO前处理、OI值、ECMO前的PaO2、PaCO2差异无统计学意义(P>0.05)。存活组ECMO前动脉血气pH值显著高于死亡组(P<0.001),BE值显著高于死亡组(P<0.05)。两组患儿Lac水平随着时间的延长而降低,存活组在ECMO支持前、开始ECMO支持后6h、12h和36h死亡组患儿体内的Lac水平显著低于存活组(P<0.05),两组之间各时间点Lac清除率无显著差异。结论 ECMO支持前pH、BE值和各时间点Lac水平对需ECMO支持严重呼吸衰竭的新生儿预后有一定预示作用,有助于尽早鉴别需ECMO支持呼吸衰竭新生儿。 展开更多
关键词 体外膜氧合 新生儿 呼吸衰竭 血气 乳酸 清除率
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Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1
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作者 Nai-jun Miao Hong-yan Xie +13 位作者 Dan Xu Jian-yong Yin Yan-zhe Wang Bao Wang Fan Yin Zhuan-li Zhou Qian Cheng Pan-pan Chen Li Zhou Hong Xue Wei Zhang Xiao-xia Wang Jun Liu Li-min Lu 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第6期790-800,共11页
Caspase-11 is a key upstream modulator for activation of inflammatory response under pathological conditions. In this study, we investigated the roles of caspase-11 in the maturation of interleukin-1β (IL-1β) and de... Caspase-11 is a key upstream modulator for activation of inflammatory response under pathological conditions. In this study, we investigated the roles of caspase-11 in the maturation of interleukin-1β (IL-1β) and development of renal interstitial fibrosis in vivo and in vitro. Mice were subjected to unilateral ureteral obstruction (UUO). The mice were treated with either caspase-11 inhibitor wedelolactone (Wed, 30 mg/kg/day, ig) for 7 days or caspase-11 siRNA (10 nmol/20 g body weight per day, iv) for 14 days. The mice were euthanized on day 14, their renal tissue and blood sample were collected. We found that the obstructed kidney had significantly higher caspase-11 levels and obvious tubular injury and interstitial fibrosis. Treatment with Wed or caspase-11 siRNA significantly mitigated renal fibrosis in UUO mice, evidenced by the improved histological changes. Furthermore, caspase-11 inhibition significantly blunted caspase-1 activation, IL-ip maturation, transforming growth factor-p (TGF-P), fibronectin, and collagen I expressions in the obstructed kidney. Renal tubular epithelial NRK-52E cells were treated in vitro with angiotensin (Ang, 1 pmol/L), which stimulated caspase-11 activation and IL-ip maturation. Treatment with IL-1β (20ng/ml) significantly increased the expression of TGF-β, fibronectin, and collagen I in the cells. Ang ll-induced expression of TGF-β, fibronectin, and collagen I were suppressed by caspase-11 siRNA or Wed. Finally, we revealed using co-immunoprecipitation that caspase-11 was able to interact with caspase-1 in NRK-52E cells. These results suggest that caspase-11 is involved in UUO-induced renal fibrosis. Elevation of caspase-11 in the obstructed kidney promotes renal fibrosis by stimulating caspase-1 activation and IL-1β maturation. 展开更多
关键词 caspase-11 INTERLEUKIN-1Β angiotensin UNILATERAL ureteral OBSTRUCTION renal fibrosis
Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice
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作者 CHEN Mei-Yu LI Hong +5 位作者 LU Xiao-Xiao LING Li-Jun WENG Hong-Bo SUN Wei CHEN Dao-Feng ZHANG Yun-Yi 《中国天然药物:英文版》 SCIE CAS CSCD 2019年第3期187-197,共11页
