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急性脑血管病心电图分析及临床意义研究 认领
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作者 金海霞 周建华 《临床医学进展》 2018年第8期765-768,共4页
目的:探究急性脑血管病的心电图特点及其在临床中的作用。方法:选择2015.08~2017.08期间于我院治疗的100例急性脑血管病患者作为研究对象,将其设为本研究的试验组(研究组);选择同期于我院进行健康体检的100例非脑血管病受检者,设其为对... 目的:探究急性脑血管病的心电图特点及其在临床中的作用。方法:选择2015.08~2017.08期间于我院治疗的100例急性脑血管病患者作为研究对象,将其设为本研究的试验组(研究组);选择同期于我院进行健康体检的100例非脑血管病受检者,设其为对照组。对所有的研究对象进行心电图检查,并对比二者在检查结果上的不同。结果:与对照组比较,研究组的动态心电图异常检出率明显增高;研究组与对照组相比,SDNN、rMSSD及SDANN等心率变异性时域指标均降低,且差异有统计学意义(P <0.05)。结论:急性脑血管病患者的心电图资料与患者病情密切相关,病情越重,心电图异常改变越多,其对临床上治疗预防脑血管病提供有效的参考依据。 展开更多
关键词 急性脑血管病 心电图 临床意义 脑心综合征
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影响糖尿病患者糖化血红蛋白含量的主要危险因素统计分析 认领
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作者 江峻瑜 张天芳 《统计学与应用》 2017年第4期455-459,共5页
本文的目的在于找出影响糖尿病患者糖化血红蛋白含量的主要危险因素。通过收集某医院在2015年1月至2016年12月间的糖尿病患者的临床及实验室数据资料,从中随机抽取10例具代表性、完善性的数据资料,然后使用超拉丁方抽样的方法对这些数... 本文的目的在于找出影响糖尿病患者糖化血红蛋白含量的主要危险因素。通过收集某医院在2015年1月至2016年12月间的糖尿病患者的临床及实验室数据资料,从中随机抽取10例具代表性、完善性的数据资料,然后使用超拉丁方抽样的方法对这些数据资料进行加工处理,得到一组全新的抽样数据。之后使用minitab软件工具对抽样数据作多元线性回归分析,得出同时具有医学意义和统计学意义的可靠结论。 展开更多
关键词 糖化血红蛋白 超拉丁方 相关系数 回归分析
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Role of Serum Procalcitonin Level in Differentiating between Pulmonary Tuberculosis and Community-Acquired Pneumonia 认领
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作者 Mohammad Shameem Mazhar Alam +3 位作者 Shagufta Moin Rakesh Bhargava Zuber Ahmad Jamal Akhtar 《临床医学国际期刊(英文)》 2014年第15期902-909,共8页
Pulmonary Tuberculosis (PTB) and Community-Acquired Pneumonia (CAP) are common causes of consolidation patch in chest radiograph. Sputum Z-N staining is positive in 30% to 60% cases only and sputum examination has poo... Pulmonary Tuberculosis (PTB) and Community-Acquired Pneumonia (CAP) are common causes of consolidation patch in chest radiograph. Sputum Z-N staining is positive in 30% to 60% cases only and sputum examination has poor yield in CAP. This study aimed to assess the value of serum Procalcitonin (PCT) levels in patients with Pulmonary Tuberculosis (PTB) and Community-Acquired Pneumonia (CAP). Patients with new opacity in chest radiograph were included in the study. Serum sample were taken at admission and stored. Patient’s diagnosis were confirmed and categorized into pulmonary TB group (32) and community-acquired pneumonia group (23). Their mean PCT level was compared with mean PCT level of 25 controls. Serum procalcitonin levels were found to be significantly elevated in patients of community-acquired pneumonia as compared to patients of pulmonary tuberculosis. In presence of consolidation in x-ray chest, increased level of serum procalcitonin might be used to differentiate pulmonary tuberculosis from community-acquired pneumonia. High level of serum procalcitonin was associated with high mortality rate in community-acquired pneumonia patients. 展开更多
关键词 PROCALCITONIN TUBERCULOSIS COMMUNITY-ACQUIRED PNEUMONIA
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Mental Health Literacy and the Belief in the Supernatural 认领
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作者 Leslie Lim Justine Goh +1 位作者 Yiong-Huak Chan Shi-Hui Poon 《精神病学期刊(英文)》 2015年第4期334-341,共8页
