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Development and validation of a simple and multifaceted instrument,GERD-TEST,for the clinical evaluation of gastroesophageal reflux and dyspeptic symptoms 预览
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作者 Koji Nakada Nobuyuki Matsuhashi +4 位作者 Katsuhiko Iwakiri Atsushi Oshio Takashi Joh Kazuhide Higuchi Ken Haruma 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第28期5216-5228,共13页
AIM To evaluate the psychometric properties of a newly developed questionnaire,known as the gastroesophageal reflux and dyspepsia therapeutic efficacy and satisfaction test(GERD-TEST),in patients with GERD.METHODS Jap... AIM To evaluate the psychometric properties of a newly developed questionnaire,known as the gastroesophageal reflux and dyspepsia therapeutic efficacy and satisfaction test(GERD-TEST),in patients with GERD.METHODS Japanese patients with predominant GERD symptoms recruited according to the Montreal definition were treated for 4 wk using a standard dose of proton pump inhibitor(PPI). The GERD-TEST and the Medical Outcome Study Short Form-8 Health Survey(SF-8) were administered at baseline and after 4 wk of treatment. The GERD-TEST contains three domains: the severity of GERD and functional dyspepsia(FD) symptoms(5 items),the level of dissatisfaction with daily life(DS)(4 items),and the therapeutic efficacy as assessed by the patients and medication compliance(4 items).RESULTS A total of 290 patients were eligible at baseline; 198 of these patients completed 4 wk of PPI therapy. The internal consistency reliability as evaluated using the Cronbach’s α values for the GERD,FD and DS subscales ranged from 0.75 to 0.82. The scores for the GERD,FD and DS items/subscales were significantly correlated with the physical and mental component summary scores of the SF-8. After 4 wk of PPI treatment,the scores for the GERD items/subscales were greatly reduced,ranging in value from 1.51 to 1.87 and with a large effect size(P < 0.0001,Cohen’s d; 1.29-1.63). Statistically significant differences in the changes in the scores for the GERD items/subscales were observed between treatment responders and non-responders(P < 0.0001).CONCLUSION The GERD-TEST has a good reliability,a good convergent and concurrent validity,and is responsive to the effects of treatment. The GERD-TEST is a simple,easy to understand,and multifaceted PRO instrument applicable to both clinical trials and the primary care of GERD patients. 展开更多
关键词 治疗学的功效和满足测试的 Gastroesophageal 倒流和消化不良 报导病人的结果 Gastroesophageal 倒流疾病 有效性 可靠性
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Is endoscopic papillary balloon dilatation really a risk factor for post-ERCP pancreatitis? 预览
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作者 Toshio Fujisawa Koichi Kagawa +3 位作者 Kantaro Hisatomi Kensuke Kubota Atsushi Nakajima Nobuyuki Matsuhashi 《世界胃肠病学杂志:英文版》 SCIE CAS 2016年第26期5909-5916,共8页
