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Construction of an Hα diagnostic system and its application to determine neutral hydrogen densities on the Keda Torus eXperiment
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作者 朱军锋 兰涛 +18 位作者 庄革 邓体建 吴捷 许航齐 陈晨 张森 邬佳仁 祖一鸣 李弘 谢锦林 刘阿娣 刘子奚 吴征威 汪海 温晓辉 周海洋 肖持进 丁卫星 刘万东 《中国物理B:英文版》 SCIE EI CAS CSCD 2019年第10期428-434,共7页
A 10-channel Hα diagnostic system has been designed with the rapid response rate of 300 kHz, spatial resolution of about 40 mm, and overlap between adjacent channels of about 3%, and it has been implemented successfu... A 10-channel Hα diagnostic system has been designed with the rapid response rate of 300 kHz, spatial resolution of about 40 mm, and overlap between adjacent channels of about 3%, and it has been implemented successfully on Keda Torus eXperiment(KTX), a newly constructed, reversed field pinch(RFP) experimental device at the University of Science and Technology of China(USTC). This diagnostic system is a very important tool for the initial KTX operations. It is compact,with an aperture slit replacing the traditional optical lens system. A flexural interference filter is designed to prevent the center wavelength from shifting too much as the increase of angle from vertical incidence. To eliminate the stray light,the interior of the system is covered with the black aluminum foil having a very high absorptivity. Using the Hαemission data, together with the profiles of electron temperature and density obtained from the Langmuir probe, the neutral density profiles have been calculated for KTX plasmas. The rapid response rate and good spatial resolution of this Hαdiagnostic system will be beneficial for many studies in RFP plasma physics. 展开更多
关键词 DIAGNOSTIC NEUTRAL density Keda TORUS eXperiment(KTX) device
基于用户情感倾向感知的微博情感分析方法
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作者 吴洁 朱小飞 +3 位作者 张宜浩 龙建武 黄贤英 杨武 《山东大学学报:理学版》 CAS CSCD 北大核心 2019年第3期46-55,共10页
微博言论往往带有强烈的情感色彩,对微博言论的情感分析是获取用户观点态度的重要方法。许多学者都是将研究的重点集中在句子词性、情感符号以及情感语料库等方面,然而用户自身的情感倾向性并没有受到足够的重视,因此,提出了一种新的微... 微博言论往往带有强烈的情感色彩,对微博言论的情感分析是获取用户观点态度的重要方法。许多学者都是将研究的重点集中在句子词性、情感符号以及情感语料库等方面,然而用户自身的情感倾向性并没有受到足够的重视,因此,提出了一种新的微博情感分类方法,其通过建模用户自身的情感标志得分来帮助识别语句的情感特征,具体地讲,将带有情感信息的微博语句词向量序列输入到长短期记忆网络(LSTM),并将LSTM输出的特征表示与用户情感得分进行结合作为全连接层的输入,并通过Softmax层实现了对微博文本的情感极性分类。实验表明,提出的方法UA-LSTM在情感分类任务上的表现超过的所有基准方法,并且比最优的基准方法MF-CNN在F1值上提升了3.4%,达到0.91。 展开更多
关键词 情感分析 长短期记忆网络 用户情感倾向
