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OCTA在青少年眼底检查及其与眼轴关系研究中的应用 预览
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作者 仇长宇 石圆圆 +6 位作者 宫玉波 赵宏伟 许倩倩 赵军 高薇 曲丽燕 罗灵 《国际眼科杂志》 CAS 北大核心 2019年第6期1086-1088,共3页
目的:研究光学相干断层扫描血管成像(OCTA)检查在青少年受检者中的检查情况及其与眼轴之间的关系。方法:前瞻性非随机临床研究。收集青少年受检者33例66眼的临床资料进行分析。所有受检者行裸眼视力、屈光度、矫正视力检查后,行眼轴测量... 目的:研究光学相干断层扫描血管成像(OCTA)检查在青少年受检者中的检查情况及其与眼轴之间的关系。方法:前瞻性非随机临床研究。收集青少年受检者33例66眼的临床资料进行分析。所有受检者行裸眼视力、屈光度、矫正视力检查后,行眼轴测量及OCTA检查。采用SPSS19.0软件分析OCTA各检测结果及其与眼轴之间的关系。结果:受检者眼轴长度平均为24.46±1.50mm,黄斑区平均血管密度为(47.88±2.56)%,黄斑区平均神经纤维层厚度为278.61±15.08μm,视盘周围平均血管密度为(57.79±2.99)%;视盘周围平均毛细血管密度为(53.08±3.49)%;其中眼轴长度与黄斑区神经纤维层厚度呈负相关(P=0.006),眼轴与其他检测结果均不相关。结论:青少年眼底OCTA的检测指标中,黄斑区神经纤维层厚度与眼轴之间呈负相关,血管密度方面的检测指标与眼轴均无相关性。 展开更多
关键词 光学相干断层扫描血管成像 青少年 黄斑 视盘 眼轴 相关性
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HPLC-LTQ-Orbitrap方法分析丹参的代谢轮廓
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作者 Huan-huan PANG Mei-fang JIANG +4 位作者 Qin-hui WANG Xiao-ye WANG Wei GAO Zhi-hao TIAN Jian-mei HUANG 《浙江大学学报:B卷英文版》 SCIE CAS CSCD 2018年第3期227-244,共18页
目的:对丹参50%乙醇提取物的体内外物质基础进行系统全面的分析。创新点:首次采用高效液相色谱-质谱联用(HPLC-LTQOrbitrap)方法对丹参50%乙醇提取物的体内外化学和代谢成分进行全面分析。方法:建立HPLC-LTQ-Orbitrap方法,对丹参50... 目的:对丹参50%乙醇提取物的体内外物质基础进行系统全面的分析。创新点:首次采用高效液相色谱-质谱联用(HPLC-LTQOrbitrap)方法对丹参50%乙醇提取物的体内外化学和代谢成分进行全面分析。方法:建立HPLC-LTQ-Orbitrap方法,对丹参50%乙醇提取物的化学成分以及给药后大鼠血浆、尿液、粪便和胆汁生物样品中的化学和代谢成分进行分析。结论:在正负离子模式下,在丹参提取物中鉴定出共69个化合物,包括丹酚酸类化合物23个,丹参酮类化合物33个,以及未知化合物13个;在大鼠灌胃给予丹参提取物后的生物样本中鉴定出共118个化合物,包括血浆中35个,尿液中63个,粪便中62个,以及胆汁中18个。 展开更多
关键词 丹参 化学轮廓 代谢轮廓 HPLC-LTQ-Orbitrap
难治性化脓性角膜溃疡的姑息性手术治疗 预览
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作者 郝兆芹 高伟 +1 位作者 马强 王小东 《国际眼科杂志》 CAS 北大核心 2018年第10期1883-1885,共3页
目的:探讨异体巩膜移植联合自体结膜瓣遮盖术治疗难治性化脓性角膜溃疡的临床效果。方法:采用回顾性分析,选择2015-06/2017-06因化脓性角膜溃疡入院患者20例20眼,药物治疗无效,无法行穿透性角膜移植而行异体巩膜移植联合自体结膜瓣遮... 目的:探讨异体巩膜移植联合自体结膜瓣遮盖术治疗难治性化脓性角膜溃疡的临床效果。方法:采用回顾性分析,选择2015-06/2017-06因化脓性角膜溃疡入院患者20例20眼,药物治疗无效,无法行穿透性角膜移植而行异体巩膜移植联合自体结膜瓣遮盖术治疗,观察此种姑息手术的术中并发症、术后巩膜和结膜瓣生长、术后并发症等情况。结果:20例20眼患者中,18眼异体巩膜和结膜瓣生长良好,治愈率90%,1眼结膜瓣愈合不良行羊膜移植手术修复,1眼因玻璃体腔感染较重、感染复发行眼内容物剜除术;术中晶状体脱出2眼(10%),均予以摘除; 3眼(15%)患者术后出现继发性青光眼,行睫状体冷冻术治愈。结论:异体巩膜移植联合自体结膜瓣遮盖术是一种姑息性手术方法,是控制药物治疗无效而又无法行穿透性角膜移植手术的严重化脓性角膜溃疡患者眼部感染并保持其眼球外形的有效方式,可替代以往的眼内容物剜除术以控制感染,既可避免患者失去眼球带来的眼部病痛和心理创伤,又为后期改善外观节省费用。 展开更多
关键词 化脓性角膜溃疡 异体巩膜移植 结膜瓣遮盖
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情绪调节研究方法的蜕变:从有意情绪调节到自动化情绪调节 被引量:1
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作者 高伟 陈圣栋 +2 位作者 龙泉杉 杨洁敏 袁加锦 《科学通报》 CSCD 北大核心 2018年第4期415-424,共10页
寻找有效的情绪调节方式对人们理解情绪调节的机制以及治疗抑郁症等心理疾病都有着重要的意义.由于传统的有意情绪调节具有消耗认知资源的缺陷,近些年越来越多的研究者开始关注较少地乃至不消耗认知资源即可降低情绪负面反应的情绪调节... 寻找有效的情绪调节方式对人们理解情绪调节的机制以及治疗抑郁症等心理疾病都有着重要的意义.由于传统的有意情绪调节具有消耗认知资源的缺陷,近些年越来越多的研究者开始关注较少地乃至不消耗认知资源即可降低情绪负面反应的情绪调节——自动化情绪调节.自动化情绪调节良好的调节效果已被研究者证实,但自动化情绪调节的研究方法与调节方式尚未得到系统阐述.本文系统阐述了自动化情绪调节的研究方法,并将自动化情绪调节的相关研究按照实验任务类型进行了分类,发现该领域研究范式可划分为3种任务类型,即句子整理任务、词语配对任务和执行意图范式,并由此重点对比了自动化情绪调节在3种任务类型下的操纵方式、行为及生理反应.结果发现,相比于前两种无意识启动的任务,执行意图范式可以帮助个体在不消耗认知资源条件下进行有意识情绪调节.更为重要的是,3种任务对自动化情绪调节的操纵有着相同的内在机制,即情绪调节目标的启动.据此,本文进一步提出了将自动化情绪调节与心理学疗法相结合的设想,这可能为抑郁症等心理疾病的治疗提供新的思路. 展开更多
关键词 自动化情绪调节 目标追求 句子整理任务 词语配对 执行意图
Single amino acid mutation of SR-BI decreases infectivity of hepatitis C virus derived from cell culture in a cell culture model 预览
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作者 Rong Gao Wei Gao +2 位作者 Gang Xu Jie Xu Hao Ren 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第28期5158-5166,共9页
