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自噬调控多功能蛋白p62/SQSTM1参与肿瘤及其微环境的研究进展 认领
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作者 陈佳锋 傅修涛 丁振斌 《中国临床医学》 2020年第2期321-326,共6页
自噬是细胞内高度保守循环利用细胞代谢产物及陈旧细胞器的降解途径。自噬参与肿瘤的发生、发展及转移,甚至决定肿瘤预后。多功能蛋白p62/SQSTM1不仅作为重要的自噬接头蛋白参与降解过程,还是多个关键信号通路的调控枢纽,在肿瘤及其微... 自噬是细胞内高度保守循环利用细胞代谢产物及陈旧细胞器的降解途径。自噬参与肿瘤的发生、发展及转移,甚至决定肿瘤预后。多功能蛋白p62/SQSTM1不仅作为重要的自噬接头蛋白参与降解过程,还是多个关键信号通路的调控枢纽,在肿瘤及其微环境中发挥了重要作用。本文综述p62/SQSTM1的结构功能及其作用机制的研究进展,旨在为利用自噬调节剂治疗肿瘤寻找关键突破点提供新的理论基础。 展开更多
关键词 p62/SQSTM1 自噬 肿瘤 肿瘤微环境
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Contemporary indications for and outcomes of hepatic resection for neuroendocrine liver metastases 认领
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作者 Steven D Scoville Dimitrios Xourafas +3 位作者 Aslam M Ejaz Allan Tsung Timothy Pawlik Jordan M Cloyd 《世界胃肠外科杂志:英文版(电子版)》 2020年第4期159-170,共12页
BACKGROUND Although surgical resection is associated with the best long-term outcomes for neuroendocrine liver metastases(NELM),the current indications for and outcomes of surgery for NELM from a population perspectiv... BACKGROUND Although surgical resection is associated with the best long-term outcomes for neuroendocrine liver metastases(NELM),the current indications for and outcomes of surgery for NELM from a population perspective are not well understood.AIM To determine the current indications for and outcomes of liver resection(LR)for NELM using a population-based cohort.METHODS A retrospective review of the 2014-2017 American College of Surgeons National Surgical Quality Improvement Program and targeted hepatectomy databases was performed to identify patients who underwent LR for NELM.Perioperative characteristics and 30-d morbidity and mortality were analyzed.RESULTS Among 669 patients who underwent LR for NELM,the median age was 60(interquartile range:51-67)and 51%were male.While the number of metastases resected ranged from 1 to 9,the most common(45%)number of tumors resected was one.The majority(68%)of patients had a largest tumor size of<5 cm.Most patients underwent partial hepatectomy(71%)while fewer underwent a right or left hepatectomy or trisectionectomy.The majority of operations were open(82%)versus laparoscopic(17%)or robotic(1%).In addition,30%of patients underwent intraoperative ablation while 45%had another concomitant operation including cholecystectomy(28.8%),bowel resection(20.2%),or partial pancreatectomy(3.4%).Overall 30-d morbidity and mortality was 29%and 1.3%,respectively.On multivariate analysis,American Society of Anesthesiologists class≥3[odds ratios(OR),OR=2.089,95%confidence intervals(CI):1.197-3.645],open approach(OR=1.867,95%CI:1.148-3.036),right hepatectomy(OR=1.618,95%CI:1.014-2.582),and prolonged operative time of>230 min(OR=1.731,95%CI:1.168-2.565)were associated with higher 30-d morbidity while intraoperative ablation and concomitant procedures were not.CONCLUSION LR for NELM was performed with relatively low postoperative morbidity and mortality.Concomitant procedures performed at the time of LR did not increase morbidity. 展开更多
