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Current Status of Conventional and Molecular Interventions for Blast Resistance in Rice 预览
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作者 Deepti SRIVASTAVA Md SHAMIM +6 位作者 Mahesh KUMAR Anurag MISHRA Pramila PANDEY Deepak KUMAR Prashant YADAV Mohammed Harrish SIDDIQUI Kapildeo Narayan SINGH 《水稻科学:英文版》 CSCD 2017年第6期299-321,共23页
Pyricularia oryzae anamorph of Magnaporthe oryzae is one of the most notorious fungal pathogens causing severe economic loss in rice production worldwide. Various methods, viz. cultural, biological and molecular appro... Pyricularia oryzae anamorph of Magnaporthe oryzae is one of the most notorious fungal pathogens causing severe economic loss in rice production worldwide. Various methods, viz. cultural, biological and molecular approaches, are utilized to counteract this pathogen. Moreover, some tolerant or resistant rice varieties have been developed with the help of breeding programmes. Isolation and molecular characterization of different blast resistance genes now open the gate for new possibilities to elucidate the actual allelic variants of these genes via various molecular breeding and transgenic approaches. However, the behavioral pattern of this fungus breakups the resistance barriers in the resistant or tolerant rice varieties. This host-pathogen barrier will be possibly countered in future research by comparative genomics data from available genome sequence data of rice and M. oryzae for durable resistance. Present review emphasized fascinating recent updates, new molecular breeding approaches, transgenic and genomics approaches (i.e. miRNA and genome editing) for the management of blast disease in rice. The updated information will be helpful for the durable, resistance breeding programme in rice against blast pathogen. 展开更多
关键词 BACKCROSS BREEDING gene PYRAMIDING ALLELE mining transgenic technology RICE blast resistance CRISPR/Cas9 MOLECULAR BREEDING bioinformatics approach
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Thermal decomposition and kinetics of plastic bonded explosives based on mixture of HMX and TATB with polymer matrices 预览
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作者 Arjun Singh Tirupati C. Sharma +3 位作者 Mahesh Kumar Jaspreet Kaur Narang Prateek Kishore Alok Srivastava 《Defence Technology(防务技术)》 CAS CSCD 2017年第1期22-32,共11页