Objective: Mental health literacy affects treatment seeking. We compare literacy levels of psychiatric outpatients and a control group of outpatients seeking treatment for non-psychiatric disorders in the same hospita... Objective: Mental health literacy affects treatment seeking. We compare literacy levels of psychiatric outpatients and a control group of outpatients seeking treatment for non-psychiatric disorders in the same hospital. We hypothesized higher levels of mental health literacy among psychiatric patients than controls, with younger age and higher educational levels associated with better literacy. We also hypothesized that there would be an inverse relationship between educational level and the belief in the supernatural causality of mental disorders. Methods: Literacy was estimated by showing psychiatric outpatients and a control group of non-psychiatric patients vignettes depicting a case of major depression and a case of generalised anxiety disorder. Their opinions regarding diagnosis, etiology, treatment, and attitudes towards mental health services were ascertained by structured questionnaires. Results: Psychiatric patients did not demonstrate superior mental health literacy compared to controls, with the exception of knowing where to obtain a psychiatric referral. Lower age and higher education levels of psychiatric patients were associated with better literacy. The higher the education level is, the less likely to attribute the causality of mental disorders to supernatural elements. Conclusion: This study highlights the need for a program of psycho-education targeting patients, their relatives, and the public. 展开更多
关键词 MENTAL HEALTH LITERACY Age EDUCATION Level BELIEF in the SUPERNATURAL
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Pulmonary Fibrosis Due to Nitrofurantoin Therapy: A Case Report 认领
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作者 Leonidas Grigorakos Garyphallia Poulakou +5 位作者 Daria Lazarescu Pavlos Myrianthefs Nikolaos Markou Maria Bikou Adamantia Petineli Konstantinos Kokkinis 《呼吸病期刊(英文)》 2017年第3期117-124,共8页
We report the case of a patient with pulmonary fibrosis, developed as an adverse reaction to nitrofurantoin therapy received for totally 6 months for the prevention of recurrent urinary tract infections. Chest X-ray a... We report the case of a patient with pulmonary fibrosis, developed as an adverse reaction to nitrofurantoin therapy received for totally 6 months for the prevention of recurrent urinary tract infections. Chest X-ray and CT scan revealed extensive elements of interstitial pulmonary fibrosis. After diagnosis, administration of nitrofurantoin was immediately stopped;and specific prolonged therapy with low-dose corticosteroids per os and inhaled steroids were administered. The patient responded successfully both clinically and biochemically and possible digestive system side effects were prevented through the administration of gastroprotection medication. For the prevention of urinary tract infection, the patient received well tolerated therapy with fosfomycin which was further continued as a prophylactic agent. 展开更多
关键词 NITROFURANTOIN LUNG TOXICITY FIBROSIS FOSFOMYCIN
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Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of<i>Asparagus racemosus</i>Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats 认领
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作者 Abdullah Al Mamun Mahbubul Hossain +8 位作者 Md. Sahab Uddin Md. Tanjir Islam Sajjad Hossain Md. Sarwar Hossain Md. Farhad Hossain Ataur Rahman Sujan Mamunur Rashid Md. Mahbubur Rahman A. F. M. Towheedur Rahman 《药理与制药(英文)》 2017年第2期52-74,共23页