Houttuynia cordata polysaccharide (HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infe... Houttuynia cordata polysaccharide (HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were infected with H1N1 virus and orally administrated HCP at a dosage of 40 mg(kg^-1(d^-1. H1N1 infection caused pulmonary and intestinal injury and gut microbiota imbalance. HCP significantly suppressed the expression of hypoxia inducible factor-1α and decreased mucosubstances in goblet cells, but restored the level of zonula occludens-1 in intestine. HCP also reversed the composition change of intestinal microbiota caused by H1N1 infection, with significantly reduced relative abundances of Vibrio and Bacillus, the pathogenic bacterial genera. Furthermore, HCP rebalanced the gut microbiota and restored the intestinal homeostasis to some degree. The inhibition of inflammation was associated with the reduced level of Toll-like receptors and interleukin-1β in intestine, as well as the increased production of interleukin-10. Oral administration of HCP alleviated lung injury and intestinal dysfunction caused by H1N1 infection. HCP may gain systemic treatment by local acting on intestine and microbiota. This study proved the high-value application of HCP. 展开更多
关键词 HIN1 INFLUENZA virus Houttuynia cordata Inflammation INTESTINAL Barrier MICROBIOTA POLYSACCHARIDE
Effectiveness of Integrative Medicine Therapy on Coronary Artery Disease Prognosis: A Real-World Study
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作者 ZHAO Kang TIAN Jin-fan +7 位作者 ZHAO Cong YUAN Fei GAO Zhu-ye LI Li-zhi LIU Hong-xu WANG Xian GE Chang-jiang LU Shu-zheng 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第1期9-15,共7页
Objective: To evaluate the effectiveness of integrative medicine(IM) on patients with coronary artery disease(CAD) and investigate the prognostic factors of CAD in a real-world setting. Methods: A total of 1,087 hospi... Objective: To evaluate the effectiveness of integrative medicine(IM) on patients with coronary artery disease(CAD) and investigate the prognostic factors of CAD in a real-world setting. Methods: A total of 1,087 hospitalized patients with CAD from four hospitals in Beijing, China were consecutively selected between August 2011 and February 2012. The patients were assigned to two groups based on the treatment: Chinese medicine(CM) plus conventional treatment, i.e., IM therapy(IM group); or conventional treatment alone(CT group). The endpoint was major adverse cardiac events [MACE; including cardiac death, myocardial infarction(MI), and revascularization]. Results: A total of 1,040 patients finished the 2-year follow-up. Of them, 49.4%(514/1,040) received IM therapy. During the 2-year follow-up, the total incidence of MACE was 11.3%. Most of the events involved revascularization(9.3%). Cardiac death/MI occurred in 3.0% of cases. For revascularization, logistic stepwise regression analysis revealed that age 65 years [odds ratio(OR), 2.224], MI(OR, 2.561), diabetes mellitus(OR, 1.650), multi-vessel lesions(OR, 2.554), baseline high sensitivity C-reactive protein level 3 mg/L(OR, 1.678), and moderate or severe anxiety/depression(OR, 1.849) were negative predictors(P<0.05); while anti-platelet agents(OR, 0.422), β-blockers(OR, 0.626), statins(OR, 0.318), and IM therapy(OR, 0.583) were protective predictors(P<0.05). For cardiac death/MI, age 65 years(OR, 6.389) and heart failure(OR, 7.969) were negative predictors(P<0.05), while statin use(OR, 0.323) was a protective predictor(P<0.05) and IM therapy showed a beneficial tendency(OR, 0.587), although the difference was not statistically significant(P=0.218). Conclusion: In a real-world setting, for patients with CAD, IM therapy was associated with a decreased incidence of revascularization and showed a potential benefit in reducing the incidence of cardiac death or MI. 展开更多
