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Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve:galectin-3 participation 预览
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作者 Henrique Rocha Mendonca Raul Carpi-Santos +1 位作者 Karin da Costa Calaza Ana Maria Blanco Martinez 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期625-635,共11页
Diabetes is a lifelong disease characterized by glucose metabolic imbalance,in which low insulin levels or impaired insulin signaling lead to hyperglycemic state.Within 20 years of diabetes progression,95%of patients ... Diabetes is a lifelong disease characterized by glucose metabolic imbalance,in which low insulin levels or impaired insulin signaling lead to hyperglycemic state.Within 20 years of diabetes progression,95%of patients will have diabetic retinopathy,the leading cause of visual defects in working-age people worldwide.Although diabetes is considered a microvascular disease,recent studies have shown that neurodegeneration precedes vascular changes within the diabetic visual system,albeit its mechanisms are still under investigation.Neuroinflammation and oxidative stress are intrinsically related phenomena,since macrophage/microglia and astrocytes are the main sources of reactive oxygen species during central nervous system chronic degenerative diseases,and both pathological processes are increased in the visual system during diabetes.The present review will focus on recent findings of the contribution of oxidative stress derived from neuroinflammation in the early neurodegenerative aspects of the diabetic visual system and their relationship with galectin-3. 展开更多
关键词 diabetes diabetic RETINOPATHY GALECTIN-3 NEURODEGENERATION NEUROINFLAMMATION optic nerve oxidative stress retina
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Prevalence of diabetic retinopathy, proliferative diabetic retinopathy and non-proliferative diabetic retinopathy in Asian T2DM patients: a systematic review and Metaanalysis
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作者 Qian-Hui Yang Yan Zhang +1 位作者 Xiao-Min Zhang Xiao-Rong Li 《国际眼科杂志:英文版》 SCIE CAS 2019年第2期302-311,共10页
AIM:To investigate the pooled prevalence of diabetic retinopathy(DR), proliferative DR(PDR) and nonproliferative DR(NPDR) in Asian type 2 diabetes mellitus(T2 DM) patients. METHODS:We performed a systematic search onl... AIM:To investigate the pooled prevalence of diabetic retinopathy(DR), proliferative DR(PDR) and nonproliferative DR(NPDR) in Asian type 2 diabetes mellitus(T2 DM) patients. METHODS:We performed a systematic search online search using PubMed, EMBASE, Web of Science, the Cochrane Library, and China WeiPu Library to identify eligible studies that reported the prevalence of DR, PDR and NPDR in Asian T2 DM patients. Effect size(ES) with 95% confidence interval(CI) was used to evaluate the prevalence of