AIM To investigate the effect of a single amino acid mutation in human class B scavenger receptor I(SR-BI) on the infectivity of cell culture-derived hepatitis C virus(HCVcc) in SR-BI knock-down Huh7-si SR-BI cells.ME... AIM To investigate the effect of a single amino acid mutation in human class B scavenger receptor I(SR-BI) on the infectivity of cell culture-derived hepatitis C virus(HCVcc) in SR-BI knock-down Huh7-si SR-BI cells.METHODS Site-directed mutagenesis was used to construct the SR-BI S112 F mutation,and the mutation was confirmed by nucleotide sequencing. SR-BI knock-down Huh7-si SR-BI cells were transfected with SR-BI S112 F,SR-BI wild type(WT) and control plasmids,and then infected with HCVpp(HCV pseudoparticles) and hepatitis C virus derived from cell culture(HCVcc). A fluorescence assay was performed to analyze the effect of the S112 F mutation on HCV entry; quantitative real-time PCR,immunofluorescence,and Western blot assays were used to analyze the effect of the S112 F mutation on HCV infectivity. CHO cells expressing WT and SRBI S112 F were incubated with the HCV E2 protein expressed in HEK 293 T cells,and flow cytometry was performed to examine the ability of SR-BI S112 F to bind to the HCV E2 protein. Huh7-si SR-BI cells were transfected with SR-BI WT and the S112 F mutant,andthen Di I-HDL was added and images captured under the microscope to assess the ability of SR-BI S112 F to take up HDL.RESULTS The SR-BI S112 F mutation was successfully constructed. The S112 F mutation decreased the expression of the SR-BI m RNA and protein. SR-BI S112 F decreased HCV entry and HCVcc infectivity in Huh7-si SR-BI cells. The S112 F mutation impaired the binding of SR-BI to HCV E2 protein and decreased the HDL uptake of SR-BI.CONCLUSION The S112 F single amino acid mutation in SR-BI decreased the levels of the SR-BI m RNA and protein,as well as the ability of SR-BI to bind to the HCV E2 protein. Amino acid 112 in SR-BI plays important roles in HCV entry and the infectivity of HCVcc in vitro. 展开更多
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Physiognomy: Personality Traits Prediction by Learning
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作者 Ting Zhang Ri-Zhen Qin +3 位作者 Qiu-Lei Dong Wei Gao Hua-Rong Xu Zhan-Yi Hu 《国际自动化与计算杂志:英文版》 EI CSCD 2017年第4期386-395,共10页
Evaluating individuals personality traits and intelligence from their faces plays a crucial role in interpersonal relationship and important social events such as elections and court sentences. To assess the possible ... Evaluating individuals personality traits and intelligence from their faces plays a crucial role in interpersonal relationship and important social events such as elections and court sentences. To assess the possible correlations between personality traits(also measured intelligence) and face images, we first construct a dataset consisting of face photographs, personality measurements,and intelligence measurements. Then, we build an end-to-end convolutional neural network for prediction of personality traits and intelligence to investigate whether self-reported personality traits and intelligence can be predicted reliably from a face image. To our knowledge, it is the first work where deep learning is applied to this problem. Experimental results show the following three points: 1)'Rule-consciousness' and 'Tension' can be reliably predicted from face images. 2) It is difficult, if not impossible, to predict intelligence from face images, a finding in accord with previous studies. 3) Convolutional neural network(CNN) features outperform traditional handcrafted features in predicting traits. 展开更多
关键词 人格特征 预测 学习 卷积神经网络 人脸图像 地貌 力测量 人际关系
Molecular cloning and functional identification of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Tripterygium wilfordii
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作者 Qiqing Cheng Yuru Tong +3 位作者 Zihao Wang Ping Su Wei Gao Luqi Huang 《药学学报:英文版》 CSCD 2017年第2期208-214,共7页