热等静压温度和粉末粒度对Ti2AlNb合金组织与性能的影响
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作者 刘巧沐 吴杰 +3 位作者 陈玉龙 陈乾明 裴会平 徐磊 《材料研究学报》 EI CAS CSCD 北大核心 2019年第3期161-169,共9页
采用无坩埚感应熔炼超声气体雾化法制备了成分为Ti-22Al-24Nb-0.5Mo(原子分数,%)的预合金粉末,通过预合金粉末热等静压工艺制备了Ti2AlNb粉末冶金合金。研究结果表明,热等静压温度显著影响Ti2Al Nb粉末冶金合金的显微组织,需严格控制。... 采用无坩埚感应熔炼超声气体雾化法制备了成分为Ti-22Al-24Nb-0.5Mo(原子分数,%)的预合金粉末,通过预合金粉末热等静压工艺制备了Ti2AlNb粉末冶金合金。研究结果表明,热等静压温度显著影响Ti2Al Nb粉末冶金合金的显微组织,需严格控制。为了对比研究,选取了平均粒度分别为70μm和200μm的两种Ti2AlNb预合金粉末,制备坯料并测试性能,探讨了粉末粒度的选取原则,分析了粉末粒度对Ti2AlNb粉末冶金合金显微组织和力学性能的影响。研究结果表明,粉末粒度对合金室温拉伸强度无显著影响,但会对高温拉伸强度和高温持久寿命产生显著影响,由粗粉(平均粒度200μm)制成的合金高温持久寿命较细粉(平均粒度70μm)的降低大约40%。 展开更多
关键词 金属材料 热等静压工艺 粉末粒度 Ti2AlNb合金 力学性能
不同程度真菌性角膜溃疡的综合治疗 预览
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作者 惠玲 宋金鑫 +4 位作者 程燕 吴洁 朱海峰 程钰 刘先宁 《国际眼科杂志》 CAS 北大核心 2019年第4期654-656,共3页
目的:探讨不同程度的真菌性角膜溃疡综合治疗的效果及临床转归。方法:收集我院2017-11/2018-02确诊为真菌性角膜溃疡患者85例85眼,根据病情的严重程度,采取11项综合措施治疗,围手术期药物治疗,应用相应的手术治疗,所有患者随访6~8mo,观... 目的:探讨不同程度的真菌性角膜溃疡综合治疗的效果及临床转归。方法:收集我院2017-11/2018-02确诊为真菌性角膜溃疡患者85例85眼,根据病情的严重程度,采取11项综合措施治疗,围手术期药物治疗,应用相应的手术治疗,所有患者随访6~8mo,观察角膜溃疡愈合情况及最终疾病转归。结果:真菌性角膜溃疡平均住院时间12d,85眼中有79眼(93%)治愈,好转5眼(6%),无效1眼(1%)。结论:真菌性角膜溃疡采用全身及局部药物治疗,联合手术治疗,据病变深度及范围分别行角膜清创术、碘酊烧灼术、羊膜移植术、结膜瓣遮盖术、治疗性角膜移植术等综合方法治疗,才能收到理想的治疗效果,保留及恢复视力。 展开更多
关键词 角膜溃疡 真菌性 综合治疗
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Future changes in thermal comfort conditions over China based on multi-RegCM4 simulations 预览
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作者 GAO Xue-Jie WU Jie +7 位作者 SHI Ying WU Jia HAN Zhen-Yu ZHANG Dong-Feng TONG Yao LI Rou-Ke XU Ying GIORGI Filippo 《大气和海洋科学快报:英文版》 CSCD 2018年第4期291-299,共9页
使用4个不同全球模式模拟结果,驱动RegCM4区域气候模式,进行了RCP4.5中等温室气体排放情景下东亚地区21世纪气候变化的高分辨率(25 km)模拟。本文基于此套模拟集合,使用综合考虑了气温、相对湿度和风速因素的人体热感受指数有效温度(ET)... 使用4个不同全球模式模拟结果,驱动RegCM4区域气候模式,进行了RCP4.5中等温室气体排放情景下东亚地区21世纪气候变化的高分辨率(25 km)模拟。本文基于此套模拟集合,使用综合考虑了气温、相对湿度和风速因素的人体热感受指数有效温度(ET),给出了未来中国区域热舒适条件的变化。分析中同时考虑了未来人口数量和分布情景所引起的暴露度变化。研究发现,未来中国区域的ET的普遍升高引起炎热天气的人口暴露度大幅度增加(到21世纪末相对于当代全国平均将增加6倍‘人-天’(person–days),凉、冷和寒冷天气的暴露度则减少。同时尽管舒适日数有所增加,但相应的人-天数目则有22%的减少。不同因素(气候、人口和两者的相互作用)对于上述变化的贡献分析表明,在舒适度的热端,气候因素的作用更重要,而人口因素则在冷端起着主导作用。总体而言,即使是在中等水平温室气体排放情景下,中国区域未来的热强度也将增加,尽管结果表现出很强的地理依赖特征。相对使用单纯气候因素的结果,人口暴露度的引入对变化信号有着强烈的调制作用,从而更加强调了在与气候变化相关的风险评估分析中,考虑社会-经济因素的重要性。 展开更多
关键词 Thermal COMFORT CONDITIONS REGCM CLIMATE change POPULATION
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原发性翼状胬肉患者泪液中TNF-α和IFN-γ的表达 预览 被引量:1