关键词 CARCINOID Neuroendocrine tumor Primary tumor resection Intraoperative ablation CHOLECYSTECTOMY Small bowel resection
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miR-605-3p通过靶向ZIK1抑制肝细胞癌迁移和侵袭 认领
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作者 胡艳 黄智平 +2 位作者 周维 张红卫 俞雷 《实用肿瘤杂志》 CAS 2020年第1期30-36,共7页
目的探讨miR-605-3p对肝细胞癌细胞迁移和侵袭能力的影响及其相关机制。方法采用定量PCR检测80例肝癌组织及其配对癌旁组织以及肝癌细胞株(Huh7、HCC-LM3、Hep3B以及SMMC-7721)和肝细胞株(THLE-3)中miR-605-3p的表达水平。生物信息学分... 目的探讨miR-605-3p对肝细胞癌细胞迁移和侵袭能力的影响及其相关机制。方法采用定量PCR检测80例肝癌组织及其配对癌旁组织以及肝癌细胞株(Huh7、HCC-LM3、Hep3B以及SMMC-7721)和肝细胞株(THLE-3)中miR-605-3p的表达水平。生物信息学分析预测miR-605-3p结合的靶蛋白,Western blot检验ZIK1蛋白的表达情况,荧光素酶报告验证miR-605-3p与ZIK1之间的相互关联。Kaplan-Meier曲线和Log-rank分析方法比较miR-605-3p高、低表达组无进展生存期和总生存期。将SMMC-772细胞分为模拟物转染组、抑制物转染组、模拟物对照组和抑制物对照组。CCK8增殖实验检测细胞增殖能力,细胞划痕实验和transwell侵袭实验检测细胞迁移和侵袭。结果miR-605-3p在肝癌组织中表达下调(P<0.05)。以miR-605-3p在肝癌组织中位表达分为高表达和低表达组,miR-605-3p在肝癌组织低表达患者5年总生存率(21.6%vs 48.3%,P<0.05)和无进展生存率均低于高表达患者(9.5%vs 30.8%,P<0.05)。miR-605-3p抑制剂可以增强肝癌细胞迁移和侵袭能力(均P<0.05)。生物信息学分析证实,ZIK1蛋白是miR-605-3p肝癌细胞中的直接作用靶点。结论miR-605-3p在肝癌发生和发展过程中发挥作用,通过调控ZIK1的表达影响肝癌细胞的迁移和侵袭能力。 展开更多
关键词 肝细胞/病理学 微RNAS 细胞运动 肿瘤侵润 生物标记 肿瘤 肿瘤细胞 培养的 聚合酶链反应
Experimental study on the relationship between traumatic stress and tumor growth,proliferation,and metastasis 认领
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作者 Weigang Cao Baoan Qiu 《肿瘤学与转化医学:英文版》 2020年第2期52-56,共5页
Objective This study aimed to investigate the relationship between traumatic stress and tumor growth,proliferation,and metastasis.Methods A scalding method was used as an injurious factor to induce traumatic stress in... Objective This study aimed to investigate the relationship between traumatic stress and tumor growth,proliferation,and metastasis.Methods A scalding method was used as an injurious factor to induce traumatic stress in Wistar rats.The rats were randomly divided into three groups—the control group,mild-scald group,and severe-scald group,with 14 rats in each group.Wistar rats were used to subculture the Walker-256 cell line for the generation of tumor ascites.Tumor cells from the ascites were cultured and used to establish a rat subcutaneous xenograft model.After 7 days,the mild-burn group and the severe-burn group were subjected burns to 10%and 15%of their backs,respectively.Blood was taken from the tail vein of rats at different times to detect changes in blood cortisol,IL-1β,and TNF-αlevels.Pathological specimens were collected 14 days later,and immunohistochemistry was performed to examine vascular endothelial growth factor(VEGF),proliferating cell nuclear antigen(PCNA),E-cadherin,and vimentin.Results Cortisol,IL-1βand TNF-αlevels were significantly higher in the scalding groups than in the control group.Tumor examination was performed after 14 days.The changes in tumor size showed that the tumor volume in the control group(0.593±0.195 cm3)and the mild-scald group(0.782±0.344 cm3)were not significantly different.However,the tumor volume was significantly