The 4-hydroxy-3-methylbut-2-enyl diphosphate reductase(HDR) is the last step key enzyme of the methylerythritol phosphate(MEP) pathway,synthesizing isopentenyl diphosphate and its allyl isomer dimethylallyl diphosphat... The 4-hydroxy-3-methylbut-2-enyl diphosphate reductase(HDR) is the last step key enzyme of the methylerythritol phosphate(MEP) pathway,synthesizing isopentenyl diphosphate and its allyl isomer dimethylallyl diphosphate,which is important for regulation of isoprenoid biosynthesis.Here the full-length cDNA of HDR,designated TwHDR(GenBank Accession No.KJ933412.1),was isolated from Tripterygium wilfordii for the first time.TwHDR has an open reading frame(ORF) of 1386 bp encoding461 amino acids.TwHDR exhibits high homology with HDRs of other plants,with an N-terminal conserved domain and three conserved cysteine residues.TwHDR cDNA was cloned into an expression vector and transformed into an Escherichia coli hdr mutant.Since loss-of-function E.coli hdr mutant is lethal,the result showed that transformation of TwHDR cDNA rescued the E.coli hdr mutant.This complementation assay suggests that the TwHDR cDNA encodes a functional HDR enzyme.The expression of TwHDR was induced by methyl-jasmonate(MJ) in T.wilfordii suspension cells.The expression of TwHDR reached the highest level after 1 h of MJ treatment.These results indicate that we have identified a functional TwHDR enzyme,which may play a pivotal role in the biosynthesis of diterpenoid triptolide in T.wilfordii. 展开更多
Removal of rhodamine B from aqueous solutions using vanadium pentoxide/titanium butyl oxide hybrid xerogels
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作者 Surayya Mukhtar 《中国物理B:英文版》 SCIE EI CAS CSCD 2017年第5期407-413,共7页
A stable and insoluble V_2O_5·n H_2O/tetra-n-butyl titanate(TBO) hybrid xerogel was synthesized by the sol–gel method. This novel material proved to be an efficient absorbent with an absorption capacity of 179 m... A stable and insoluble V_2O_5·n H_2O/tetra-n-butyl titanate(TBO) hybrid xerogel was synthesized by the sol–gel method. This novel material proved to be an efficient absorbent with an absorption capacity of 179 mg·g~(-1)for Rhodamine B(Rh B) in water due to its unique layered structure, which can effectively accommodate Rh B molecules between its layers as demonstrated by XRD and FTIR spectroscopic analyses. 展开更多
Molecular cloning and functional identification of sterol C24-methyltransferase gene from Tripterygium wilfordii
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作者 Hongyu Guan Yujun Zhao +9 位作者 Ping Su Yuru Tong Yujia Liu Tianyuan Hu Yifeng Zhang Xianan Zhang Jia Li Xiaoyi Wu Luqi Huang Wei Gao 《药学学报:英文版》 CSCD 2017年第5期603-609,共7页
Sterol C24-methyltransferase(SMT) plays multiple important roles in plant growth and development. SMT1, which belongs to the family of transferases and transforms cycloartenol into 24-methylene cycloartenol, is involv... Sterol C24-methyltransferase(SMT) plays multiple important roles in plant growth and development. SMT1, which belongs to the family of transferases and transforms cycloartenol into 24-methylene cycloartenol, is involved in the biosynthesis of 24-methyl sterols. Here, we report the cloning and characterization of a cDNA encoding a sterol C24-methyltransferase from Tripterygium wilfordii(Tw SMT1). Tw SMT1(Gen Bank access number KU885950) is a 1530 bp cDNA with a 1041 bp open reading frame predicted to encode a 346-amino acid, 38.62 k Da protein. The polypeptide encoded by the SMT1 cDNA was expressed and purified as a recombinant protein from Escherichia coli(E. coli) and showed SMT activity. The expression of Tw SMT1 was highly up-regulated in T. wilfordii cell suspension cultures treated with methyl jasmonate(Me JA). Tissue expression pattern analysis showed higher expression in the phellem layer compared to the other four organs(leaf, stem, xylem and phloem), which is about ten times that of the lowest expression in leaf. The results are meaningful for the study of sterolbiosynthesis of T. wilfordii and will further lay the foundations for the research in regulating both the content of other main compounds and growth and development of T. wilfordii. 展开更多