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作者 程燕 刘先宁 +3 位作者 吴洁 肖湘华 潘士印 朱秀萍 《国际眼科杂志》 CAS 北大核心 2018年第2期376-378,共3页
目的:检测原发性翼状胬肉患者泪液中肿瘤坏死因子α(tumor necrosis factor alpha,TNF-α)、γ干扰素(interferon gamma,IFN-γ)的含量,探讨翼状胬肉发生的泪液机制。方法:用酶联免疫吸附方法(ELISA)对单眼原发性翼状胬肉患... 目的:检测原发性翼状胬肉患者泪液中肿瘤坏死因子α(tumor necrosis factor alpha,TNF-α)、γ干扰素(interferon gamma,IFN-γ)的含量,探讨翼状胬肉发生的泪液机制。方法:用酶联免疫吸附方法(ELISA)对单眼原发性翼状胬肉患者60例60眼(静止期组30例30眼、活动期组30例30眼)和正常对照组健康志愿者30例30眼泪液中TNF-α、IFN-γ的含量进行定量测定,并进行统计学分析。结果:原发性翼状胬肉患者患眼泪液中TNF-α、IFN-γ的含量与正常对照组比较,差异均具有统计学意义(P〈0.05)。原发翼状胬肉患者患眼泪液中TNF-α含量均高于正常对照组,而IFN-γ含量均低于正常对照组,差异均有统计学意义(P〈0.05)。结论:泪液中TNF-α、IFN-γ含量的变化在促进翼状胬肉的发生发展中可能发挥重要作用,为原发性翼状胬肉的药物治疗提供了新思路。 展开更多
关键词 TNF-Α IFN-Γ 原发性翼状胬肉
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企业知识搜索行为的权衡:一个多因素模型的检验
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作者 王建刚 吴洁 《南大商学评论》 CSSCI 2018年第1期133-156,共24页
组织间关系异质性如何以及在何种条件下塑造企业的知识搜索行为?以321家上市企业作为样本数据,检验了关系异质性对两种知识搜索行为(即本地搜索与非本地搜索)的影响,企业的研发强度和环境丰裕程度的调节效应。研究表明,关系异质性负向... 组织间关系异质性如何以及在何种条件下塑造企业的知识搜索行为?以321家上市企业作为样本数据,检验了关系异质性对两种知识搜索行为(即本地搜索与非本地搜索)的影响,企业的研发强度和环境丰裕程度的调节效应。研究表明,关系异质性负向影响本地搜索,但正向影响非本地搜索;研发强度、环境丰裕度单独或共同增强了关系异质性对本地搜索的负向影响,以及对非本地搜索的正向影响。这些结果反映了企业对本地与非本地搜索的权衡。相比本地搜索,企业更倾向于非本地搜索。同时,研发强度和环境丰裕度能够强化企业的权衡。这些研究发现揭示了在不同因素的相互作用下,关系异质性与知识搜索间复杂的作用机制和企业对知识搜索的权衡,促进了对考虑不同因素的相互作用下的知识搜索行为与模式的理解。 展开更多
关键词 权衡 知识搜索 关系异质性 研发强度 环境丰裕度
阿托品凝胶、盐酸环喷托酯和复方托吡卡胺睫状肌麻痹效果比较 预览 被引量:2
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作者 杨琳娟 张小玲 +4 位作者 郝扬 吴捷 史强 胡晓 赵亚玲 《国际眼科杂志》 CAS 北大核心 2018年第9期1665-1668,共4页
目的:比较阿托品凝胶、盐酸环喷托酯和复方托吡卡胺在近视中小学生睫状肌麻痹验光中的效果,为科学验光和准确矫正提供理论依据。方法:选取2017-07/08在我院经小瞳验光诊断为近视的中小学生420例818眼,按年龄分为3组,分别采用阿托品凝胶... 目的:比较阿托品凝胶、盐酸环喷托酯和复方托吡卡胺在近视中小学生睫状肌麻痹验光中的效果,为科学验光和准确矫正提供理论依据。方法:选取2017-07/08在我院经小瞳验光诊断为近视的中小学生420例818眼,按年龄分为3组,分别采用阿托品凝胶、盐酸环喷托酯和复方托吡卡胺进行睫状肌麻痹验光(散瞳验光)及小瞳复光。结果:阿托品组、盐酸环喷托酯组、复方托吡卡胺组睫状肌麻痹验光与小瞳复光等效球镜符合率分别是:81.0%、81.3%和79.4%;睫状肌麻痹验光与小瞳复光等效球镜之差阿托品组为-0.113依0.226D,差异有统计学意义(t=-4.663,P<0.001);盐酸环喷托酯组为-0.025依0.192D,复方托吡卡胺组为-0.026依0.193D,差异均无统计学意义(t=-1.665,P=0.099;t=1.760,P=0.080)。结论:对>8岁的近视中小学生,首次睫状肌麻痹验光可采用快速散瞳,以减少对学习生活的影响;快速散瞳者复光配镜时可按小瞳结果直接给予处方,阿托品散瞳者小瞳复光近视屈光度高于散瞳时,配镜时需参考散瞳结果,选择最佳矫正视力的最低负镜度,避免近视过矫。 展开更多
关键词 近视 睫状肌麻痹验光 小瞳复光 等效球镜 配镜处方
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双曲空间上的Alexandrov-Fenchel不等式
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作者 葛宇新 王国芳 吴洁 《中国科学:数学》 CSCD 北大核心 2018年第1期131-146,共16页
本文在双曲空间H^n(n≥5)中建立如下的双曲Alexandrov-Fenchel不等式:若超曲面为h-凸的,则有∫∑σ4dμ≥Cn-1^4wn-1{(|Σ|/wn-1)^1/2)+(|Σ|/wn-1)^1/2n-5/n-1}^2等号成立当且仅当Σ为H^n中的测地球面.
