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Dark matter direct search sensitivity of the PandaX-4T experiment
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作者 HongGuang Zhang Abdusalam Abdukerim +59 位作者 Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou 《中国科学:物理学、力学、天文学英文版》 SCIE EI CAS CSCD 2019年第3期49-57,共9页
The PandaX-4T experiment,a 4-ton scale dark matter direct detection experiment,is being planned at the China Jinping Underground Laboratory.In this paper we present a simulation study of the expected background in thi... The PandaX-4T experiment,a 4-ton scale dark matter direct detection experiment,is being planned at the China Jinping Underground Laboratory.In this paper we present a simulation study of the expected background in this experiment.In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy,the total electron recoil background is found to be 4.9×10^-5 kg^-1d^-1,keV^-1.The nuclear recoil background in the same region is 2.8×10^-7 kg^-1d^-1keV^-1.With an exposure of 5.6 ton-years,the sensitivity of PandaX-4T could reach a minimum spin-independent dark matter-nucleon cross section of 6×10^-48 cm^2 at a dark matter mass of 40 GeV/c^2. 展开更多
关键词 DARK MATTER WIMPS DIRECT detection XENON
The efficacy and safety of nimodipine in acute ischemic stroke patients with mild cognitive impairment: a double-blind, randomized,placebo-controlled trial
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作者 Huaguang Zheng Yilong Wang +24 位作者 Anxin Wang Hao Li David Wang Xingquan Zhao Penglian Wang Haipeng Shen Lijun Zuo Yuesong Pan Zixiao Li Xia Meng Xianwei Wang Weixiong Shi Yi Ju Liping Liu Kehui Dong Chunxue Wang Rubo Sui Rong Xue Xiaoping Pan Xiaoyua Niu Benyan Luo Yi Sui Huali Wang Tao Feng Yongjun Wang 《科学通报:英文版》 SCIE EI CSCD 2019年第2期101-107,共7页
Nimodipine might be effective in subcortical vascular dementia(VaD). Its benefit in preventing further cognitive decline in patients with acute ischemic stroke(AIS) and vascular mild cognitive impairment(VaMCI) remain... Nimodipine might be effective in subcortical vascular dementia(VaD). Its benefit in preventing further cognitive decline in patients with acute ischemic stroke(AIS) and vascular mild cognitive impairment(VaMCI) remains to be established. In this multicenter, double-blind trial, we randomly assigned 654 eligible patients to nimodipine 30 mg three times a day or placebo. The primary outcome was any cognitive decline defined by the changes on the Mini-Mental State Examination(DMMSE à3) or vascular AD assessment scale cognitive subscale(DADAS-cog . 4) at 6 months. Secondary outcomes included any distribution shift of DADAS-cog, DMMSE or cognitive improvement defined by DADAS-cog à2, or DMMSE . 0. The primary outcome in the nimodipine group and placebo group were similar for DMMSE à3(4.18% and 7.22%, respectively, P = 0.15) and DADAS-cog . 4(8.36% and 8.93% respectively,P = 0.88). The distribution shift of DADAS-cog and DMMSE differed significantly between the two groups(P = 0.03 and P = 0.05 respectively). Cognitive improvement occurred in 55.4% in the nimodipine group and 43.6% in the placebo group measured by DADAS-cog à2(Odds Ratio, 1.54;95% confidence interval[CI] 1.10–2.14, P < 0.01) or 84.0% and 74.6% respectively by DMMSE . 0(Odds Ratio, 1.79;95% CI 1.18–2.70, P < 0.01). Nimodipine was associated with better cognitive function in the memory domain. The adverse events rate was similar in two groups. This study is registered with ClinicalTrials.gov,NCT01220622. Nimodipine did not show benefit to prevent cognitive decline in AIS patients with VaMCI, but improved cognition moderately, especially measured in the memory domain. 展开更多
关键词 NIMODIPINE Acute ischemic stroke MILD COGNITIVE IMPAIRMENT COGNITIVE DECLINE Prevention
The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize
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作者 Chunhui Li Wei Song +23 位作者 Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao 《分子植物:英文版》 SCIE CAS CSCD 2019年第3期402-409,共8页
Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HIL... Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. 展开更多
关键词 HZs comparative GENOMIC ANALYSIS TANDEM DUPLICATION PEDIGREE ANALYSIS identity-by-descent
The enhanced X-ray Timing and Polarimetry mission eXTP
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作者 ShuangNan Zhang Andrea Santangelo +112 位作者 Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang S?ren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J. M. in 't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jorn Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen YuPeng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino José Luis Gálvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng 《中国科学:物理学、力学、天文学英文版》 SCIE EI CAS CSCD 2019年第2期3-27,共25页