关键词 CORONARY ARTERY disease Chinese MEDICINE INTEGRATIVE MEDICINE EFFECTIVENESS real-world STUDY
质控血清09CS中13个肺炎球菌荚膜多糖抗体IgG含量检测范围的确定 预览
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作者 石刚 王欣茹 +6 位作者 李红 刘茹凤 郭丽娜 卢旭 黄洋 陈翠萍 叶强 《微生物学免疫学进展》 2019年第3期22-26,共5页
目的 建立09CS作为质控血清用于13价肺炎球菌多糖蛋白结合疫苗(13PCV)临床血清样本检测中的检测值范围。方法 用WHO推荐的检测人血清中抗肺炎球菌荚膜多糖抗体IgG的定量ELISA,以国际人肺炎球菌标准血清007sp为标准,将09CS作为待测血清,... 目的 建立09CS作为质控血清用于13价肺炎球菌多糖蛋白结合疫苗(13PCV)临床血清样本检测中的检测值范围。方法 用WHO推荐的检测人血清中抗肺炎球菌荚膜多糖抗体IgG的定量ELISA,以国际人肺炎球菌标准血清007sp为标准,将09CS作为待测血清,检测其在13个血清型(1、3、4、5、6A、6B、7F、9V、14、18C、19A、19F、23F型)中抗荚膜多糖抗体IgG含量的值。连续检测09CS血清100余次,计算99%置信区间的各血清型几何平均抗体浓度、标准偏差(SD)和变异系数(CV)。结果 检测得到09C中13个血清型抗荚膜多糖IgG抗体含量以及在99%置信区间(CI)下±2.58倍SD的检测值范围;13个血清型检测结果的CV分别为10.86%、12.52%、13.96%、14.98%、28.77%、11.16%、14.96%、9.31%、10.43%、7.28%、10.86%、12.52%、13.96%,除6A型外,各型CV均低于15%,表明试验间精密度良好;检测次数异常率低于10%。结论 09CS可作为质控血清,用于13价肺炎球菌结合疫苗临床血清中抗荚膜多糖抗体IgG含量的ELISA检测。 展开更多
关键词 肺炎链球菌 质控血清 酶联免疫吸附测定
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Mn3O4 nanoparticles@reduced graphene oxide composite:An efficient electrocatalyst for artificial N2 fixation to NH3 at ambient conditions
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作者 Hong Huang Feng Gong +10 位作者 Yuan Wang Huanbo Wang Xiufeng Wu Wenbo Lu Runbo Zhao Hongyu Chen Xifeng Shi Abdullah M.Asiri Tingshuai Li Qian Liu Xuping Sun 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第5期1093-1098,共6页
Currently,industrial-scale NH3 production almost relies on energy-intensive Haber-Bosch process from atmospheric N2 with large amount of CO2 emission,while low-cost and high-efficient catalysts are demanded for the N2... Currently,industrial-scale NH3 production almost relies on energy-intensive Haber-Bosch process from atmospheric N2 with large amount of CO2 emission,while low-cost and high-efficient catalysts are demanded for the N2 reduction reaction (NRR).In this study,Mn3O4 nanoparticles@reduced graphene oxide (Mn3O4@rGO) composite is reported as an efficient NRR electrocatalyst with excellent selectivity for NH3 formation.In 0.1 M Na2SO4 solution,such catalyst obtains a NH3 yield of 17.4 μg·h^-1·mg^-1cat.and a Faradaic efficiency of 3.52% at-0.85 V vs.reversible hydrogen electrode.Notably,it also shows high electrochemical stability during electrolysis process.Density functional theory (DFT) calculations also demonstrate that the (112) planes of Mn3O4 possess superior NRR activity. 展开更多
关键词 Mn3O4@rGO COMPOSITE ELECTROCATALYST NH3synthesis N2reduction reactionam bient conditions
聚酰亚胺阻燃涤纶混纺织物的性能研究 预览
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作者 刘梅城 洪杰 +1 位作者 陆艳 周成逸 《棉纺织技术》 CAS 北大核心 2019年第5期60-63,共4页
研究聚酰亚胺阻燃涤纶混纺织物的性能。设计了6种不同混纺比的聚酰亚胺阻燃涤纶混纺纱,并制备了对应的平纹织物。测试了6种织物阻燃性、透气性、弯曲性和撕破性等。结果表明:6种织物的纬向阻燃性能均优于经向阻燃性能;聚酰亚胺混纺织物... 研究聚酰亚胺阻燃涤纶混纺织物的性能。设计了6种不同混纺比的聚酰亚胺阻燃涤纶混纺纱,并制备了对应的平纹织物。测试了6种织物阻燃性、透气性、弯曲性和撕破性等。结果表明:6种织物的纬向阻燃性能均优于经向阻燃性能;聚酰亚胺混纺织物透气性明显优于纯聚酰亚胺织物,聚酰亚胺比例25%的织物在阻燃性、撕破性都出现一个低谷值;织物的刚性随着聚酰亚胺比例的增加而增大。认为:聚酰亚胺比例75%的混纺织物性价比高,应用价值大。 展开更多
