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The enhanced X-ray Timing and Polarimetry mission eXTP
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作者 ShuangNan Zhang Andrea Santangelo +112 位作者 Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang S?ren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J. M. in 't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jorn Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen YuPeng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino José Luis Gálvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng 《中国科学:物理学、力学、天文学英文版》 SCIE EI CAS CSCD 2019年第2期3-27,共25页
In this paper we present the enhanced X-ray Timing and Polarimetry mission----eXTP,eXTP is a space science mission designed to study fundamental physics under extreme conditions of density,gravity and magnetism.The mi... In this paper we present the enhanced X-ray Timing and Polarimetry mission----eXTP,eXTP is a space science mission designed to study fundamental physics under extreme conditions of density,gravity and magnetism.The mission aims at determining the equation of state of matter at supra-nuclear density,measuring effects of QED,and understanding the dynamics of matter in strong-field gravity.In addition to investigating fundamental physics,eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects.In particular,its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources. The paper provides a detailed description of:(1)the technological and technical aspects,and the expected performance of the instruments of the scientific payload;(2)the elements and functions of the mission,from the spacecraft to the ground segment. 展开更多
关键词 X-RAY INSTRUMENTATION X-RAY POLARIMETRY X-RAY TIMING space mission:eXTP
Accretion in strong field gravity with eXTP
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作者 Alessandra De Rosa Phil Uttley +99 位作者 LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci Niccoló Bucciantini Fiamma Capitanio Riccardo Ciolfi Wei K. Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovvciak Andrew C. Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J. Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andrea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T. O'Brien Julian P. Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L. Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M. Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J. M. in 't Zand Andrzej A. Zdziarski XinLin Zhou 《中国科学:物理学、力学、天文学英文版》 SCIE EI CAS CSCD 2019年第2期45-73,共29页
In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry (eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive b... In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry (eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced “spectral-timing-polarimetry” techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process. 展开更多
关键词 X-RAY BLACK HOLES PHYSICS ACCRETION
The next-generation sphingosine-1 receptor modulator BAF312(siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis 预览
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作者 Petra Hundehege Manuela Cerina +13 位作者 Susann Eichler Christian Thomas Alexander M. Herrmann Kerstin Goel Thomas Müntefering Juncal Fernandez-Orth Stefanie Bock Venu Narayanan Thomas Budde Erwin-Josef Speckmann Heinz Wiendl Anna Schubart Tobias Ruck Sven G. Meuth 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期1950-1960,共11页
