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胃癌肿瘤血管生成
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作者 杨佳华 刘颖斌 《中国实用外科杂志》 CSCD 北大核心 2011年第S1期57-58,共2页
【正】大量的实验已经证明新生血管的形成是肿瘤生长和播散的基础。血管生成的过程是在促血管生成因子和抑制血管生成因子的平衡中完成。在正常组织中,新生血管生成会受到严格控制,但是在肿瘤组织内血管生成未受到相应控制,肿瘤组织能... 【正】大量的实验已经证明新生血管的形成是肿瘤生长和播散的基础。血管生成的过程是在促血管生成因子和抑制血管生成因子的平衡中完成。在正常组织中,新生血管生成会受到严格控制,但是在肿瘤组织内血管生成未受到相应控制,肿瘤组织能得到充分的营养物质和氧气,从而导致肿瘤的生长和转移。抑制肿瘤的血管生成已经是重要的抗肿瘤治疗方法。1血管内皮生长因子(VEGF)在胃癌中的表达及其与微血管密度(MVD)的关系人的VEGF家族成员包括:VEGF-A(即通常所指的 展开更多
关键词 胃癌 肿瘤血管生成
Chemopreventive drugs:Mechanisms via inhibition of cancer stem cells in colorectal cancer
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作者 Tae Il Kim 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2014年第14期3835-3846,共12页
Recent epidemiological studies,basic research and clinical trials on colorectal cancer(CRC)prevention have helped identify candidates for effective chemopreventive drugs.However,because of the conflicting results of c... Recent epidemiological studies,basic research and clinical trials on colorectal cancer(CRC)prevention have helped identify candidates for effective chemopreventive drugs.However,because of the conflicting results of clinical trials or side effects,the effective use of chemopreventive drugs has not been generalized,except for patients with a high-risk for developing hereditary CRC.Advances in genetic and molecular technologies have highlighted the greater complexity of carcinogenesis,especially the heterogeneity of tumors.We need to target cells and processes that are critical to carcinogenesis for chemoprevention and treatment of advanced cancer.Recent research has shown that intestinal stem cells may serve an important role in tumor initiation and formation of cancer stem cells.Moreover,studies have shown that the tumor microenvironment may play additional roles in dedifferentiation,to enable tumor cells to take on stem cell features and promote the formation of tumorigenic stem cells.Therefore,early tumorigenic changes of stem cells and signals for dedifferentiation may be good targets for chemoprevention.In this review,I focus on cancer stem cells in colorectal carcinogenesis and the effect of major chemopreventive drugs on stem cell-related pathways. 展开更多
关键词 COLORECTAL CANCER CHEMOPREVENTION CANCER stem cell
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Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker 被引量:1
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作者 SusenBurock PiaHerrmann +3 位作者 InaWendler MarkusNiederstrasser Klaus-DieterWernecke UlrikeStein 《世界胃肠病学杂志:英文版》 SCIE CAS 2015年第1期333-341,共9页