关键词 Alexandrov-Fenchel不等式 逆曲率流 双曲空间
复方倍他米松对异种角膜板层移植术后免疫排斥反应的影响 预览
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作者 程燕 刘先宁 +3 位作者 吴洁 肖湘华 潘士印 朱秀萍 《国际眼科杂志》 CAS 北大核心 2018年第1期21-26,共6页
目的:观察结膜下注射复方倍他米松对鸵鸟-兔眼板层角膜移植术后免疫排斥反应的缓释治疗作用。方法:16只6周龄健康新西兰白兔角膜(单眼)行板层角膜移植术,植片应用鸵鸟脱细胞的角膜基质,术后分成两组,实验组术毕及术后结膜下注射复... 目的:观察结膜下注射复方倍他米松对鸵鸟-兔眼板层角膜移植术后免疫排斥反应的缓释治疗作用。方法:16只6周龄健康新西兰白兔角膜(单眼)行板层角膜移植术,植片应用鸵鸟脱细胞的角膜基质,术后分成两组,实验组术毕及术后结膜下注射复方倍他米松注射液(每隔7d—次),对照组术毕及术后结膜下注射地塞米松磷酸钠注射液(每隔7d—次)。分别于术后1、2wk,1、2mo取兔角膜组织做石蜡包埋切片,进行HE染色观察组织特点,同时进行间接免疫荧光法检测CD4+、CD8+T淋巴细胞的变化。结果:术后2mo,实验组角膜植片在位,并保持透明,新生血管极少,组织切片HE染色和间接免疫荧光染色结果显示,仅见少许中性粒细胞浸润,未见CD4+、CD8+T淋巴细胞;对照组炎症反应明显,角膜植片混浊,组织切片HE染色和间接免疫荧光染色结果显示,炎性反应以中性粒细胞浸润为主,可见CD4+、CD8+T淋巴细胞。结论:复方倍他米松作为长效缓释剂可有效抑制鸵鸟-兔板层角膜移植术后免疫排斥反应,延长植片的存活时间。 展开更多
关键词 鸵鸟去细胞角膜基质 异种板层角膜移植 免疫排斥反应 CD4+T淋巴细胞 CD8+T淋巴细胞
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Prediction of Primary Climate Variability Modes at the Beijing Climate Center
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作者 Hong-Li REN Fei-Fei JIN +13 位作者 Lianchun SONG Bo LU Ben TIAN Jinqing ZUO Ying LIU Jie WU Chongbo ZHAO Yu NIE Peiqun ZHANG Jin BA Yujie WU Jianghua WAN Yuping YAN Fang ZHOU 《气象学报:英文版》 SCIE CSCD 2017年第1期204-223,共20页
Climate variability modes, usually known as primary climate phenomena, are well recognized as the most important predictability sources in subseasonal–interannual climate prediction. This paper begins by reviewing th... Climate variability modes, usually known as primary climate phenomena, are well recognized as the most important predictability sources in subseasonal–interannual climate prediction. This paper begins by reviewing the research and development carried out, and the recent progress made, at the Beijing Climate Center(BCC) in predicting some primary climate variability modes. These include the El Ni?o–Southern Oscillation(ENSO), Madden–Julian Oscillation(MJO), and Arctic Oscillation(AO), on global scales, as well as the sea surface temperature(SST) modes in the Indian Ocean and North Atlantic, western Pacific subtropical high(WPSH), and the East Asian winter and summer monsoons(EAWM and EASM, respectively), on regional scales. Based on its latest climate and statistical models, the BCC has established a climate phenomenon prediction system(CPPS) and completed a hindcast experiment for the period 1991–2014. The performance of the CPPS in predicting such climate variability modes is systematically evaluated. The results show that skillful predictions have been made for ENSO, MJO, the Indian Ocean basin mode, the WPSH, and partly for the EASM, whereas less skillful predictions were made for the Indian Ocean Dipole(IOD) and North Atlantic SST Tripole, and no clear skill at all for the AO, subtropical IOD, and EAWM. Improvements in the prediction of these climate variability modes with low skill need to be achieved by improving the BCC's climate models, developing physically based statistical models as well as correction methods for model predictions.Some of the monitoring/prediction products of the BCC-CPPS are also introduced in this paper. 展开更多
Circulating miR-125a but not miR-125b is decreased in active disease status and negatively correlates with disease severity as well as inflammatory cytokines in patients with Crohn’s disease 预览
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作者 Chen-Ming Sun Jie Wu +2 位作者 Heng Zhang Gan Shi Zhi-Tao Chen 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第44期7888-7898,共11页