In this paper we present the enhanced X-ray Timing and Polarimetry mission----eXTP,eXTP is a space science mission designed to study fundamental physics under extreme conditions of density,gravity and magnetism.The mi... In this paper we present the enhanced X-ray Timing and Polarimetry mission----eXTP,eXTP is a space science mission designed to study fundamental physics under extreme conditions of density,gravity and magnetism.The mission aims at determining the equation of state of matter at supra-nuclear density,measuring effects of QED,and understanding the dynamics of matter in strong-field gravity.In addition to investigating fundamental physics,eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects.In particular,its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources. The paper provides a detailed description of:(1)the technological and technical aspects,and the expected performance of the instruments of the scientific payload;(2)the elements and functions of the mission,from the spacecraft to the ground segment. 展开更多
关键词 X-RAY INSTRUMENTATION X-RAY POLARIMETRY X-RAY TIMING space mission:eXTP
Synthesis of novel nanomaterials and their application in efficient removal of radionuclides
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作者 Xiangxue Wang Long Chen +15 位作者 Lin Wang Qiaohui Fan Duoqiang Pan Jiaxing Li Fangting Chi Yi Xie Shujun Yu Chengliang Xiao Feng Luo Jun Wang Xiaolin Wang Changlun Chen Wangsuo Wu Weiqun Shi Shuao Wang Xiangke Wang 《中国科学:化学英文版》 SCIE EI CAS CSCD 2019年第8期933-967,共35页
With the development of nuclear energy, large amounts of radionuclides are inevitably released into the natural environment. It is necessary to eliminate radionuclides from wastewater for the protection of environment... With the development of nuclear energy, large amounts of radionuclides are inevitably released into the natural environment. It is necessary to eliminate radionuclides from wastewater for the protection of environment. Nanomaterials have been considered as the potential candidates for the effective and selective removal of radionuclides from aqueous solutions under complicated conditions because of their high specific surface area, large amounts of binding sites, abundant functional groups, pore-size controllable and easily surface modification. This review mainly summarized the recent studies for the synthesis, fabrication and surface modification of novel nanomaterials and their applications in the efficient elimination and solidification of radionuclides,and discussed the interaction mechanisms from batch experiments, spectroscopy analysis and theoretical calculations. The sorption capacities with other materials, advantages and disadvantages of different nanomaterials are compared, and at last the perspective of the novel nanomaterials is summarized. 展开更多
关键词 NANOMATERIALS radionuclides REMOVAL PRECONCENTRATION INTERACTION MECHANISM
Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology 预览
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作者 Xuchao Zhang Zhiyong Liang +47 位作者 Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu 《癌症生物学与医学:英文版》 CAS CSCD 2019年第1期189-204,共16页
Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial ... Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. 展开更多
关键词 Next-generation sequencing TECHNOLOGY CANCER CONSENSUS
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Abnormal expression of miR-331 leads to impaired heart function
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作者 Jin-Jing Zhang Li-Peng Wang +7 位作者 Rong-Chang Li Meng Wang Zeng-Hui Huang Min Zhu Jia-Xing Wang Xiu-Jie Wang Shi-Qiang Wang Ming Xu 《科学通报:英文版》 SCIE EI CSCD 2019年第14期1011-1017,共7页