AIM: To evaluate the diagnostic and prognostic value of circulating Metastasis Associated in Colon Cancer 1(MACC1) transcripts in plasma of gastric cancer patients.METHODS: We provide for the first time a blood-based ... AIM: To evaluate the diagnostic and prognostic value of circulating Metastasis Associated in Colon Cancer 1(MACC1) transcripts in plasma of gastric cancer patients.METHODS: We provide for the first time a blood-based assay for transcript quantification of the metastasis inducer MACC1 in a prospective study of gastric cancer patient plasma.MACC1 is a strong prognostic biomarker for tumor progression and metastasis in a variety of solid cancers.We conducted a study to define the diagnostic and prognostic power of MACC1 transcripts using 76 plasma samples from gastric cancer patients,either newly diagnosed with gastric cancer,newly diagnosed with metachronous metastasis of gastric cancer,as well as follow-up patients.Findings were controlled by using plasma samples from 54 tumor-free volunteers.Plasma was separated,RNA was isolated,and levels of MACC1 as well as S100A4 transcripts were determined by quantitative RT-PCR.RESULTS: Based on the levels of circulating MACC1 transcripts in plasma we significantly discriminated tumorfree volunteers and gastric cancer patients(P < 0.001).Levels of circulating MACC1 transcripts were increased in gastric cancer patients of each disease stage,compared to tumor-free volunteers: patients with tumors without metastasis(P = 0.005),with synchronous metastasis(P = 0.002),with metachronous metastasis(P = 0.005),and patients during follow-up(P = 0.021).Sensitivity was 0.68(95%CI: 0.45-0.85) and specificity was 0.89(95%CI: 0.77-0.95),respectively.Importantly,gastric cancer patients with high circulating MACC1 transcript levels in plasma demonstrated significantly shorter survival whencompared with patients demonstrating low MACC1 levels(P = 0.0015).Furthermore,gastric cancer patients with high circulating transcript levels of MACC1 as well as of S100A4 in plasma demonstrated significantly shorter survival when compared with patients demonstrating low levels of both biomarkers or with only one biomarker elevated(P = 0.001).CONCLUSION: Levels of circulating MACC1 transcripts in plasma of 展开更多
关键词 Gastric cancer PLASMA CIRCULATING TRANSCRIPTS MACC
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Survival in gastric cancer in relation to postoperative adjuvant therapy and determinants
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作者 SevgiOzden ZerrinOzgen +4 位作者 HazanOzyurt CengizGemici GokhanYaprak HuseyinTepetam AlpaslanMayadagli 《世界胃肠病学杂志:英文版》 SCIE CAS 2015年第4期1222-1233,共12页
AIM: To evaluate survival data in patients with gastric cancer in relation to postoperative adjuvant therapy and survival determinantsMETHODS: A total of 201 patients(mean ± SD age: 56.0 ± 11.9 years, 69.7% ... AIM: To evaluate survival data in patients with gastric cancer in relation to postoperative adjuvant therapy and survival determinantsMETHODS: A total of 201 patients(mean ± SD age: 56.0 ± 11.9 years, 69.7% were males) with gastric carcinoma who were operated and followed up at Lutfi Kirdar Kartal Training and Research Hospital between 1998 and 2010 were included in this retrospective study. Follow up was evaluated divided into two consecutive periods(before 2008 and 2008-2010, respectively) based