In recent years, the popularity of medicinal plants as a remedy has been increased manifold due to having minimal adverse effects. The current study aimed to compare the hypoglycemic, hypolipidemic and hepatoprotectiv... In recent years, the popularity of medicinal plants as a remedy has been increased manifold due to having minimal adverse effects. The current study aimed to compare the hypoglycemic, hypolipidemic and hepatoprotective effects of the ethanolic extract of Asparagus racemosus (EEAR) Linn. alone and combinedly with conventional antidiabetic agents (gliclazide and pioglitazone) in alloxan-induced diabetic rats. Diabetes was induced in male Wister albino rats by the administration of single intra-peritoneal injection of alloxan monohydrate (120 mg/kg b.w.). Effect of oral administration of two different doses of EEAR (200 and 400 mg/kg b.w.), gliclazide (10 mg/kg b.w.) and pioglitazone (10 mg/70kg/b.w.) alone for 2 weeks and a combination of EEAR (200 mg/kg b.w.) with either gliclazide (10 mg/kg b.w.) or pioglitazone (10 mg/70kg/b.w.) for 2 weeks were examined on hypoglycemic activity on 0th, 5th, 10th and 14th day of treatment. After 2 weeks of treatment, hypolipidemic and hepatoprotective effects were estimated by serum biochemical markers such as total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate trans-aminases (SGPT) and total protein (TP) with the help of commercially available kits. The survival rate, body weight and organ weight were also measured. Alloxan treatment resulted in persistent hyperglycemia, hyperlipidemia and liver dysfunction in rats. Treatment with EEAR at different doses improved hyperglycemia significantly (p th and 14th day of treatment in a dose-dependent mood when compared to the disease control rats, gliclazide treated rats and pioglitazone treated rats. The combination therapy significantly (p th, 10th and 14th day of treatment as compared to that of disease control rats, gliclazide treated rats and pioglitazone treated rats. Proposed adjunct therapy also markedly (p < 0.001;p < 0.01, p < 0.001) improved serum TG, HDL and LD 展开更多
关键词 Diabetes Mellitus Asparagus racemosus GLICLAZIDE PIOGLITAZONE COMBINATION Therapy
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The Role of Color Doppler Ultrasound Arterial Mapping for Decision Making in the Treatment of Patients with Lower Extremity Peripheral Arterial Disease 认领
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作者 Ali Babaei Jandaghi Zahra Mardanshahi +5 位作者 Ahmad Alizadeh Iraj Baghi Hossein Hemmati Narges Tabarzan Baboli Shabnam Alizadeh Arasi Amin Keshavarzzirak 《外科学(英文)》 2013年第10期415-420,共6页
Purpose: To assess the efficacy of color Doppler imaging for decision making in the treatment of patients with lower extremity peripheral arterial disease (PAD) compared to digital subtraction angiography (DSA). Mater... Purpose: To assess the efficacy of color Doppler imaging for decision making in the treatment of patients with lower extremity peripheral arterial disease (PAD) compared to digital subtraction angiography (DSA). Materials and Methods: Color Doppler scan was done on patients suspected for lower limb PAD, a day prior to the DSA which was done by a vascular surgeon. Also, for the patients who were candidates for endovascular intervention based on the color Doppler arterial mapping results, endovascular interventions were performed at the same time if the DSA findings