MicroRNAs (miRNAs) play important roles in maintaining normal heart function. Abnormal expression of miR-331 has been observed in the hearts of patients with atrial fibrillation and Marfan syndrome. However, whether m... MicroRNAs (miRNAs) play important roles in maintaining normal heart function. Abnormal expression of miR-331 has been observed in the hearts of patients with atrial fibrillation and Marfan syndrome. However, whether miR-331 regulates cardiac function under physiological and pathological conditions still remains unknown. In the present study, we investigated the function and underlying mechanisms of miR-331 in a pressure overload-induced heart failure model and miR-331 transgenic rat model. First, we found that the expression of miR-331-3p exhibited a 1.7-fold increase in hypertrophy compared with that in the sham group (P<0.01), yet the expression of miR-331-5p remained unchanged. Furthermore, overexpression of miR-331 in cardiomyocytes and defective excitation-contraction (E-C) coupling efficiency were observed. Luciferase assays showed that miR-331-3p suppressed JPH2 expression by binding to the coding region of JPH2 mRNA. Finally, in the miR-331 transgenic rat model, JPH2 expression was suppressed at both the mRNA and protein levels in vivo, which resulted in impairment of both the E-C coupling efficiency of cardiomyocytes and systolic function of the heart. This finding mechanistically linked miR-331 to JPH2 downregulation and suggested an important role for the abnormal expression of miR-331 leading to the dysfunction of E-C coupling in heart failure. 展开更多
关键词 MiR-331 Excitation-contraction coupling Junctophilin 2 HEART function
Performances of a prototype point-contact germanium detector immersed in liquid nitrogen for light dark matter search
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作者 Hao Jiang LiTao Yang +70 位作者 Qian Yue KeJun Kang JianPing Cheng YuanJing Li Henry Tsz-King Wong M.Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He JinWei Hu QingDong Hu HanXiong Huang LiPing Jia HauBin Li Hong Li JianMin Li Jin Li Xia Li XueQian Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu YuanYuan Liu ZhongZhi Liu Hao Ma JingLu Ma Hui Pan Jie Ren XiChao Ruan B.Sevda Vivek Sharma ManBin Shen Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang JiMin Wang Li Wang Qing Wang Yi Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue SongWei Yang Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue XiongHui Zeng Ming Zeng Zhi Zeng FengShou Zhang YunHua Zhang MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu ZhongHua Zhu 《中国科学:物理学、力学、天文学英文版》 SCIE EI CAS CSCD 2019年第3期58-65,共8页
The CDEX-10 experiment searches for light weakly interacting massive particles,a form of dark matter,at the China Jinping Underground Laboratory,where approximately 10 kg of germanium detectors are arranged in an arra... The CDEX-10 experiment searches for light weakly interacting massive particles,a form of dark matter,at the China Jinping Underground Laboratory,where approximately 10 kg of germanium detectors are arranged in an array and immersed in liquid nitrogen.Herein,we report on the experimental apparatus,detector characterization,and spectrum analysis of one prototype detector.Owing to the higher rise-time resolution of the CDEX-10 prototype detector as compared with CDEX-IB,we identified the origin of an observed category of extremely fast events.For data analysis of the CDEX-10 prototype detector,we introduced and applied an improved bulk/surface event discrimination method.The results of the new method were compared to those of the CDEX-IB spectrum.Both sets of results showed good consistency in the 0-12 keVee energy range,except for the 8.0 keV K-shell X-ray peak from the external copper. 展开更多
关键词 WIMP ρPCGe liquid nitrogen bulk/surface event DISCRIMINATION EXTREMELY fast events
Ideal Cardiovascular Health is Inversely Associated with Subclinical Atherosclerosis: A Prospective Analysis 预览
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作者 WANG Long NIU Jing Ya +12 位作者 ZHAO Zhi Yun LI Mian XU Min LU Jie Li WANG Tian Ge CHEN Yu Hong WANG Shuang Yuan DAI Meng LI Lin LIU Shan Shan WANG Wei Qing XU Yu BI Yu Fang 《生物医学与环境科学:英文版》 SCIE CAS CSCD 2019年第4期260-271,共12页
Objective Ideal cardiovascular health(CVH) could predict a lower risk of developing cardiovascular diseases. This study was conducted to investigate the association between ideal CVH and subclinical atherosclerosis in... Objective Ideal cardiovascular health(CVH) could predict a lower risk of developing cardiovascular diseases. This study was conducted to investigate the association between ideal CVH and subclinical atherosclerosis in a population cohort of Chinese adults aged ≥ 40 years. Methods This study was designed as a cross-sectional analysis of 8,395 participants who had complete data at baseline and a prospective analysis of 4,879 participants who had complete data at 4.3 years of follow-up. Ideal CVH metrics were defined according to the American Heart Association. Subclinical atherosclerosis was evaluated by plaques in carotid arteries, carotid intima-media thickness(CIMT), brachial-ankle