on introduction of 3-D conformal technique in radiotherapy at our clinic in 2008. Data on patient demographics, clinical and histopathological characteristics of gastric carcinoma and the type of treatment applied after surgery [postoperative adjuvant treatment protocols including chemoradiotherapy(CRT) and chemotherapy(CT), supportive therapy or follow up without any treatment] were recorded. The median duration and determinants of local recurrence free(LRF) survival, distant metastasis free(DMF) survival and overall survival were evaluated in the overall population as well as with respect to follow up years [1998-2008(n = 127) vs 2008-2010(n = 74)].RESULTS: Median duration for LRF survival, DMF survival and overall survival were 31.9, 24.1 and 31.9 mo, respectively in patients with postoperative adjuvant CRT. No significant difference was noted in median duration for LRF survival, DMF survival and overall survival with respect to treatment protocols in the overall population and also with respect to followed up periods. In the overall population, CT protocols FUFA [5-fluorouracil(400 mg/m2) and leucovorin-folinic acid(FA, 20 mg/m2)](29.9 mo) and UFT + Antre [a fixed combination of the oral FU prodrug tegafur(flouroprymidine, FT, 300 mg/m2 per day) with FA(Antrex?), 15 mg tablet, two times a day](42.5 mo) was significantly associated with longer LRF survival times than other CT protocols(P = 0.036), while no difference was noted between CT protocols in terms of DMF survival and overall survival. Among patients receiv 展开更多
关键词 GASTRIC CARCINOMA Local RECURRENCE free SURVIVAL D
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Lymphangitic spread from appendiceal adenocarcinoma to ileocecal valve, mimicking Crohn’s disease
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作者 TriciaMurdock NicholasLim MaryamZenali 《世界胃肠病学杂志:英文版》 SCIE CAS 2015年第7期2206-2209,共4页
Due to the anatomical peculiarity of the appendix,diagnosis of tumors arising from this area can be challenging by clinicoradiologic means.We report a case of a rare primary appendiceal signet ring carcinoma with an u... Due to the anatomical peculiarity of the appendix,diagnosis of tumors arising from this area can be challenging by clinicoradiologic means.We report a case of a rare primary appendiceal signet ring carcinoma with an uncommon presentation.An 86-year-old woman was admitted toour hospital with subacute epigastric pain.Computed tomography demonstrated bowel wall thickening with fat stranding in the ileocecal region.The leading diagnostic consideration was inflammatory bowel disease.Upon colonoscopy,a swollen,distorted ileocecal valve was identified.The remaining colon was otherwise unremarkable.Extensive biopsy sampling of the ileocecal region and colon was performed.A lymphangitic signet ring carcinoma within the ileocecal region was diagnosed on biopsy;there was no dysplasia or carcinoma of the remaining biopsies.By cytomorphology and immunoprofile,a lymphangitic signet ring carcinoma of appendiceal origin was the primary consideration,further confirmed upon subsequent laparotomy.This case represents an unusual pattern of appendiceal tumor spread with localized,lymphangitic involvement,creating a milieu which closely simulates Crohn’s disease on imaging modalities. 展开更多