are correlated with the color Doppler map. The grading for evaluated segments was normal, insignificant stenosis (<50%), hemodynamically significant stenosis (≥50%) and occlusion. We yielded the diagnostic efficacy indices of Doppler for detecting arterial stenosis in each 18 different arterial segments below the renal arteries including, infrarenal aorta, common and external iliac, common femoral, superficial femoral (proximal, middle and distal segments), deep femoral, popliteal artery, tibioperoneal trunk, anterior and posterior tibial arteries (proximal, middle and distal segments) and peroneal artery (proximal and distal segments). Then, we yielded the kappa agreement between Doppler and DSA findings considering the grade of stenosis in 18 arterial segments separately. Results: Totally 115 lower extremities (2045 arterial segments) were evaluated in 90 patients [mean age: 60.8 ± 8.9 (range: 47 - 84 years old)] of which 68 (75.6%) were men. The sensitivity of color Doppler for all arterial segments was 90% or higher except for common iliac artery, distal segment of superficial femoral artery and proximal segments of anterior and posterior tibialis and peroneal arteries. However, the specificity was 89% or higher, in all arterial segments. Kappa agreement was 0.72 or higher in all segments (All P-Values 0.001). Conclusion: This study suggests that considering excellent capability of color Doppler sonography in the evaluation of lower extremity art 展开更多
关键词 Lower EXTREMITY Peripheral ARTERIAL Disease Color Doppler SONOGRAPHY ARTERIAL MAPPING Digital SUBTRACTION ANGIOGRAPHY
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Hepatitis B and Hepatitis C among Human Immunodeficiency Virus Infected Patients at a District Hospital in Mwanza, Tanzania 认领
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作者 Mariam M. Mirambo Benson R. Kidenya +7 位作者 Vitus Silago Emmanuel Mkumbo Awadh Mujuni Kennedy J. Mmanga Japhet J. Mwihambi Shimba Henerico Carolyne A. Minja Stephen E. Mshana 《艾滋病(英文)》 2019年第1期1-10,共10页
Human immunodeficiency virus (HIV), hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections have been a major public health problem. HIV patients with HBV and HCV infection are at high risk of liver diseases wh... Human immunodeficiency virus (HIV), hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections have been a major public health problem. HIV patients with HBV and HCV infection are at high risk of liver diseases which is associated with increased mortality. This study aims at determining the prevalence of hepatitis B surface antigen (HBsAg), HCV antibodies and HBV antibodies (anti-HBsAg) among HIV seropositive adults attending care and treatment clinic at Sengerema district hospital in Mwanza, Tanzania. A cross-sectional hospital based study was conducted between February and March 2017 among 243 HIV adult patients at Sengerema designated district hospital, Mwanza, Tanzania. Socio-demographic and other relevant information were collected using pre-tested questionnaires. Detection of HBsAg and HCV antibodies was done by commercial rapid immunochromatographic test while the detection of anti-HBsAg was done using enzyme linked immunosorbent assay. Data were analyzed by using STATA version 13. The median age of the study participants was 43, interquartile range (IQR): 37 - 51 years. The majority 172 (70.8) of study participants were female and the majority (88%) of