This work describes thermal decomposition behaviour of plastic bonded explosives(PBXs) based on mixture of 1,3,5,7-tetranitro-1,3,5,7-tetrazocane(HMX) and 2,4,6-triamino-1,3,5-trinitrobenzene(TATB)with Viton A as poly... This work describes thermal decomposition behaviour of plastic bonded explosives(PBXs) based on mixture of 1,3,5,7-tetranitro-1,3,5,7-tetrazocane(HMX) and 2,4,6-triamino-1,3,5-trinitrobenzene(TATB)with Viton A as polymer binder. Thermal decomposition of PBXs was undertaken by applying simultaneous thermal analysis(STA) and differential scanning calorimetry(DSC) to investigate influence of the HMX amount on thermal behavior and its kinetics. Thermogravimetric analysis(TGA) indicated that the thermal decomposition of PBXs based on mixture of HMX and TATB was occurred in a three-steps. The first step was mainly due to decomposition of HMX. The second step was ascribed due to decomposition of TATB, while the third step was occurred due to decomposition of the polymer matrices. The thermal decomposition % was increased with increasing HMX amount. The kinetics related to thermal decomposition were investigated under non-isothermal for a single heating rate measurement. The variation in the activation energy of PBXs based on mixture of HMX and TATB was observed with varying the HMX amount. The kinetics from the results of TGA data at various heating rates under non-isothermal conditions were also calculated by Flynn—Wall—Ozawa(FWO) and Kissinger-Akahira-Sunose(KAS)methods. The activation energies calculated by employing FWO method were very close to those obtained by KAS method. The mean activation energy calculated by FWO and KAS methods was also a good agreement with the activation energy obtained from single heating rate measurement in the first step decomposition. 展开更多
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Analysis of Power in an Argon Filled Pulsed Dielectric Barrier Discharge
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作者 U. N. PAL Pooja GULATI +3 位作者 Ram PRAKASH Mahesh KUMAR V. SRIVASTAVA S. KONAR 《等离子体科学和技术:英文版》 SCIE EI CAS CSCD 2013年第7期635-639,共5页
In this paper an argon filled coaxial dielectric barrier discharge (DBD) has been studied to understand the detail of power transfer from a unipolar square pulse to plasma during discharge. A dielectric barrier discha... In this paper an argon filled coaxial dielectric barrier discharge (DBD) has been studied to understand the detail of power transfer from a unipolar square pulse to plasma during discharge. A dielectric barrier discharge based diffuse pulse discharge and its electrical characteristics are investigated. A quartz coaxial DBD tube filled at different pressures is used in the experiment. A unipolar pulse voltage of different peak voltages and frequencies has been applied to the discharge electrodes for the generation of microdischarges. Two current pulses are used for two consecutive discharges per applied voltage pulse. The second discharge, which occurs at the falling flank of the voltage pulse, is induced by the charges stored on the dielectric barrier during the first discharge. It has been deduced that the power supplied to ignite the first discharge is partly stored to ignite the second discharge when the applied voltage decays. This process ultimately leads to much improved power transfer to the plasma. The knowledge obtained from dynamic processes of the DBDs in the discharge gap explains quantitatively the mechanism of ignition, development and extinction of the DBDs. 展开更多