Quantum twisted double-slits experiments: confirming wavefunctions' physical reality
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作者 Zhi-Yuan Zhou Zhi-Han Zhu +7 位作者 Shi-Long Liu Yin-Hai Li Shuai Shi Dong-Sheng Ding Li-Xiang Chen Wei Gao Guang-Can Guo Bao-Sen Shi 《科学通报:英文版》 SCIE EI CSCD 2017年第17期1185-1192,共8页
Are quantum states real? This most fundamental question in quantum mechanics has not yet been satisfactorily resolved, although its realistic interpretation seems to have been rejected by various delayedchoice experim... Are quantum states real? This most fundamental question in quantum mechanics has not yet been satisfactorily resolved, although its realistic interpretation seems to have been rejected by various delayedchoice experiments. Here, to address this long-standing issue, we present a quantum twisted double-slit experiment. By exploiting the subluminal feature of twisted photons, the real nature of a photon during its time in flight is revealed for the first time. We found that photons' arrival times were inconsistent with the states obtained in measurements but agreed with the states during propagation. Our results demonstrate that wavefunctions describe the realistic existence and evolution of quantum entities rather than a pure mathematical abstraction providing a probability list of measurement outcomes. This finding clarifies the long-held misunderstanding of the role of wavefunctions and their collapse in the evolution of quantum entities. 展开更多
关键词 双缝实验 波函数 量子态 扭曲 物理 量子力学 到达时间 传播过程
Synthesis, structure and luminescent properties of yellow phosphor La3Si6N11 :Ce^3+ for high power white-LEDs
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作者 Fu Du Weidong Zhuang +5 位作者 Ronghui Liu Yuanhong Liu Wei Gao Xia Zhang Yuan Xue Hongrui Hao 《中国稀土学报:英文版》 SCIE EI CAS CSCD 2017年第11期1059-1064,共6页
A series of high phase purity blue light excitable yellow-emitting La3_xSi6Nu:xCe~+ phosphors weresynthesized by the high temperature solid state reactions method. The structure and luminescentproperties were invest... A series of high phase purity blue light excitable yellow-emitting La3_xSi6Nu:xCe~+ phosphors weresynthesized by the high temperature solid state reactions method. The structure and luminescentproperties were investigated. The phase structure was studied by means of X-ray diffraction, structuresrefinements and energy dispersive X-ray spectroscopy. The phosphors effectively excited by the light of450 nm and show intense yellow emission at 535 nm with FWHM of 115 nm corresponding to the5d → 2F5/2 and 5d → 2F7/2 transitions of Ce3+. In addition, the optimized La2.86Si6Nn :0.14Ce3+ exhibits aweak thermal quenching, which remains 98.2% of the initial emission intensity when heated to 200 ℃,the thermal quenching properties exhibit a modest decline when the temperature returned to roomtemperature. The above results indicate that La3Si6Nu:Ce3+ can be regarded as a high promisingphosphor for applications in high power white-light LED. 展开更多
关键词 High phase purityLa3Si6Nll :Ce3+Small thermal quenchingHigh power WHITE-LIGHT LED
空间太阳能电站微波能量传输验证方案设计 预览 被引量:5