larger in the severeburn group(1.806±0.838 cm3)than in the control and the mild-burn groups(P<0.05).Tumor tissue immunohistochemistry showed that the percentage of cells expressing PCNA in the control group,mildscald group,and severe-scald group was 57.1%,71.4%and 85.7%,respectively,and the differences among the groups were statistically significant.The number of VEGF-positive cells in the mild-and severescald groups was significantly higher than those of the control group(P<0.05).The number of E-cadherinpositive cells in the tumor tissues was significantly lower in the severe-scald group than that in the control and mild-scald groups.Vimentin showed th 展开更多
关键词 stress response Wistar rats TUMOR SCALDING
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体外三维培养技术在肿瘤中的应用及进展 认领
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作者 孙跃峰 江剑 +1 位作者 王玲 王宏 《大连医科大学学报》 CAS 2020年第2期166-171,共6页
肿瘤是一种由多种致癌基因功能的获得,抑癌基因功能的丢失以及环境因素共同决定的复杂疾病。肿瘤细胞的表型异质性、细胞生物学背景以及肿瘤微环境是决定肿瘤发展过程的关键因素。体外三维细胞培养(three-dimensional cell culture,3DCC... 肿瘤是一种由多种致癌基因功能的获得,抑癌基因功能的丢失以及环境因素共同决定的复杂疾病。肿瘤细胞的表型异质性、细胞生物学背景以及肿瘤微环境是决定肿瘤发展过程的关键因素。体外三维细胞培养(three-dimensional cell culture,3DCC)可以更好地模拟真实的肿瘤细胞微环境,对探索肿瘤的发生、侵袭以及转移的分子机制起到了决定性作用。本文将结合近年来相关文献,对3DCC的建立方法及其在恶性肿瘤中的应用进展作一综述。 展开更多
关键词 三维细胞培养 肿瘤 支架 肿瘤微环境
肿瘤微环境调控能量代谢的机制及分子影像在该领域的研究进展 认领
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作者 张国建 白智刚 +2 位作者 王文睿 王雪梅 鲁海文 《医学综述》 2020年第1期59-62,70共5页
目前肺癌的各种治疗方法大多集中于肿瘤细胞本身,对于肿瘤生存的微环境及肿瘤能量代谢关注较少。肿瘤能量代谢对肺癌的发生、发展、侵袭及转移具有极其重要的作用,而乏氧微环境可能是驱动能量代谢的关键因素,但作用机制尚未完全阐明。... 目前肺癌的各种治疗方法大多集中于肿瘤细胞本身,对于肿瘤生存的微环境及肿瘤能量代谢关注较少。肿瘤能量代谢对肺癌的发生、发展、侵袭及转移具有极其重要的作用,而乏氧微环境可能是驱动能量代谢的关键因素,但作用机制尚未完全阐明。针对肿瘤微环境与能量代谢的关系及机制进行探讨,能够指导临床从能量代谢的角度寻求肿瘤治疗策略,为肿瘤治疗提供有效靶点。而利用正电子发射计算机断层显像/CT、磁共振成像等分子影像学检查方法对肿瘤能量代谢进行活体水平评估,能为临床提供一种无创的检测手段。 展开更多
关键词 肿瘤 分子影像 肿瘤微环境 能量代谢
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Torsion of Ovarian Tumor in the Elderly: About a Case 认领
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作者 Amadou Bah Ibrahima Diakite +18 位作者 Amadou Maiga Boubacar Yoro Sidibe Madiassa Konaté Zakari Saye Boureima Kelly Tany Koné Siaka Konate Arouna A. Doumbia Bathio Traore Boubacar Karembe Mohamed Lamine Diakite Amadou A. Traoré Abdoulaye Diarra Moustapha Issa Mangane Abdoul Hamidou Almeimoune Bakary T. Dembélé Alhassane Traoré Lassana Kanté Adégné Pierre Togo 《外科学(英文)》 2020年第4期69-73,共5页
We report a case of torsion of an ovarian tumor in a 68-year-old woman with no medical and surgical history. The diagnosis was made in front of an intermittently painful pelvic mass. The treatment consisted of a left ... We report a case of torsion of an ovarian tumor in a 68-year-old woman with no medical and surgical history. The diagnosis was made in front of an intermittently painful pelvic mass. The treatment consisted of a left annexectomy;the anatomopathological examination revealed a fibro-inflammatory and hemorrhagic cyst. Postoperative results were simple with a 12-month follow-up. 展开更多
关键词 TUMOR OVARY CYST SURGERY