关键词 介质阻挡放电 脉冲等离子体 电力传输 氩气 填充 地球化学特征 峰值电压 脉冲放电
Neem by-products in the fight against mosquito-borne diseases:Biotoxicity of neem cake fractions towards the rural malaria vector Anopheles culicifacies(Diptera:Culicidae)
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作者 Balamurugan Chandramohan Kadarkarai Murugan +9 位作者 Pari Madhiyazhagan Kalimuthu Kovendan Palanisamy Mahesh Kumar Chellasamy Panneerselvam Devakumar Dinesh Jayapal Subramaniam Rajapandian Rajaganesh Marcello Nicoletti Angelo Canale Giovanni Benelli 《亚太热带生物医学杂志:英文版》 CAS 2016年第6期472-476,共5页
Objective: To evaluate the ovicidal, larvicidal and adulticidal potential of neem cake fractions of different polarity against the rural malaria vector Anopheles culicifacies(An.culicifacies).Methods: Neem cake fracti... Objective: To evaluate the ovicidal, larvicidal and adulticidal potential of neem cake fractions of different polarity against the rural malaria vector Anopheles culicifacies(An.culicifacies).Methods: Neem cake fractions’ total methanol extract(NTMeOH), total ethyl acetate extract(NTAc OEt), ethyl acetate fraction after repartition with NTMe OH(NRAc OEt),butanol fraction after repartition with NTMeOH(NRBuOH), and aqueous fraction after repartition of NTMeOH(NRH2O) were tested against An. culicifacies eggs, fourth instar larvae and adults.Results: In larvicidal experiments, NTMeOH, NTAcOEt, NRAcOEt, NRBuOH and NRH2O achieved LC50 values of 1.32, 1.50, 1.81, 1.95 and 2.54 mg/L, respectively. All fractions tested at 150 mg/L were able to reduce egg hatchability of more than 50%, with the exception of NTAc OEt and NRAc OEt. In adulticidal assays, NTMeOH, NTAcOEt,NRAcOEt, NRBuOH and NRH2O achieved LC50 values of 3.01, 2.95, 3.23, 3.63 and3.00 mg/L, respectively.Conclusions: Overall, this study suggests that the methanolic fractions of neem cake may be considered as a new and cheap source of highly effective compounds against the rural malaria vector An. culicifacies. 展开更多
关键词 ARBOVIRUS AZADIRACHTA indica BIOSAFETY BOTANICAL by-products Eco-friendly pesticides Mosquito-borne diseases
Microbial Biomass Dynamics in a Tropical Agroecosystem: Influence of Herbicide and Soil Amendments 被引量:1
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作者 Alka SINGH Mahesh Kumar SINGH Nandita GHOSHAL 《土壤圈:英文版》 SCIE CAS CSCD 2016年第2期257-264,共8页