DR, PDR and NPDR in Asian T2 DM patients, respectively. RESULTS:There were 41 references and 48 995 T2 DM patients involved in this study. The prevalence of DR, PDR, and NPDR was 28%, 6%, and 27% in T2 DM patients, respectively;while the prevalence of PDR and NPDR in DR patients was 17% and 83%, respectively. Subgroup analysis showed that prevalence of DR in T2 DM patients from Singaporean, Indian, South Korean, Malaysian, Asian, and Chinese was 33%, 42%, 16%, 35%, 21% and 25%, respectively. In T2 DM patients with NPDR from Indian, South Korean, Malaysian, Asian, Chinese, higher prevalence was found than that in PDR patients(45% vs 17%, 13% vs 3%, 30% vs 5%, 23% vs 2% and 22% vs 3%), as well as in DR patients(74% vs 26%, 81% vs 19%, 86% vs 14%, 92% vs 8% and 85% vs 15%). The prevalence of PDR in T2 DM from India was higher than patients fromother locations of Asia, and the same results were also observed in NPDR patients. CONCLUSION:In either T2 DM Asian patients or DR patients, NPDR is more common than PDR. Based on our results, we should pay more attention to NPDR screening and management in T2 DM patients, and we also recommend suitable interventions to prevent its progression. 展开更多
关键词 PREVALENCE PROLIFERATIVE DIABETIC RETINOPATHY nonproliferative DIABETIC RETINOPATHY ASIAN type 2 diabetes MELLITUS
Ocular Fundus Abnormalities in Pre-Dialytic Chronic Kidney Disease Patients 预览
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作者 Mohammad Kamrul Ahsan Muhammad Rafiqul Alam +7 位作者 Asia Khanam A. H. Hamid Ahmed Md. Omar Faroque K. B. M. Hadiuzzaman A. K. M. Shahidur Rahman Rafi Nazrul Islam Manik Chandra Mondal Md. Azizur Rahman 《生物科学与医学(英文)》 2019年第11期20-35,共16页
Background: Chronic kidney disease (CKD) affects 10% - 16% of the adult population. Although ocular findings related to renal insufficiency include cataract, conjunctival calcification, lid edema, conjunctival pallor ... Background: Chronic kidney disease (CKD) affects 10% - 16% of the adult population. Although ocular findings related to renal insufficiency include cataract, conjunctival calcification, lid edema, conjunctival pallor and xanthalesma, by far the most important is retinopathy. Objective: To evaluate the ocular fundus abnormalities in pre-dialytic chronic kidney disease patients of the adult population. Methodology: This cross-sectional observational study was conducted in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from April 2012 to March 2014. A total of 100 hospital admitted CKD patients were purposively selected for this study. Age, gender, blood pressure, Body Mass Index (BMI), 24 hours Urinary Total Protein (UTP), haemoglobin level, serum creatinine, serum cholesterol, serum triglyceride and color fundus photography findings of both eyes were recorded for each patient. Inter-group comparisons were made between patients with retinopathy and those