pulse wave velocity(baPWV), and urinary albumin-to-creatinine ratio(UACR). Results Both the prevalence and incidence of atherosclerosis measures were found to be decreased with increasing numbers of ideal CVH metrics at baseline(all P values for trend < 0.01). The levels of CIMT and UACR at follow-up showed an inverse and significant association with the numbers of ideal CVH metrics at baseline(both P values for trend < 0.05) but a borderline significant association with baPWV(P for trend = 0.0505). Taking participants with 0-1 ideal metric as reference, we found that participants with 5-6 ideal metrics had significantly lower risks of developing carotid plaques(odds ratio, OR = 0.46;95% confidence interval, CI 0.27-0.79), increased CIMT(OR = 0.60;95% CI 0.42-0.84), and increased baPWV(OR = 0.57;95% CI 0.34-0.97) after full adjustments. A significant interactive effect of age and CVH was detected on CIMT and baPWV progression(both P values for interaction < 0.05). Conclusion The numbers of ideal CVH metrics showed a significant and inverse association with the risk of developing subclinical atherosclerosis in middle-aged and elderly Chinese adults, whereas its dose-response effect was attenuated in individuals aged ≥ 60 years and partially weakened in male participants. 展开更多
关键词 CARDIOVASCULAR health SUBCLINICAL ATHEROSCLEROSIS COHORT
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Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program
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作者 Xi Chen Lin Wang +8 位作者 Rujin Huang Hui Qiu Peizhe Wang Daren Wu Yonglin Zhu Jia Ming Yangming Wang Jianbin Wang Jie Na 《蛋白质与细胞:英文版》 SCIE CAS CSCD 2019年第5期327-346,共20页
Primitive mammalian heart transforms from a single tube to a four-chambered muscular organ during a short developmental window.We found that knocking out global microRNA by deleting Dgcr8 microprocessor in Mespl cardi... Primitive mammalian heart transforms from a single tube to a four-chambered muscular organ during a short developmental window.We found that knocking out global microRNA by deleting Dgcr8 microprocessor in Mespl cardiovascular progenitor cells lead to the formation of extremely dilated and enlarged heart due to defective cardiomyocyte(CM)differentiation.Transcriptome analysis revealed unusual upregulation of vascular gene expression in Dgcr8 cKO hearts.Single cell RNA sequencing study further confirmed the increase of angiogenesis genes in single Dgcr8 cKO CM.We also performed global microRNA profiling of E9.5 heart for the first time,and identified that miR-541 was transiently highly expressed in E9.5 hearts.Interestingly,introducing miR-541 back into microRNA-free CMs partially rescued their defects,downregulated angiogenesis genes and significantly upregulated cardiac genes.Moreover,miR-541 can target Ctgf and inhibit endothelial function.Our results suggest that micro-RNAs are required to suppress abnormal angiogenesis gene program to maintain CM differentiation. 展开更多
关键词 MICRORNA Dgcr8 Cardiovascular PROGENITOR cells miRNA-541 Single cell RNA sequencing
Cerebral functional abnormalities in patients with nasopharyngeal carcinoma after radiotherapy:an observational magnetic resonance resting-state study
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作者 Wen-Ting Ren Ye-Xiong Li +12 位作者 Kai Wang Li Gao Jun-Lin Yi Xiao-Dong Huang Jing-Wei Luo Run-Ye Wu Yong Yang Jian-Yang Wang Wen-Qing Wang Jing-Bo Wang Feng Ye Han Ouyang Jian-Rong Dai 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第13期1563-1571,共9页
Background:Nasopharyngeal carcinoma (NPC) is sensitive to radiotherapy (RT).However,neurocognitive complications such as memory loss and learning and attention deficits emerge in the survivors of NPC who received RT.I... Background:Nasopharyngeal carcinoma (NPC) is sensitive to radiotherapy (RT).However,neurocognitive complications such as memory loss and learning and attention deficits emerge in the survivors of NPC who received RT.It remains unclear how radiation affects patient brain function.This pilot study aimed at finding cerebral functional alterations in NPC patients who have received RT.Methods:From September 2014 to December 2016,42 individuals,including 22 NPC patients and 20 normal volunteer controls in National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences,and Peking Union Medical College,were recruited in this study.All patients received resting-state functional magnetic resonance imaging scans and neurocognitive tests 1 day before the initiation of RT (baseline) and 1 