除草剂的影响独自并且在有有在土壤的动力学上对比资源质量的土壤修正案的联合,微生物引起的生物资源 C (MBC ) , N (MBN ) ,和 P (MBP ) 在热带 dryland agroecosystem 在 rice-wheat-summer 休闲庄稼顺序通过二个年度周期被学习。... 除草剂的影响独自并且在有有在土壤的动力学上对比资源质量的土壤修正案的联合,微生物引起的生物资源 C (MBC ) , N (MBN ) ,和 P (MBP ) 在热带 dryland agroecosystem 在 rice-wheat-summer 休闲庄稼顺序通过二个年度周期被学习。实验与有 N in the forms of 化肥,小麦稻草, Sesbania aculeata,和农场院子粪肥(FYM ) 的相等的数量的各种各样的土壤修正案独自或在联合包括了除草剂(butachlor ) 的申请。微生物引起的生物资源显示出的土壤在两个庄稼周期的不同时间的变化,减少了从对形成谷物的舞台植物,然后在庄稼成熟舞台增加了到最大值。土壤 MBC 在处理由在减少的独自一个的处理在成长大米的时期期间订的除草剂 + FYM,除草剂 + 小麦稻草,除草剂 + 化肥,和除草剂跟随了的除草剂 + Sesbania aculeata 是最高的。在成长小麦的时期和夏天休闲期间,而除草剂 + FYM,除草剂 + Sesbania,和除草剂 + 化肥治疗显示出类似的层次,土壤 MBC 为除草剂 + 小麦稻草治疗达到了最大值。除了土壤 MBN 在成长大米的时期期间在在除草剂 + 小麦稻草处理上的除草剂 + 化肥处理是更高的之外,土壤 MBN 的全面趋势类似于土壤 MBC 和 MBP 的那些。尽管有通过在有除草剂的联合的外长的土壤修正案的 N 的相等的数量的增加,玷污微生物引起的生物资源回答差别到处理。修正案的资源质量更多在动力学上读了影响玷污微生物引起的生物资源,它可以在干燥热带为 rainfed agroecosystems 的长期的可持续性有含意。 展开更多
关键词 土壤微生物生物量碳 土壤改良剂 生物量动态 热带地区 除草剂 农业生态系统 土壤微生物量 农田生态系统
Endotherapy of leaks and fistula 预览 被引量:1
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作者 Mahesh Kumar Goenka Usha Goenka 《世界胃肠内镜杂志:英文版(电子版)》 2015年第7期702-713,共12页
包含的穿孔,漏缝和管胃肠(官方补给) 道正在增加在临床的实践遇到了。为他们有被保守途径包括内视镜的治疗代替的外科的途径的管理有一个变化范例。片断(通过范围并且在范围上) 并且盖住的 stent 是为为官方补给的漏缝和管的 endothera... 包含的穿孔,漏缝和管胃肠(官方补给) 道正在增加在临床的实践遇到了。为他们有被保守途径包括内视镜的治疗代替的外科的途径的管理有一个变化范例。片断(通过范围并且在范围上) 并且盖住的 stent 是为为官方补给的漏缝和管的 endotherapy 的前面跑步者。在最近介绍的范围片断上,能对待更大的缺点与相比通过范围片断。盖住的 stents 适合与钠变窄联系的更大的缺点和那些。然而颈的食管,胃食道的连接,胃和恰好结肠的损害可能对片断治疗而非 stenting 更好。这块地里的最近的开发包括与吸设备,可被细菌破坏的 stent,血纤维蛋白胶水的使用和某缝术 endo 设备由海绵组成的 endovac 治疗的使用。没有外科或内视镜的干预的保守治疗,可能对病人的一个小子集合适。一个算法基于地点,缺点的尺寸,联系苛评,感染和可得到的专家知识需要被发展减少这个困难的临床的问题的死亡和病态。 展开更多
关键词 穿孔 起作用的波斯特 内视镜检查法 内视镜 外科 STENT 缝术 ENDOCLIP 抓紧
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Association of Mycoplasma pneumoniae infection and childhood asthma 预览
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作者 YADAV Shakti Nrisingh GAUTAM Mahesh Kumar JIANG Li 《东南大学学报:医学版》 CAS 北大核心 2015年第2期280-285,共6页
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Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4
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作者 Puttanarasaiah Mahesh Kumar Marikunte V Venkataranganna +2 位作者 Kirangadur Manjunath Gollapalle L Viswanatha Godavarthi Ashok 《中国天然药物》 SCIE CAS CSCD 2014年第12期895-900,共6页
The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria(MFMC) on PPARγ(Peroxisome Proliferator Activated Receptor gamma) and GLUT-4(Glucose transporter-4) wi... The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria(MFMC) on PPARγ(Peroxisome Proliferator Activated Receptor gamma) and GLUT-4(Glucose transporter-4) with respect to glucose transport. Various concentrations of MFMC ranging from 62.5 to 500 μg·mL-1 were evaluated for glucose uptake activity in vitro using L6 myotubes, rosiglitazone