Autoimmune diseases of the central nervous system(CNS) like multiple sclerosis(MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stag... Autoimmune diseases of the central nervous system(CNS) like multiple sclerosis(MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced in the relapsing forms of the disease, whereas progressive MS(PMS) shows significant neuroaxonal damage and grey and white matter atrophy. Hence, disease-modifying treatments beneficial in patients with relapsing MS have limited success in PMS. BAF312(siponimod) is a novel sphingosine-1-phosphate receptor modulator shown to delay progression in PMS. Besides reducing inflammation by sequestering lymphocytes in lymphoid tissues, BAF312 crosses the blood-brain barrier and binds its receptors on neurons, astrocytes and oligodendrocytes. To evaluate potential direct neuroprotective effects, BAF312 was systemically or locally administered in the CNS of experimental autoimmune encephalomyelitis mice with distinct grey-and white-matter lesions(focal experimental autoimmune encephalomyelitis using an osmotic mini-pump). Ex-vivo flow cytometry revealed that systemic but not local BAF312 administration lowered immune cell infiltration in animals with both grey and white matter lesions. Ex-vivo voltage-sensitive dye imaging of acute brain slices revealed an altered spatio-temporal pattern of activation in the lesioned cortex compared to controls in response to electrical stimulation of incoming white-matter fiber tracts. Here, BAF312 administration showed partial restore of cortical neuronal circuit function. The data suggest that BAF312 exerts a neuroprotective effect after crossing the blood-brain barrier independently of peripheral effects on immune cells. Experiments were carried out in accordance with German and EU animal protection law and approved by local authorities(Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen;87-51.04.2010.A331) on December 28, 2010. 展开更多
关键词 multiple SCLEROSIS FOCAL experimental autoimmune ENCEPHALOMYELITIS CORTICAL grey MATTER white MATTER BAF312 neuroaxonal damage neuroprotection
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A new mutually destabilized reactive hydride system:LiBH4-Mg2NiH4 预览
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作者 Nils Bergemann Claudio Pistidda +6 位作者 Maike Uptmoor Chiara Milanese Antonio Santoru Thomas Emmler Julián Puszkiel Martin Dornheim Thomas Klassen 《能源化学:英文版》 SCIE EI CAS CSCD 2019年第7期240-254,共15页
In this work,the hydrogen sorption properties of the LiBH4-Mg2NiH4 composite system with the molar ratio 2:2.5 were thoroughly investigated as a function of the applied temperature and hydrogen pressure.To the best of... In this work,the hydrogen sorption properties of the LiBH4-Mg2NiH4 composite system with the molar ratio 2:2.5 were thoroughly investigated as a function of the applied temperature and hydrogen pressure.To the best of our knowledge,it has been possible to prove experimentally the mutual destabilization between LiBH4 and Mg2NiH4.A detailed account of the kinetic and thermodynamic features of the dehydrogenation process is reported here. 展开更多
关键词 Hydrogen storage Metal hydrides BOROHYDRIDES REACTIVE HYDRIDE Composites(RHC) Mutual DESTABILIZATION TERNARY borides
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老海勒鲁普高中体育馆
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作者 Ana Merino Anders Hjortnas +43 位作者 Christian Alvarez Dennis Rasmussen Gül Ertekin Henrick Poulsen Hjalti Gestsson Jan Magasanik Jakob Lange Jacob Thomsen Jeppe Ecklon Ji-young Yoon Michael Sch?nemann Narisara Schr?der Riccardo Mariano Rune Hansen Snorre Nash Thomas Juul-Jensen Vincent He Xu Li Agnete Jukneviciute Ambra Chiesa Brigitta Gulyás Dennis Rasmussen Enea Michelesio Greta Krenciute H?gni Laksáfoss Isabella Eriksson Jan Magasanik Mikkel Marcker Stubgaard Jeppe Ecklon Kamilla Heskje Michael Sch?nemann Narisara Schr?der Thomas Juul-Jensen Brigitta Gulyás Enea Michelesio Jakob Lange Mikkel Marcker Stubgaard Narisara Schroder Tobias Hjortdal Iwan Baan Peter Moldow Rasmus Hjortshoj Jens Lindhe 朱翰林(译) 《城市环境设计》 2019年第2期114-127,共14页
位于哥本哈根北部的老海勒鲁普高中,内部拥有1100m~2的多功能大厅和最新的两层建筑,为现有学生提供了广阔的社交和创意展示空间,同时提升学校的容量,以应对持续增长的人口需求。原本校园旁边的一栋建筑里,体育设施匮乏而无法满足需求;... 位于哥本哈根北部的老海勒鲁普高中,内部拥有1100m~2的多功能大厅和最新的两层建筑,为现有学生提供了广阔的社交和创意展示空间,同时提升学校的容量,以应对持续增长的人口需求。原本校园旁边的一栋建筑里,体育设施匮乏而无法满足需求;老海勒鲁普高中也缺少大型多功能空间,用以举办体育活动、毕业典礼和社交聚会。 展开更多