day after the completion of RT;the 20 normal controls were also subjected to the same scans and tests.The amplitude of the low-frequency fluctuations (ALFF) in blood oxygen level-dependent signals and functional connectivity (FC) were used to characterize cerebral functional changes.Independent t test,paired t test,and analysis of variances were used to obtain statistical significance across groups.Results:After RT,NPC patients showed significantly decreased ALFF values in the calcarine sulcus,lingual gyrus,cuneus,and superior occipital gyrus and showed significantly reduced FC mainly in the default mode network (P < 0.05,corrected by AlphaSim).Relative to the controls,ALFF was decreased in the lingual gyrus,calcarine sulcus,cingulate cortex,medial prefrontal gyrus (P < 0.05,corrected by AlphaSim),and FC reduction was found in multiple cerebellar-cerebral regions,including the cerebellum,parahippocampus,hippocampus,fusiform gyrus,inferior frontal gyrus,inferior occipital gyrus,precuneus,and cingulate cortex (P < 0.001,corrected by AlphaSim).Conclusions:Cerebral functional alterations occur immediately after RT.This study may provide an explanation for the cognitive deficits in the morph 展开更多
关键词 RADIOTHERAPY NASOPHARYNGEAL carcinoma MRI Functional
Identification of new fusion genes and their clinical significance in endometrial cancer
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作者 Tian Yao Jin-Jin Liu +7 位作者 Li-Jun Zhao Jing-Yi Zhou Jia-Qi Wang Yue Wang Zhi-Qi Wang Li-Hui Wei Jian-Liu Wang Xiao-Ping Li 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第11期1314-1321,共8页
Background:Fusion genes may play an important role in tumorigenesis, prognosis, and drug resistance;however, studies on fusion genes in endometrial cancer (EC) are rare. This study aimed to identify new fusion genes a... Background:Fusion genes may play an important role in tumorigenesis, prognosis, and drug resistance;however, studies on fusion genes in endometrial cancer (EC) are rare. This study aimed to identify new fusion genes and to explore their clinical significance in EC. Methods: A total of 28 patients diagnosed with EC were enrolled in this study. RNA sequencing was used to obtain entire genomes and transcriptomes. STAR-comparison and STAR-fusion prediction were applied to predict the fusion genes. Chi-square tests and Student t tests were used to verify the clinical significance with SPSS 13.0 software. Results: New fusion genes were found, and the number of fusion genes varied from 3 to 110 among all patients with EC. The type of fusion genes varied and included messenger RNA (mRNA)-mRNA, long non-coding RNA (lncRNA)-lncRNA, and lncRNAmRNA. There were six fusion genes with high fusion rates, namely, RF11-123010.4-GRIP1-RP11-444D3.1-SOXS,RP11-680G10.1-GSE1,NRIP1-AF127936.7,RP11-96H19.1-RP11-446N19.1,andDPH7-PTP4A3. Further studies showed that these fusion genes are related to stage, grade, and recurrence, in which NRIP1-AF127936.7andDPH7-PTP4A3 were found only in stage Ⅲ patients with EC. DPH7-PTP4A3was found in grades 2 and 3, and recurrent patients with EC. Conclusion: Fusion genes play an essential role in EC. Six genes that are overexpressed with high fusion rates are identified. NRIP1-AF127936.7and DPH7-PTP4A3 might be related to stage, and DPH7-PTP4A3 be related to grade and recurrence. 展开更多
关键词 FUSION GENES ENDOMETRIAL CANCER DRUG resistance PROGNOSIS
Monitoring gas-and particulate-phase short-chain polychlorinated paraffins in the urban air of Dalian by a self-developed passive sampler
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作者 Yifan Wang Xiuhua Zhu +7 位作者 ,Yuan Gao Hao Bai Pengyuan Wang Jiping Chen ,Heping Yuan Longxing Wang Xiaoxiao Li Wei Wang 《环境科学学报:英文版》 SCIE EI CAS CSCD 2019年第6期287-295,共9页
The concentration of short-chain polychlorinated paraffins(SCCPs) in the urban air of Dalian,China was monitored from September 2016 to August 2017 with a self-developed passive sampler(PAS1) and an active high-volume... The concentration of short-chain polychlorinated paraffins(SCCPs) in the urban air of Dalian,China was monitored from September 2016 to August 2017 with a self-developed passive sampler(PAS1) and an active high-volume sampler, simultaneously. PAS1 successfully collected the entire target SCCPs in the ambient air. Air SCCPs sampled by PAS1 were found be in the linear uptake stage during 181 days of sampling. Passive and active samples showed comparable congener profiles, and the dominant contributors of SCCPs in the two kinds of samples were similar. A significant