participants had CD4 count of greater than 200 counts/μl. The prevalence of HBsAg, HCV antibodies and anti-HBsAg were 26/243 (10.7%, 95% confidence interval [CI]: 7 - 14), 20/243 (8.2%, 95% CI: 4.7 - 11.6) and (100/243) 41.2%, 95% CI: 35 - 47, respectively. Co-infection with HCV (OR: 4.45, 95% CI: 1.51 - 13.21, P = 0.007) was independenlty found to predict HbsAg positivity. History of blood transfusion (OR: 2.34, 95% CI: 1.08 - 5.06, P = 0.028) was significantly associated with anti-HBsAg among HIV infected individuals while, the rate of anti-HBsAg was found to decrease by 2.02 IU/L in a year increase in age. About one tenth of HIV infected individuals are co-infected with HCV and HBV with more than one third being positive for anti-HBsAg. There is a paramount need to emphasize the need for regular screening and proper management of these patients to r 展开更多
关键词 HEPATITIS B HEPATITIS C HIV Sengerema Tanzania
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Clinico-Angiographic Profile and Prevalence of Restenosis in Patients Undergoing Percutaneous Transluminal Coronary Angioplasty to Left Main Coronary Artery: An Observational Cohort Study 认领
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作者 Dolly Mathew C. G. Sajeev 《心血管病(英文)》 2017年第11期413-422,共10页
Background: Patients who underwent percutaneous coronary intervention in left main coronary artery (LMCA) requires special concern, being high risk and increasing patient population. The aim of this study was to asses... Background: Patients who underwent percutaneous coronary intervention in left main coronary artery (LMCA) requires special concern, being high risk and increasing patient population. The aim of this study was to assess the clinical profile, angiographic status, and prevalence of restenosis in patients who underwent percutaneous transluminal coronary angioplasty (PTCA) in LMCA. Materials and Methods: This observational cohort study included 17 patients who underwent PTCA in LMCA during one-year study period at tertiary care centers in Government Medical College, Kozhikode, India. Data including various risk factors, clinical and angiographic details, stent used, procedural complications and outcomes including rate of restenosis were analyzed. Results: A total of 17 patients (mean age 53.88 ± 9.80 years) with 76.47% of males were included in the study. Smoking and hypertension were the most common risk factors presented in 52.94% and 47.06% of patients respectively. Single vessel disease (SVD) of LMCA was the most common pattern observed in 47.10%;the rate of restenosis was observed in 11.76% patients. Revascularization was performed in one patient (5.88%) with coronary artery bypass graft and in one patient (5.88%) with PTCA using drug eluting stent (DES). The overall procedural success was 88.24% in this study. Survival rate was 100% at one-year follow-up period. Conclusion: Our study involved patients who underwent PTCA in LMCA, showed smoking as a most prevalent risk factor for coronary artery disease and SVD as a most common pattern, comparatively low rate of restenosis and 100% of survival rate at one-year follow-up period. 展开更多
关键词 CORONARY ARTERY Disease Drug Eluting Stent In-Stent RESTENOSIS Left Main CORONARY ARTERY Percutaneous TRANSLUMINAL CORONARY ANGIOPLASTY
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Temporal Trends in Radiation Dose Associated with Coronary Computed Tomography Angiography 认领