without retinopathy. Results: Out of 100 adult non-dialytic CKD patients, 43 (43%) had ocular fundus abnormalities, among them 27 (62.8%) were male and 16 (37.2%) were female. The risk of development of retinopathy was significantly higher among older patients (p = 0.006), those with low haemoglobin level (p = 0.0001) and high blood pressure. Retinopathy was significantly (p = 0.0001) increased with reduction of e-GFR. There was no relationship between BMI and high serum triglyceride level with retinal abnormality. Among 43 (43%) patients with retinal abnormality, 30 (69.76%) patients showed only hypertensive retinopathy and 5 (11.6%) patients showed only diabetic retinopathy. Mixed hypertensive and diabetic retinopathy was found in 8 (18.6%) patients. Maculopathy was seen in 11 (25.58%) patients, of whom 3 (6.98%) had hypertensive retinopathy and 8 (18.87%) had diabetic retinopathy. Optic atrophy was seen in 2 (4.6%) patients and drusen like retinal deposits were seen in 2 (4.6%) patients. Conclusion: Ocular fu 展开更多
关键词 Chronic KIDNEY Disease (CKD) OCULAR FUNDUS RETINOPATHY
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Increased plasma galectin-1 correlates with advanced glycation end products and interleukin-1β in patients with proliferative diabetic retinopathy
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作者 Keitaro Hase Atsuhiro Kanda +1 位作者 Kousuke Noda Susumu Ishida 《国际眼科杂志:英文版》 SCIE CAS 2019年第4期692-694,共3页
Dear Editor,Galectin-1, one of galactoside-binding lectin family proteins, has been shown to regulate cell growth, migration, and proliferation, where it binds many receptors depending on their glycosylation profile, ... Dear Editor,Galectin-1, one of galactoside-binding lectin family proteins, has been shown to regulate cell growth, migration, and proliferation, where it binds many receptors depending on their glycosylation profile, rather than its specific receptors. 展开更多
关键词 INCREASED plasma GALECTIN-1 CORRELATES with advanced glycation end products and INTERLEUKIN-1Β in patients with proliferative DIABETIC RETINOPATHY DIABETIC RETINOPATHY
Ⅱ型糖尿病并发视网膜病变患者外周血炎症因子及血管内皮生长因子指标变化的临床研究
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作者 陈丽娜 刘焕梅 《中国实用医刊》 2019年第8期45-48,共4页
目的探讨Ⅱ型糖尿病并发视网膜病变(PDR)患者外周血炎症因子及血管内皮生长因子(VEGF)指标的变化情况。方法选取2016年10月至2018年9月胶州市人民医院治疗的216例Ⅱ型糖尿病患者的临床资料,根据患者是否发生PDR将其分为PDR组(n=102)与非... 目的探讨Ⅱ型糖尿病并发视网膜病变(PDR)患者外周血炎症因子及血管内皮生长因子(VEGF)指标的变化情况。方法选取2016年10月至2018年9月胶州市人民医院治疗的216例Ⅱ型糖尿病患者的临床资料,根据患者是否发生PDR将其分为PDR组(n=102)与非PDR组(n=114)。检测并比较两组患者外周血相关指标和生化指标。外周血相关指标包括:C-反应蛋白(CRP)、血管内皮生长因子(VEGF)、白细胞介素-10(IL-10)与白细胞介素-6(IL-6)。生化指标包括总胆固醇(TC)、三酰甘油(TG)与糖化血红蛋白(HbA1c),每个指标检测3次取平均值。结果与非PDR组比较,PDR组患者外周血IL-6与VEGF水平升高(t=5.777、19.057,P均<0.01)。与非PDR组患者比较,PDR组患者HbA1c水平升高(t=16.570,P<0.01)。Pearson相关性检验表明,IL-6、HbA1c与VEGF呈正相关(r=0.714、0.676,P均<0.01)。结论Ⅱ型糖尿病合并PDR患者外周血VEGF水平显著升高,可能与促炎介质及高血糖共同导致患者发生眼部病变。 展开更多
关键词 Ⅱ型糖尿病 视网膜病变 炎症因子 血管内皮生长因子