关键词 Signet RING CARCINOMA Crohn’s disease INFLAMMATORY
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18F-Fluorodeoxyglucose positron emission tomography/computed tomography comparison of gastric lymphoma and gastric carcinoma
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作者 Xiao-Feng Li Qiang Fu +5 位作者 You-Wen Dong Jian-Jing Liu Xiu-Yu Song Dong Dai Cong Zuo Wen-Gui Xu 《世界胃肠病学杂志:英文版》 SCIE CAS 2016年第34期7787-7796,共10页
AIM To compare 18F-fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT) features in gastric lymphoma and gastric carcinoma.METHODS Patients with newly diagnosed gastric lymphoma or gastr... AIM To compare 18F-fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT) features in gastric lymphoma and gastric carcinoma.METHODS Patients with newly diagnosed gastric lymphoma or gastric carcinoma who underwent 18F-FDG PET/CT prior to treatment were included in this study. We reviewed and analyzed the PET/CT features of gastric wall lesions,including FDG avidity,pattern(focal/diffuse),and intensity [maximal standard uptake value:(SUVmax)]. The correlation of SUVmax with gastricclinicopathological variables was investigated by χ2 test,and receiver-operating characteristic(ROC) curve analysis was performed to determine the differential diagnostic value of SUVmax-associated parameters in gastric lymphoma and gastric carcinoma. RESULTS Fifty-two patients with gastric lymphoma and 73 with gastric carcinoma were included in this study. Abnormal gastric FDG accumulation was found in 49 patients(94.23%) with gastric lymphoma and 65 patients(89.04%) with gastric carcinoma. Gastric lymphoma patients predominantly presented with type Ⅰ and type Ⅱ lesions,whereas gastric carcinoma patients mainly had type Ⅲ lesions. The SUVmax(13.39 ± 9.24 vs 8.35 ± 5.80,P < 0.001) and SUVmax/THKmax(maximal thickness)(7.96 ± 4.02 vs 4.88 ± 3.32,P < 0.001) were both higher in patients with gastric lymphoma compared with gastric carcinoma. ROC curve analysis suggested a better performance of SUVmax/THKmax in the evaluation of gastric lesions between gastric lymphoma and gastric carcinoma in comparison with that of SUVmax alone.CONCLUSION PET/CT features differ between gastric lymphoma and carcinoma,which can improve PET/CT evaluation of gastric wall lesions and help differentiate gastric lymphoma from gastric carcinoma. 展开更多
关键词 GASTRIC LYMPHOMAS GASTRIC CARCINOMAS 18F-FLUORODEOXYGLUCOSE positron emission tomography/ computed TOMOGRAPHY MAXIMAL standard uptake value MAXIMAL thickness Differential diagnosis
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Diabetes mellitus may affect the long-term survival of hepatitis B virus-related hepatocellular carcinoma patients after liver transplantation