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作者 董亚洲 董士伟 +4 位作者 王颖 付文丽 李小军 高式昌 韦高 《中国空间科学技术》 CSCD 北大核心 2017年第3期11-18,共8页
微波能量传输技术作为空间太阳能电站(Space Solar Power Station,SSPS)的关键技术之一,目前的研究和验证工作均集中在各单项技术的突破和验证,缺乏针对SSPS系统特点的全面优化设计。文章根据SSPS的工作模式给出了全面验证空间太阳能... 微波能量传输技术作为空间太阳能电站(Space Solar Power Station,SSPS)的关键技术之一,目前的研究和验证工作均集中在各单项技术的突破和验证,缺乏针对SSPS系统特点的全面优化设计。文章根据SSPS的工作模式给出了全面验证空间太阳能电站微波能量传输的验证系统方案设计,对收发天线进行了一体化设计,利用了幅度近似高斯分布的发射阵列场分布设计和低反射的接收整流阵列设计,以高精度来波方向测量和高精度移相控制为波束指向控制的技术途径。对验证系统的波束收集效率进行了分析,收集效率可达94.2%,比传统均匀分布系统高出17.6%。验证系统可从系统规模缩比、波束扫描范围、发射天线口径场分布、整流天线处功率密度、反向波束控制方法等方面模拟SSPS微波能量传输工作模式,推动SSPS系统技术的发展。 展开更多
关键词 空间太阳能电站 微波能量传输 场分布 整流天线
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Effects of High Frequency Repetitive Transcranial Magnetic Stimulation on KCC2 Expression in Rats with Spasticity Following Spinal Cord Injury 预览
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作者 高伟 于利国 +3 位作者 刘雅丽 陈沫 王熠钊 黄晓琳 《华中科技大学学报:医学英德文版》 SCIE CAS 2017年第5期777-781,共5页
The effect of high-frequency repetitive transcranial magnetic stimulation(r TMS) on potassium-chloride cotransporter-2(KCC2) protein expression following spinal cord injury(SCI) and the action mechanism were investiga... The effect of high-frequency repetitive transcranial magnetic stimulation(r TMS) on potassium-chloride cotransporter-2(KCC2) protein expression following spinal cord injury(SCI) and the action mechanism were investigated. SCI models were established in SD rats. Five groups were set up randomly: normal control group, SCI 7-day(7 D) model group, SCI 14-day(14 D) model group, SCI-7 DrTMS group and SCI-14 DrTMS group(n=5 each). The rats in SCI rTMS groups were treated with 10 Hz rTMS from 8 th day and 15 th day after SCI respectively, once every day, 5 days every week, a total of 4 weeks. After the model establishment, motor recovery and spasticity alleviation were evaluated with BBB scale once a week till the end of treatment. Finally, different parts of tissues were dissected out for detection of variations of KCC2 protein using Western blotting and polymerase chain reaction(PCR) technique. The results showed that the BBS scores after treatment were significantly higher in SCI-7 DrTMS group than in SCI-14 DrTMS group(P<0.05). As compared with normal control groups, The KCC2 protein in SCI model groups was down-regulated after SCI, and the decrease was much more significant in SCI-14 D model group than in SCI-7 D group(P<0.05). As compared with SCI model groups, KCC2 protein in rTMS groups was up-regulated after the treatment(P<0.05). The up-regulation of KCC2 protein content and expression was more obvious in SCI-7 DrTMS group than in SCI-14 DrTMS group(P<0.05). It was concluded that 10 Hz rTMS can alleviate spasticity in rats with SCI, which might be attributed to the up-regulation of KCC2 protein. It was also suggested that the high-frequency rTMS treatment after SCI at early stage might achieve more satisfactory curative effectiveness. 展开更多
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飞秒激光辅助LASIK制瓣术中发生前房气泡的影响因素和处理 预览
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作者 李仲佶 段宇辉 +2 位作者 米生健 高玮 李金科 《国际眼科杂志》 CAS 2017年第12期2363-2366,共4页
目的:探讨飞秒激光辅助LASIK制瓣术中发生前房气泡的影响因素和处理方法。方法:飞秒激光辅助LASIK手术患者4 859例9 671眼,回顾性分析比较其中发生前房气泡眼的术前、术中及术后各参数。 结果:患者51眼发生前房气泡,发生率为0.53... 目的:探讨飞秒激光辅助LASIK制瓣术中发生前房气泡的影响因素和处理方法。方法:飞秒激光辅助LASIK手术患者4 859例9 671眼,回顾性分析比较其中发生前房气泡眼的术前、术中及术后各参数。 结果:患者51眼发生前房气泡,发生率为0.53%。术后1mo裸眼视力(-0.076±0.09)与术前最佳矫正视力(-0.08±0.04)相比差异无统计学意义(t=-0.34,P=0.74)。33眼(65%)不影响瞳孔跟踪,18眼(35%)在去红外跟踪模式下完成手术。跟踪组(31例33眼)术后1mo裸眼视力为-0.06±0.08,去跟踪组(18例18眼)术后1mo裸眼视力为-0.11±0.09,两组相比差异无统计学意义(t=1.82,P=0.07)。前房气泡在角膜缘9:00位发生率最高,其次为3:00位。其中47例双眼手术单眼发生前房气泡,发生前房气泡眼与其对侧眼各参数(术前等效球镜、角膜曲率、角膜直径、前房容积、前房深度、前房角度和术中飞秒激光能量等)差异均无明显统计学意义(P〉0.05)。结论:前房气泡是飞秒激光辅助LASIK手术中少见的并发症,会干扰准分子激光切削时的眼球跟踪,如术中妥善处理对术后早期视力无明显影响。发生前房气泡的直接或间接因素尚不清楚。 展开更多