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Advances in research on relationship between tumor immune escape and tumor microenvironment 认领
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作者 Jin-Feng Liu 《肿瘤微环境研究》 2020年第1期7-15,共9页
Tumor immune escape is an important way for tumor cells to evade surveillance and attack by host immune system and promote tumor survival and proliferation.Immunotherapy for immune escape has made significant progress... Tumor immune escape is an important way for tumor cells to evade surveillance and attack by host immune system and promote tumor survival and proliferation.Immunotherapy for immune escape has made significant progress in recent years.Immunotherapy involves multiple factors and pathways,and is associated with changes in tumor cells themselves and tumor microenvironments,and the mechanisms are complex.At present,there are still many challenges in the clinical practice process.Starting from the tumor microenvironment,the article describes the role of various cells in the tumor microenvironment on tumor cell immune escape. 展开更多
关键词 TUMOR TUMOR MICROENVIRONMENT IMMUNE ESCAPE IMMUNE cell Mechanism
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Research progress on the role of cancer-associated fibroblasts in tumorigenesis and development 认领
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作者 Xiao-Hui Liu Xiong-Zhi Wu 《肿瘤微环境研究》 2020年第1期29-33,共5页
Tumor microenvironment plays a very important role in the growth,invasion and metastasis of tumor cells.The tumor interstitial microenvironment is an important part of the tumor microenvironment,which includes two par... Tumor microenvironment plays a very important role in the growth,invasion and metastasis of tumor cells.The tumor interstitial microenvironment is an important part of the tumor microenvironment,which includes two parts:the non-cellular and cellular components of the tumor interstitium,specifically including the extracellular matrix,blood vessels,and interstitial cells.Among them,activated interstitial fibroblasts,namely cancer-associated fibroblasts(CAFs),are the main components of tumor interstitial cells,which are most closely related to tumor interstitial fibrosis and tumor progress,and are expected to become a new target for cancer treatment. 展开更多
关键词 Cancer-associated FIBROBLASTS TUMOR MICROENVIRONMENT TUMOR ANGIOGENESIS INVASION Metastasis
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肿瘤相关巨噬细胞研究进展 认领
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作者 吴从严 楼美清 +1 位作者 贾玉 赵耀东 《现代肿瘤医学》 CAS 2020年第3期508-512,共5页
巨噬细胞起源于骨髓造血干细胞和胚胎时期卵黄囊组织,根据其活化的状态、发挥的功能以及分泌因子的不同,将其分为经典活化的M1型巨噬细胞和选择性活化的M2型巨噬细胞。它们具有很强的可塑性,当局部微环境改变时,M1和M2之间可以发生相互... 巨噬细胞起源于骨髓造血干细胞和胚胎时期卵黄囊组织,根据其活化的状态、发挥的功能以及分泌因子的不同,将其分为经典活化的M1型巨噬细胞和选择性活化的M2型巨噬细胞。它们具有很强的可塑性,当局部微环境改变时,M1和M2之间可以发生相互转化。其中极化的M2型巨噬细胞被认为是肿瘤相关巨噬细胞(TAM),在肿瘤发生发展中起到重要作用,它通常由血液中单核祖细胞趋化至肿瘤组织,然后在肿瘤微环境的作用下诱导产生。而转录因子、细胞表面标记、分泌的细胞因子等标志物常被用来对其进行鉴定。近年来,TAM作为肿瘤研究中的热点,已经被证明在促进肿瘤生长、血管生成、肿瘤侵袭、抑制抗肿瘤免疫反应、耐药/耐放疗中发挥重要作用。 展开更多
关键词 肿瘤 巨噬细胞 肿瘤相关巨噬细胞
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2456例唾液腺肿瘤临床病理分析 认领