linear correlation was observed between the total concentration of SCCPs sampled by PAS1 and active sampler in the four seasons. The passive sampling rates of the PAS1 for the gas and particulate phases of SCCPs were measured. The quantitative structure–property relationship of the sampling rate of PAS1(Rair) for gas-phase SCCPs was studied. From the molecular point of view, Rairwas mainly affected by the molecular weight and sub-cooled liquid vapor pressure of SCCPs. In general, SCCPs in the urban air of Dalian mainly existed in gas phase,lower molecular weight SCCPs primarily occurred in the gas phase, whereas higher molecular weight SCCPs were predominately adsorbed or absorbed on airborne particles. The air concentration of SCCPs in the four seasons were different, the correlation of the concentration of SCCPs in the air with the meteorology parameters was conducted. The exposure risk by intake air SCCPs of the residents around the sampling sites was evaluated according to the European risk assessment standards. 展开更多
关键词 Ambient air Short-chain POLYCHLORINATED paraf FINS PASSIVE SAMPLER Active sampling PASSIVE sampling
Application of a hybrid gravity-driven membrane filtration and dissolved ozone flotation(MDOF)process for wastewater reclamation and membrane fouling mitigation
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作者 Xin Jin Wei Wang +5 位作者 Shuai Wang Pengkang Jin Xiaochang C.Wang Wushou Zhang Weijun An Yong Wang 《环境科学学报:英文版》 SCIE EI CAS CSCD 2019年第7期17-27,共11页
This study proposed a novel membrane filtration and dissolved ozone flotation integrated(MDOF) process and tested it at pilot scale. Membrane filtration in the MDOF process was operated in gravity-driven mode, and req... This study proposed a novel membrane filtration and dissolved ozone flotation integrated(MDOF) process and tested it at pilot scale. Membrane filtration in the MDOF process was operated in gravity-driven mode, and required no backwashing, flushing, or chemical cleaning. Because ozone was added in the MDOF process, ozonation, coagulation, and membrane filtration could occur in a single reactor. Moreover, in situ ozonation occurred in the MDOF process, which differs from the conventional pre-ozonation membrane filtration process. Significant enhancement of turbidity removal was further achieved through the addition of membrane filtration. Membrane fouling was mitigated in the MDOF process compared to the MDAF process. In situ ozonation in the MDOF process decreased the fluorescence intensity and transformed the high MW dissolved organics into small MW compounds. For the fouling layer, the extracellular polymeric substance(EPS) contents and cake layer morphology were analyzed. The results indicated that the contents of EPS decreased. Furthermore, a thinner and more loosely structured cake layer formed in the MDOF process. Because coagulation and ozonation occurred simultaneously in a single reactor, the generation of hydroxyl radicals was enhanced through the catalytic effect of Al-based coagulants on ozone decomposition, which further alleviated membrane fouling in the MDOF process. 展开更多
关键词 Dissolved OZONE FLOTATION Gravity-driven MEMBRANE filtration MEMBRANE fouling In situ ozonation
Altered Local Field Potential Relationship Between the Parafascicular Thalamic Nucleus and Dorsal Striatum in Hemiparkinsonian Rats
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作者 Haiyan Zhang Jing Yang +9 位作者 Xuenan Wang Xiaomeng Yao Hongyu Han Yunfeng Gao Hongli Chang Tianyu Xiang Shuang Sun Yanan Wang Xiusong Wang Min Wang 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第2期315-324,共10页
The thalamostriatal pathway is implicated in Parkinson’s disease(PD);however, PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex(CM/Pf, or the Pf in rodents... The thalamostriatal pathway is implicated in Parkinson’s disease(PD);however, PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex(CM/Pf, or the Pf in rodents) and the dorsal striatum(DS) remain unclear.Therefore, we simultaneously recorded local field potentials(LFPs) in both the Pf and DS of hemiparkinsonian and control rats during epochs of rest or treadmill walking. The dopamine-lesioned rats showed increased LFP power in the beta band(12 Hz–35 Hz) in the Pf and DS during both epochs, but decreased LFP power in the delta(0.5 Hz–3 Hz) band in the Pf during rest epochs and in the DS during both epochs, compared to control rats. In addition,exaggerated low gamma(35 Hz–70 Hz) oscillations after dopamine loss were restricted to the Pf regardless