AIM To determine the association of circulating mi R-125 a/b expression with the risk and disease severity of Crohn’s disease(CD), and with inflammatory cytokines.METHODS Plasma samples were collected from patients w... AIM To determine the association of circulating mi R-125 a/b expression with the risk and disease severity of Crohn’s disease(CD), and with inflammatory cytokines.METHODS Plasma samples were collected from patients with active CD(A-CD), or CD in remission(R-CD) and from healthy controls(HCs). The levels of the inflammatory cytokines interleukin-17(IL-17), tumour necrosis factor-α(TNF-α), and interferon-γ(IFN-γ) were measured by enzyme-linked immunosorbent assay. The expression of mi R-125 a/b was assessed by quantitative polymerase chain reaction(q PCR).RESULTS Twenty-nine A-CD patients, 37 R-CD patients, and 37 HCs were included in the study. Plasma mi R-125 a expression was decreased in A-CD patients comparedwith that in R-CD patients(P < 0.001) and HCs(P < 0.001). mi R-125 a expression levels enabled the differentiation of A-CD from R-CD patients [area under curve(AUC) = 0.854] and from HCs(AUC = 0.780), whereas mi R-125 b expression did not. mi R-125 a was negatively correlated with C-reaction protein(CRP)(P = 0.017), erythrocyte sedimentation rate(ESR)(P = 0.026), Crohn’s disease activity index(CDAI)(P = 0.003), IL-17(P = 0.015), and TNF-α(P = 0.004) in A-CD patients. Furthermore, mi R-125 a was negatively associated with CRP(P = 0.038) and CDAI(P = 0.021) in R-CD patients. Regarding mi R-125 b, no association with CRP, CDAI, IL-17, TNF-α, or IFN-γ was found in A-CD or in R-CD patients. mi R-125 a levels gradually increased in A-CD patients who achieved clinical remission(P = 0.009) after 3-mo treatment, whereas they remained unchanged among patients who failed to achieve remission. No changes in mi R-125 b expression were detected in remission or non-remission patients after treatment. CONCLUSION Circulating mi R-125 a but not mi R-125 b is decreased in patients with active disease status and negatively correlates with disease severity and inflammatory cytokines in patients with CD. 展开更多
关键词 Crohns 疾病 miR-125 疾病风险 疾病严厉 煽动性的 cytokines
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The Tat Protein Enhances CTL Responses and Therapeutic Immunity of Gag-Specific Exosome-Targeted T Cell-Based Gag/Tat-Texo Vaccine in Transgenic HLA-A2 Mice 预览
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作者 Aizhang Xu Jie Wu +3 位作者 Yufeng Xie Rajni Chibbar Andrew Fleywald Jim Xiang 《疫苗(英文)》 2017年第2期11-25,共15页
Human immunodeficiency virus type-1 (HIV-1) chronic infection causes millions of deaths each year. We previously developed a novel HIV-1 Gag-spe cific exosome (EXO)-targeted T cell-based vaccine (Gag-Texo) using ConAs... Human immunodeficiency virus type-1 (HIV-1) chronic infection causes millions of deaths each year. We previously developed a novel HIV-1 Gag-spe cific exosome (EXO)-targeted T cell-based vaccine (Gag-Texo) using ConAstimulated polyclonal CD8+T (ConA-T) cells armed with Gag-specific dendritic cell (DC)-released EXOs, and showed that Gag-Texo stimulated more efficient cytotoxic T lymphocyte (CTL) responses than DCs. Tat HIV-1 early regulatory protein possesses immunomodulatory and adjuvant properties. To enhance Gag-Texo immunogenicity, we generated Tat-engineered OVA/Tat Texo and Gag/Tat-Texo vaccines using ConA-T cells armed with EXOs release by DCs infected with recombinant OVA/Tat- and Gag/Tat-expressing adenoviruses (AdVOVA/Tat and AdVGag/Tat). We then assessed vaccination-stimulated CTL responses in naive mice, and therapeutic immunity in transgenic HLA-A2 mice bearing Gag/HLA-A2-expressing BL6-10OVA/A2 melanoma lung metastases. We demonstrate that the OVA/Tat-Texo vaccine enhances functional OVA-specific CTL responses, compared to the OVA-Texo vaccine, and broadens CTL responses recognizing the cryptic OVA epitope in C57BL/6 mice. Furthermore, we determine that the Gag/Tat-Texo not only stimulates more efficient CTL responses than Gag-Texo, but also induces enhanced therapeutic immunity. We show that, 30% of Gag/Tat-Texo-immunized mice are free of tumor lung-metastases, compared to all Gag-Texo-immunized mice displaying lung-metastasis. In addition, the average number of tumor lung metastases colonies (32/lung) in the Gag/Tat-Texo-immunized mice was also significantly lower than that (78/lung) observed in Gag-Texo-immunized mice. Taken together, this indicates that HIV-1 Gag/Tat-Texo capable of stimulating enhanced Gag-specific CTL responses and therapeutic immunity may become a new immunotherapeutic vaccine candidate for controlling virus in HIV-1 patients. 展开更多