was used as a reference standard. The MFMC showed significant and dose-dependent increase in glucose uptake at the tested concentrations, further, the glucose uptake activity of MFMC(500 μg·mL-1) was comparable with rosigilitazone. Furthermore, MFMC has shown up-regulation of GLUT-4 and PPARγ gene expressions in L6 myotubes. In addition, the MFMC when incubated along with cycloheximide(CHX), which is a protein synthesis inhibitor, has shown complete blockade of glucose uptake. This indicates that new protein synthesis is required for increased GLUT-4 translocation. In conclusion, these findings suggest that MFMC is enhancing the glucose uptake significantly and dose dependently through the enhanced expression of PPARγ and GLUT-4 in vitro. 展开更多
Larvicidal efficacy of Catharanthus roseus Linn.(Family:Apocynaceae) leaf extract and bacterial insecticide Bacillus thuringiensis against Anopheles stephensi Liston.
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作者 Chellasamy Panneerselvam Kadarkarai Murugan +5 位作者 Kalimuthu Kovendan Palanisamy Mahesh Kumar Sekar Ponarulselvam Duraisamy Amerasan Jayapal Subramaniam Jiang-Shiou Hwang 《亚太热带医药杂志:英文版》 SCIE CAS 2013年第11期847-853,共7页
Objective:To explore the larvicidal activity of Catharanthus roseus(C.roseus) leaf extract and Raeillus thuringiensis(B.thuringiensis) against the malarial vector Anopheles stephensi(An. stephensi),when being u... Objective:To explore the larvicidal activity of Catharanthus roseus(C.roseus) leaf extract and Raeillus thuringiensis(B.thuringiensis) against the malarial vector Anopheles stephensi(An. stephensi),when being used alone or together.Methods:The larvicidal activity was assayed at various concentrations under the laboratory and field conditions.The LC<sub>50</sub> and LC<sub>90</sub> values of the C.roseus leaf extract were determined by probit analysis.Results:The plant extract showed larvicidal effects after 24 h of exposure;however,the highest larval mortality was found in the petroleum ether extract of C.roseus against the first to fourth instars larvae with LC<sub>50</sub>=3.34,4.48, 5.90 and 8.17 g/L,respectively;B.thuringiensis against the first to fourth instars larvae with LC<sub>50</sub>=1.72.1.93.2.17 and 2.42 g/L.respectively:and the combined treatment with LC<sub>50</sub>=2.18.2.41. 2.76 and 3.22 g/L,respectively.No mortality was observed in the control.Conclusions:The petroleum ether extract of C.roseus extract and B.thuringiensis have potential to be used as ideal eco-friendly agents for the control of An.stephensi in vector control programs.The combined treatment with this plant crude extract and bacterial toxin has better larvicidal efficacy against An.stephensi. 展开更多
关键词 CATHARANTHUS roseus Bacillus THURINGIENSIS Anopheles STEPHENSI LARVICIDAL activity