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作者 王张嵩 谢舒乐 +4 位作者 张汉卿 方泽震 李群星 范松 李劲松 《口腔疾病防治》 2020年第5期298-302,共5页
目的探讨唾液腺肿瘤的发病、病理类型等临床特点。方法收集中山大学孙逸仙纪念医院口腔颌面外科1973年1月至2018年12月间确诊的唾液腺肿瘤病例2456例患者的相关资料,回顾分析其性别、年龄、病理类型、发病部位、良恶性构成比等特点。结... 目的探讨唾液腺肿瘤的发病、病理类型等临床特点。方法收集中山大学孙逸仙纪念医院口腔颌面外科1973年1月至2018年12月间确诊的唾液腺肿瘤病例2456例患者的相关资料,回顾分析其性别、年龄、病理类型、发病部位、良恶性构成比等特点。结果46年间收治的唾液腺肿瘤患者2456例,女性比例占41.9%,男性占58.1%,40~60岁年龄段为发病高峰,其中良性肿瘤1863例(75.9%),恶性肿瘤593例(24.1%),良恶性之比为3.1∶1。良性肿瘤构成比前2位是多形性腺瘤(58.7%)、Warthin瘤(33.6%),恶性肿瘤构成比前2位是黏液表皮样癌(27.7%)、腺样囊性癌(26.1%)。最常见的良性肿瘤多形性腺瘤的好发部位是腮腺、腭部、颌下腺,而恶性肿瘤中粘液表皮样癌则常见于腮腺和腭部的小唾液腺。本组资料中唾液腺肿瘤发病呈逐年递增的趋势,近10年病例占总病例数的53.3%。结论唾液腺肿瘤病人数量逐年增加;唾液腺肿瘤的总发生率男性高于女性;大唾液腺以良性肿瘤为主,小唾液腺恶性肿瘤多见;多形性腺瘤、Warthin瘤、黏液表皮样癌最常见;40~60岁是唾液腺良、恶性肿瘤高发年龄段。 展开更多
关键词 唾液腺 肿瘤 多形性腺瘤 WARTHIN瘤 黏液表皮样癌 腺样囊性癌 病理学 回顾性分析
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肿瘤脂代谢基础及转化研究进展 认领
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作者 白明 杨佳宇 +2 位作者 王培云 左梦思 巴一 《肿瘤综合治疗电子杂志》 2020年第1期97-101,共5页
糖类、脂类、蛋白质是人体的三大营养素,其中脂类包括甘油三酯、磷脂和固醇。脂类为机体提供所需的能量和必需脂肪酸,是人体细胞组织的组成成分。多种脂类分子和代谢中间产物参与细胞信号转导及炎性反应过程,促进肿瘤的发生、发展。此外... 糖类、脂类、蛋白质是人体的三大营养素,其中脂类包括甘油三酯、磷脂和固醇。脂类为机体提供所需的能量和必需脂肪酸,是人体细胞组织的组成成分。多种脂类分子和代谢中间产物参与细胞信号转导及炎性反应过程,促进肿瘤的发生、发展。此外,脂肪酸生物合成酶也参与肿瘤的脂质代谢。而且,血脂异常也与多种实体肿瘤密切相关。因此,脂质代谢异常与肿瘤的发生、发展密切相关。本文论述了肿瘤脂代谢信号通路、相关基因、参与脂质代谢过程的相关酶、炎性细胞和炎性因子对肿瘤发生发展的影响以及几种与血脂异常密切相关的实体肿瘤,为提高肿瘤治疗疗效提供参考。 展开更多
关键词 肿瘤 脂代谢 脂筏标记蛋白 肿瘤坏死因子-Α 三磷酸腺苷柠檬酸裂解酶
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血小板介导肿瘤细胞生长和转移的机制研究进展 认领
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作者 董超男 翟文萍 王雪野 《医学综述》 2020年第4期695-699,共5页
血小板是骨髓中成熟巨核细胞脱落的细胞质片段,其基本功能是参与凝血、免疫反应及组织修复、重建等过程。近年来发现,血小板在肿瘤的形成和发展中起着至关重要的作用,其可促进肿瘤细胞的生长、转移,增强侵袭能力,协助逃避免疫系统监视,... 血小板是骨髓中成熟巨核细胞脱落的细胞质片段,其基本功能是参与凝血、免疫反应及组织修复、重建等过程。近年来发现,血小板在肿瘤的形成和发展中起着至关重要的作用,其可促进肿瘤细胞的生长、转移,增强侵袭能力,协助逃避免疫系统监视,促进血管生成及血栓形成。同时肿瘤细胞也可通过直接接触或间接作用使血小板活化,扰乱凝血系统,进一步增强肿瘤细胞的转移。因此,抗血小板可能成为抗肿瘤协同治疗的潜在靶点。 展开更多
关键词 血小板 肿瘤 肿瘤转移 血管生成 血小板活化
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基于“络病学说”分析虫类药在肿瘤患者治疗中的应用 认领
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作者 陆鑫熠 任建琳 +4 位作者 吕祥 张莹瑄 张功 王慧 吴杏黎 《世界中医药》 CAS 2020年第6期938-944,948共8页
“络病学说”作为重要的中医基础病机之一,近年来被广泛应用于肿瘤类疾病的临床诊疗中,其对于肿瘤的发生发展以及转移等机制研究与治疗均有理论指导意义。“络病”在形态与功能上与现代医学中的肿瘤微血管、微循环概念相似;瘀阻络脉与... “络病学说”作为重要的中医基础病机之一,近年来被广泛应用于肿瘤类疾病的临床诊疗中,其对于肿瘤的发生发展以及转移等机制研究与治疗均有理论指导意义。“络病”在形态与功能上与现代医学中的肿瘤微血管、微循环概念相似;瘀阻络脉与肿瘤患者血液高凝状态类似,故运用“通络法”抗肿瘤具有充足的理论依据。虫类药是动物药的别称,作为通络药的代表,善于搜刮剔络,在肿瘤的防治中起到了活血化瘀通络、攻毒散结通络、搜风解毒通络以及补益培本通络等作用。通过梳理“络病学说”的起源、发展与成熟阶段的主要思想内涵,整理并总结现代肿瘤治疗中“络病学说”的相关研究与应用,并分析虫类药在通络法中的具体应用,以期为开展中医络病防治肿瘤的临床应用提供理论依据。 展开更多
关键词 络病理论 虫类药 肿瘤 通络法 肿瘤血管新生
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Chimeric antigen receptor T cells in solid tumors: a war against the tumor microenvironment 认领
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作者 Zijun Zhao Xiaoyun Xiao +4 位作者 Phei Er Saw Wei Wu Hongyan Huang Jiewen Chen Yan Nie 《中国科学:生命科学英文版》 SCIE CAS CSCD 2020年第2期180-205,共26页