LncRNA在视网膜病中的作用
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作者 涂园园 朱曼辉 管怀进 《国际眼科纵览》 2019年第4期260-264,共5页
长链非编码RNA(long non-coding RNA,LncRNA)是一类长度>200nt,生物来源广泛、二级及三级结构高度保守的RNA分子.LncRNA生物学功能丰富,它们仅有有限的编码蛋白质的能力,绝大多数以RNA的形式在转录水平、转录后水平、表观遗传学修饰... 长链非编码RNA(long non-coding RNA,LncRNA)是一类长度>200nt,生物来源广泛、二级及三级结构高度保守的RNA分子.LncRNA生物学功能丰富,它们仅有有限的编码蛋白质的能力,绝大多数以RNA的形式在转录水平、转录后水平、表观遗传学修饰等多个层面上调控基因的表达.LncRNA通过调节视网膜血管内皮、色素上皮细胞及神经细胞等功能在视网膜病中发挥重要作用,为防治研究视网膜疾病提供一定的策略和方向. 展开更多
关键词 长链非编码RNA 视网膜病
Does the scleral encircling band provide a protective effect against the progression of diabetic retinopathy?
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作者 Hossam Youssef Abouelkheir Amani E Badawi +5 位作者 Amr M.Abdelkader Amr El-Kanishy Sameh Saleh Waleed Ali Abou Samra Manal Ali Kasem Tharwat Mokbel 《国际眼科杂志:英文版》 SCIE CAS 2019年第9期1408-1414,共7页
AIM: To evaluate the effect of scleral encircling bands on the development and progression of diabetic retinopathy(DR) in diabetic patients.METHODS: The medical records of diabetic patients who underwent unilateral re... AIM: To evaluate the effect of scleral encircling bands on the development and progression of diabetic retinopathy(DR) in diabetic patients.METHODS: The medical records of diabetic patients who underwent unilateral retinal detachment(RD) surgery using scleral buckle and encircling band were reviewed retrospectively. Both eyes of patients were included in the study: one eye in each patient had a scleral buckle with encircling band(the operated eye) and the other one is the non-operated eye. The demographic characters, duration of diabetes and period between surgery and the last recall visit were retrieved from each patient. All the cases underwent fundus photo and fluorescein angiography(when indicated) to confirm the DR staging.RESULTS: Totally 25 patients fulfilled the inclusion and the exclusion criteria were become eligible for the study. A total of 50 eyes of 25 patients were enrolled in this analysis. The mean period of time passed from surgery with encircling band and the last reassessment visit was 12.5±2 y. Even though DR could develop in the operated eyes, it was at a less degree of severity compared to the non-operated eyes of same patients(P=0.027).CONCLUSION: Scleral encircling bands have protective effects against the development and progression of DR. 展开更多
关键词 diabetic RETINOPATHY scleral ENCIRCLING BANDS RETINAL DETACHMENT
早产儿视网膜病变筛查结果及高危因素研究 预览 被引量:1
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作者 吴华启 刘志坚 刘强 《吉林医学》 CAS 2019年第2期206-207,共2页
目的:探讨早产儿视网膜病变筛查结果及其高危因素。方法:选取出生的胎龄≤33周早产儿174例,对早产儿性别、胎龄、体重、贫血与否、呼吸机使用与否、输血情况等资料进行记录,分析探究早产儿视网膜病变高危因素。结果:筛查结果显示早产儿... 目的:探讨早产儿视网膜病变筛查结果及其高危因素。方法:选取出生的胎龄≤33周早产儿174例,对早产儿性别、胎龄、体重、贫血与否、呼吸机使用与否、输血情况等资料进行记录,分析探究早产儿视网膜病变高危因素。结果:筛查结果显示早产儿视网膜病变28例,其中1期病变4例,2期病变12例,3期病变12例;早产儿视网膜病变组出生胎龄小于非视网膜病变组,出生体重低于非视网膜病变组,呼吸机使用、输血占比均高于非视网膜病变组,差异有统计学意义(P <0. 05)。结论:早产儿视网膜病变临床较为常见,具体发病与胎龄、体重、输血、呼吸机使用等因素密切相关,为了及时有效地控制病情,临床应做好筛查工作,明确高危因素,以此开展科学、有效的预防和控制工作。 展开更多