Endoscopic papillary balloon dilatation(EPBD) is useful for decreasing early complications of endoscopic retrograde cholangio-pancreatography(ERCP), including bleeding, biliary infection, and perforation, but it is ge... Endoscopic papillary balloon dilatation(EPBD) is useful for decreasing early complications of endoscopic retrograde cholangio-pancreatography(ERCP), including bleeding, biliary infection, and perforation, but it is generally avoided in Western countries because of a relatively high reported incidence of post-ERCP pancreatitis(PEP). However, as the efficacy of endoscopic papillary largeballoon dilatation(EPLBD) becomes widely recognized, EPBD is attracting attention. Here we investigate whether EPBD is truly a risk factor for PEP, and seek safer and more effective EPBD procedures by reviewing past studies. We reviewed thirteen randomised control trials comparing EPBD and endoscopic sphincterotomy(EST) and ten studies comparing direct EPLBD and EST. Three randomized controlled trials of EPBD showed significantly higher incidence of PEP than EST, but no study of EPLBD did. Careful analysis of these studies suggested that longer and higher-pressure inflation of balloons might decrease PEP incidence. The paradoxical result that EPBD with small-calibre balloons increases PEP incidence while EPLBD does not may be due to insufficient papillary dilatation in the former. Insufficient dilatation could cause the high incidence of PEP through the use of mechanical lithotripsy and stress on the papilla at the time of stone removal. Sufficient dilation of the papilla may be useful in preventing PEP. 展开更多
关键词 ENDOSCOPIC PAPILLARY BALLOON DILATATION Post-endoscopic RETROGRADE cholangio-pancreatography pancrea
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Pancreatic paraganglioma with draining vessels 预览
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作者 YoshitsuguMisumi ToshioFujisawa +6 位作者 HirotsuguHashimoto KoichiKagawa TamakiNoie HideyukiChiba HajimeHoriuchi YasushiHarihara NobuyukiMatsuhashi 《世界胃肠病学杂志:英文版》 SCIE CAS 2015年第31期9442-9447,共6页
A pancreatic paraganglioma is a rare neoplasm that is difficult to distinguish from a pancreatic neuroendocrine tumour. Here we present a case of pancreatic paraganglioma that was surgically resected following preoper... A pancreatic paraganglioma is a rare neoplasm that is difficult to distinguish from a pancreatic neuroendocrine tumour. Here we present a case of pancreatic paraganglioma that was surgically resected following preoperative diagnosis of a pancreatic neuroendocrine tumour. Careful evaluation of the endoscopic ultrasonography findings revealed abundant draining ves-sels,which could have led to a correct preoperative diagnosis of pancreatic paraganglioma. 展开更多
关键词 PARAGANGLIOMA NEUROENDOCRINE TUMOUR Draining vesse
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Prospective controlled study on the effects of polyethylene glycol in capsule endoscopy 预览 被引量:2
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作者 Takafumi Ito Ken Ohata +4 位作者 Akiko Ono Hideyuki Chiba Yosuke Tsuji Hajime Sato Nobuyuki Matsuhashi 《世界胃肠病学杂志:英文版》 SCIE CAS CSCD 2012年第15期 1789-1792,共4页
瞄准:为了有希望地证实聚乙烯乙二醇(木钉) 的小数量是否在咽下内视镜检查法以后摄取了,囊改进图象质量和结束率。方法:44 个连续病人指了我们因为囊内视镜检查法(CE ) 被使随机化到二个组。所有病人被限制在考试前为 12 h 清除液体... 瞄准:为了有希望地证实聚乙烯乙二醇(木钉) 的小数量是否在咽下内视镜检查法以后摄取了,囊改进图象质量和结束率。方法:44 个连续病人指了我们因为囊内视镜检查法(CE ) 被使随机化到二个组。所有病人被限制在考试前为 12 h 清除液体。在组 A (22 个盒子) 的病人没收到另外的准备,当那些在在咽下囊以后开始 30 min 的 2 h 时期以内在组 B (20 个盒子) 摄取了木钉的 500 mL 时。清楚的液体和饭分别地在囊摄取以后被给予 2 h 和 4 h。图象质量如下作为设想的肠表面区域的百分比被估计:1:<25% ;2:25%-49% ;3:50%-74% ;4:75%-89% ;5:>90% 。小肠记录到时间被划分成五个片断,并且为每个片断的分数被评估。所有 CE 考试与 Pillcam SB 囊内视镜检查法系统被执行(给定的成像公司有限公司, Yoqnem ) 。结果:这研究在 2009 年 12 月结束了,因为样品尺寸被认为足够大。44 个病人的一个总数被注册。因为小肠图象不能从这些病人被获得,在组 B 的二个病人从分析被排除;一个人有一个完整的胃,当其它介绍了与时一巨大胃流血。因此,从组 A 的 22 个病人和从组 B 的 20 个病人完成了学习。在年龄没有重要差别(P = 0.22 ) ,性别(P = 0.31 ) ,并且为 CE 的指示。没有重要不利事件发生在任何学习病人。在组 A,当囊远侧地进行了,图象质量败坏了。在组 B,然而,图象质量被维持到远侧的小肠。在每五个片断,可见性分数比在组 A 在组 B 是显著地更高的(片断 1:4.3 散慲摬桥摹?? 展开更多