关键词 飞秒激光 前房气泡 准分子激光原位角膜磨镶术
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Analysis of the Zeeman effect on Dα spectra on the EAST tokamak
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作者 高伟 黄娟 +8 位作者 吴承瑞 许棕 侯玉梅 金钊 陈颖杰 张鹏飞 张凌 吴振伟 EAST Team 《中国物理B:英文版》 SCIE EI CAS CSCD 2017年第4期276-282,共7页
基于被动光谱学,在血浆的边界区域的原子排放系列被一个高决定测量了在东方 tokamak 的光分光镜的多信道的分析(OSMA ) 系统。切开的 Zeeman 光谱线被观察了。由使用一个非线性的最少的广场方法的一个恰当的过程被使用适合并且分析原... 基于被动光谱学,在血浆的边界区域的原子排放系列被一个高决定测量了在东方 tokamak 的光分光镜的多信道的分析(OSMA ) 系统。切开的 Zeeman 光谱线被观察了。由使用一个非线性的最少的广场方法的一个恰当的过程被使用适合并且分析原子系列的所有极化和部件获得本地血浆的信息。光谱线形状从不同区域根据排放系列被调查(例如,低地的方面和高地的方面) 沿着看的弦。每个极化部件被适合并且基于不同原子生产过程分类进三个精力范畴(冷、温暖、热的部件) ,在与由计算坡度的转变精力分发一致光谱侧面。一个重氢原子的排放位置,磁场紧张,和流动速度也在上下文被讨论。 展开更多
关键词 EAST 塞曼效应 托卡马克 原子发射光谱 非线性最小二乘法 Α谱 三维 等离子体
The clinical association of programmed cell death protein 4(PDCD4) with solid tumors and its prognostic significance:a meta-analysis 预览 被引量:1
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作者 John Zeng Hong Li Wei Gao +4 位作者 Wai-Kuen Ho Wen Bin Lei William Ignace Wei Jimmy Yu-Wai Chan Thian-Sze Wong 《癌症:英文版》 SCIE CAS CSCD 2016年第12期683-698,共16页
Background: Programmed cell death protein 4(PDCD4) is a novel tumor suppressor protein involved in pro?grammed cell death. Its association with cancer progression has been observed in multiple tumor models, but eviden... Background: Programmed cell death protein 4(PDCD4) is a novel tumor suppressor protein involved in pro?grammed cell death. Its association with cancer progression has been observed in multiple tumor models, but evidence supporting its association with solid tumors in humans remains controversial. This study aimed to determine the clinical signiicance and prognostic value of PDCD4 in solid tumors.Methods: A systematic literature review was performed to retrieve publications with available clinical informa?tion and survival data. The eligibility of the selected articles was based on the criteria of the Dutch Cochrane Centre proposed by the Meta?analysis Of Observational Studies in Epidemiology group. Pooled odds ratios(ORs), hazard ratios(HRs), and 95% conidence intervals(CIs) for survival analysis were calculated. Publication bias was examined by Begg's and Egger's tests.Results: Clinical data of 2227 cancer patients with solid tumors from 23 studies were evaluated. PDCD4 expression was signiicantly associated with the diferentiation status of head and neck cancer(OR 4.25, 95% CI 1.87–9.66) and digestive system cancer(OR 2.87, 95% CI 1.84–4.48). Down?regulation of PDCD4 was signiicantly associated with short overall survival of patients with head and neck(HR: 3.44, 95% CI 2.38–4.98), breast(HR: 1.86, 95% CI 1.36–2.54), digestive system(HR: 2.12, 95% CI 1.75–2.56), and urinary system cancers(HR: 3.16, 95% CI 1.06–9.41).Conclusions: The current evidence suggests that PDCD4 down?regulation is involved in the progression of several types of solid tumor and is a potential marker for solid tumor prognoses. Its clinical usefulness should be conirmed by large?scale prospective studies. 展开更多
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Left atrial area index predicts adverse cardiovascular events in patients with unstable angina pectoris 预览
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作者 Yi-Fan LI Wei-Hong LI +4 位作者 Zhao-Ping LI Xin-Heng FENG Wei-Xian XU Shao-Min CHEN Wei GAO 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2016年第8期652-657,共6页