关键词 早产儿 视网膜病变 发病情况 影响因素
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The process of retinal vascularization in retinopathy of prematurity after ranibizumab treatment in China
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作者 Qing-Yu Meng Yong Cheng +1 位作者 Ming-Wei Zhao Jian-Hong Liang 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1146-1150,共5页
AIM: To explore the process of retinal vascularization and risk factors for retinopathy of prematurity (ROP) treated with intravitreal ran ibizumab (IVR) as mono therapy.METHODS: Infants with type 1 ROP who received I... AIM: To explore the process of retinal vascularization and risk factors for retinopathy of prematurity (ROP) treated with intravitreal ran ibizumab (IVR) as mono therapy.METHODS: Infants with type 1 ROP who received IVR as primary treatment from August 2014 to October 2016 at Peking University People's HospitaPs Ophthalmology Department were included in the study. All eyes received 0.25 mg ranibizumab at initial treatment. Retinal vascularization was evaluated clinically. Potential risk factors were also recorded and examined.RESULTS: Retinal vascularization was completed in 126 eyes (62.7%), and retinal vascularization terminated in zone Ⅱ and zone Ⅲ with 16 eyes (7.9%) and 44 eyes (21.9%), respectively, after more than 1-year follow-up. In multivariate regression analysis, lower birth weight (BW), severity of ROP and repeated injections were found to be risk factors for peripheral avascular area (P<0.05).CONCLUSION: In our retrospective study, 29.8% of the ROP eyes treated with ranibizumab have peripheral avascular area at the last follow-up. Lighter BW and the severity of ROP are risk factors. Furthermore, repeated injections also increase the risk of retinal peripheral avascular area remaining in ROP patients. 展开更多
关键词 RETINAL VASCULARIZATION RETINOPATHY of PREMATURITY RANIBIZUMAB AVASCULAR RETINAL area
Artificial intelligence on diabetic retinopathy diagnosis: an automatic classification method based on grey level co-occurrence matrix and naive Bayesian model
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作者 Kai Cao Jie Xu Wei-Qi Zhao 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1158-1162,共5页
AIM: To develop an automatic tool on screening diabetic retinopathy(DR) from diabetic patients.METHODS: We extracted textures from eye fundus images of each diabetes subject using grey level co-occurrence matrix metho... AIM: To develop an automatic tool on screening diabetic retinopathy(DR) from diabetic patients.METHODS: We extracted textures from eye fundus images of each diabetes subject using grey level co-occurrence matrix method and trained a Bayesian model based on these textures. The receiver operating characteristic(ROC) curve