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作者 Paolo Marraccini Alessandro Mazzarisi +7 位作者 Clara Carpeggiani Mathis Schluter Marco Brambilla Massimiliano Bianchi Lorenzo Faggioni Giuseppe Coppini Carlo Bartolozzi Eugenio Picano 《放射学期刊(英文)》 2014年第1期101-110,共10页
Background: In 2010, the International Atomic Energy Agency launched the “3A’s campaign” as an effective tool for primary cancer prevention. In 2011, the American Association of Physicists in Medicine recommended t... Background: In 2010, the International Atomic Energy Agency launched the “3A’s campaign” as an effective tool for primary cancer prevention. In 2011, the American Association of Physicists in Medicine recommended the size specific dose estimate (SSDE). Objectives: To audit doses of Coronary CT Angiography (Coronary CTA) in tertiary care referral center. Methods: We reviewed 998 consecutive Coronary CTA (from 2007 to 2012). Doses (CTDIvol mGy), DLP (mGy*cm), effective dose (DLP*0.014, mSv) were on-line archived. SSDE was estimated retrospectively. Appropriateness score was evaluated for exams performed from the 2010. Results: Overall median dose per Coronary CTA was 49.7 mGy for CTDIvol, 55.5 mGy for SSDE, 994.96 mGy*cm for DLP, 13.9 mSv for effective dose. Median DLP decreased over time (1452.94 in 2007, 1605.56 in 2008, 1113.49 in 2009, 759.99 in 2010, 448.61 in 2011 and 497.88 mGy*cm in 2012, p < 0.0001). SSDE was proportional to the size dependent factor (SDF);in patients with SDF > 1 (88%) CTDIvol underestimated SSDE (48.49 vs 57.19 mGy), whilst in patients with SDF < 1 (12%) CTDIvol overestimated SSDE (56.46 vs 50.3 mGy). Scans were appropriate in 58%, uncertain in 24%, and inappropriate in 18% of cases. Doses were similar in appropriate, uncertain or inappropriate examinations and in excellent-to-good (81%) vs. sufficient-to-poor (19%) image quality exams. Conclusions: Coronary CTA reference doses can be very misleading. SSDE can allow individual technique optimization. The dose is similar in appropriate and inappropriate examinations, and unrelated to image quality. The rate of inappropriate examinations is still too high even after dissemination of guidelines. 展开更多
关键词 ISCHEMIC Heart Disease X RAY CARDIAC COMPUTED Tomography CARDIOVASCULAR Imaging Radiation DOSING
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Sodium Fluoride Induces Hepato-Renal Oxidative Stress and Pathophysiological Changes in Experimental Animals 认领
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作者 Azab Elsayed Azab Mohamed Omer Albasha +1 位作者 J. M. Jbireal Almokhtar A. Adwas 《细胞凋亡(英文)》 2018年第1期1-23,共23页
The liver is a primary site for xenobiotics detoxification, and its metabolism is readily altered by toxicity. The kidney is a common target for toxic xenobiotics due to its capacity to extract and concentrate toxic s... The liver is a primary site for xenobiotics detoxification, and its metabolism is readily altered by toxicity. The kidney is a common target for toxic xenobiotics due to its capacity to extract and concentrate toxic substances by highly specialized cells. So, they are the target organs of sodium fluoride toxicity. The aim of this review is to highlight on hepatorenal oxidative stress and pathophysiological changes induced by treatment of experimental animals with sodium fluoride. Our review shows fluoride toxicosis caused an elevation in the serum activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, acid