Mosquito larvicidal and pupicidal activity of Euphorbia hirta Linn.(Family:Euphorbiaceae) and Bacillus sphaericus against Anopheles stephensi Liston.(Diptera:Culicidae)
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作者 C.Panneerselvam K.Murugan +2 位作者 K.Kovendan P.Mahesh Kumar J.Subramaniam 《亚太热带医药杂志:英文版》 SCIE CAS 2013年第2期102-109,共8页
【正】Objective:To explore the larvicidal and pupicidal activity of Euphorbia hirta(E.hirta) leaf extract and Bacillus sphaericus(B.sphaericus) against the malarial vector.Anopheles siephensi(An. stephensi).Met... 【正】Objective:To explore the larvicidal and pupicidal activity of Euphorbia hirta(E.hirta) leaf extract and Bacillus sphaericus(B.sphaericus) against the malarial vector.Anopheles siephensi(An. stephensi).Methods:The larvicidal and pupicidal activity was assayed against An.stephensi at various concentrations ranging from(75-375 ppm) under the laboratory as well as field conditions. The LC<sub>50</sub> and LC<sub>90</sub> value of the E.hirta leaf extract was determined by probit analysis.Results: The plant extract showed larvicidal effects after 24 h of exposure;however,the highest larval mortality was found in the methanol extract of E.hirta against the first to fourth instars larvae and pupae of values LC<sub>50</sub>=137.40,172.65,217.81,269.37 and 332.39 ppm;B.sphaericus against the first to fourth instars larvae and pupae of values LC<sub>50</sub>= 44.29,55.83,68.51,82.19 and 95.55 ppm, respectively.Moreover,combined treatment of values of LC<sub>50</sub>= 79.13,80.42,86.01,93.00 and 98.12 ppm,respectively.No mortality was observed in the control.Conclusions:These results suggest methanol leaf extracts of E.hirta and B.sphaericus have potential to be used as an ideal ecofriendly approach for the control of the malarial vector.An.stephensi as target species of vector control programs.This study provides the first report on the combined mosquito larvicidal and pupicidal activity of this plant crude extract and bacterial toxin against An.stephensi mosquitoes. 展开更多
关键词 Euphorbia hirta ANOPHELES STEPHENSI Bacillus sphaericus LARVICIDAL and pupicidal ACTIVITY Field trial Malarial vector
Genetically modified mouse models for the study of nonalcoholic fatty liver disease 预览 被引量:6
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作者 Perumal Nagarajan M Jerald Mahesh Kuma +3 位作者 Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma 《世界胃肠病学杂志:英文版》 SCIE CAS CSCD 2012年第11期1141-1153,共13页