was used to estimate the sensitivity and specificity of the Bayesian model.RESULTS: A total of 1000 eyes fundus images from diabetic patients in which 298 eyes were diagnosed as DR by two ophthalmologists. The Bayesian model was trained using four extracted textures including contrast, entropy, angular second moment and correlation using a training dataset. The Bayesian model achieved a sensitivity of 0.949 and a specificity of 0.928 in the validation dataset. The area under the ROC curve was 0.938, and the 10-fold cross validation method showed that the average accuracy rate is 93.5%.CONCLUSION: Textures extracted by grey level cooccurrence can be useful information for DR diagnosis, and a trained Bayesian model based on these textures can be an effective tool for DR screening among diabetic patients. 展开更多
关键词 GREY level CO-OCCURRENCE matrix BAYESIAN textures artificial INTELLIGENCE receiver operating characteristiccurve diabetic RETINOPATHY
某三级甲等医院住院糖尿病患者视网膜病变知晓率调查 预览
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作者 吴真祎 彭涛 +1 位作者 谢美娜 沈秋华 《中国医院统计》 2019年第2期127-129,共3页
目的调查分析本院糖尿病患者对视网膜病变知识的知晓和掌握程度,并对健康宣教后的效果进行评价。方法选取2017年10月至2018年10月在我院内分泌科住院的100例糖尿病患者作为研究对象,患者均行眼底镜照相,部分行眼底荧光素钠血管造影检查... 目的调查分析本院糖尿病患者对视网膜病变知识的知晓和掌握程度,并对健康宣教后的效果进行评价。方法选取2017年10月至2018年10月在我院内分泌科住院的100例糖尿病患者作为研究对象,患者均行眼底镜照相,部分行眼底荧光素钠血管造影检查,采用视网膜病变知识表对患者疾病知识掌握情况进行观察和记录,并通过卡方检验对健康宣教前后患者的行为方式及疾病进展情况进行检验。结果患者对糖尿病致眼部病变的知识掌握率为42.00%,对激光治疗视网膜病变的知晓率为40.00%,对生活行为方式影响疾病进展的知识掌握率为40.00%,低于宣教后(P<0.05);经教育后,患者对糖尿病致眼部病变的知识掌握率上升,高于宣教前(P<0.05);健康宣教前后,糖尿病患者行为方式(包括定期进行眼底检查、根据医生的要求进行眼底检查以及积极配合治疗)存在统计学差异(P<0.05);而在教育前后,糖尿病视网膜病变的疾病进展情况比较无统计学差异(P>0.05)。结论全院糖尿病患者均存在视网膜病变知识掌握率较低的情况,自我管理水平较差。通过加强对患者全面性和可行度高的健康教育引导,可以有助于避免疾病的进展。 展开更多
关键词 糖尿病 视网膜病变 健康教育 知识掌握
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糖尿病视网膜病变的数码眼底照相筛查临床探讨 预览
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作者 杨晔 莫松深 +2 位作者 褚哲 汤艳玺 程浩 《哈尔滨医药》 2019年第1期52-53,共2页
目的探讨数码眼底照相在糖尿病患者眼底筛查以及糖尿病视网膜病变(DR)诊断分期中的应用价值,以指导本病症临床诊治工作。方法选择2016年11月至2017年12月我院眼科收诊的240例(461只眼)患者,采用TOPCON TRC.50DX眼底彩色数码照相机进行... 目的探讨数码眼底照相在糖尿病患者眼底筛查以及糖尿病视网膜病变(DR)诊断分期中的应用价值,以指导本病症临床诊治工作。方法选择2016年11月至2017年12月我院眼科收诊的240例(461只眼)患者,采用TOPCON TRC.50DX眼底彩色数码照相机进行眼底照相检查,并对DR进行诊断分期。结果参与本研究的240例糖尿病患者检查出DR的62例,其中I期24例,Ⅱ期16例,Ⅲ期10例,IV期6例,V期5例,VI期1例,可采用分期治疗原则对DR患者进行治疗。结论可采用数码眼底照相方式筛查DR,提升早期检出率,指导防盲治盲工作,该检查技术在严格疾患筛查中有一定推广价值。 展开更多
关键词 糖尿病 视网膜病变 数码眼底照相 诊断分期 临床诊断
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Widefield optical coherence tomography of foveal dragging in retinopathy of prematurity
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作者 Victor M.Villegas Stephen G.Schwartz +2 位作者 Audina M.Berrocal Timothy G.Murray Harry W. Flynn Jr. 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1219-1223,共5页