BackgroundThe 左 atrial 尺寸被看作了不利心血管的结果的一个有用标记。然而,左 atrial 区域索引(LAAI ) 是否与不稳定的心绞痛(UAP ) 在病人为预后有预兆的价值,不是众所周知的。这研究被瞄准估计在 LAAI 之间的协会,在 UAP patie... BackgroundThe 左 atrial 尺寸被看作了不利心血管的结果的一个有用标记。然而,左 atrial 区域索引(LAAI ) 是否与不稳定的心绞痛(UAP ) 在病人为预后有预兆的价值,不是众所周知的。这研究被瞄准估计在 LAAI 之间的协会,在 UAP patients.MethodsWe 的结果注册了作为 UAP 诊断的 391 个在里面医院病人的一个总数。临床并且在基线的 echocardiographic 数据被收集。病人是跟随的 for&#x000a0; adverse&#x000a0 的发展; cardiovascular&#x000a0;(CV ) 事件,为心绞痛的包括的医院重新接纳,尖锐心肌的梗塞(AMI ) ,充血的心失败(CHF ) ,击和所有原因 mortality.ResultsDuring 26.3 &#x000b1 的一吝啬的后续时间;8.6 个月, 98 个不利 CV 事件发生了(为心绞痛,四 AMI,四 CHF,一中风和五所有原因死亡的 84 医院重新接纳) 。在一个 multivariate 考克斯模型, LAAI [或:1.140, 95% CI:1.016-1.279, P = 0.026 ] ,心脏舒张的血压(或:0.976, 95% CI:0.956-0.996, P = 0.020 ) 并且脉搏压力(或:1.020, 95% CI:1.007-1.034, P = 0.004 ) 为在 UAP patients.ConclusionsLAAI 的不利 CV 事件的独立预言者是独立于的不利 CV 事件的一个预言者临床并且在 UAP 病人的另外的 echocardiographic 参数。 展开更多
关键词 不利心血管的事件 atrial 区域索引 预示的因素 不稳定的心绞痛
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Direct Reduction of High-phosphorus Oolitic Hematite Ore Based on Biomass Pyrolysis
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作者 Dong-bo HUANG Yan-bing ZONG +2 位作者 Ru-fei WEI Wei GAO Xiao-ming LIU 《钢铁研究学报:英文版》 SCIE CAS CSCD 2016年第9期874-883,共10页
Direct reduction of high-phosphorus oolitic hematite ore based on biomass pyrolysis gases(CO,H_2,and CH_4),tar,and char was conducted to investigate the effects of reduction temperature,iron ore-biomass mass ratio,and... Direct reduction of high-phosphorus oolitic hematite ore based on biomass pyrolysis gases(CO,H_2,and CH_4),tar,and char was conducted to investigate the effects of reduction temperature,iron ore-biomass mass ratio,and reduction time on the metallization rate.In addition,the effect of particle size on the dephosphorization and iron recovery rate was studied by magnetic separation.It was determined that the metallization rate of the hematite ore could reach 99.35% at iron ore-biomass mass ratio of 1∶0.6,reduction temperature of 1 100℃,and reduction time of 55 min.The metallization rate and the aggregation degree of iron particles increase with the increase of reduction temperature.The particle size of direct reduced iron(DRI) has a great influence on the quality of the iron concentrate during magnetic separation.The separation degree of slag and iron was improved by the addition of 15 mass% sodium carbonate.DRI with iron grade of 89.11%,iron recovery rate of 83.47%,and phosphorus content of 0.28% can be obtained when ore fines with particle size of-10 μm account for 78.15%. 展开更多
关键词 鲕状赤铁矿 热解气体 生物质 原基 高磷 直接还原铁 还原温度 金属化率
Minimizing tacrolimus decreases the risk of new-onsetdiabetes mellitus after liver transplantation 预览 被引量:1
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作者 Jiu-Lin Song Wei Gao +11 位作者 Yan Zhong Lu-Nan Yan Jia-Yin Yang Tian-Fu Wen Bo Li Wen-Tao Wang Hong Wu Ming-Qing Xu Zhe-Yu Chen Yong-Gang Wei Li Jiang Jian Yang 《世界胃肠病学杂志:英文版》 SCIE CAS 2016年第6期2133-2141,共9页
AbstractAIM: To investigate the impact of minimum tacrolimus(TAC) on new-onset diabetes mellitus (NODM) afterliver transplantation (LT).METHODS: We retrospectively analyzed the data of973 liver transplant reci... AbstractAIM: To investigate the impact of minimum tacrolimus(TAC) on new-onset diabetes mellitus (NODM) afterliver transplantation (LT).METHODS: We retrospectively analyzed the data of973 liver transplant recipients between March 1999and September 2014 in West China Hospital LiverTransplantation Center. Following the exclusion ofineligible recipients, 528 recipients with a TAC-dominantregimen were included in our study. We calculatedand determined the mean trough concentration ofTAC (cTAC) in the year of diabetes diagnosis in NODMrecipients or in the last