不含酒精的脂肪肝疾病(NAFLD ) 与肥胖,胰岛素抵抗,和类型被联系 2 糖尿病。NAFLD 代表疾病从的一个大系列(1 ) 脂肪肝(肝的脂肪变性) ;(2 ) 有发炎和坏死的脂肪变性;到(3 ) 肝硬化。学习 NAFLD/nonalcoholic steatohepatitis (NASH... 不含酒精的脂肪肝疾病(NAFLD ) 与肥胖,胰岛素抵抗,和类型被联系 2 糖尿病。NAFLD 代表疾病从的一个大系列(1 ) 脂肪肝(肝的脂肪变性) ;(2 ) 有发炎和坏死的脂肪变性;到(3 ) 肝硬化。学习 NAFLD/nonalcoholic steatohepatitis (NASH ) 的动物模型是极其有用的,因为仍然有在 NASH 的病理要阐明的许多事件。确定的动物模型的学习在脂肪变性和 steatohepatitis 的致病提供了许多线索,但是这些仍然保持不完全地理解。不同老鼠模型能在二个大组被分类。第一遗传上包括修改(转基因或猛烈) 自发地得肝疾病的老鼠,和第二只老鼠包括获得疾病在以后的老鼠饮食或药理学操作。尽管在 NAFLD 的致病导致肝的脂肪变性的发展的分子的机制是复杂的,遗传上修改的动物模型可以是为 NAFLD 的处理的一把钥匙。为 NASH 的理想的动物模型应该非常类似于在人观察的病理学的特征。迄今为止,没有单个动物模型包含了人的疾病前进的完整的光谱,但是他们能模仿人的疾病的特别特征。因此,研究人员选择适当动物模型,是重要的。这评论讨论在关于 NAFLD 的研究开发并且使用的各种各样的遗传上修改的动物模型。 展开更多
关键词 转基因小鼠模型 脂肪肝 酒精性 转基因动物模型 肝病 人类疾病 NASH 发病机制
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Single center experience of capsule endoscopy in patients with obscure gastrointestinal bleeding 预览 被引量:7
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作者 Mahesh Kumar Goenka Shounak Majumder Sanjeev Kumar Pradeepta Kumar Sethy Usha Goenka 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2011年第6期774-778,共5页
瞄准:识别预定与阴暗胃肠的流血在病人由囊内视镜检查法(CE ) 最大化诊断产量的最佳(OGIB ) 。方法:我们识别了从 2003 年 8 月在我们的机构经历了 CE 到 2009 年 12 月的病人。耐心的医药记录被考察决定 OGIB 的类型(玄术,公开) , ... 瞄准:识别预定与阴暗胃肠的流血在病人由囊内视镜检查法(CE ) 最大化诊断产量的最佳(OGIB ) 。方法:我们识别了从 2003 年 8 月在我们的机构经历了 CE 到 2009 年 12 月的病人。耐心的医药记录被考察决定 OGIB 的类型(玄术,公开) , CE 结果和复杂并发症,并且关于流血的发作 CE 预定。结果:从为 OGIB 调查的 385 个病人,(74%) 284 把某损害被 CE 检测了。在 222 个病人(58%) ,明确的损害被检测那能不含糊地解释 OGIB。对 Crohns 疾病,肺结核或 non-steroidal 第二等的小肠溃疡 / 侵蚀反煽动性的代理人使用是检测的最普通的损害。有公开官方补给的流血为的病人 < 在 CE 前的 48 h 有最高诊断的收益(87%) 。这显著地更大(P < 0.05 ) 与那相比在有在 48 以前的公开流血的病人有秘密 OGIB (59%) 的 h (68%) ,以及那些。结论:我们在 OGIB 的管理建立了早 CE 的重要性。在公开流血的 48 h 以内的 CE 为损害察觉有最大的潜力。 展开更多
关键词 消化道出血 患者 原因 内镜 胶囊 非甾体抗炎药 发病类型 行政
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晚期视网膜母细胞瘤53例的临床挑战 预览
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作者 Partab Rai Imtiaz Ali Shah +3 位作者 Ashok kumar Narsani Mahesh Kumar, Lohana Muhammad Khan Memon Manzoor Ahmed Memon 《国际眼科杂志》 CAS 2009年第2期 227-230,共4页
目的:评价肿瘤的位置、大小、组织学以及复发率。 方法:前瞻性研究Larkana的Chandka医学院附属医院眼科的53例组织学诊断为视网膜母细胞瘤患者,肿瘤侵及眼球、眼眶、颅内以及其他组织。为研究肿瘤广泛性,检查包括:眼眶X线片,眼球... 目的:评价肿瘤的位置、大小、组织学以及复发率。 方法:前瞻性研究Larkana的Chandka医学院附属医院眼科的53例组织学诊断为视网膜母细胞瘤患者,肿瘤侵及眼球、眼眶、颅内以及其他组织。为研究肿瘤广泛性,检查包括:眼眶X线片,眼球B超,眼眶及头颅CT扫描/MRI,全骨扫描,胸部前后位X线片,腹部B超,腰椎穿刺,全血细胞计数,包括肝肾功能检查的血生化,根据肿瘤的位置、大小、复发及转移选择包括手术、局部放疗、系统化疗的治疗方案。有局部和系统转移的患者,由Larkana的核医学和放疗机构的肿瘤专家进行局部放疗和系统化疗。术后1,3,6,12mo复查随访,随后5a及5a以上,1a复查一次。评估肿瘤的位置、大小、组织类型和复发率。 结果:患者53例,年龄8mo~8岁。男25例(47%),女28例(53%)。肿瘤的眼别,左眼25例(47%),右眼19例(36%),双眼9例(17%)。患者的首发症状,斜视3例(6%),假性眼内炎4例(8%),眼眶炎性假瘤6例(11%),转移性包块7例(13%),蕈样生长的包块8例(15%),白瞳征12例(23%),眼眶浸润13例(25%)。行单纯眼球摘除术19例(36%),行眼球摘除及改良型眶内容物剜除术并局部放疗和系统化疗19例(36%),行眼球摘除及完全型眶内容物剜除术并局部放疗和系统化疗15例(28%)。肿瘤的组织类型,含大量染色质的高分化视网膜母细胞瘤25例(47%),高度未分化视网膜母细胞瘤28例(53%)。首次手术后,由于手术切除点以上视神经受累,眼眶浸润和系统转移,发生复发和转移37例(70%)。 结论:儿童红眼或白瞳征在确诊之前应怀疑视网膜母细胞瘤,应该及时经眼科专家检查,因为患者在肿瘤初期的早期表现提示会降低肿瘤的扩散、复发和死亡率。 展开更多
关键词 晚期症状 视网膜母细胞瘤 挑战
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细菌性角膜溃疡的医院流行病学,诱因和微生物诊断 预览 被引量:2