phosphatase, and the level of total bilirubin, and reduction in the serum levels of total protein, albumin, and globulins, and serious histopathological changes in the hepaic tissues. Also, NaF administration caused increases in serum urea, creatinine, uric acid, sodium ions, and chloride ions levels and serious histopathological changes in the kidney tissues. Treatment of experimental animals with NaF induced oxidative stress in hepatic and renal tissues. It can be concluded that administration of sodium fluoride to experimental animals induced oxidative stress, serious hepatorenal histopathological changes, and disturbance in liver and kidney functions. So, human should be advised to decrease exposure to sodium fluoride to decrease the harmful effects of NaF on liver and kidney. 展开更多
关键词 Sodium FLUORIDE TOXICITY Oxidative Stress Hepatorenal HISTOPATHOLOGICAL CHANGES Hepatorenal Pathophysiological CHANGES
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胰激肽原酶联合来氟米特治疗糖尿病肾病的临床疗效及对尿液外泌体源性足细胞标志蛋白与亮氨酸氨基肽酶的影响 认领
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作者 姜涛 《中国药物经济学》 2020年第2期58-61,共4页
目的探讨胰激肽原酶联合来氟米特治疗糖尿病肾病糖尿病肾病(DN)的临床疗效,以及对尿液外泌体源性足细胞标志蛋白(PCX)及亮氨酸氨基肽酶(ALP)的影响。方法选取2018年4月至2019年4月于大连市金州区中医医院内分泌科接受治疗的82例DN患者... 目的探讨胰激肽原酶联合来氟米特治疗糖尿病肾病糖尿病肾病(DN)的临床疗效,以及对尿液外泌体源性足细胞标志蛋白(PCX)及亮氨酸氨基肽酶(ALP)的影响。方法选取2018年4月至2019年4月于大连市金州区中医医院内分泌科接受治疗的82例DN患者作为研究对象,随机分为对照组和观察组,每组41例。对照组予以胰激肽原酶治疗,观察组在对照组治疗基础上应用来氟米特治疗,治疗周期为6周。比较两组血肌酐、尿素氮、24 h尿蛋白定量、PCX、LAP及临床疗效。结果治疗前两组PCX及ALP水平、血肌酐、尿素氮、24 h尿蛋白定量比较,差异无统计学意义(P>0.05);治疗后两组各指标均有所降低,且观察组优于对照组(P<0.05);对照组和观察组治疗有效率分别为75.61%和92.27%,观察组治疗有效率显著优于对照组,差异有统计学意义(P<0.05)。结论胰激肽原酶联合来氟米特治疗DN临床疗效显著,可有效降低尿液外泌体源性PCX、LAP水平。 展开更多
关键词 糖尿病肾病 外泌体 来氟米特 胰激肽原酶
基于“邪毒致变”与Wnt/β-catenin信号通路探讨Hp相关胃病良恶性病理演变证候特征的思考 认领
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作者 胡玲 《中国中西医结合消化杂志》 CAS 2020年第2期83-86,共4页
幽门螺旋杆菌(helicobacter pylori,Hp)相关胃病包括慢性浅表性和糜烂性胃炎、胃溃疡、萎缩性胃炎以及胃癌,几乎涵盖了胃黏膜从炎症、萎缩、肠化生、异型增生、癌变之良恶性病理演变的全过程。从"炎癌链"角度理解,Hp感染引起... 幽门螺旋杆菌(helicobacter pylori,Hp)相关胃病包括慢性浅表性和糜烂性胃炎、胃溃疡、萎缩性胃炎以及胃癌,几乎涵盖了胃黏膜从炎症、萎缩、肠化生、异型增生、癌变之良恶性病理演变的全过程。从"炎癌链"角度理解,Hp感染引起胃黏膜慢性非可控性炎症是癌变发生前的第一步[1-3]。 展开更多
关键词 Hp相关胃病 邪毒致变 WNT/Β-CATENIN信号通路 病理演变 证候特征
冠状动脉造影联合FFR在冠心病介入治疗中的应用分析 认领
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作者 张文祥 王照林 +2 位作者 王子超 唐存亮 郝毅 《中西医结合心血管病电子杂志》 2019年第34期114-114,121共2页
目的探讨在冠心病患者介入治疗中冠状动脉造影+FFR(血流储备分数)的应用效果。方法抽选2018年9月~2020年1月在我院开展介入治疗的冠心病患者(100例)开展研究,随机数表法分成甲组与乙组,甲组50例,乙组50例。乙组常规介入治疗,甲组在介入... 目的探讨在冠心病患者介入治疗中冠状动脉造影+FFR(血流储备分数)的应用效果。方法抽选2018年9月~2020年1月在我院开展介入治疗的冠心病患者(100例)开展研究,随机数表法分成甲组与乙组,甲组50例,乙组50例。乙组常规介入治疗,甲组在介入术中开展冠状动脉造影+FFR,总结支架置入的数量、不良事件。结果甲组支架置入的数量、不良事件总发生率都优于乙组,差异显著,差异有统计学意义(P<0.05)。结论对于冠心病患者来说,在介入治疗中开展冠状动脉造影+FFR可降低不良事件发生的风险,并减少支架置入的数量,在临床值的推广应用。 展开更多
关键词 冠心病 介入治疗 冠状动脉造影 FFR 应用效果
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Liddle综合征家系上皮钠通道β亚单位基因移码突变及临床研究一例 认领
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作者 范鹏 卢超霞 +6 位作者 杨坤璂 陆培培 张莹 孟旭 罗芳 张学 周宪梁 《中国循环杂志》 CSCD 北大核心 2018年第S01期27-27,共1页
目的:本研究旨在探究一例临床疑似Liddle综合征的先证者及其家系成员上皮钠通道β亚单位基因突变情况、相关的临床表型和二者之间的关联性。方法:收集疑似Liddle综合征先证者及其家系成员的临床资料,进行常规查体和化验检查,主要包括动... 目的:本研究旨在探究一例临床疑似Liddle综合征的先证者及其家系成员上皮钠通道β亚单位基因突变情况、相关的临床表型和二者之间的关联性。方法:收集疑似Liddle综合征先证者及其家系成员的临床资料,进行常规查体和化验检查,主要包括动脉血压水平、血钾、血浆肾素和醛固酮水平测定等。 展开更多
关键词 上皮钠通道 移码突变 Liddle Β亚单位 综合征 临床研究
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174例社区获得性肺炎患者肺炎支原体、肺炎衣原体联合检测结果分析 认领
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作者 马颖 《首都食品与医药》 2020年第3期133-134,共2页