关键词 Tat T-Cell VACCINE Gag EXOSOME CTL Therapeutic IMMUNITY TRANSGENIC HLA-A2 MICE
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P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome 预览
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作者 Jie Wu Yan Cheng +5 位作者 Rong Zhang Dong Liu Yu-mei Luo Kun-Lun Chen Song Ren Jun Zhang 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第34期6339-6349,共11页
AIM To evaluate the role of P2Y1 R in visceral hypersensitivity in rats with experimental irritable bowel syndrome.METHODS A rat model of irritable bowel syndrome was generated by intra-colonic administration of aceti... AIM To evaluate the role of P2Y1 R in visceral hypersensitivity in rats with experimental irritable bowel syndrome.METHODS A rat model of irritable bowel syndrome was generated by intra-colonic administration of acetic acid(AA) and assessed by histology and myeloperoxidase(m PO) activity assay. Then P2Y1 R expression in the colonic tissue was detected by Western blot. In order to explore the regulatory role of P2Y1 R in visceral hypersensitivity, an agonist(m RS2365) and an antagonist(m RS2179) of P2Y1 R were intra-colonically administered and effects were tested through a colorectal distension test. The abdominal withdrawal reflex and abdominal electromyography were tested during the course. RESULTS model assessment tests showed an obvious inflammatoryreaction that appeared on the 2nd d after the AA injection, and the inflammatory reaction gradually recovered and almost disappeared on the 7th d. The model finished on day 8 and showed a clear feature of IBS that had no organic lesion. The average expression of P2Y1 R was significantly higher in the AA group than in the na?ve group(0.319 ± 0.02 vs 0.094 ± 0.016, P < 0.001). m RS2365 could effectively raise the colonic hypersensitivity status at intervention doses of 10(AUC value from 0.30 ± 0.089 to 1.973 ± 0.127 mv?s, P < 0.01) and 100 μmol/L(AUC value from 0.290 ± 0.079 to 1.983 ± 0.195 mv?s, P < 0.01); m RS2179 could effectively reduce the hypersensitivity status at intervention dose of 100 μmol/L(from a mean baseline AUC value of 1.587 ± 0.099 mv?s to 0.140 ± 0.089 mv?s, P < 0.0001). Differences between the m RS2179 group(1.88 ± 1.45) and either the m RS2365 group(3.96 ± 0.19) or the combined treatment(m RS2179 and m RS2365) group(3.28 ± 0.11) were significant(P < 0.01).CONCLUSION P2Y1 R plays a regulatory role in visceral hypersensitivity in rats with experimental IBS. Specific antagonists of P2Y1 R may have potential therapeutic value in treating abdominal pain in IBS. 展开更多
关键词 急躁的肠症候群 P2Y1 受体 规定 治疗 内脏的超敏性
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Efficacy of thalidomide therapy in pediatric Crohn’s disease with evidence of tuberculosis 预览
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作者 Lin Wang Yan Hong +2 位作者 Jie Wu Ying-Kit Leung Ying Huang 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第43期7727-7734,共8页
AIM To evaluate the efficacy of thalidomide for treating troublesome cases of pediatric Crohn’s disease(CD) with tuberculosis infection.METHODS A retrospective study of clinical outcome among children treated with th... AIM To evaluate the efficacy of thalidomide for treating troublesome cases of pediatric Crohn’s disease(CD) with tuberculosis infection.METHODS A retrospective study of clinical outcome among children treated with thalidomide was conducted. All patients had evidence of tuberculosis infection with a failure of anti-tuberculosis treatment for more than one year,and were subsequently diagnosed with CD. All the patients received thalidomide treatment with a starting dose of 1.2-2.5 mg/kg per day. Remission was defined as pediatric CD activity index less than or equal to 10.RESULTS Ten patients with CD were treated with thalidomide at an average age of 7.2 years and followed up for a median of 22.2 mo. Clinical remission rate was 60% after 9-12 mo of thalidomide treatment. One patient with no response had an interleukin-10 receptor alpha gene mutation. Erythrocyte sedimentation rate,C-reactive protein and platelet count showed a dramatic decrease; hemoglobin level and weight improved significantly after thalidomide treatment when compared with the baseline values.CONCLUSION Thalidomide is an effective and safe drug for remission of CD in pediatric patients who have been treated for tuberculosis. 展开更多
