期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Interplay of transcription factors and microRNAs during embryonic hematopoiesis
1
作者 Xueping Gong Ruihua Chao +9 位作者 Pengxiang Wang Xiaoli Huang Jingjing Zhang Xiaozhou Zhu Yanyang Zhang Xue Yang Chao Hou Xiangjun Ji Tieliu Shi Yuan Wang 《中国科学:生命科学英文版》 SCIE CAS CSCD 2017年第2期168-177,共10页
Hematopoietic stem cells (HSCs), which are localized in the bone marrow of adult mammals, come from hematopoietic endothelium during embryonic stages. Although the basic processes of HSC generation and differentiation... Hematopoietic stem cells (HSCs), which are localized in the bone marrow of adult mammals, come from hematopoietic endothelium during embryonic stages. Although the basic processes of HSC generation and differentiation have been described in the past, the epigenetic regulation of embryonic hematopoiesis remains to be fully described. Here, by utilizing an in vitro differentiation system of mouse embryonic stem cells (ESCs), we identified more than 20 microRNAs that were highly enriched in embryonic hematopoietic cells, including some (e.g. miR-10b, miR-15b, and miR-27a) with previously unknown functions in blood formation. Luciferase and gene expression assays further revealed combinational binding and regulation of these microRNAs by key transcription factors in blood cells. Finally, bioinformatics and functional analyses supported an interactive regulatory control between transcription factors and microRNAs in hematopoiesis. 展开更多
关键词 microRNA 造血干细胞 转录因子 胚胎期 相互作用 小鼠胚胎干细胞 遗传调控 成年哺乳动物
上一页 1 下一页 到第
使用帮助 返回顶部 意见反馈