关键词 体育馆 多功能大厅 多功能厅 足球场
Observatory science with eXTP
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作者 Jean J. M. in 't Zand Enrico Bozzo +103 位作者 JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A. Drake Margarita Hernanz Peter A. Jenke Thomas J. Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M. Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M. Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A. Andersson M. Cristina Baglio David R. Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Jo ao Braga S?ren Brandt Edward F. Brown Niccolò Bucciantini Luciano Burderi Edward M. Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jérome Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D. Ferdman Marco Feroci Federico Fraschetti Duncan K. Galloway Angelo F. Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego Gotz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O. Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G. Jonker Jordi José Jelle S. Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A. Lutovinov Denys Malyshev Julien Malza 《中国科学:物理学、力学、天文学英文版》 SCIE EI CAS CSCD 2019年第2期97-138,共42页
In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry (eXTP) mission for studies related toObservatory Science targets. These include flaring stars, supernova remnants, accreting wh... In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry (eXTP) mission for studies related toObservatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-raybinaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellentlysuited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium ledby the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in themid 2020s. 展开更多
关键词 space research instruments nuclear ASTROPHYSICS flare stars ACCRETION and ACCRETION disks mass loss and stellar winds cataclysmic BINARIES X-RAY BINARIES supernova REMNANTS active galactic nuclei X-RAY BURSTS gamma-ray BURSTS gravitational waves
供应链4.0:实时物流过程概述
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作者 Thomas Mailander Thomas Wieβflecker 《现代制造》 2019年第11期46-47,共2页
买家在选好商品最后按下图标按钮“订购”之前,还要快速的查看一下:您订购的货物何时发货。三天内发货?太长了!宁愿再上网查查,看看是否有其他供应商能够更快的发货。满足这些物流要求的企业应是什么样的?全球著名的德国邮递公司DHL公... 买家在选好商品最后按下图标按钮“订购”之前,还要快速的查看一下:您订购的货物何时发货。三天内发货?太长了!宁愿再上网查查,看看是否有其他供应商能够更快的发货。满足这些物流要求的企业应是什么样的?全球著名的德国邮递公司DHL公司在最新版的物流趋势雷达(Logistic Trends Radar)调查中采访了一万多名物流专家和物流技术专家,并根据他们的答复整理出了物流领域未来发展的主要趋势。 展开更多
关键词 物流过程 供应链 LOGISTIC 实时 技术专家 RADAR 图标按钮 供应商
品牌目标的第一条原则是不作恶
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作者 Thomas Barta 骆佳(译) 《国际品牌观察》 2019年第4期45-46,共2页
品牌营销领域的从业者应该都梦想着为那些拥有受人尊敬的品牌目标的企业工作。上世纪80年代,每一位读过Stephen Covey (史蒂芬·柯维)的《高效能人士的7个习惯》(the 7 Habits ofHighly Effective People)的营销人员可能都会问自己... 品牌营销领域的从业者应该都梦想着为那些拥有受人尊敬的品牌目标的企业工作。上世纪80年代,每一位读过Stephen Covey (史蒂芬·柯维)的《高效能人士的7个习惯》(the 7 Habits ofHighly Effective People)的营销人员可能都会问自己一个问题:“我生命中的大目标是什么?” 展开更多
关键词 品牌 《高效能人士的7个习惯》 标的 企业工作 营销领域 80年代 营销人员 从业者
超级高铁
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作者 Erik Berg Kreider Adi Krainer +23 位作者 Ashton Stare Cheyenne Vandevoorde Cristian Lera Daniele Pronesti Derek Wong Domenic Schmid Evan Wiskup Francesca Portesine Hugo Soo Kristian Hindsberg Lam Le Nguyen Lasse Kristensen Linda Halim Maureen Rahman Ovidiu Munteanu Pei Pei Yang Ryan Duval Stephen Steckel Terrence Chew Thomas Christoffersen Tore Banke Veronica Moretti Yehezkiel Wiliardy 曲鸿(译) 《城市环境设计》 2019年第2期260-267,共8页
BIG的创始合伙人比亚克评价说:'通过超级高铁,我们定义了一个由客舱和站门组成的交通出行生态系统。人们不必等车,也不再需要候车厅,超级高铁用接近超音速的速度将集体社会和个人自由联系在一起。在未来,这种崭新的出行方式将改变... BIG的创始合伙人比亚克评价说:'通过超级高铁,我们定义了一个由客舱和站门组成的交通出行生态系统。人们不必等车,也不再需要候车厅,超级高铁用接近超音速的速度将集体社会和个人自由联系在一起。在未来,这种崭新的出行方式将改变我们对时空的习惯认知,我们脑海中对城市版图的理解也将随之改变。' 展开更多
关键词 传送器 目的地
Comprehensive lifestyle intervention vs soy protein-based meal regimen in non-alcoholic steatohepatitis 预览