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作者 Qing Zhang Yong-Lin Deng +9 位作者 Chang Liu Li-Hong Huang Lei Shang Xin-Guo Chen Le-Tian Wang Jin-Zan Du Ying Wang Pei-Xiao Wang Hui Zhang Zhong-Yang Shen 《世界胃肠病学杂志:英文版》 SCIE CAS 2016年第43期9571-9585,共15页
AIM to determine whether diabetes mellitus(DM) affects prognosis/recurrence after liver transplantation(Lt) for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC). METHODS A retrospective study was conducted... AIM to determine whether diabetes mellitus(DM) affects prognosis/recurrence after liver transplantation(Lt) for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC). METHODS A retrospective study was conducted between January 2000 and August 2013 on 1631 patients with HBV-related HCC who underwent Lt with antiviral prophylaxis. Patient data were obtained from the China Liver transplant Registry(https://www.cltr.org/). to compare the outcomes and tumor recurrence in the HBV-related HCC patients with or without DM, statistical analyses were conducted using χ2 tests, Mann-Whitney tests, the Kaplan-Meier method, log-rank tests and multivariate step-wise Cox regression analysis. RESULTS Univariate analysis of 1631 patients who underwent Lt found overall 1-, 3- and 5-year survival rates of 79%, 73% and 71% respectively in the DM patients, and 84%, 78% and 76% in the non-DM patients respectively. Overall survival rate differences after Lt between the two groups were significant(P = 0.041), but recurrence-free survival rates were not(P = 0.096). By stratified analysis, the overall survival rates in DM patients for age > 50 years(P = 0.002), the presence of vascular invasion(P = 0.096), tumors ≤ 3 cm(P = 0.047), two to three tumor nodules(P = 0.007), Child-Pugh grade B(P = 0.018), and preLt alanine aminotransferase levels between 40 and 80 IU/L(P = 0.017) were significantly lower than in non-DM patients. Additionally, serum α-fetoprotein level > 2000 ng/m L(P = 0.052) was associated with a significant survival difference trend between DM and non-DM patients. Multivariate analysis showed that the presence of DM(P < 0.001, HR = 1.591; 95%CI: 1.239-2.041) was an independent predictor associated with poor survival after Lt. CONCLUSION HBV-related HCC patients with DM have decreased long-term overall survival and poor Lt outcomes. Prevention strategies for HCC patients with DM are recommended. 展开更多
关键词 糖尿病 mellitus Hepatocellular 肝炎 B 病毒 肝移植 幸存
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Pancreatic neuroendocrine neoplasms: Magnetic resonance imaging features according to grade and stage
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作者 Riccardo De Robertis Sara Cingarlini +11 位作者 Paolo Tinazzi Martini Silvia Ortolani Giovanni Butturini Luca Landoni Paolo Regi Roberto Girelli Paola Capelli Stefano Gobbo Giampaolo Tortora Aldo Scarpa Paolo Pederzoli Mirko D’Onofrio 《世界胃肠病学杂志:英文版》 SCIE CAS 2017年第2期275-285,