Chimeric antigen receptor(CAR) T cell is a novel approach, which utilizes anti-tumor immunity for cancer treatment. As compared to the traditional cell-mediated immunity, CAR-T possesses the improved specificity of tu... Chimeric antigen receptor(CAR) T cell is a novel approach, which utilizes anti-tumor immunity for cancer treatment. As compared to the traditional cell-mediated immunity, CAR-T possesses the improved specificity of tumor antigens and independent cytotoxicity from major histocompatibility complex molecules through a monoclonal antibody in addition to the Tcell receptor. CAR-T cell has proven its effectiveness, primarily in hematological malignancies, specifically where the CD19 CAR-T cells were used to treat B-cell acute lymphoblastic leukemia and B-cell lymphomas. Nevertheless, there is little progress in the treatment of solid tumors despite the fact that many CAR agents have been created to target tumor antigens such as CEA,EGFR/EGFRvIII, GD2, HER2, MSLN, MUC1, and other antigens. The main obstruction against the progress of research in solid tumors is the tumor microenvironment, in which several elements, such as poor locating ability, immunosuppressive cells,cytokines, chemokines, immunosuppressive checkpoints, inhibitory metabolic factors, tumor antigen loss, and antigen heterogeneity, could affect the potency of CAR-T cells. To overcome these hurdles, researchers have reconstructed the CAR-T cells in various ways. The purpose of this review is to summarize the current research in this field, analyze the mechanisms of the major barriers mentioned above, outline the main solutions, and discuss the outlook of this novel immunotherapeutic modality. 展开更多
关键词 CHIMERIC ANTIGEN T cell SOLID TUMOR TUMOR MICROENVIRONMENT
程序性死亡蛋白-1抗体治疗晚期胃癌的临床研究新进展 认领
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作者 祁松奎 解倩倩 《中国继续医学教育》 2020年第3期71-73,共3页
目前化疗仍为晚期胃癌的标准治疗手段,而多数患者诊断时已接近晚期。近年新兴的免疫治疗手段程序性死亡蛋白-1(PD-1,programmed death l)抗体,通过阻断肿瘤细胞逃避自身免疫机制,重新激活自身免疫对肿瘤的杀伤作用,从而达到肿瘤的治疗... 目前化疗仍为晚期胃癌的标准治疗手段,而多数患者诊断时已接近晚期。近年新兴的免疫治疗手段程序性死亡蛋白-1(PD-1,programmed death l)抗体,通过阻断肿瘤细胞逃避自身免疫机制,重新激活自身免疫对肿瘤的杀伤作用,从而达到肿瘤的治疗作用。针对晚期胃癌的PD-1抗体治疗的临床研究已在国内外开展,大部分均有较好效果。本文对近年免疫治疗中的PD-1抗体在晚期胃癌的重要临床研究进展进行介绍。 展开更多
关键词 胃癌 PD-1抗体 免疫治疗 肿瘤 药物治疗 消化道肿瘤
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Objective response rate assessment in oncology:Current situation and future expectations 认领
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作者 Nuri Faruk Aykan Tahsin Oatl? 《世界临床肿瘤学杂志(英文版)》 2020年第2期53-73,共21页
The tumor objective response rate(ORR)is an important parameter to demonstrate the efficacy of a treatment in oncology.The ORR is valuable for clinical decision making in routine practice and a significant end-point f... The tumor objective response rate(ORR)is an important parameter to demonstrate the efficacy of a treatment in oncology.The ORR is valuable for clinical decision making in routine practice and a significant end-point for reporting the results of clinical trials.World Health Organization and Response Evaluation Criteria in Solid Tumors(RECIST)are anatomic response criteria developed mainly for cytotoxic