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作者 Peter Deibert Adhara Lazaro +7 位作者 Denise Schaffner Aloys Berg Daniel Koenig Wolfgang Kreisel Manfred W Baumstark Daniel Steinmann Martin Buechert Thomas Lange 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第9期1116-1131,共16页
BACKGROUND Non-alcoholic steatohepatitis(NASH)has become one of the leading causes of liver disease in the western world.In obese patients weight reduction is recommended.Up to now there are no specific guidelines for... BACKGROUND Non-alcoholic steatohepatitis(NASH)has become one of the leading causes of liver disease in the western world.In obese patients weight reduction is recommended.Up to now there are no specific guidelines for weight loss in order to reduce hepatic fat content.AIM To investigate the effects of a 24-wk guided lifestyle intervention program compared to a meal replacement regimen based on soy protein.METHODS Twenty-six subjects with NASH participated in a randomized single-center study.They were randomly assigned to either meal replacement group(MR-G)with soy-yogurt-honey preparation or to guided lifestyle change group(LC-G)with endurance activity and nutrition counselling.Serum alanine transaminase(ALT),aspartate transaminase(AST),lipid parameters,and adipokines were measured.Liver fat content and lipid composition were determined by magnetic resonance imaging and magnetic resonance spectroscopy.Body fat mass and lean body mass were assessed using Bod Pod?device.Pre-and post-intervention monitoring of parameters was performed.Statistical analyses were conducted with SPSS software,results were expressed as median(interquartile range).RESULTS Twenty-two subjects(MR-G,n=11 and LC-G,n=11)completed the study(9 women,13 men;age 52.1(15.0)years,body mass index(BMI)32.3(3.3)kg/m2).In both groups a significant weight loss was achieved(MR-G:-6.4(3.6)kg,P<0.01;LC-G:-9.1(10.4)kg,P<0.01).BMI dropped in both groups(MR-G:-2.3(1.5)kg/m2,P=0.003;LC-G:-3.0(3.4)kg/m2,P=0.006).Internal fat and hepatic lipid content were markedly reduced in both groups in comparable amount.There was a strong correlation between reduction in liver fat and decrease in ALT.Likewise,both groups showed an improvement in glycemic control and lipid profile.Changes in adipokines,particularly in adiponectin and leptin were closely related to intrahepatic lipid changes.CONCLUSION Comprehensive lifestyle intervention and meal replacement regimen have comparable effects on body and liver fat,as well as decrease in markers of hepatic inflammation among NASH 展开更多
关键词 Non-alcoholic STEATOHEPATITIS MEAL replacement therapy SOY protein LIFESTYLE change Weight reduction Obesity
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狮航生气了后果很严重
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作者 Harry Suhartono Angus Whitley +1 位作者 Thomas Kutty Abraham 徐安琪(译) 《商业周刊(中文版)》 2019年第1期12-13,共2页
尽管航空公司和飞机制造商通常会就从定价到交货日期等所有问题进行紧张激烈的谈判,但他们对外宣布消息时通常都是面带笑容的。但波音公司(Boeing Co.)最重要的客户之一、印尼狮子航空(PT Lion Mentari Airlines)却并非如此。自2018年1... 尽管航空公司和飞机制造商通常会就从定价到交货日期等所有问题进行紧张激烈的谈判,但他们对外宣布消息时通常都是面带笑容的。但波音公司(Boeing Co.)最重要的客户之一、印尼狮子航空(PT Lion Mentari Airlines)却并非如此。自2018年10月一架全新的737窄体客机坠毁,导致189人丧生以来,该航空公司所有者鲁斯迪·基拉纳(Rusdi Kirana)一直在直言不讳地批评波音。 展开更多
关键词 生气 航空公司 波音公司 飞机制造商 交货日期 所有者
Investment pays off 预览
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作者 Thomas Martin 《中国纺织:英文版》 2019年第3期56-57,共2页
The experience of the Brazilian spinning mill Sergipe of using the new fully automated rotor spinning machine R 66 has been nothing but positive. No wonder, as the R 66 meets the highest quality standards at low produ... The experience of the Brazilian spinning mill Sergipe of using the new fully automated rotor spinning machine R 66 has been nothing but positive. No wonder, as the R 66 meets the highest quality standards at low production costs. 展开更多
关键词 BRAZILIAN SPINNING HAS been NOTHING quality standards
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你猜亚马逊当下最缺谁?