of the behavioral state. Furthermore, enhanced synchronization of LFP oscillations was found between the Pf and DS after the dopamine lesion. Significant increases occurred in the mean coherence in both theta(3 Hz–7 Hz) and beta bands,and a significant increase was also noted in the phase coherence in the beta band between the Pf and DS during rest epochs. During the treadmill walking epochs, significant increases were found in both the alpha(7 Hz–12 Hz)and beta bands for two coherence measures. Collectively,dramatic changes in the relative LFP power and coherence in the thalamostriatal pathway may underlie the dysfunction of the basal ganglia-thalamocortical network circuits in PD, contributing to some of the motor and non-motor symptoms of the disease. 展开更多
关键词 Parkinson’s disease Parafascicular THALAMIC NUCLEUS DORSAL STRIATUM Local field potential Synchronization
Design,synthesis and antimycobacterial activity of novel nitrobenzamide derivatives
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作者 Hongjian Wang Kai Lv +9 位作者 Xiaoning Li Bo Wang Apeng Wang Zeyu Tao Yunhe Geng Bin Wang Menghao Huang Mingliang Liu Huiyuan Guo Yu Lu 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第2期413-416,共4页
We report herein the design and synthesis of a series of novel nitrobenzamide derivatives. Results reveal that many of them display considerable in vitro antitubercular activity. Four N-benzyl or N- (pyridine-2-yl)met... We report herein the design and synthesis of a series of novel nitrobenzamide derivatives. Results reveal that many of them display considerable in vitro antitubercular activity. Four N-benzyl or N- (pyridine-2-yl)methyl 3,5-dinitrobenzamides A6, All, Cl and C4 have not only the same excellent MIC values of<0.016 μg/mL against both drug-sensitive MTB strain H37 Rv and two drug-resistant clinical isolates as PBTZ169 and the lead 1, but also acceptable safety indices (SI > 1500), opening a new direction for further development. 展开更多
关键词 Nitrobenzamides SYNTHESIS ANTIMYCOBACTERIAL activity TUBERCULOSIS
Successful opening in-stent chronic total occlusion lesion of coronary artery by excimer laser coronary angioplasty 预览
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作者 Jing BAI Hai-Xia WANG +7 位作者 Jiang-Tao WANG Jing ZHAO Liang PENG Xue-Dong YANG Zhe TANG Shaheena Nazneen Gao-Kun WANG Yu WANG 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2019年第6期502-506,共5页
In percutaneous coronary intervention (PCI), chronic total occlusion (CTO) coronary artery disease still remains difficult to treat. One of the reasons for the failure is the hard of the CTO lesions that balloon is di... In percutaneous coronary intervention (PCI), chronic total occlusion (CTO) coronary artery disease still remains difficult to treat. One of the reasons for the failure is the hard of the CTO lesions that balloon is difficult to pass through or expand. Previous methods to deal with CTO lesions that cannot be passed by balloon, include selecting reinforced catheter (such as 5 in 6 guiding catheter, Guidzilla catheter, or Tornus microcatheter), guidewire extrusion or rotary grinding technology. In recent years, excimer laser coronary angioplasty (ELCA) has been gradually applied to CTO lesions. Using inert halide as the laser medium, ELCA emits a 308 nm high-intensity unidirectional light wave with absorption depth of only 50 μmL, resulting in less thermal effect and less damage to non-target lesions. In this paper, we will describe a successful PCI case of an in-stent CTO lesion using ELCA with long term coronary angiography follow-up. 展开更多
关键词 Chronic total OCCLUSION Drug coating BALLOON EXCIMER laser CORONARY ANGIOPLASTY Percutaneous CORONARY intervention
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Ultrasound:The Potential Power for Cardiovascular Disease Therapy 预览
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作者 Xiaoyu Zheng Qingyao Liao +7 位作者 Yue Wang Hua Li Xiaodong Wang Yaohui Wang Wentao Wu Junlin Wang Ling Xiao Jing Huang 《心血管创新与应用》 2019年第B07期125-134,共10页
Ultrasound can be considered a mechanical wave for both clinical diagnostic and therapeutic purposes on the basis of its good penetrability and directivity while spreading in solid organs or tissues without any ionizi... Ultrasound can be considered a mechanical wave for both clinical diagnostic and therapeutic purposes on the basis of its good penetrability and directivity while spreading in solid organs or tissues without any ionizing radiation.As a powerful form of energy,ultrasound,is used for deep-tissue therapy with different sonication parameters.The feasibility of minimally invasive or noninvasive acoustic treatment of a variety of diseases,such as hypertension,arrhythmia,hypertrophic cardiomyopathy,and myocardial infraction,is being explored in animal experiments and clinical trials.In this review,we summarize the biomedical effects of acoustic intervention in experimental and clinical studies,current challenges,and the potential of ultrasound for cardiovascular disease therapy. 展开更多