关键词 煽动性的肠疾病 肠的肺结核 -- 有小瘤的治疗 镇静药 孩子
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Hot Deformation Mechanism and Ring Rolling Behavior of Powder Metallurgy Ti_2AlNb Intermetallics
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作者 Zheng-Guan Lu Jie Wu +2 位作者 Rui-Peng Guo Lei Xu Rui Yang 《金属学报:英文版》 SCIE EI CAS CSCD 2017年第7期621-629,共9页
粉末冶金学(下午) Ti-22Al-24Nb-0.5Mo (at.%) 合金被热均衡说的压准备。以便学习下午的可行性?+?戒指滚动为准备 Ti <sub>2</sub 联合了过程> AlNb 戒指,下午 Ti <sub>2</sub 的热机械模拟测试> AlNb 合金... 粉末冶金学(下午) Ti-22Al-24Nb-0.5Mo (at.%) 合金被热均衡说的压准备。以便学习下午的可行性?+?戒指滚动为准备 Ti <sub>2</sub 联合了过程> AlNb 戒指,下午 Ti <sub>2</sub 的热机械模拟测试> AlNb 合金被进行,二位矩形的首相响( 150 ?在高度的公里, 75 ?在厚度的公里, 350 ?在外部直径的公里)作为一个确认实验被卷。试验性的结果证明流动 Ti 强调 <sub>2</sub > AlNb 合金在变丑的开始展出了重要落下(真紧张 < 0.1 ) ,并且随紧张的增加变得稳定。下午 Ti <sub>2</sub 的压力不稳定性现象 > AlNb 合金比的更明显做合金。在变丑的起始的阶段的流动压力变化与 Ti <sub>2</sub 的阶段转变有关 > 强烈取决于热处理和热机械变丑的 AlNb 合金处理。在卷过程的戒指的起始的舞台期间处理窗户是很关键的。健全下午 Ti <sub>2</sub > AlNb 矩形的戒指空白(高度 ?=? 150 ? 公里,厚度 ?=? 30 ? 公里,外部直径 ?=? 750 ? 公里) 被使用改进的热保藏方法成功地在二张通行证卷并且优化了滚动参数。下午 Ti <sub>2</sub 的张力的性质 > AlNb 合金被改进,并且孔在戒指滚动以后被减少。 展开更多
关键词 变形机理 粉末冶金 锻造合金 Windows 行为 滚动 轧制过程 验证实验
Evolutionary Cryptography Theory-Based Generating Method for Secure ECs
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作者 Chao Wang Feng Hu +1 位作者 Huanguo Zhang Jie Wu 《清华大学学报:自然科学英文版》 EI CAS CSCD 2017年第5期499-510,共12页
Ant Colony Optimization(ACO) has the character of positive feedback,distributed searching,and greedy searching.It is applicable to optimization grouping problems.Traditional cryptographic research is mainly based on p... Ant Colony Optimization(ACO) has the character of positive feedback,distributed searching,and greedy searching.It is applicable to optimization grouping problems.Traditional cryptographic research is mainly based on pure mathematical methods which have complicated theories and algorithm.It seems that there is no relationship between cryptography and ACO.Actually,some problems in cryptography are due to optimization grouping problems that could be improved using an evolutionary algorithm.Therefore,this paper presents a new method of solving secure curve selection problems using ACO.We improved Complex Multiplication(CM)by combining Evolutionary Cryptography Theory with Weber polynomial solutions.We found that ACO makes full use of valid information generated from factorization and allocates computing resource reasonably.It greatly increases the performance of Weber polynomial solutions.Compared with traditional CM,which can only search one root once time,our new method searches all roots of the polynomial once,and the average time needed to search for one root reduces rapidly.The more roots are searched,the more ECs are obtained. 展开更多
关键词 进化算法 安全曲线 密码学 生成方法 ECS 蚁群优化算法 分布式搜索 蚁群算法
Simple Method for Realizing Weil Theorem in Secure ECC Generation
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作者 Feng Hu Chao Wang +1 位作者 Huanguo Zhang Jie Wu 《清华大学学报:自然科学英文版》 EI CAS CSCD 2017年第5期511-519,共9页