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作者 spencer Soper Thomas Black +1 位作者 王湛(译) 程玺(译) 《商业周刊(中文版)》 2019年第1期16-18,共3页
亚马逊并未规划一个淘汰驾驶员的未来,而是十分依赖这些司机当杰夫·贝索斯(Jeff Bezos)在哥伦比亚广播公司(CBS)的《60分钟》(60 Minutes)节目里誓言要让快递无人机满天飞时,他颠覆了全世界的想象。五年过去了,这位亚马逊公司(Amaz... 亚马逊并未规划一个淘汰驾驶员的未来,而是十分依赖这些司机当杰夫·贝索斯(Jeff Bezos)在哥伦比亚广播公司(CBS)的《60分钟》(60 Minutes)节目里誓言要让快递无人机满天飞时,他颠覆了全世界的想象。五年过去了,这位亚马逊公司(Amazon.com Inc.)的首席执行官如今正在押注一种更接地气的技术:驾驶员。就是人类驾驶员。 展开更多
关键词 亚马逊公司 哥伦比亚广播公司 《60分钟》 首席执行官 驾驶员 .com 贝索斯 无人机
Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment 预览
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作者 Nathalie Bock Ali Shokoohmand +6 位作者 Thomas Kryza Joan Rohl Jonelle Meijer Phong A. Tran Colleen C. Nelson Judith A. Clements Dietmar W. Hutmacher 《骨研究:英文版》 SCIE CAS CSCD 2019年第2期157-170,共14页
While stromal interactions are essential in cancer adaptation to hormonal therapies,the effects of bone stroma and androgen deprivation on cancer progression in bone are poorly understood.Here,we tissue-engineered and... While stromal interactions are essential in cancer adaptation to hormonal therapies,the effects of bone stroma and androgen deprivation on cancer progression in bone are poorly understood.Here,we tissue-engineered and validated an in vitro microtissue model of osteoblastic bone metastases,and used it to study the effects of androgen deprivation in this microenvironment.The model was established by culturing primary human osteoprogenitor cells on melt electrowritten polymer scaffolds,leading to a mineralized osteoblast-derived microtissue containing,in a 3D setting,viable osteoblastic cells,osteocytic cells,and appropriate expression of osteoblast/osteocyte-derived mRNA and proteins,and mineral content.Direct co-culture of androgen receptordependent/ independent cell lines (LNCaP,C4-2B,and PC3) led cancer cells to display functional and molecular features as observed in vivo.Co-cultured cancer cells showed increased affinity to the microtissues,as a function of their bone metastatic potential.Cocultures led to alkaline phosphatase and collagen-I upregulation and sclerostin downregulation,consistent with the clinical marker profile of osteoblastic bone metastases.LNCaP showed a significant adaptive response under androgen deprivation in the microtissues,with the notable appearance of neuroendocrine transdifferentiation features and increased expression of related markers (dopa decarboxylase,enolase 2).Androgen deprivation affected the biology of the metastatic microenvironment with stronger upregulation of androgen receptor,alkaline phosphatase,and dopa decarboxylase,as seen in the transition towards resistance.The unique microtissues engineered here represent a substantial asset to determine the involvement of the human bone microenvironment in prostate cancer progression and response to a therapeutic context in this microenvironment. 展开更多
关键词 ENGINEERING OSTEOBLASTIC METASTASES the adaptive response METASTATIC MICROENVIRONMENT
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和托马斯·品钦一起打桥牌(下) 预览
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作者 Thomas Schaub 张晶晶 《大学英语》 2019年第6期25-38,共14页
Things did not delay in turning more curious yet. Between 1032 and 1036 was a driveway, two strips2 of cement for car wheels, weeds growing between them. Why not? I asked myself, might as well. Sure enough, in back of... Things did not delay in turning more curious yet. Between 1032 and 1036 was a driveway, two strips2 of cement for car wheels, weeds growing between them. Why not? I asked myself, might as well. Sure enough, in back of 1032 Bancroft Way was a small white bungalow with a few wooden steps up to a door, on which were tacked3 the numbers "1”"0”“3” and "4.” So the phone book was correct. As I stood there on the threshold4 of some discovery, wondering what or who was on the other side of that door, a large black dog came at me, snarling5 and barking. 展开更多
关键词 托马斯 there BETWEEN BETWEEN 桥牌 品钦 ENOUGH MORE
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冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化 被引量:1