关键词 ULTRASOUND CARDIOVASCULAR DISEASE THERAPY
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Association between Coronary Atherosclerotic Plaque Composition and Cardiovascular Disease Risk 预览
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作者 LI Lin WANG Long +14 位作者 LIU Shan Shan ZHAO Zhi Yun LI Mian WANG Tian Ge XU Min LU Jie Li CHEN Yu Hong WANG Shuang Yuan DAI Meng HOU Ya Nan WU Xue Yan MA Li Na WANG Wei Qing XU Yu BI Yu Fang 《生物医学与环境科学:英文版》 SCIE CAS CSCD 2019年第2期75-86,共12页
Objective The objective of this study is to determine whether coronary atherosclerotic plaque composition is associated with cardiovascular disease(CVD) risk in Chinese adults. Methods We performed a cross-sectional a... Objective The objective of this study is to determine whether coronary atherosclerotic plaque composition is associated with cardiovascular disease(CVD) risk in Chinese adults. Methods We performed a cross-sectional analysis in 549 subjects without previous diagnosis or clinical symptoms of CVD in a community cohort of middle-aged Chinese adults. The participants underwent coronary computed tomography(CT) angiography for the evaluation of the presence and composition of coronary plaques. CVD risk was evaluated by the Framingham risk score(FRS) and the 10-year atherosclerotic cardiovascular disease(ASCVD) risk score. Results Among the 549 participants, 267(48.6%) had no coronary plaques, 201(36.6%) had noncalcified coronary plaques, and 81(14.8%) had calcified or mixed coronary plaques. The measures of CVD risk including FRS and ASCVD risk score and the likelihood of having elevated FRS significantly increased across the groups of participants without coronary plaques, with noncalcified coronary plaques, and with calcified or mixed coronary plaques. However, only calcified or mixed coronary plaques were significantly associated with an elevated ASCVD risk score [odds ratio(OR) 2.41;95% confidence interval(CI) 1.09-5.32] compared with no coronary plaques, whereas no significant association was found for noncalcified coronary plaques and elevated ASCVD risk score(OR 1.25;95% CI 0.71-2.21) after multivariable adjustment. Conclusion Calcified or mixed coronary plaques might be more associated with an elevated likelihood of having CVD than noncalcified coronary plaques. 展开更多
关键词 Coronary PLAQUE COMPOSITION FRAMINGHAM RISK SCORE 10-year ATHEROSCLEROTIC cardiovascular disease RISK SCORE
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Preparation and properties of a new porous ceramic material used in clean energy field
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作者 Shuming Wang Xiaofang Zhang +6 位作者 Fenghua Kuang Jiangshan Li Yanxin Wang Ruiping Wang Yanru Wang Xin Lin Jianming Li 《材料科学技术学报:英文版》 SCIE EI CAS CSCD 2019年第7期1255-1260,共6页
At high tem perature, the oxide redox reactions of ceria can split H2O and CO2 to produce H2 and CO, so porous ceria with high temperature resistance and high specific surface area has an important foreground in clean... At high tem perature, the oxide redox reactions of ceria can split H2O and CO2 to produce H2 and CO, so porous ceria with high temperature resistance and high specific surface area has an important foreground in clean energy applications. In this work, a reticulated porous ceria ceramic material with interconnected porous structure was prepared by the impregnation technique using organic polyurethane sponges as template. The influences of pretreated sponge, dipping time length, pore size and sintering temperature on the porosity and strength of the porous ceria ceramics were system atically studied. With the increasing sintering temperature, the glass phase occurred and led to an increase in strength, but an decrease in porosity. Eventually, we analyzed the relationships betw een porosity and strength of these porous materials, aiming to provide theoretical and practical references for its application in clean-energy field. 展开更多
关键词 POROUS CERAMICS POROUS CERIA IMPREGNATION Clean-energy
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