chemotherapy.These criteria are based on the visual assessment of tumor size in morphological images provided by computed tomography(CT)or magnetic resonance imaging.Anatomic response criteria may not be optimal for biologic agents,some disease sites,and some regional therapies.Consequently,modifications of RECIST,Choi criteria and Morphologic response criteria were developed based on the concept of the evaluation of viable tumors.Despite its limitations,RECIST v1.1 is validated in prospective studies,is widely accepted by regulatory agencies and has recently shown good performance for targeted cancer agents.Finally,some alternatives of RECIST were developed as immune-specific response criteria for checkpoint inhibitors.Immune RECIST criteria are based essentially on defining true progressive disease after a confirmatory imaging.Some graphical methods may be useful to show longitudinal change in the tumor burden over time.Tumor tissue is a tridimensional heterogenous mass,and tumor shrinkage is not always symmetrical;thus,metabolic response assessments using positron emission tomography(PET)or PET/CT may reflect the viability of cancer cells or functional changes evolving after anticancer treatments.The metabolic response can show the benefit of a treatment earlier than anatomic shrinkage,possibly preventing delays in drug approval.Computer-assisted automated volumetric assessments,quantitative multimodality imaging in radiology,new tracers in nuclear medicine and finally artificial intelligence have great potential in future evaluations. 展开更多
关键词 Objective RESPONSE rate TUMOR SHRINKAGE World Health Organization CRITERIA RESPONSE Evaluation CRITERIA in Solid TUMORS Immune RESPONSE Evaluation CRITERIA in Solid TUMORS CRITERIA Early TUMOR SHRINKAGE Depth of RESPONSE Waterfall PLOT Spider PLOT Swimmer PLOT
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The practical value of serum TK1 concentration expression in clinical research of malignant tumors 认领
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作者 Qiang Lv Yuan-Hong Zhao +5 位作者 Yu Lu Rui-Xue Yang Yuan-Tao Zhong Jie Wang Zhi-Li Zhao Long Zhang 《TMR肿瘤》 2020年第3期112-118,共7页
Objective:To investigate the expression of serum thymidine kinase 1(TK1)in malignant tumors and its relationship with common tumor markers.Methods:195 cancer patients in the First Teaching Hospital of Tianjin Universi... Objective:To investigate the expression of serum thymidine kinase 1(TK1)in malignant tumors and its relationship with common tumor markers.Methods:195 cancer patients in the First Teaching Hospital of Tianjin University of traditional Chinese medicine were selected as the subjects.The serum TK1 concentration was measured by enzyme-linked immune-electrotransfer blot and the correlation between TK1 concentration and some biological parameters of tumor patients were analyzed retrospectively.Results:The positive rate of serum TK1 in patients with tumor stage IV was higher than that in other stages(29.9%>16.4%,P=0.029<0.05).The positive rate of