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作者 Ashok Kumar Narsani Shaft Muhammad Jatoi Mahesh Kumar Lohana Syed Asher Dabir Siddiqa Gul Mahtab Alam Khanzada 《国际眼科杂志》 CAS 2009年第3期 409-413,共5页
目的:确定细菌性角膜溃疡的发病诱因,临床和微生物特性。 方法:本研究涉及300例(300眼)临床上疑似微生物感染的角膜溃疡患者。通过病史回顾和裂隙灯检查获得病例资料。采用标准技术完成角膜刮片检查。取部分刮片样本加入100g/h... 目的:确定细菌性角膜溃疡的发病诱因,临床和微生物特性。 方法:本研究涉及300例(300眼)临床上疑似微生物感染的角膜溃疡患者。通过病史回顾和裂隙灯检查获得病例资料。采用标准技术完成角膜刮片检查。取部分刮片样本加入100g/h的氢氧化钾液后,以及采用革兰氏和吉姆萨染色,再直接在显微镜下观察是否存在真菌、细菌和棘阿米巴。另一部分刮片样本直接接种在血琼脂、麦康基琼脂、巧克力琼脂和萨布罗琼脂表面。通过角膜刮片检查,细菌性角膜溃疡被确诊为化脓性角膜溃疡浸润和表层上皮细胞缺失伴细菌感染。对患者应用抗菌治疗。 结果:在随访期间,因丢失而被排除的有60个病例。在剩下的240人中,被确诊为细菌性角膜溃疡的156人(65%),大多数为男性(102眼),年龄分布14—74岁。角膜溃疡位于角膜中央的96人(61.5%),位于外周的60人(38.5%)。溃疡深度〈1/3角膜厚度的82人(52.6%)。前房炎症为:Tyndall现象和浮游细胞^1+-2+64人。角膜涂片中分离出细菌的有125人(80%),其中69%为革兰氏阳性,39%为革兰氏阴性。革兰氏阴性菌感染患者伴有重症前房炎症(P=0.003)并且深度〉2/3角膜厚度(P=0.001)。分离得到的最常见致病微生物为金黄色葡萄球菌。治疗后40%的患者视力恢复到入院时的水平甚至更好,其余60%的患者预后差。 结论:细菌性角膜溃疡是一种严重的眼部感染性疾病,对眼部存在视力威胁,在治疗上仍具挑战性。快速分离细菌和眼部抗生素的应用是治疗此类疾病的关键。 展开更多
关键词 细菌性角膜炎 植物性外伤 微生物
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巴基斯坦南部84例真菌性角膜炎的研究 预览 被引量:1
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作者 Ashok Kumar Narsani Siddiqa Gul +3 位作者 Syed Asher Dabir Shafi Muhammad Jatoi Mahtab Alam Khanzada Mahesh Kumar 《国际眼科杂志》 CAS 2008年第9期 1736-1739,共4页
目的:确定真菌性角膜炎的易感因素、致病真菌,以及提高相应的实验室诊断能力。方法:240例240眼临床疑似微生物感染的角膜溃疡患者进入本研究。通过病史回溯及裂隙灯检查获得病例资料。采用标准技术完成角膜刮片检查。取部分刮片样本加... 目的:确定真菌性角膜炎的易感因素、致病真菌,以及提高相应的实验室诊断能力。方法:240例240眼临床疑似微生物感染的角膜溃疡患者进入本研究。通过病史回溯及裂隙灯检查获得病例资料。采用标准技术完成角膜刮片检查。取部分刮片样本加入10%的氢氧化钾液后,以及采用革兰氏和吉姆萨染色,在直接在显微镜下观察是否存在真菌、细菌和棘阿米巴。另一部分刮片样本直接接种在血琼脂、麦康基琼脂、巧克力琼脂和萨布罗琼脂表面。结果:在纳入本研究的240例伴有脓性分泌物的角膜溃疡患者中,84例(35%)被确认为真菌感染。其中48例(57.1%)为男性,其余36例(42.9%)为女性。年龄分布从22-80岁。其中60例(71.4%)为农村患者,其余24例(28.6%)为城市居民。18例(21.4%)曾有植物外伤史。病变高发于10月至11月间。在84例确诊为真菌性角膜炎的患眼,致病原因为单纯真菌者74眼(80.10%),其余10眼(11.90%)为真菌合并细菌感染。分离得到的最常见致病微生物为白色念珠菌,在66眼(78.6%)中被发现。结论:在巴基斯坦南部,感染性角膜溃疡中,最常见的是真菌性角膜炎,而白色念珠菌是最常见的致病原。采用加入10%的氢氧化钾液后直接显微镜下观察是此类感染原简单、迅速、价廉及可信的诊断方法。 展开更多
关键词 真菌性角膜炎 农业 念珠菌
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巴基斯坦海德拉巴124例眼球穿通伤的临床分析 预览 被引量:1
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作者 Ashok Kumar Narsani Syed Asher Dabir Siddiqa Gul Shafi Muhammad Jatoi Mahtab Alam Khanzada Mahesh Kumar 《国际眼科杂志》 CAS 2008年第11期 2164-2166,共3页
目的:分析眼球穿通伤的常见病因,确定这些病例的最终视力。 方法:总共124例(124眼)年龄为6 ~60岁的眼球穿通伤患者就诊于Liaquat大学眼科,分析眼球穿通伤的常见病因及最终视力。 结果:本研究包括124例眼球穿通伤患者,平均年龄35... 目的:分析眼球穿通伤的常见病因,确定这些病例的最终视力。 方法:总共124例(124眼)年龄为6 ~60岁的眼球穿通伤患者就诊于Liaquat大学眼科,分析眼球穿通伤的常见病因及最终视力。 结果:本研究包括124例眼球穿通伤患者,平均年龄35(6 ~60)岁,男性为主,占86.3%,大多数患者小于20岁(71%)。眼球穿通伤最常见于职工,占76%。51%的患者最佳矫正视力位于光感至0.1之间。我们可靠记录了124例患者的最初视力和最终视力,结果发现不良的最终视力和差的最初视力之间关系密切。 结论:眼球穿通伤是一种常见事故,尤其发生在青年男性中,常导致患者眼视力下降。缺乏保护措施的工作环境和儿童玩耍危险物品是常致严重的眼外伤的原因。 展开更多
关键词 穿通性 眼外伤 视力结果
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