Dear Editor,Despite substantial advances in neonatal medicine, retinopathy of prematurity (ROP) continues to be a serious therapeutic challenge⑴.Visual acuity loss in patients with ROP has been associated with struct... Dear Editor,Despite substantial advances in neonatal medicine, retinopathy of prematurity (ROP) continues to be a serious therapeutic challenge⑴.Visual acuity loss in patients with ROP has been associated with structural retinal abnormalities (including retinal detachment, retinal folds, and pigmentary retinopathy), cataract, glaucoma, and amblyopia due to refractive error or strabismus[2]. 展开更多
关键词 RETINOPATHY of prematurity(ROP) foveal DRAGGING structural RETINAL ABNORMALITIES
激光治疗与玻璃体腔注射对高危增殖期糖尿病视网膜病变的疗效比较 预览
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作者 王路 《大医生》 2019年第13期20-21,共2页
目的比较激光治疗与玻璃体腔注射对糖尿病视网膜病变的疗效。方法选取2017年1月至2019年1月句容市人民医收治的高危增殖期糖尿病视网膜病变60例患者,实施奇偶数法分为对照组与观察组,各30例,对照组进行激光治疗,观察组进行玻璃体腔注射... 目的比较激光治疗与玻璃体腔注射对糖尿病视网膜病变的疗效。方法选取2017年1月至2019年1月句容市人民医收治的高危增殖期糖尿病视网膜病变60例患者,实施奇偶数法分为对照组与观察组,各30例,对照组进行激光治疗,观察组进行玻璃体腔注射雷珠单抗治疗。比较两组血管内皮生长因子水平、并发症发生率、视网膜厚度、最佳矫正视力。结果治疗后观察组血清血管内皮生长因子(VEGF)水平、视网膜厚度及并发症发生率低于对照组,最佳矫正视力(BCVA)高于对照组(P<0.05)。结论对高危增殖期糖尿病视网膜病变患者实施玻璃体腔注射雷珠单抗治疗效果显著。 展开更多
关键词 糖尿病 视网膜病变 激光 玻璃体腔注射
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系统性红斑狼疮视网膜病变临床表现和实验室检查分析 预览
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作者 李芝婵 《临床医药文献杂志(电子版)》 2019年第75期7-8,共2页
目的关于系统性红斑狼疮(SLE)视网膜病变临床表现和实验室检查的探讨。方法选择收治SLE合并视网膜病变患者60例,所有患者均于2018年1月~2018年12月在我院接受治疗,对其临床表现和实验室检查结果进行研究。结果患者均存在不同程度的其他... 目的关于系统性红斑狼疮(SLE)视网膜病变临床表现和实验室检查的探讨。方法选择收治SLE合并视网膜病变患者60例,所有患者均于2018年1月~2018年12月在我院接受治疗,对其临床表现和实验室检查结果进行研究。结果患者均存在不同程度的其他器官受累情况,70.0%患者受累部位皮肤,46.67%患者受累部位是肾脏,43.33%患者受累部位是中枢神经系统;患者均处于狼疮活动期,其中70.0%患者为中度活动,实验室检查显示患者抗核抗体均为阳性,其中60.0%患者双链DNA为阳性,33.3%患者抗心磷脂抗体阳性;60例患者累及88只眼,其中伴有视力下降56例,因视力下降来院就诊14例,视力在0.1~0.5之间44只,视力在0.5以上28只眼,视力0.1以下16只;依据患者情况开展针对性治疗后,46例患者症状得到改善,14例症状无明显改善。结论视网膜病变会严重影响SLE患者视力,并对多器官造成累及,患者通常病情发展迅速。所以合并视网膜病变的SLE患者,尤其是活动期患者必须接受眼底检查,在明确诊断病情的基础上,进行针对性治疗。 展开更多
关键词 视网膜病变 系统性红斑狼疮 静脉阻塞
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康柏西普在糖尿病视网膜病变术前应用时机的研究
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作者 王嫣 张正培 +1 位作者 李甦雁 刘海洋 《中华眼外伤职业眼病杂志》 2019年第5期356-360,共5页
目的观察康柏西普在增生性糖尿病性视网膜病变(PDR)术前应用的最佳时机。方法回顾性分析2017年5月至2018年7月PDR进行玻璃体切除术75例(75眼),随机分为A、B两组,A组38例(38眼),于术前7天玻璃体内注射康柏西普;B组37例(37眼),于术前3天... 目的观察康柏西普在增生性糖尿病性视网膜病变(PDR)术前应用的最佳时机。方法回顾性分析2017年5月至2018年7月PDR进行玻璃体切除术75例(75眼),随机分为A、B两组,A组38例(38眼),于术前7天玻璃体内注射康柏西普;B组37例(37眼),于术前3天玻璃体内注射康柏西普。观察比较两组手术耗时、术中术后并发症和术后6个月的视力。结果两组患者术后视力均较术前明显提高(t=8.854,P=0.000);术后复发玻璃体积血者,A组1眼(2.6%),B组7眼(18.9%),(P=0.028)。术后出现高眼压,A组有5眼(13.2%),B组有7眼(18.9%),两组比较差异无统计学意义(χ^2=0.463,P=0.496)。两组患者手术耗时、术中视网膜出血情况、医源性裂孔发生率、硅油或气体填充率,差异均无统计学意义(P=0.502、0.518、0.304、0.444、0.720)。结论康柏西普在PDR行玻璃体切除术前应用能显著提高患者视力,术前7天应用康柏西普者术后玻璃体积血的发生率较术前3天应用者少。 展开更多
关键词 康柏西普 玻璃体内注射 视网膜病变 糖尿病性 增生性 玻璃体切除术
早产儿视网膜病变与母体因素的相关性研究 预览
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作者 卢跃兵 孙爽 黄云云 《临床研究》 2019年第8期28-29,共2页