AIM To describe magnetic resonance(MR) imaging features of pancreatic neuroendocrine neoplasms(Pan NENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and todetermine th... AIM To describe magnetic resonance(MR) imaging features of pancreatic neuroendocrine neoplasms(Pan NENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and todetermine the accuracy of MR imaging features in predicting their biological behavior.METHODS This study was approved by our institutional review board; requirement for informed patient consent was waived due to the retrospective nature of the study. Preoperative MR examinations of 55 Pan NEN patients(29 men, 26 women; mean age of 57.6 years, range 21-83 years) performed between June 2013 and December 2015 were reviewed. Qualitative and quantitative features were compared between tumor grades and stages determined by histopathological analysis.RESULTS Ill defined margins were more common in G2-3 and stage Ⅲ-Ⅳ PanN ENs than in G1 and low-stage tumors(P < 0.001); this feature had high specificity in the identification of G2-3 and stage Ⅲ-Ⅳ tumors(90.3% and 96%, 95%CI: 73.1-97.5 and 77.7-99.8). The mean apparent diffusion coefficient value was significantly lower in G2-3 and stage Ⅲ-Ⅳ lesions compared to well differentiated and low-stage tumors(1.09 × 10-3 mm2/s vs 1.45 × 10-3 mm2/s and 1.10 × 10-3 mm2/s vs 1.53 × 10-3 mm2/s, P = 0.003 and 0.001). Receiving operator characteristic analysis determined optimal cutoffs of 1.21 and 1.28 × 10-3 mm2/s for the identification of G2-3 and stage Ⅲ-Ⅳ tumors, with sensitivity and specificity values of 70.8/80.7% and 64.5/64%(95%CI: 48.7-86.6/60-92.7 and 45.4-80.2/42.6-81.3).CONCLUSION MR features of PanN ENs vary according to their grade of differentiation and their stage at diagnosis and could predict the biological behavior of these tumors. 展开更多
关键词 胰腺的 neuroendocrine 肿瘤 世界健康组织分类 2010 散开加权的成像 欧洲 Neuroendocrine 肿瘤社会阶段系统 磁性的回声成像
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顺铂治疗胃癌的临床应用进展 被引量:2
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作者 于勇 卢佃华 +1 位作者 杜鹏程 苏玉华 《中国药师》 CAS 2004年第3期 199-201,共3页
顺铂(cisplatin),是临床应用最为广泛的一种抗癌药物.近年来,应用顺铂治疗胃癌取得了长足进展.顺铂的主要副作用是骨髓抑制,为减轻其毒副作用,增加疗效,临床采用了多种联合化疗方案,大部分具有减毒增效的作用.此外,在顺铂治疗胃癌的细... 顺铂(cisplatin),是临床应用最为广泛的一种抗癌药物.近年来,应用顺铂治疗胃癌取得了长足进展.顺铂的主要副作用是骨髓抑制,为减轻其毒副作用,增加疗效,临床采用了多种联合化疗方案,大部分具有减毒增效的作用.此外,在顺铂治疗胃癌的细胞生物学及分子生物学方面也进行了大量的研究,对顺铂抗癌作用机制的阐明以及临床合理用药具有重要的意义. 展开更多
关键词 顺铂 胃癌 治疗
原发性胆囊癌CT误诊原因分析
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作者 谢胜利 杨红梅 +1 位作者 阎辉 赵绪珍 《临床误诊误治》 2004年第3期 205,共1页
原发性胆囊癌是恶性程度较高的肿瘤,有文献报道CT诊断正确率为50%~60%[1],易造成误诊.我院1995年5月~2003年6月经手术病理证实的胆囊癌24例,其中CT误诊14例(58%),现分析报告如下.
关键词 原发性胆囊癌 CT检查 影像学诊断 误诊 胆囊炎 胆囊息肉
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新型造影剂与灰阶超声造影技术对肝肿瘤的诊断价值 预览 被引量:153
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作者 陈敏华 严昆 《中华超声影像学杂志》 CSCD 2004年第1期 38-42,共5页