How to quickly compute the number of points on an Elliptic Curve(EC) has been a longstanding challenge.The computational complexity of the algorithm usually employed makes it highly inefficient.Unlike the general EC,a... How to quickly compute the number of points on an Elliptic Curve(EC) has been a longstanding challenge.The computational complexity of the algorithm usually employed makes it highly inefficient.Unlike the general EC,a simple method called the Weil theorem can be used to compute the order of an EC characterized by a small prime number,such as the Kobltiz EC characterized by two.The fifteen secure ECs recommended by the National Institute of Standards and Technology(NIST) Digital Signature Standard contain five Koblitz ECs whose maximum base domain reaches 571 bits.Experimental results show that the computation speed decreases for base domains exceeding 600 bits.In this paper,we propose a simple method that combines the Weil theorem with Pascals triangle,which greatly reduces the computational complexity.We have validated the performance of this method for base fields ranging from 2~(100) to 2~(1000).Furthermore,this new method can be generalized to any ECs characterized by any small prime number. 展开更多
关键词 Weil定理 安全系统 ECC 单方 计算复杂度 数字签名标准 美国国家标准 电子商务
TIPS versus Endoscopic Therapy for Variceal Rebleeding in Cirrhosis: A Meta-analysis Update 预览
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作者 张虎 张辉 +4 位作者 李晖 张姮 郑丹 孙琛明 吴杰 《华中科技大学学报:医学英德文版》 SCIE CAS 2017年第4期475-485,共11页
Endoscopic therapy(ET) is most common method for preventing variceal bleeding in cirrhosis, but the outcomes are not perfect. Recently, transjugular intrahepatic portosystemic shunt(TIPS) is introduced into clinical p... Endoscopic therapy(ET) is most common method for preventing variceal bleeding in cirrhosis, but the outcomes are not perfect. Recently, transjugular intrahepatic portosystemic shunt(TIPS) is introduced into clinical practice. However, the beneficial effects of TIPS compared to ET on cirrhotic patients is unknown. The aim of this study was to evaluate and compare the effects of TIPS with those of the most frequently used ET for prevention of variceal rebleeding(VRB) in liver cirrhosis. The PubMed, EMBASE, and Cochrane Library databases were searched from inception to February 2017. The primary study outcomes included the incidence of VRB, all-cause mortality, bleeding-related death, and the incidence of post-treatment hepatic encephalopathy(PTE). The odds ratios(ORs) with 95% confidence intervals(CI) were pooled for dichotomous variables. Subgroup analyses were performed. Twenty-four studies were eligible and they included 1120 subjects treated with TIPS and 1065 subjects treated with ET. Although there was no significant difference in survival and PTE, TIPS was superior to ET in decreasing the incidence of VRB(OR=0.27; 95% CI, 0.19–0.39, P<0.00001), and decreasing the incidence of bleeding-related death(OR=0.21; 95% CI, 0.13–0.32, P<0.00001). Subgroup analysis found a lower mortality(OR=0.48; 95% CI, 0.23–0.97; P=0.04) without any increased incidence of PTE(OR=1.37; 95% CI, 0.75–2.50; P=0.31) in the studies of a greater proportion(≥40%) of patients with Child-Pugh class C cirrhosis receiving TIPS, and TIPS with covered stent did not increase the risk of PTE compared to ET(OR=1.52, 95% CI =0.82–2.80, P=0.18). It was concluded that TIPS with covered stent might be considered the preferred choice of therapy in patients with severe liver disease for secondary prophylaxis. 展开更多
关键词 TIPS 静脉曲张 肝硬化 Meta分析 治疗 出血 内镜 PUBMED
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2273例结、直肠息肉及腺癌的特点统计 预览
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作者 许庆洪 陈志涛 吴杰 《世界华人消化杂志》 CAS 2017年第15期1416-1421,共6页
目的研究结直肠息肉的好发年龄、部位、病理类型.方法本文研究对象为计数资料,使用IBM SPSS分析软件,对年龄与息肉(包括腺癌)、息肉良恶性、与腺瘤的发生部位、与腺瘤的病理类型进行冇2检验,P〉0.05表示影响因素对两组差异无影响;P〈0... 目的研究结直肠息肉的好发年龄、部位、病理类型.方法本文研究对象为计数资料,使用IBM SPSS分析软件,对年龄与息肉(包括腺癌)、息肉良恶性、与腺瘤的发生部位、与腺瘤的病理类型进行冇2检验,P〉0.05表示影响因素对两组差异无影响;P〈0.05表示影响因素对两组差距有影响.结果在2273例患者中,1245例(54.8%)发生在60岁以上,887例(39.0%)发生在45-59岁之间.925例非肿瘤性息肉者中,420例(45.4%)例发生在45-59岁之间,419例(45.5%)例发生在60岁以上.绒毛状腺瘤的癌变率最高(37.5%).年龄与腺瘤的病理类型不相关.发生在直肠、乙状结肠、升结肠的腺癌最多,分别占所有腺癌的34.1%(134/393)、21.1%(83/393)、15.8%(62/393).癌变率最高的为肝曲58.5%(20/34),其次为回盲部52.8%(19/36)升结肠45.6%(62/136).结论息肉及腺癌的发生体现在与年龄相关,可能是由于肥胖、糖尿病等代谢方面的因素及长期的炎症反应所导致. 展开更多
关键词 结直肠腺癌 腺瘤 年龄 炎症反应
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