目的研究早产儿视网膜病变(ROP)与母体因素的相关性。方法选取2016年1月-2018年12月郑州大学附属儿童医院出生的早产儿320例,其中271例未发生视网膜病变,49例发生视网膜病变,将49例发生视网膜病变的患儿转至眼科收治,分析49例早产儿发... 目的研究早产儿视网膜病变(ROP)与母体因素的相关性。方法选取2016年1月-2018年12月郑州大学附属儿童医院出生的早产儿320例,其中271例未发生视网膜病变,49例发生视网膜病变,将49例发生视网膜病变的患儿转至眼科收治,分析49例早产儿发生视网膜病变的因素,与母体因素(胎盘异常、宫内感染)具有相关性。结果49例发生视网膜病变的早产儿中,宫内感染10例,宫内感染率20.41%;胎盘异常22例,异常率44.90%;母体妊娠期疾病(高血压或糖尿病)6例,基础疾病率12.24%;羊水异常2例,异常率4.08%;与未发生视网膜病变早产儿情况相比,宫内感染11例,宫内感染率4.06%;胎盘异常90例,异常率33.21%,母体妊娠期疾病(高血压或糖尿病)32例,基础疾病率11.81%;羊水异常3例,异常率4.43%;研究结果对比,宫内感染、胎盘异常比较差异显著(P<0.05);羊水异常与基础疾病比较无显著差异(P>0.05)。结论对比分析结果表明,ROP与母体因素宫内感染和胎盘异常具有正相关,宫内感染与胎盘异常更容易引发早产儿视网膜病变,而妊娠基础疾病高血压或糖尿病等疾病、羊水异常等与早产儿视网膜病变无相关性。 展开更多
关键词 早产儿 视网膜病变 母体因素 相关性 研究
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玻璃体切除联合康柏西普治疗糖尿病视网膜病变
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作者 范卫华 《中华眼外伤职业眼病杂志》 2019年第5期361-364,共4页
目的评价玻璃体切除术联合康柏西普治疗增生型糖尿病视网膜病变(PDR)的临床效果。方法前瞻性病例对照研究。2016年10月至2017年12月收治的PDR62例(86眼),随机分为两组:单纯玻璃体切除术31例(41眼)为对照组,玻璃体切除术联合康柏西普玻... 目的评价玻璃体切除术联合康柏西普治疗增生型糖尿病视网膜病变(PDR)的临床效果。方法前瞻性病例对照研究。2016年10月至2017年12月收治的PDR62例(86眼),随机分为两组:单纯玻璃体切除术31例(41眼)为对照组,玻璃体切除术联合康柏西普玻璃体内注射31例(45眼)为联合组。术前、术后3个月和6个月检测最佳矫正视力(BCVA)、黄斑视网膜厚度以及黄斑中心区厚度(CMT),并记录并发症情况。结果联合组总有效率优于对照组(95.56%vs75.61%),差异有统计学意义(χ^2=5.5444,P=0.0185)。联合组术前、术后3个月和6个月BCVA(LogMAR)分别为1.13±0.19、0.71±0.22、0.38±0.16;而对照组分别为1.12±0.18、0.73±0.20、0.53±0.18。联合组术后6个月BCVA优于对照组,差异有统计学意义(t=4.0910,P=0.0001)。两组手术前后CMT、黄斑视网膜厚度及术后并发症发生率差异均无统计学意义(P>0.05)。结论采用玻璃体切除术联合康柏西普治疗PDR具有良好的临床效果。 展开更多
关键词 视网膜病变 糖尿病性 增生性 玻璃体切除术 康柏西普 视功能 黄斑中心区厚度
后巩膜加固术联合玻璃体切除术治疗高度近视黄斑劈裂
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作者 李琳 《中华眼外伤职业眼病杂志》 2019年第7期542-545,共4页
目的探讨后巩膜加固术联合玻璃体切除和内界膜剥除术治疗高度近视黄斑劈裂的临床效果。方法回顾性分析2014年3月至2017年2月本院高度近视黄斑劈裂37例(37眼)的资料,所有患者均应用后巩膜加固术联合玻璃体切除、内界膜剥除和空气填充术治... 目的探讨后巩膜加固术联合玻璃体切除和内界膜剥除术治疗高度近视黄斑劈裂的临床效果。方法回顾性分析2014年3月至2017年2月本院高度近视黄斑劈裂37例(37眼)的资料,所有患者均应用后巩膜加固术联合玻璃体切除、内界膜剥除和空气填充术治疗,部分合并白内障者,再联合超声乳化人工晶状体植入术。随访12个月。结果术后37眼视网膜黄斑劈裂均完全闭合。术后3个月黄斑中心区视网膜厚度均低于术前(P<0.05)。术后6个月最佳矫正视力高于术前(P<0.05),且术后12个月高于术后6个月者(P<0.05)。眼轴长度术后6个月短于术前(P<0.05),且术后12个月短于术后6个月者(P<0.01)。一过性高眼压2眼,无二次手术者,未发生其他并发症。结论后巩膜加固术联合玻璃体切除和内界膜剥除治疗高度近视黄斑劈裂,效果较好。 展开更多
关键词 加固术 后巩膜 视网膜病变 近视 高度 劈裂 黄斑
Effect of Huoxue Jiedu Recipe on the Apoptosis and Cytokine in Diabetic Retinopathy
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作者 姚青 《中国医学文摘:内科学分册(英文版)》 2019年第2期72-73,共2页
Objective To observe the effects of Huoxue Jiedu Recipe(HXJD) on the apoptosis and the expression of NF-_κB and Caspase-3 in the reina tissue of early diabetic rats. Methods The diabetic rat model was established by ... Objective To observe the effects of Huoxue Jiedu Recipe(HXJD) on the apoptosis and the expression of NF-_κB and Caspase-3 in the reina tissue of early diabetic rats. Methods The diabetic rat model was established by using one single intraperitoneal injection of streptozotocin (STZ,65 mg /kg). 展开更多
关键词 EFFECT of Huoxue Jiedu RECIPE APOPTOSIS in Diabetic RETINOPATHY
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