year of the follow-up in non-NODM recipients. A cutoff of mean cTAC value forpredicting NODM 6 mo after LT was identified usinga receptor operating characteristic curve. TAC-relatedcomplications after LT was evaluated by χ^2 test, andthe overall and allograft survival was evaluated usingthe Kaplan-Meier method. Risk factors for NODM afterLT were examined by univariate and multivariate Cox regression.RESULTS: Of the 528 transplant recipients, 131(24.8%) developed NODM after 6 mo after LT, andthe cumulative incidence of NODM progressivelyincreased. The mean cTAC of NODM group recipientswas significantly higher than that of recipients in thenon-NODM group (7.66 ± 3.41 ng/mL vs 4.47 ± 2.22ng/mL, P 〈 0.05). Furthermore, NODM group recipientshad lower 1-, 5-, 10-year overall survival rates (86.7%,71.3%, and 61.1% vs 94.7%, 86.1%, and 83.7%, P 〈0.05) and allograft survival rates (92.8%, 84.6%, and75.7% vs 96.1%, 91%, and 86.1%, P 〈 0.05) thanthe others. The best cutoff of mean cTAC for predictingNODM was 5.89 ng/mL after 6 mo after LT. Multivariateanalysis showed that old age at the time of LT (〉 50years), hypertension pre-LT, and high mean cTAC (≥5.89 ng/mL) after 6 mo after LT were independent riskfactors for developing NODM. Concurrently, recipientswith a low cTAC (〈 5.89 ng/mL) were less likely tobecome obese (21.3% vs 30.2%, P 〈 0.05) or todevelop dyslipidemia (27.5% vs 44.8%, P 〈0.05),ch 展开更多
关键词 Liver transplantation Minimum TACROLIMUS NEW-ONSET diabetes mellitus IMMUNOSUPPRESSANTS ALLOGRAFTS failure
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Mercury mass flow in iron and steel production process and its implications for mercury emission control
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作者 Fengyang Wang Shuxiao Wang +4 位作者 Lei Zhang Hai Yang Wei Gao Qingru Wu Jiming Hao 《环境科学学报:英文版》 SCIE EI CAS CSCD 2016年第5期293-301,共9页
The iron and steel production process is one of the predominant anthropogenic sources of atmospheric mercury emissions worldwide. In this study, field tests were conducted to study mercury emission characteristics and... The iron and steel production process is one of the predominant anthropogenic sources of atmospheric mercury emissions worldwide. In this study, field tests were conducted to study mercury emission characteristics and mass flows at two iron and steel plants in China. It was found that low-sulfur flue gas from sintering machines could contribute up to41% of the total atmospheric mercury emissions, and desulfurization devices could remarkably help reduce the emissions. Coal gas burning accounted for 17%–49% of the total mercury emissions, and therefore the mercury control of coal gas burning, specifically for the power plant burning coal gas to generate electricity, was significantly important. The emissions from limestone and dolomite production and electric furnaces can contribute29.3% and 4.2% of the total mercury emissions from iron and steel production. More attention should be paid to mercury emissions from these two processes. Blast furnace dust accounted for 27%–36% of the total mercury output for the whole iron and steel production process. The recycling of blast furnace dust could greatly increase the atmospheric mercury emissions and should not be conducted. The mercury emission factors for the coke oven,sintering machine and blast furnace were 0.039–0.047 g Hg/ton steel, and for the electric furnace it was 0.021 g Hg/ton steel. The predominant emission species was oxidized mercury, accounting for 59%–73% of total mercury emissions to air. 展开更多
关键词 钢铁生产过程 汞排放控制 质量流量 煤气燃烧 高炉粉尘 排放量 大气汞 世界范围
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