关键词 聚酰亚胺 阻燃涤纶 混纺比 断裂强力 经密 阻燃性 透气性
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2018年中国钛工业发展报告 预览
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作者 贾翃 逯福生 郝斌 《钛工业进展》 CAS 北大核心 2019年第3期42-48,共7页
依据中国有色金属工业协会钛锆铪分会对中国海绵钛、钛锭、钛加工材等主要钛产品的产能、产量、价格、进出口量等统计数据,对中国钛工业2018年生产和贸易的总体运营状况进行了评价。分析了2018年中国钛工业的产业结构、经营形势及市场... 依据中国有色金属工业协会钛锆铪分会对中国海绵钛、钛锭、钛加工材等主要钛产品的产能、产量、价格、进出口量等统计数据,对中国钛工业2018年生产和贸易的总体运营状况进行了评价。分析了2018年中国钛工业的产业结构、经营形势及市场供需与消费情况,指出我国钛行业存在的问题主要有钛原料品质差、采选冶工艺落后、加工材品种缺项、生产工艺落后及自主创新能力不足。我国今后5~8年应以满足钛合金的高端需求为重点发展方向,努力形成稳定的高端航空航天钛合金加工材供应体系。 展开更多
关键词 中国钛工业 产量 价格 进出口 产业结构
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Polydatin prevents the induction of secondary brain injury after traumatic brain injury by protecting neuronal mitochondria 预览
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作者 Li Li Hong-Ping Tan +8 位作者 Cheng-Yong Liu Lin-Tao Yu Da-Nian Wei Zi-Chen Zhang Kui Lu Ke-Sen Zhao Marc Maegele Dao-Zhang Cai Zheng-Tao Gu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第9期1573-1582,共10页
Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To inve... Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To investigate the protective effect of polydatin after traumatic brain injury,a rat brain injury model of lateral fluid percussion was established to mimic traumatic brain injury insults.Rat models were intraperitoneally injected with polydatin(30 mg/kg)or the SIRT1 activator SRT1720(20 mg/kg,as a positive control to polydatin).At 6 hours post-traumatic brain injury insults,western blot assay was used to detect the expression of SIRT1,endoplasmic reticulum stress related proteins and p38 phosphorylation in cerebral cortex on the injured side.Flow cytometry was used to analyze neuronal mitochondrial superoxide,mitochondrial membrane potential and mitochondrial permeability transition pore opened.Ultrastructural damage in neuronal mitochondria was measured by transmission electron microscopy.Our results showed that after treatment with polydatin,release of reactive oxygen species in neuronal mitochondria was markedly reduced;swelling of mitochondria was alleviated;mitochondrial membrane potential was maintained;mitochondrial permeability transition pore opened.Also endoplasmic reticulum stress related proteins were inhibited,including the activation of p-PERK,spliced XBP-1 and cleaved ATF6.SIRT1 expression and activity were increased;p38 phosphorylation and cleaved caspase-9/3 activation were inhibited.Neurological scores of treated rats were increased and the mortality was reduced compared with the rats only subjected to traumatic brain injury.These results indicated that polydatin protectrd rats from the consequences of traumatic brain injury and exerted a protective effect on neuronal mitochondria.The mechanisms may be linked to increased SIRT1 expression and activity,which inhibits the p38 phosphorylation-mediated mitochondrial apoptotic pathway.This study was approved by the Animal Care and Use Committe 展开更多
关键词 nerve REGENERATION traumatic brain injury POLYDATIN MITOCHONDRIA endoplasmic reticulum stress SIRT1 reactive oxygen species p38 MITOCHONDRIAL membrane potential MITOCHONDRIAL permeability transition pore lateral fluid PERCUSSION neural REGENERATION
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