目的了解社区获得性肺炎(CAP)患者肺炎支原体(M p)和肺炎衣原体(Cp)感染情况,为早期诊断CAP提供临床检测参考。方法检测174例CAP患者的血清Mp抗体及Cp抗体,并将检测结果进行分析。结果174例CAP患者中,Mp-IgM检出阳性患者52例,占比29.89%... 目的了解社区获得性肺炎(CAP)患者肺炎支原体(M p)和肺炎衣原体(Cp)感染情况,为早期诊断CAP提供临床检测参考。方法检测174例CAP患者的血清Mp抗体及Cp抗体,并将检测结果进行分析。结果174例CAP患者中,Mp-IgM检出阳性患者52例,占比29.89%;Cp-IgM检出阳性患者21例,占比12.07%;Mp-IgM和Cp-IgM均呈阳性患者18例,占比10.34%。结论Mp和Cp联合检测更能提高临床对CAP的诊断准确率。 展开更多
关键词 社区获得性肺炎(CAP) 肺炎支原体(Mp) 肺炎衣原体(Cp)
基于不同糖代谢状态下的急性冠脉综合征患者血清半胱氨酸蛋白酶抑制剂C与冠脉病变的相关性分析 认领
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作者 祝雪丽 熊尚全 +1 位作者 詹萍 林超 《血管与腔内血管外科杂志》 2019年第6期513-516,共4页
目的探讨不同糖代谢状态下急性冠脉综合征(ACS)患者血清半胱氨酸蛋白酶抑制剂C(简称胱抑素C)与冠脉病变的相关性。方法选择福建中医药大学附属人民医院于2017年8月至2019年8月收治的194例ACS患者,根据患者糖代谢状态的异同进行分组,分... 目的探讨不同糖代谢状态下急性冠脉综合征(ACS)患者血清半胱氨酸蛋白酶抑制剂C(简称胱抑素C)与冠脉病变的相关性。方法选择福建中医药大学附属人民医院于2017年8月至2019年8月收治的194例ACS患者,根据患者糖代谢状态的异同进行分组,分为糖尿病组(n=49)、糖尿病前期组(n=72)和正常组(n=73),测定各组糖代谢指标、血清胱抑素C水平及冠脉病变严重程度。ACS患者冠脉病变影响因素的多因素行Logistic回归分析。结果糖尿病组患者的空腹血糖、糖化血红蛋白、血清胱抑素C和Genisi评分均高于正常组和糖尿病前期组患者,差异有统计学意义(P<0.05);糖化血红蛋白是ACS患者冠脉病变的独立危险因素(P<0.05)。结论ACS患者的血清胱抑素C及Genisi评分均随血糖的升高而升高,但血清胱抑素C不是ACS患者冠脉病变的独立危险因素。 展开更多
关键词 糖代谢 急性冠脉综合征 半胱氨酸蛋白酶抑制剂C
运动激发前后早期糖尿病肾病患者尿液生物标志物含量的改变及其临床意义 认领
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作者 刘传芝 辛雨 付晗 《临床和实验医学杂志》 2020年第5期509-512,共4页
目的探讨运动激发前后早期糖尿病肾病(DN)患者尿液生物标志物含量的改变及其临床意义。方法前瞻性选取2016年1月至2019年1月间在北部战区总医院就诊的早期DN患者110例作为早期DN组,同期该院进行体检的健康志愿者100例作为正常对照组。... 目的探讨运动激发前后早期糖尿病肾病(DN)患者尿液生物标志物含量的改变及其临床意义。方法前瞻性选取2016年1月至2019年1月间在北部战区总医院就诊的早期DN患者110例作为早期DN组,同期该院进行体检的健康志愿者100例作为正常对照组。观察两组研究对象静息状态下(T0)、激发试验后30 min内(T1)肾小球性尿液指标、肾小管性尿液指标的含量;检测两组研究对象基础状态下的肾功能指标含量。采用Pearson检验评估早期DN患者尿液指标含量与肾功能的相关关系。结果T1时,早期DN组尿液中肾小球性尿液指标尿微量白蛋白(MA)、尿转铁蛋白(Tf)、免疫球蛋白G4(Ig G4)、尿唾液酸(SA)的含量高于正常对照组;肾小管性尿液指标尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL),视黄醇结合蛋白(RBP)、α1微球蛋白(α1-MG)的含量高于正常对照组(P<0.05),Tamm-Horsfall蛋白(T-H)的含量低于正常对照组(P<0.05)。早期DN组患者尿液中肾小球性尿液指标MA、Tf、IgG4、SA的含量高于T0时;肾小管性尿液指标NGAL、RBP、α1-MG的含量高于T0时,T-H的含量低于T0时(P<0.05)。早期DN组患者的GFR水平低于正常对照组,UTP水平高于正常对照组(P<0.05)。Pearson检验发现,T1时早期DN患者尿液MA、Tf、Ig G4、SA、NGAL、RBP、α1-MG的含量与GFR含量呈负相关(P<0.05),与UTP含量呈正相关(P<0.05);T-H的含量与GFR水平呈正相关(P<0.05),与UTP水平呈负相关(P<0.05)。结论运动激发试验后,肾小球性/肾小管性尿液指标可动态反映早期DN患者的肾功能改变,且与具体肾功能指标水平直接相关,是衡量DN患者肾功能状态的敏感及准确指标。 展开更多
关键词 早期糖尿病肾病 运动激发试验 尿液生物标志物
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观察利伐沙班在急性肺栓塞(PE)抗凝治疗中的疗效及安全性 认领
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作者 潘运昌 张城 《保健文汇》 2019年第10期261-262,共2页
目的:探讨利伐沙班在急性肺栓塞(PE)抗凝治疗中的疗效及安全性。方法:根据研究需要,将2016年3月-2019年6月本院收治的急性肺栓塞(PE)患者分为两组,对其中的40例观察组患者采用利伐沙班和低分子肝素进行抗凝治疗,对40例参照组患者采用华... 目的:探讨利伐沙班在急性肺栓塞(PE)抗凝治疗中的疗效及安全性。方法:根据研究需要,将2016年3月-2019年6月本院收治的急性肺栓塞(PE)患者分为两组,对其中的40例观察组患者采用利伐沙班和低分子肝素进行抗凝治疗,对40例参照组患者采用华法林联合低分子肝素抗凝治疗。对80例患者的治疗效果和临床用药安全性进行分析。结果:治疗后,两组患者的临床指标比治疗前显著改善,差异有统计学意义(P<0.05)。两组间比较,差异无统计学意义(P>0.05)。两组治疗效果比较,观察组治疗总改善率为90.00%,参照组为87.50%,组间比较,没有显著差异(P>0.05)。治疗后,两组不良反应发生情况比较,观察组不良反应发生率为10.00%,参照组为30.00%,组间比较,观察组更低(P<0.05)。结论:使用利伐沙班对急性肺栓塞患者进行抗凝治疗,可以显著改善凝血功能指标,临床用药具有一定的安全性。 展开更多
关键词 利伐沙班 急性肺栓塞 抗凝治疗 安全性
过敏性疾病过敏原检验结果之影响因素分析 认领
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作者 李薇 朱家明 董晓冉 《商丘师范学院学报》 CAS 2019年第12期1-8,共8页
针对过敏性疾病的影响因素问题,根据过敏原检验结果的数据,结合时间、季节、性别和年龄4个影响因素,运用模糊C均值聚类、多元统计分析、贴近度计算、皮尔逊相关系数计算方法,构建了过敏性疾病分类模型、过敏原检测结果差异性模型及相关... 针对过敏性疾病的影响因素问题,根据过敏原检验结果的数据,结合时间、季节、性别和年龄4个影响因素,运用模糊C均值聚类、多元统计分析、贴近度计算、皮尔逊相关系数计算方法,构建了过敏性疾病分类模型、过敏原检测结果差异性模型及相关性判定模型,运用MATLAB软件进行求解,得到4个影响因素对过敏性疾病的影响、不同类型病人过敏原检测结果的差异、环境指标PM2.5对过敏原检测结果具有强相关性等结论,并给出相关结论和建议. 展开更多
关键词 过敏性疾病 模糊C均值聚类 多元统计分析 皮尔逊相关系数
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