关键词 聚乙二醇 胶囊 内镜 图像质量 检查 PEG 样本大小 内窥镜
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post-ESD 上的 lafutidine 对 rabeprazole 的未来的使随机化的试用胃的溃疡 预览
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作者 Tomohiko Richard Ohya Hiroki Endo +9 位作者 Kei Kawagoe Tatsuro Yanagawa Katsuhiro Hanawa Ken Ohata Masako Asayama Kantaro Hisatomi Takuma Teratani Toshiaki Gunji Hajime Sato Nobuyuki Matsuhashi 《世界胃肠内镜杂志:英文版(电子版)》 2010年第1期36-40,共5页
AIM:To compare the effects of rabeprazole and lafutidine on post-endoscopic submucosal dissection(ESD) gastric ulcers.METHODS:Patients with gastric tumors indicated for ESD were prospectively studied.After ESD,all pa... AIM:To compare the effects of rabeprazole and lafutidine on post-endoscopic submucosal dissection(ESD) gastric ulcers.METHODS:Patients with gastric tumors indicated for ESD were prospectively studied.After ESD,all patients were treated with intravenous omeprazole for the first 3 d.Patients were then randomly assigned to oral lafutidine or rabeprazole.Ulcer size,ulcer size reduction rate,and ulcer stage were evaluated 4 wk later.Occurrence of complication was monitored throughout the 4-wk period.RESULTS:Sixty five patients were enrolled in the study,and 60 patients were subjected to the final analysis.In the lafutidine group(30 lesions in 29 patients),initial and 4-wk post-ESD ulcer sizes were 33.3 ± 9.2 and 10.5 ± 4.8 mm,respectively.In the rabeprazole group(34 lesions in 31 patients),the values were 34.7 ± 11.3 and 11.8 ± 6.7 mm,respectively.Ulcer size reduction rates in lafutidine and rabeprazole groups were 32.3% and 33.5%,respectively(P=0.974).Ulcer stage 4 wk post-ESD did not differ significantly between the two groups(P=0.868).Two cases in the rabeprazole group and no cases in the lafutidine group developed ulcer bleeding during the oral dose period,although the difference of bleeding rate between the two groups was not statistically significant(P=0.157).CONCLUSION:Lafutidine and rabeprazole have equivalent therapeutic effects on post-ESD gastric ulcers. 展开更多
关键词 CYTOPROTECTION Endoscopic SUBMUCOSAL dissection Gastric ulcer HISTAMINE H2 receptor ANTAGONISTS LAFUTIDINE Proton pump inhibitors RABEPRAZOLE
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Risk factors for bleeding after endoscopic submucosal dissection for gastric lesions 预览 被引量:13
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作者 Yosuke Tsuji Ken Ohata Takafumi Ito Hideyuki Chiba Tomohiko Ohya Toshiaki Gunji Nobuyuki Matsuhashi 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2010年第23期共5页
AIM:To assess risk factors for bleeding after gastric endoscopic submucosal dissection(ESD) and to develop preventive measures.METHODS:This retrospective study was performed in a tertiary referral center.A total of 32... AIM:To assess risk factors for bleeding after gastric endoscopic submucosal dissection(ESD) and to develop preventive measures.METHODS:This retrospective study was performed in a tertiary referral center.A total of 328 patients underwent ESD for 398 gastric neoplasms between July 2007 and June 2009.The main outcome was association between post-ESD bleeding and the following:age;sex;comorbidities;daily use of medicine potentially related to gastric injury/bleeding;location,size,and histological depth of lesi... 展开更多
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