serum TK1 in patients with carbohydrate antigen 199(CA199)positive was higher than the negative(43.5%>19.6%,P=0.036<0.05).There was a positive correlation between serum TK1 and CA199(r=0.244,P=0.043<0.05).Conclusion:The expression of TK1 in serum is related to the proliferation of tumor cells.It is consistent with the concentration of CA199,which can be used as a combined choice for the study of digestive tract tumors,especially pancreatic cancer markers. 展开更多
关键词 Serum thymidine kinase 1 Tumor marker TUMOR Clinical Digestive system
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Salvage of Failed Osteoarticular Tibia Allografts with Knee Arthroplasties 认领
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作者 G. Ulrich Exner Pascal A. Schai +1 位作者 Tobias C. Bühler Theodore I. Malinin 《矫形学期刊(英文)》 2020年第4期67-76,共10页
Background: Limb preservation in musculoskeletal tumor surgery has largely replaced amputation. Biologic reconstructions are now performed as preferred choice;if not feasible options are “megaprostheses”, allografts... Background: Limb preservation in musculoskeletal tumor surgery has largely replaced amputation. Biologic reconstructions are now performed as preferred choice;if not feasible options are “megaprostheses”, allografts or composites. Endoprosthetic reconstructions usually provide immediate function, but fail at long term. Osteochondral allografts allow for one-to-one restoration and have potential for incorporation;however degeneration of the cartilage requiring revision almost inevitably will occur. In most cases, revision is then done by endoprosthetic replacement. Aim: In our patients, resurfacing of retained allografts failed. Problems encountered are presented and solutions proposed. Case Presentation: Resurfacing over retained allografts in the 2 index cases has resulted in failures related to fractures and instability. Revision with massive constrained endoprostheses was needed. Based on the experience with these failures, primary endoprosthetic replacement anchored in vital bone in a following case resulted in stable function. Conclusion: Knee replacement for advanced degeneration of the osteochondral allograft apparently needs choosing increased femoro-tibial constraint systems and stem extensions anchored to vital host bone. 展开更多
关键词 Tumor ALLOGRAFT ARTHROPLASTY
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Notch信号通路在肿瘤微环境中的调控作用 认领
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作者 刘晓聪 温俊杰 +2 位作者 郭家定 宁云山 李妍 《中国肿瘤》 CAS CSCD 北大核心 2020年第1期48-54,共7页
肿瘤细胞与肿瘤微环境(tumor microenvironment,TME)之间通过多种信号通路相互作用,其中Notch信号被认为是重要的信号通路之一。现已证实Notch信号与TME之间的相互作用参与调节肿瘤的血管生成、肿瘤干细胞干性的维持、免疫细胞的浸润和... 肿瘤细胞与肿瘤微环境(tumor microenvironment,TME)之间通过多种信号通路相互作用,其中Notch信号被认为是重要的信号通路之一。现已证实Notch信号与TME之间的相互作用参与调节肿瘤的血管生成、肿瘤干细胞干性的维持、免疫细胞的浸润和对治疗的抗性。此外,Notch信号还介导许多分子的分泌,影响TME中的细胞功能。大量研究表明,Notch信号在TME中的作用与不同肿瘤中Notch的促癌和抑癌特性有关。该综述讨论了Notch信号在调节TME不同组分之间的相互作用中发挥的重要作用,还从治疗的角度讨论了Notch―TME相互作用的结果。 展开更多
关键词 NOTCH信号通路 肿瘤 肿瘤微环境
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