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作者 Lorenz Raber Gary S Mintz +19 位作者 Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi 《中华心血管病杂志》 CAS CSCD 北大核心 2019年第1期5-25,共21页
欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的... 欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 展开更多
关键词 冠状动脉疾病 超声检查 介入性 体层摄影术 光学相干 经皮冠状动脉介入 治疗
人族肖像
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作者 Thomas Cavaille-Fol 王佳蕾(编译) 《新发现》 2019年第2期48-54,共7页
我们的祖先以及远古的人族表亲究竟长什么样?最新出炉的肖像重建工程给岀了答案:"古生物复原艺术家”借助解剖学知识和尖端基因分析成功重塑了他们的面庞。一幅幅人族肖像跃然纸上……
关键词 肖像 基因分析 重建工程 解剖学 艺术家 古生物 祖先 复原
Standardization of exercise intensity and consideration of a dose—response is essential.Commentary on"Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models",by Lourenco et al.,published 2019 in Nature Medicine
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作者 Thomas Gronwald Ana Cristina de Bem Alves +3 位作者 Eric Murillo-Rodriguez Alexandra Latini Juliane Schuette Henning Budde 《运动与健康科学:英文版》 SCIE 2019年第4期353-354,共2页
Over the past decade,several biochemical pathways have been investigated to understand the underlying mechanisms involved in the beneficial effects of physical exercise on cognition.1,2 Lourenco et al.,3 in an elegant... Over the past decade,several biochemical pathways have been investigated to understand the underlying mechanisms involved in the beneficial effects of physical exercise on cognition.1,2 Lourenco et al.,3 in an elegant study published in Nature Medicine,examined the relationship between exercise training and hippocampal memory function.Mechanistically,the authors showed that FNDC5/irisin is an important mediator of beneficial effects of physical exercise in a mouse model of Alzheimer's disease. 展开更多
关键词 exercise intensity DOSE-RESPONSE Alzheimer's MODELS
The enhanced element enrichment in the supercritical states of granite-pegmatite systems
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作者 Rainer Thomas Paul Davidson Karen Appel 《中国地球化学学报:英文版》 EI CAS CSCD 2019年第3期335-349,共15页
In this paper, we show that supercritical fluids have a greater significance in the generation of pegmatites,and for ore-forming processes related to granites than is usually assumed. We show that the supercritical me... In this paper, we show that supercritical fluids have a greater significance in the generation of pegmatites,and for ore-forming processes related to granites than is usually assumed. We show that the supercritical melt or fluid is a silicate phase in which volatiles;principally H2O are completely miscible in all proportions at magmatic temperatures and pressures. This phase evolves from felsic melts and changes into hydrothermal fluids, and its unique properties are particularly important in sequestering and concentrating low abundance elements, such as metals. In our past research, we have focused on processes observed at upper crustal levels, however extensive work by us and other researchers have demonstrated that supercritical melt/fluids should be abundant in melting zones at deep-crustal levels too. We propose that these fluids may provide a connecting link between lower and upper crustal magmas,and a highly efficient transport mechanism for usually melt incompatible elements. In this paper, we explore the unique features of this fluid which allow the partitioning of variouselements and compounds, potentially up to extreme levels,and may explain various features both of mineralization and the magmas that produced them. 展开更多
关键词 GRANITES PEGMATITES SUPERCRITICAL state Extreme ELEMENT ENRICHMENT
清达颗粒对AngⅡ诱导的高血压小鼠肾脏损害的干预研究 预览
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作者 杨美玲 周雪玲 +5 位作者 彭美中 卢妍 彭军 陈友琴 Thomas Joseph SFERRA 褚剑锋 《中医药通报》 2019年第2期65-69,共5页
目的:探讨清达颗粒对AngⅡ诱导的高血压肾损伤小鼠血压及相关病理的影响。方法:将18只小鼠随机分为3组:对照组、模型组及给药组,其中模型组及给药组予AngⅡ通过植入式胶囊渗透压泵连续灌注28d以建立高血压模型。给药组予清达颗粒灌胃给... 目的:探讨清达颗粒对AngⅡ诱导的高血压肾损伤小鼠血压及相关病理的影响。方法:将18只小鼠随机分为3组:对照组、模型组及给药组,其中模型组及给药组予AngⅡ通过植入式胶囊渗透压泵连续灌注28d以建立高血压模型。给药组予清达颗粒灌胃给药,剂量为22.9mg/天/0.2ml,对照组和模型组予等体积的生理盐水灌胃,每天1次,连续给药28d。结果:与模型组对比,清达颗粒能够抑制血压的升高幅度,差异具有统计学意义(P<0.05);与模型组比较,清达颗粒能够明显改善肾小动脉及肾小球硬化,降低肾小球内胶原阳性比例(P<0.05)。结论:清达颗粒能降低AngⅡ诱导的高血压小鼠的血压、减轻肾脏损伤。 展开更多
关键词 清达颗粒 高血压 肾脏损伤 AngⅡ
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