目的探讨新型超声造影剂与实时灰阶造影匹配成像技术观察肝肿瘤的灌注过程及回声变化规律,探讨其对肝恶性肿瘤的诊断价值.方法 35例超声不能完全明确诊断或漏诊的肝占位患者,26例经手术或穿刺病理确诊,9例为造影CT、磁共振等临床资料证... 目的探讨新型超声造影剂与实时灰阶造影匹配成像技术观察肝肿瘤的灌注过程及回声变化规律,探讨其对肝恶性肿瘤的诊断价值.方法 35例超声不能完全明确诊断或漏诊的肝占位患者,26例经手术或穿刺病理确诊,9例为造影CT、磁共振等临床资料证实,恶性肿瘤占28例.采用第二代新型造影剂SonoVue以及Technos DU6实时超声造影匹配成像技术.造影剂注射方法分别采用静脉快速团注法和慢注法两种.首先观察了正常肝、肝硬化注射造影剂后各个时相出现的时间及峰值,在此基础上观察了肝占位病变的造影剂灌注过程.结果显示典型的原发性肝癌23例均发生动脉早期强化,21例(91%)呈快速消退即"快进快出"型,另2例<2 cm的高分化小肝癌表现为动脉早期强化,但消退缓慢.肝转移性肿瘤5例表现多样,呈动脉期或门脉期环状强化或不同程度强化,消退可快可慢.肝血管瘤3例动脉期瘤内无强化,门静脉期呈向心性填充增强,持续时间长,数分钟后消退.对原发性肝癌23例进行了两种不同注射方法的比较,发现团注法使肝癌病灶更快达到增强峰值,更有利于肝癌特征的显示.本组中31例进行了超声造影前、造影后、增强CT的诊断结果比较,肿瘤病灶的显示分别为76灶、99灶、75灶.11例恶性肿瘤病灶数目较造影前增多,其中87%(20/23灶)为3~10 mm小病灶.另5例显示原病灶范围较前增大.结论新型超声造影技术对肝占位病变的定性诊断明显优于常规超声;在显示肿瘤数目尤其发现微小病灶方面更优于增强CT,从而极大地提高了超声对肝占位病变的诊断价值. 展开更多
关键词 造影剂 灰阶超声造影 肝肿瘤 诊断 肝占位病变
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三羟异黄酮抗肝癌作用研究进展 预览 被引量:2
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作者 戴胜兰 白文元 《国外医学:肿瘤学分册》 2004年第5期 377-380,共4页
原发性肝癌为我国常见的恶性肿瘤之一,其死亡率在消化系统恶性肿瘤中列第三位,对无法手术的晚期肝癌,寻求有效的非细胞毒药物进行综合治疗以改善预后,提高生活质量十分必要.三羟异黄酮属于异黄酮化合物,为一弱植物雌激素,有研究表明三... 原发性肝癌为我国常见的恶性肿瘤之一,其死亡率在消化系统恶性肿瘤中列第三位,对无法手术的晚期肝癌,寻求有效的非细胞毒药物进行综合治疗以改善预后,提高生活质量十分必要.三羟异黄酮属于异黄酮化合物,为一弱植物雌激素,有研究表明三羟异黄酮具有抗肿瘤作用.现就三羟异黄酮与肝癌这一领域的研究进展作一综述. 展开更多
关键词 三羟异黄酮 肝癌 研究进展 植物雌激素 肿瘤化学预防剂
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经内镜网状记忆合金支架治疗食道、贲门狭窄性疾病的临床研究 预览
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作者 程岭 宋征武 +1 位作者 施光亚 张元庆 《淮海医药》 1996年第4期 3-4,共2页
经内镜网状记忆合金支架治疗食道贲门狭窄性疾病.其中食管癌7例.食管癌术后吻合口狭窄1例,伴有食管气管痿2例。其吞咽困难症状均获得明显改善,无出血穿孔等并发症.结果表明:试治疗方法简便、安全、疗效显著,网状支架组织相容性... 经内镜网状记忆合金支架治疗食道贲门狭窄性疾病.其中食管癌7例.食管癌术后吻合口狭窄1例,伴有食管气管痿2例。其吞咽困难症状均获得明显改善,无出血穿孔等并发症.结果表明:试治疗方法简便、安全、疗效显著,网状支架组织相容性好.无毒付作用。是食管、贲门狭窄性疾病较为理想的治疗方法之一。 展开更多
关键词 内镜 网状记忆合金支架 治疗 食道狭窄性疾病 贲门狭窄性疾病 食管癌
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网膜肉瘤根治性手术11例治疗体会
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作者 杨絮 赵亮 +1 位作者 孙晓义 史炼钢 《腹部外科》 2004年第3期135-135,共1页
我院从1995年~2002年10月采用根治性手术治疗网膜肉瘤共11例,经临床观察取得了满意的疗效。现报道如下。
关键词 网膜肉瘤 根治性手术 治疗 CT 疗效观察
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肝癌破裂出血的肝动脉化疗栓塞术与手术治疗疗效对比 预览 被引量:1
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作者 简永平 《现代诊断与治疗》 CAS 2016年第1期135-136,共2页
回顾性分析收治的50例肝癌破裂出血患者的临床资料,分为手术组(24例,采用手术切除治疗)和TACE组(26例,采用TACE治疗),随访1年,比较两组疗效、并发症情况及生存时间。TACE组止血成功率为100%,优于手术组的83.3%(P〈0.05);TACE组并... 回顾性分析收治的50例肝癌破裂出血患者的临床资料,分为手术组(24例,采用手术切除治疗)和TACE组(26例,采用TACE治疗),随访1年,比较两组疗效、并发症情况及生存时间。TACE组止血成功率为100%,优于手术组的83.3%(P〈0.05);TACE组并发症发生率为7.7%,低于手术组的37.5%(P〈0.05),治疗后TACE组生命体征很快稳定,复查肿瘤均减小,手术组出现术后因循环功能衰竭死亡1例,其他患者全部恢复出院;TACE组术后1年生存率为46.2%,高于手术组的16.7%(P〈0.05)。对于病情危重的肝癌破裂出血患者,TACE是一种控制出血、挽救生命的非常有效的治疗手段,可显著降低患者肿瘤腹腔种植转移率,提高生存率。 展开更多
关键词 经导管肝动脉化疗栓塞术 肝切除术 肝癌 破裂出血
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磁共振扩散加权成像对肝脏肿瘤的诊断价值 被引量:2
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作者 徐兴强 《深圳中西医结合杂志》 2016年第4期84-85,共2页
目的:探讨磁共振扩散加权成像(DWI)对肝脏肿瘤的诊断价值。方法:对在本院接受上腹部核磁共振成像检查的40例患者资料进行回顾性分析,所有患者依据要求行上腹部平扫及扩散加权成像扫描,拟合表观扩散系数(ADC)图,并对测定值加以统... 目的:探讨磁共振扩散加权成像(DWI)对肝脏肿瘤的诊断价值。方法:对在本院接受上腹部核磁共振成像检查的40例患者资料进行回顾性分析,所有患者依据要求行上腹部平扫及扩散加权成像扫描,拟合表观扩散系数(ADC)图,并对测定值加以统计分析。结果:选择低B值差,所有患者ADC值均高于高B值差时ADC值,且伴随B值差增大,则ADC值减少。且B值=500 s/mm~2时,血管瘤及肝囊肿的ADC均高于转移瘤和原发性肝癌,差异具有统计学意义(P〈0.01)。结论:应用ADC值可提高对肝脏肿瘤的诊断与鉴别能力。 展开更多
关键词 磁共振扩散加权成像 肝脏肿瘤 诊断价值
晚期胃癌应用卡培他滨维持化疗治疗的效果分析 预览 被引量:2
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作者 高健 《中国卫生标准管理》 2016年第4期97-98,共2页
目的分析晚期胃癌应用卡培他滨维持化疗治疗的临床治疗效果。方法选择2013年1月~2015年5月我院收治的72例晚期胃癌患者作为研究对象,随机把72例患者分为对照组与观察组,对照组给予常规治疗,观察组在对照组治疗基础上应用卡培他滨维持化... 目的分析晚期胃癌应用卡培他滨维持化疗治疗的临床治疗效果。方法选择2013年1月~2015年5月我院收治的72例晚期胃癌患者作为研究对象,随机把72例患者分为对照组与观察组,对照组给予常规治疗,观察组在对照组治疗基础上应用卡培他滨维持化疗治疗,比较两组临床疗效。结果观察组治疗总有效率高于对照组,观察组远期存活率优于对照组,观察组毒副反应率低于对照组,两组对比差异具有统计学意义(P〈0.05)。结论晚期胃癌应用卡培他滨维持化疗效果理想,可以提高临床疗效,降低毒副反应,提高患者远期存活率。 展开更多
关键词 晚期 胃癌 卡培他滨 化疗
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人参皂甙Rg3联合奥沙利铂、索拉非尼对于肝癌细胞凋亡的影响 预览
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作者 张秀红 《临床医学研究与实践》 2016年第4期43-43,48共2页
目的观察人参皂甙Rg3、奥沙利铂及索拉非尼对肝癌细胞凋亡的影响。方法选取人体肝癌细胞80株,随机均分为对照组与观察组,对照组采用奥沙利铂与索拉菲尼2种药物联合作用,观察组采用人参皂甙Rg3、索拉菲尼以及奥沙利铂3药联合作用,观察两... 目的观察人参皂甙Rg3、奥沙利铂及索拉非尼对肝癌细胞凋亡的影响。方法选取人体肝癌细胞80株,随机均分为对照组与观察组,对照组采用奥沙利铂与索拉菲尼2种药物联合作用,观察组采用人参皂甙Rg3、索拉菲尼以及奥沙利铂3药联合作用,观察两组肝癌细胞的增殖情况、癌细胞早期凋亡情况与癌细胞中晚期凋亡情况。结果观察组肝癌细胞的抑制率、细胞凋亡率及凋亡指数显著高于对照组(P〈0.05)。结论人参皂甙Rg3能够加速肝癌细胞的凋亡,在肝癌细胞凋亡中有着非常重要的作用。 展开更多
关键词 人参皂甙RG3 奥沙利铂 索拉菲尼
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SIB-IMRT技术在颈及胸上段食管癌中的临床应用 被引量:6
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作者 白文文 宋玉芝 +5 位作者 刘明 周志国 张若辉 李静 甄婵军 乔学英 《中华肿瘤防治杂志》 CAS 北大核心 2016年第4期248-252,共5页
目的全程局部同步推量调强放疗((simultaneous integrated boost intensity modulated radiation therapy,SIB-IMRT)技术的生物效应剂量具有可行性,但目前有前食管癌SIB-IMRT临床疗效的研究相对有限。本研究旨在观察颈及胸上段食管... 目的全程局部同步推量调强放疗((simultaneous integrated boost intensity modulated radiation therapy,SIB-IMRT)技术的生物效应剂量具有可行性,但目前有前食管癌SIB-IMRT临床疗效的研究相对有限。本研究旨在观察颈及胸上段食管癌患者SIB-IMRT的急性毒副作用、生存情况及治疗失败原因。方法收集2006—01—01—2012—08—01河北医科大学第四医院63例颈及胸上段食管鳞癌患者接受SIB-IMRT,计划靶体积(planning target volume,PTV)处方剂量50.4~60.0Gy/28-30次(1.8~2.0Gy/次),大体肿瘤体积(grosstumorvolume,GTV)处方剂量60~66Gy/28-30次(2.00~2.27Gy/次),1次/d,5次/周,全程放疗时间为5.5~6周。观察其近期疗效、急性毒副作用、治疗失败方式及1、3、5年局部控制率和生存率。结果随访率98.4%,随访结束后存活患者的中位随访时间为42个月。全组近期总有效率96.8%(61/63)。全组1、3、5年局部控制率分别为68.8%、57.1%和47.2%,生存率分别为82.5%、45.7%和31.6%,中位生存期24个月。全组单因素分析显示,瘤体最大直径是影响生存的因素,x2=8.75,P=0.003;而性别、年龄、原发部位、造影长度、N分期、选择性淋巴引流区照射和化疗与生存无明显相关。Cox多因素分析显示,瘤体最大直径影响生存的独立因素,x2=7.33,P=0.007。1、2级急性放射性肺炎的发生率分别为12.7%(8/63)和3.2%(2/63),1、2、3级急性放射性食管炎的发生率分别为58.7%(37/63)、6.3%(4/63)和1.6%(1/63),无4度骨髓抑制的发生。肿瘤局部未控和复发占总治疗失败的58.3%(21/36)。结论SIB-IMRT治疗颈及胸上段食管癌有效,且患者耐受性好,瘤体最大直径为影响生存的独立预后因素,肿瘤局部未控和复发仍为治疗失败的主要原因。其长期生存� 展开更多
关键词 食管癌 放射治疗 全程局部同步推量调强放疗 疗效
抑癌基因XEDAR和LKb1在胃癌中表达及预后关系的研究 预览
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作者 高阳 白艳红 《菏泽医学专科学校学报》 2016年第1期27-28,共2页
目的探讨抑癌基因XEDAR和LKb1在胃癌中表达及预后关系。方法采用免疫组织化学(SP)法检测115例胃癌组织和20例胃正常组织中LKB1的表达及预后关系。结果抑癌基因XEDAR在胃癌组织中有多种表达形式,其中以低表达或不表达为主。胃癌患者黏... 目的探讨抑癌基因XEDAR和LKb1在胃癌中表达及预后关系。方法采用免疫组织化学(SP)法检测115例胃癌组织和20例胃正常组织中LKB1的表达及预后关系。结果抑癌基因XEDAR在胃癌组织中有多种表达形式,其中以低表达或不表达为主。胃癌患者黏膜组织的临床分期、淋巴转移、LAuren's分型以及患者预后与抑癌基因LKB1的表达低有关(P〈0.05)。结论 XEDAR基因作为抑癌基因参与胃癌的发生和发展;胃癌组织黏膜的发展演变与LKB1的表达低有关,并且对于评估胃癌的恶性程度及其预后判断具有重要的临床参考价值。 展开更多
关键词 抑癌基因 XEDAR LKB1 胃癌
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